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B-cell acute lymphoblastic leukemia: What to know – Medical News Today

B-cell acute lymphoblastic leukemia is a type of acute lymphoblastic leukemia (ALL). It is cancer that affects white blood cells known as B-cell lymphoblasts.

Lymphocytes form part of the immune system and protect the body against infections. People who have B-cell acute lymphoblastic leukemia have too many immature B-cell lymphoblasts in their bloodstream and bone marrow that do not work correctly.

As these leukemia cells increase, there are fewer healthy, mature white blood cells that fight infections and disease, red blood cells, and platelets. People with B-cell acute lymphoblastic leukemia may experience infections and anemia. They may also bleed easily.

B-cell lymphoblastic leukemia is the most common type of acute lymphoblastic leukemias or lymphomas, making up around 75% of adult leukemia cases. It can affect both adults and children.

This article looks at B cell acute lymphoblastic leukemia, as well as its causes, symptoms, and prognosis. It also explores how doctors diagnose and treat the condition.

ALL accounts for less than 0.5% of all cancers in the United States and 80% of these cases occur in children.

Doctors do not understand the exact cause of B-cell acute lymphoblastic leukemia. They do know that it involves the DNA in the bone marrow that controls how white blood cells divide, grow, and die.

In B-cell acute lymphoblastic leukemia, mutations or changes in the DNA mean that the cells do not follow the normal process of growth and maturation. Instead, the cells replicate and divide more rapidly and release immature white blood cells. These are called leukemia cells.

Mature B-cells mark infected cells with a protein, which other immune system cells then destroy. Leukemia cells are not capable of protecting the body from infection.

Scientists remain unsure why this happens but think it may be a combination of genetic and environmental factors.

Genetic changes can make someone more likely to develop leukemia by increasing the likelihood that mutations occur within their bone marrow.

For example, in adults, a change can happen if the DNA from a chromosome breaks off and attaches to a different chromosome. This is called translocation. In adults with ALL, the most common translocation is between chromosomes 9 and 22, and results in what is called the Philadelphia chromosome.

People with chromosomal conditions like Down syndrome also have an increased risk of developing B-cell acute lymphoblastic leukemia.

Usually, people develop the DNA mutations that can lead to ALL, rather than inheriting them. They may happen because the person had exposure to radiation or cancer-causing chemicals, but often the cause is unclear. Mutations can also occur because people have undergone radiotherapy and chemotherapy for other cancer.

Certain other factors can increase a persons risk of developing B-cell acute lymphoblastic leukemia, including high birth weight and smoking.

Many ALL symptoms are due to shortages of normal mature blood cells and can include:

People may also have a swollen abdomen due to a build-up of leukemia cells in the liver and spleen. If the leukemia cells build up near the surface of the bone or inside joints, this can cause pain.

Doctors diagnose ALL by using various tests to inspect the bone marrow or blood for signs of abnormal cells and to identify specific cells. Understanding someones diagnosis helps the doctor estimate how ALL may progress and determine the best treatment for them.

Tests may include:

Doctors confirm a diagnosis of ALL if 20% of the bone marrow cells are lymphoblasts.

There are no proven methods to prevent someone from developing leukemia. In general, people should avoid unnecessary exposure to cancer-causing chemicals like benzene, pesticides, and radiation as much as possible.

People should also avoid smoking and smoke inhalation, a risk factor for many cancers, including leukemias like ALL.

For adults with ALL, doctors usually use long-term chemotherapy. More intensive regimens may result in better responses but can cause more side effects, like low white blood cell counts.

Treatment usually has induction, consolidation, and maintenance phases that span around 2 years, although the ALL subtype and other factors can affect the length and intensity of the regime.

The first phase of treatment is induction therapy, which uses medication to help stabilize and reduce the number of lymphoblasts and regulate the individuals blood cell production. After this phase, for most people, the leukemia is in remission, meaning that there are no leukemia cells in bone marrow samples, and the person has normal blood counts.

The other stages of treatment aim to destroy any remaining leukemia cells in the body. The stages vary in length and intensity depending on how the leukemia responds.

Stem cell transplants are an option for some individuals to replace bone marrow affected by lymphoblasts with healthier, new bone marrow. Doctors need to match the donor bone marrow carefully to the individual.

Children with ALL receive a similar three-phase chemotherapy regime but may also need prolonged hospital stays for treatment, as infections and other complications can occur.

Children also receive chemotherapy in the cerebrospinal fluid (CSF) to kill any cancer cells in the brain and spinal cord.

The prognosis for individuals with B-cell acute lymphoblastic leukemia depends on various factors such as the persons age at diagnosis.

Children and young people are significantly more likely to undergo successful treatment and enter remission. For children with ALL, the 5-year survival rate is 85%. For adults with ALL, the 5-year survival rate is 69.9%.

A persons white blood cell count at the point of diagnosis also plays a role. People with a lower white blood cell count are more likely to make a full recovery. Additionally, how well a person responds to chemotherapy affects their recovery.

People who have concerns about ALL should contact their doctor or healthcare practitioner for advice. Cancer facilities often have support staff who can direct people to resources and support.

In the United States, the Leukemia and Lymphoma Society and American Cancer Society offer support and information for people living with ALL and other types of leukemia.

B-cell acute lymphoblastic leukemia is one of the most common types of leukemia in children but is rare in adults.

Various treatments aim to put the individual in remission and typically involve an extended chemotherapy regime.

The outlook for individuals with B-cell acute lymphoblastic leukemia is improving, especially among children, who often make a full recovery.

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B-cell acute lymphoblastic leukemia: What to know - Medical News Today

Chronic lymphocytic leukemia and stomach pain: What is the link? – Medical News Today

Chronic lymphocytic leukemia (CLL) is a type of blood cancer. It affects lymphocytes, a type of immature white blood cell that the body produces in the bone marrow.

People with CLL may experience discomfort, swelling, and pain in the abdomen if their spleen enlarges. In rare cases, CLL can also affect mucosal tissues, such as those lining the gastrointestinal (GI) tract.

This article discusses the link between CLL and stomach pain in more detail. It also looks at ways to prevent and treat CLL, the other possible symptoms, and the outlook for people with this condition.

People with CLL may experience various symptoms involving the abdomen or stomach, such as:

In most cases, people with CLL do not experience abdominal symptoms due to the disease until it progresses and becomes more severe.

Research suggests that CLL infiltrates and affects the GI tract in about 5.713% of cases. When CLL affects the GI tract, doctors may call it Richters syndrome.

People with CLL may experience abdominal swelling, discomfort, and tenderness as a result of their spleen becoming larger. Less commonly, they may also feel full after eating small amounts of food, as the spleen can press on the stomach, making it smaller and able to hold less.

In rare cases, CLL infiltrates the lining of the GI tract, causing inflammation and ulcers or open wounds. People may experience symptoms similar to those of inflammatory bowel disease (IBD) and malabsorption disorders. These symptoms may include diarrhea, nausea, vomiting, abdominal pain and cramping, and unintentional weight loss.

CLL is cancer that develops in lymphocytes, which are white blood cells that form in the bone marrow and help fight infection.

Lymphocytes make up most of the lymph tissues in the lymph nodes, thymus gland, adenoids, tonsils, and spleen. They are also present in the GI tract, bone marrow, and respiratory system.

CLL is a type of leukemia that develops gradually over time.

About 5075% of people with CLL do not experience noticeable symptoms. Due to this, doctors diagnose most people with CLL during routine blood work.

The symptoms of CLL often begin when the cancerous cells crowd out healthy cells in the bone marrow or migrate to other organs or tissues. When symptoms first appear, they are typically mild, but they then become increasingly severe. CLL can cause many nonspecific symptoms, so a person may feel as though they have a cold or the flu.

Possible symptoms of CLL that do not relate to the abdominal area include:

Doctors do not yet have a way to prevent leukemia. However, some types of leukemia, including CLL, may have links to toxins, such as herbicides, pesticides, radon, and tobacco exposure. People can help reduce the risk of CLL by avoiding or practicing extreme caution around these toxins.

Many people do not experience symptoms of CLL for years and do not require treatment. However, as the disease progresses, these individuals may need treatment to extend their lives.

When and how a doctor treats someones CLL depends on a few factors, including:

Chemotherapy is typically the first-line therapy for CLL.

Doctors may use chemotherapy in conjunction with other treatment options, such as monoclonal antibody therapy. This therapy binds antibodies to cancer cells and destroys them. Treatment can also include medications to treat or prevent infections or improve low blood cell levels.

For instance, some people may take a combination of the monoclonal antibody rituximab and the chemotherapy drugs fludarabine and cyclophosphamide. Alongside the oral chemotherapy medication chlorambucil, doctors use obinutuzumab or ofatumumab, which have the same drug target as rituximab.

Small molecule inhibitors, such as bendamustine hydrochloride, idelalisib, and ibrutinib, can also sometimes form part of a CLL treatment regimen.

In 2017, the Food and Drug Administration (FDA) approved the combination medication Rituxan Hyecela (rituximab and hyaluronidase human) for CLL treatment.

In recurring or aggressive cases of CLL, an individual may have a blood or bone marrow stem cell transplant. This procedure replaces diseased cells with healthy blood cells that are able to mature into bone marrow cells.

Doctors may treat CLL until the symptoms lessen and then stop treatment until the symptoms worsen again.

Many people with CLL live for many years with a high quality of life.

There is no cure for CLL, so treatment aims to extend and improve someones life by reducing their symptoms. Doctors treat many people intermittently as their symptoms reoccur.

A persons outlook depends on their age, overall health, underlying conditions, and stage of CLL. Typically, people who are over the age of 65 years or have a more advanced stage of CLL have a less positive outlook.

Genetic changes in CLL cells and increased beta-2 microglobulin protein levels in the blood can make CLL more challenging to treat, potentially affecting a persons outlook.

Doctors classify people with CLL into different risk groups depending on certain factors. Based on these risk groups, the estimated percentages of people surviving 5 years or more after their diagnosis is:

People with more advanced or severe CLL may experience abdominal swelling, discomfort, tenderness, and pain. They may also feel full after eating small amounts. More rarely, someone with CLL may develop GI tract inflammation or ulcers, which can cause symptoms such as diarrhea, nausea, vomiting, cramping, and unexplained weight loss.

Anyone who thinks that they may have CLL should speak with a doctor. People with a confirmed diagnosis who experience symptoms of more advanced or severe CLL, such as abdominal pain, should also seek medical care.

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Chronic lymphocytic leukemia and stomach pain: What is the link? - Medical News Today