Stem Cell Clinic

NexImmune Establishes Research Initiative with City of Hope to Focus on Novel Immunotherapeutic Approaches to Acute Myeloid Leukemia – Yahoo Finance

By adminOctober 31, 2020Stem Cell Medical Center

City of Hope will combine its world-leading expertise with NexImmune technology to explore tumor escape mechanisms and to identify unique leukemia stem cell targets for next generation immunotherapeutics

GAITHERSBURG, Md., Oct. 27, 2020 (GLOBE NEWSWIRE) -- NexImmune, a clinical-stage biotechnology company developing unique non-genetically-engineered T cell immunotherapies, announced today that it has signed a research initiative related to its AIM nanoparticle technology with City of Hope, a world-renowned independent research and treatment center for cancer, diabetes and other life-threatening diseases.

City of Hope is a participating clinical site in the ongoing Phase 1/2 study of NEXI-001. The cancer center will leverage both patient samples from the ongoing NexImmune Phase 1/2 clinical study of NEXI-001 in acute myeloid leukemia (AML) patients with relapsed disease after allogeneic stem cell transplantation and the centers tumor repository bank of primary leukemia samples, one of the largest collections in the world, to drive the research.

NEXI-001 is a cellular product candidate that contains populations of naturally occurring CD8+ T cells directed against multiple antigen targets for AML, and it is the first clinical product generated by the Companys AIM nanoparticle technology.

NexImmune has developed a unique and versatile technology platform that lends itself very effectively to important areas of ongoing research in the field of AML, said Guido Marcucci, M.D., Chair and Professor with City of Hopes Department of Hematologic Malignancies Translational Science. Our collective goal is to translate future research findings into new, more effective T cell immunotherapies to the benefit of these very difficult to treat patients.

A key objective of the research will focus on the identification of new antigen targets that are expressed on both leukemic blasts as well as leukemic stem cells, and those which represent survival proteins to both. Once identified, these antigen targets will be loaded on NexImmune AIM-nanoparticles to expand antigen-specific CD8+ T cells, and evaluated in pre-clinical models for anti-tumor potency, tumor-specific killing, and response durability.

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In addition, the research initiative will aim to further understand different mechanisms of tumor escape, such as tumor antigen and human leukocyte antigen (HLA) downregulation due to immune pressure.

Research between NexImmune and City of Hope will inform a scientific understanding of how the immune system can address certain tumor escape mechanisms to more effectively fight aggressive cancers like AML, and how this might be accomplished with NexImmunes AIM technology and T cell products, said Monzr Al Malki, M.D., Director of City of Hopes Unrelated Donor BMT Program and Haploidentical Transplant Program and an Associate Clinical Professor with Department of Hematology and Hematopoietic Cell Transplantation. Based on our current clinical experience with this technology, were excited to learn what more this research will tell us.

City of Hope is a world-class clinical research institution that has built one of the largest banks of leukemia samples in the world, said Han Myint, M.D., NexImmune Chief Medical Officer. The depth of expertise that Drs. Marcucci, Al Malki and their team bring to this research initiative will help NexImmune continue to develop innovative products that can help patients with AML and other hard-to-treat cancers.

City of Hope is a leader in bone marrow transplantation. More than 16,000 stem cell and bone marrow transplants have been performed at City of Hope, and more than 700 are performed annually. City of Hopes BMT program is the only one in the nation that has had one-year survival above the expected rate for 15 consecutive years, based on analysis by the Center for International Blood and Marrow Transplant Research.

About NexImmune NexImmune is a clinical-stage biotechnology company developing unique approaches to T cell immunotherapies based on its proprietary Artificial Immune Modulation (AIM) technology. The AIM technology is designed to generate a targeted T cell-mediated immune response and is initially being developed as a cell therapy for the treatment of hematologic cancers. AIM nanoparticles (AIM-np) act as synthetic dendritic cells to deliver immune-specific signals to targeted T cells and can direct the activation or suppression of cell-mediated immunity. In cancer, AIM-expanded T cells have demonstrated best-in-class anti-tumor properties as characterized by in vitro analysis, including a unique combination of anti-tumor potency, antigen target-specific killing, and long-term T cell persistence. The modular design of the AIM platform enables rapid expansion across multiple therapeutic areas, with both cell therapy and injectable products.

NexImmunes two lead T cell therapy programs, NEXI-001 and NEXI-002, are in Phase 1/2 clinical trials for the treatment of relapsed AML after allogeneic stem cell transplantation and multiple myeloma refractory to >3 prior lines of therapy, respectively. The Companys pipeline also has additional preclinical programs, including cell therapy and injectable product candidates, for the treatment of oncology, autoimmune disorders, and infectious diseases.

For more information, visit http://www.neximmune.com.

Media Contact: Mike Beyer Sam Brown Inc. Healthcare Communications 312-961-2502 mikebeyer@sambrown.com

Investor Contact: Chad Rubin Solebury Trout +1-646-378-2947 crubin@soleburytrout.com

Induced Pluripotent Stem Cells Industry Market 2020 Global Trends, Key Players, Share, Growth, Analysis, Opportunities and Forecast To 2026 -…

By adminOctober 31, 2020Induced Pluripotent Stem Cells

A recent market research report added to repository of Credible Markets is an in-depth analysis of Global Induced Pluripotent Stem Cells Industry Market. On the basis of historic growth analysis and current scenario of Induced Pluripotent Stem Cells Industry market place, the report intends to offer actionable insights on global market growth projections. Authenticated data presented in report is based on findings of extensive primary and secondary research. Insights drawn from data serve as excellent tools that facilitate deeper understanding of multiple aspects of global Induced Pluripotent Stem Cells Industry market. This further helps users with their developmental strategy.

This report examines all the key factors influencing growth of global Induced Pluripotent Stem Cells Industry market, including demand-supply scenario, pricing structure, profit margins, production and value chain analysis. Regional assessment of global Induced Pluripotent Stem Cells Industry market unlocks a plethora of untapped opportunities in regional and domestic market places. Detailed company profiling enables users to evaluate company shares analysis, emerging product lines, scope of NPD in new markets, pricing strategies, innovation possibilities and much more.

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Data presented in global Induced Pluripotent Stem Cells Industry market report allows users to realize their market entry potential and devise fruitful developmental strategies to fulfil their business goals. A report sample can be requested to view the report outline before you actually purchase it.

Key players in the global Induced Pluripotent Stem Cells market covered in Chapter 12:

Bone Therapeutics SA System Biosciences Axiogenesis Regeneus Ltd. Cellectics CellTherapies P/L Cellular Dynamics Reprocell BrainStorm Cell Therapeutics Inc. Iperian Stemgent Fate Therapeutics Viacyte Lonza Organogenesis Inc. Waisman Biomanufacturing Ocata Therapeutics Inc. Medipost Co. Ltd.

In Chapter 4 and 14.1, on the basis of types, the Induced Pluripotent Stem Cells market from 2015 to 2025 is primarily split into:

Adult Sources Fetal Sources Others

In Chapter 5 and 14.2, on the basis of applications, the Induced Pluripotent Stem Cells market from 2015 to 2025 covers:

Hematopoietic stem cell transplantation Tissue repair damage Autoimmune diseases As gene therapy vectors

Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historic and forecast (2015-2026) of the following regions:

United States, Canada, Germany, UK, France, Italy, Spain, Russia, Netherlands, Turkey, Switzerland, Sweden, Poland, Belgium, China, Japan, South Korea, Australia, India, Taiwan, Indonesia, Thailand, Philippines, Malaysia, Brazil, Mexico, Argentina, Columbia, Chile, Saudi Arabia, UAE, Egypt, Nigeria, South Africa and Rest of the World

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Some Points from Table of Content

COVID-19 Outbreak-Global Induced Pluripotent Stem Cells Industry Industry Market Report-Development Trends, Threats, Opportunities and Competitive Landscape in 2020

Chapter 1 Induced Pluripotent Stem Cells Industry Introduction and Market Overview

Chapter 2 Executive Summary

Chapter 3 Industry Chain Analysis

Chapter 4 Global Induced Pluripotent Stem Cells Industry Market, by Type

Chapter 5 Induced Pluripotent Stem Cells Industry Market, by Application

Chapter 6 Global Induced Pluripotent Stem Cells Industry Market Analysis by Regions

Chapter 7 North America Induced Pluripotent Stem Cells Industry Market Analysis by Countries

Chapter 8 Europe Induced Pluripotent Stem Cells Industry Market Analysis by Countries

Chapter 9 Asia Pacific Induced Pluripotent Stem Cells Industry Market Analysis by Countries

Chapter 10 Middle East and Africa Induced Pluripotent Stem Cells Industry Market Analysis by Countries

Chapter 11 South America Induced Pluripotent Stem Cells Industry Market Analysis by Countries

Chapter 12 Competitive Landscape

Chapter 13 Industry Outlook

Chapter 14 Global Induced Pluripotent Stem Cells Industry Market Forecast

Chapter 15 New Project Feasibility Analyses

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Points Covered in the Report

The points that are discussed within the report are the major market players that are involved in the market such as market players, raw material suppliers, equipment suppliers, end users, traders, distributors and etc.

The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. This report analyzed 12 years data history and forecast.

The growth factors of the market are discussed in detail wherein the different end users of the market are explained in detail.

Data and information by market player, by region, by type, by application and etc., and custom research can be added according to specific requirements.

The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.

Impact of Covid-19 in Induced Pluripotent Stem Cells Industry Market: Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost every country around the globe with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Induced Pluripotent Stem Cells Industry market in 2020. The outbreak of COVID-19 has brought effects on many aspects, like flight cancellations; travel bans and quarantines; restaurants closed; all indoor/outdoor events restricted; over forty countries state of emergency declared; massive slowing of the supply chain; stock market volatility; falling business confidence, growing panic among the population, and uncertainty about future.

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Induced Pluripotent Stem Cells Industry Market 2020 Global Trends, Key Players, Share, Growth, Analysis, Opportunities and Forecast To 2026 -...

The Stem Cell-Derived Cells market to be in conjunction to growth from 2020 to 2030 – PRnews Leader

By adminOctober 31, 2020Induced Pluripotent Stem Cells

Stem cell-derived cells are ready-made human induced pluripotent stem cells (iPS) and iPS-derived cell lines that are extracted ethically and have been characterized as per highest industry standards. Stem cell-derived cells iPS cells are derived from the skin fibroblasts from variety of healthy human donors of varying age and gender. These stem cell-derived cells are then commercialized for use with the consent obtained from cell donors. These stem cell-derived cells are then developed using a complete culture system that is an easy-to-use system used for defined iPS-derived cell expansion. Majority of the key players in stem cell-derived cells market are focused on generating high-end quality cardiomyocytes as well as hepatocytes that enables end use facilities to easily obtain ready-made iPSC-derived cells. As the stem cell-derived cells market registers a robust growth due to rapid adoption in stem cellderived cells therapy products, there is a relative need for regulatory guidelines that need to be maintained to assist designing of scientifically comprehensive preclinical studies. The stem cell-derived cells obtained from human induced pluripotent stem cells (iPS) are initially dissociated into a single-cell suspension and later frozen in vials. The commercially available stem cell-derived cell kits contain a vial of stem cell-derived cells, a bottle of thawing base and culture base.

The increasing approval for new stem cell-derived cells by the FDA across the globe is projected to propel stem cell-derived cells market revenue growth over the forecast years. With low entry barriers, a rise in number of companies has been registered that specializes in offering high end quality human tissue for research purpose to obtain human induced pluripotent stem cells (iPS) derived cells. The increase in product commercialization activities for stem cell-derived cells by leading manufacturers such as Takara Bio Inc. With the increasing rise in development of stem cell based therapies, the number of stem cell-derived cells under development or due for FDA approval is anticipated to increase, thereby estimating to be the most prominent factor driving the growth of stem cell-derived cells market. However, high costs associated with the development of stem cell-derived cells using complete culture systems is restraining the revenue growth in stem cell-derived cells market.

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The global Stem cell-derived cells market is segmented on basis of product type, material type, application type, end user and geographic region:

Segmentation by Product Type

Segmentation by End User

The stem cell-derived cells market is categorized based on product type and end user. Based on product type, the stem cell-derived cells are classified into two major types stem cell-derived cell kits and accessories. Among these stem cell-derived cell kits, stem cell-derived hepatocytes kits are the most preferred stem cell-derived cells product type. On the basis of product type, stem cell-derived cardiomyocytes kits segment is projected to expand its growth at a significant CAGR over the forecast years on the account of more demand from the end use segments. However, the stem cell-derived definitive endoderm cell kits segment is projected to remain the second most lucrative revenue share segment in stem cell-derived cells market. Biotechnology and pharmaceutical companies followed by research and academic institutions is expected to register substantial revenue growth rate during the forecast period.

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North America and Europe cumulatively are projected to remain most lucrative regions and register significant market revenue share in global stem cell-derived cells market due to the increased patient pool in the regions with increasing adoption for stem cell based therapies. The launch of new stem cell-derived cells kits and accessories on FDA approval for the U.S. market allows North America to capture significant revenue share in stem cell-derived cells market. Asian countries due to strong funding in research and development are entirely focused on production of stem cell-derived cells thereby aiding South Asian and East Asian countries to grow at a robust CAGR over the forecast period.

Some of the major key manufacturers involved in global stem cell-derived cells market are Takara Bio Inc., Viacyte, Inc. and others.

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The Stem Cell-Derived Cells market to be in conjunction to growth from 2020 to 2030 - PRnews Leader

In Vitro Toxicology Testing Market: Facts, Figures and Analytical Insights, 2018 to 2024 – Aerospace Journal

By adminOctober 31, 2020Induced Pluripotent Stem Cells

This market research report identifies Laboratory Corporation of America Holdings, Charles River Laboratories, Inc, Thermo Fisher Scientific, Eurofins Scientific, Agilent Technologies, Inc., as the major vendors operating in the global in vitro toxicology testing market. This report also provides a detailed analysis of the market by toxicology end points (systemic toxicity, cytotoxicity testing, genotoxicity testing, ocular toxicity, organ toxicity, dermal toxicity, neurotoxicity, and others), industry type (pharmaceutical and biopharmaceutical, cosmetics, chemical, diagnostics, and food industry), and region (North America, Europe, Asia Pacific, and Rest of the World).

Infoholics market research report predicts that the globalin vitro toxicology testing marketwill grow at a CAGR of8.2%during the forecast period 20182024. The market for in vitro toxicology testing is driven by high opposition to animal testing, increased cost related to animal-based toxicity testing, and increasing R&D expenditure for early stage toxicity testing. Whereas, the lack of in vitro models and decreased adoption rate are limiting the growth of the in vitro toxicology testing market to an extent.

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According to the in vitro toxicology testing market analysis, Europe accounted for the largest share of the global in vitro toxicology testing market followed by North America in 2017. The reason is the upsurge in the investments by the European Commission in R&D to develop substitute methods to in vitro testing is driving the demand in this region. Asia Pacific is expected to grow at a high CAGR during the forecast period due to increasing number of contract research organizations offering testing services, advancements in healthcare infrastructure, increasing investments in the biopharmaceutical sector, and upward economic conditions in the region.

Competitive Analysis and Key Vendors:

There is an increase in collaborations between companies on in vitro testing of compounds. For instance, in December 2016, Evotec and Celgene entered into a drug discovery collaboration for neurodegenerative diseases. According to agreement terms, Celgene will use Evotecs unique induced pluripotent stem cell (iPSC) platform that enables systematic drug screening in patient-derived disease models. In June 2017, Censo Biotechnologies Ltd. collaborated with Evotec AG to source and provide patient-derived induced pluripotent stem cells to support Evotecs drug discovery iPSC platform. In addition, the companies are also coming up with new products for in vitro testing. For instance, in January 2018, STEMCELL Technologies Inc. released two product lines for organoid research that will enable scientists to create powerful models for studying human disease in the laboratory.

Some of the In Vitro Toxicology Testing Market key vendors are:

Other prominent vendors in the global in vitro toxicology testing market are Bio-Rad Laboratories, GE Healthcare, SGS SA, BioIVT, Abbott Laboratories, Gentronix Limited, Promega Corporation, MB Research Laboratories, Evotec AG (Cyprotex plc), Catalent, Inc., Qiagen N.V., and niche players.

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In Vitro Toxicology Testing Market by Toxicology End Points:

In 2017, the systemic toxicity accounted for the highest market share due to the availability of a wide range of sub-studies, which ensure total analysis of toxicity and safety margin of the testing compounds.

In Vitro Toxicology Testing Market by Industry type:

In 2017, the pharmaceutical and biopharmaceutical industry occupied significant market share and the cosmetics industry is expected to hold a high percentage during the forecast period. Increased support of regulatory authorities to use in vitro and in silico methods instead of animal testing to check toxicology is driving the growth of the cosmetic industry.

In Vitro Toxicology Testing Market Benefits:

The report provides detailed information about the services offered by in vitro toxicology testing in various therapeutic verticals and regions. With that, key stakeholders can find out the major trends, drivers, investments, and vertical players initiatives. Moreover, the report provides details about the major challenges that are going to have an impact on market growth. Additionally, the report gives complete details about the business opportunities to key stakeholders to expand their business and capture revenues in the specific verticals. The report will help companies interested or established in this market to analyze the various aspects of this domain before investing or expanding their business in the in vitro toxicology testing market.

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In Vitro Toxicology Testing Market: Facts, Figures and Analytical Insights, 2018 to 2024 - Aerospace Journal

Bayer Acquires AskBio to Expand Gene Therapy Platform – PharmaLive

By adminOctober 31, 2020Induced Pluripotent Stem Cells

Bayer is making a big bet on gene therapy with the acquisition of North Carolina-based Asklepios BioPharmaceutical (AskBio). Bayer is paying $2 billion upfront for AskBios AAV-based gene therapy pipeline of treatments for Pompe disease, among others, and could pay an additional $2 billion in potential milestones.

AskBios Pro10 AAV manufacturing process has become something of a standard across the industry. The platform is used by multiple companies, including Pfizer, Takeda and Viralgen Vector Core SA. The company holds over 500 patents in areas such as AAV production, chimeric vectors and self-complementary DNA. AskBios technology has already seen regulatory success. It initially developed the gene therapy for spinal muscular atrophy that Illinois-based AveXis, a subsidiary of Novartis, won approval for from the U.S. Food and Drug Administration in 2019. AskBios lead research programs, which are focused on Pompe disease, Parkinsons disease and congestive heart failure are currently in early phases of clinical development.

Under terms of the deal, Bayer will own full rights to AskBios pipeline of treatments for Pompe disease, Parkinsons disease, as well as therapies for neuromuscular, central nervous system, cardiovascular and metabolic diseases. AskBio will remain an autonomous company under the Bayer umbrella and will operate on an arms-length basis, Bayer said this morning. AskBio Chief Executive Officer Sheila Mikhail noted that her company will retain its independent structure, which she said will allow them to provide accelerated development of gene therapies to treat more patients who can benefit from them.

Our innovation in capsid re-engineering and promoter design, coupled with our scaled manufacturing processes, gives us the tools to provide gene therapy solutions to more people suffering from a wider spectrum of disease that is not being adequately treated today, added Richard Jude Samulski, AskBios chief scientific officer. Samulski was the first scientist to clone AAV.

The acquisition of AskBio will bolster Bayers cell and gene therapy business and will lay the foundation for future partnerships in the area of adeno-associated virus (AAV) therapies, Bayer said. Besides multiple clinical-stage assets for indications with highly unmet needs, the acquisition includes a state-of-the-art gene therapy technology platform as well as existing gene therapy manufacturing platform, the company added.

Lukassek/Shutterstock

The addition of AskBio will complement Bayers other cell and gene therapy company, BlueRock Therapeutics, which it acquired last year. BlueRock is developing induced pluripotent stem cells (iPSC), with its most advanced program aimed at Parkinsons disease.

Werner Baumann, chairman of the Board of Management at Bayer, said the acquisition of AskBio significantly advances the establishment of a cell and gene therapy platform that can be at the forefront of breakthrough science and contribute to the development of therapies that can prevent or cure diseases caused by genetic defects. Baumann said the goal is in line with the companys purpose of science for a better life.

As part of our strategy, we are building new therapeutic platforms including cell and gene therapies, Stefan Oelrich, president of the Bayers Pharmaceuticals Division said in a statement. As an emerging leader in the rapidly advancing field of gene therapies, the expertise and portfolio of AskBio supports us in establishing highly innovative treatment options for patients and further strengthens our portfolio. We want to help patients whose medical needs are not yet met by todays treatment options and we are looking forward to work together with the team at AskBio.

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Bayer Acquires AskBio to Expand Gene Therapy Platform - PharmaLive

Could an Imaging Test Predict How Well Youll Respond to a Stem Cell Transplant? – SurvivorNet

By adminOctober 31, 2020Stem Cell Treatment

Dr. Jakub Svoboda Penn Medicine

If youve already gone through a round of treatment for diffuse large B-cell lymphoma and it didnt work, or your cancer came back after treatment, your doctor might start talking to you about having an autologous stem cell transplant. This therapy involves getting high doses of chemotherapy to get rid of your cancer cells, followed by an infusion of stem cells taken from your blood or bone marrow before treatment, to replenish your bodys supply of healthy blood cells.

Related: What is Autologous Stem Cell Transplant?

A stem cell transplant can be a pretty grueling treatment that involves getting very high doses of chemotherapy, spending three to four weeks in the hospital, and enduring side effects like nausea, vomiting, mouth pain, infections, bleeding, and lung inflammation. And after all of that, you still may not get the results you want.

If its going to cure the patient, I think its all worthwhile to go through, Dr. Jakub Svoboda, medical oncologist at Penn Medicine, tells SurvivorNet. If, on the other hand, a stem cell transplant isnt likely to result in a cure, it may not be a good choice for you.

One clue that can help your doctor decide whether a stem cell transplant is worth the risks involved is how well you responded to chemotherapy after your cancer relapsed. People with an aggressive lymphoma that didnt respond well to chemotherapy tend not to have a good outcome from a stem cell transplant.

Having a combination imaging test called a PET/CT scan before a stem cell transplant can help pinpoint your response to chemo, and let you avoid some potentially severe side effects if this treatment isnt likely to cure you. The PET/CT technology has allowed us to select the patients who will likely benefit from autologous STEM cell transplant, Dr. Svoboda says.

The PET/CT scan combines two common cancer imaging tests. PET stands for positron emission tomography. Before the test, you get an injection of a small amount of radioactive sugar, called fluorodeoxyglucose-18 (FGD-18). Because cancer cells use a lot more energy than healthy cells, they absorb the sugar in larger amounts. As the tracer collects in the cancer, it makes those areas light up and become visible, so your doctor can see them on the scan.

CT is short for computed tomography. It takes x-rays of your body from different angles, to create a cross-sectional view of your organs and tissues. The CT scan can reveal areas of your body that are enlarged from the cancer. It alone isnt sensitive enough to pick up metabolically active areas of cancer, which is why the two tests are combined.

A computer combines the PET and CT images to give your doctor a highly detailed, three-dimensional view of your cancer. Having both of these tests together can show your doctor not only whether your cancer is shrinking, but also if its still active.

When people still have some metabolic activity within shrinking areas of cancer, they actually dont do well with the transplant, Dr. Svoboda says.

Its very helpful for doctors to have the information from a PET/CT scan, Dr. Svoboda tells SurvivorNet. You can then offer that patient a different treatment or steer them toward some of the novel therapies.

One alternative to stem cell transplant is chimeric antigen receptor (CAR) T-cell therapy. Its a promising treatment for some people with aggressive non-Hodgkin lymphoma that hasnt responded to other treatments. CAR T-cell therapy involves genetically modifying your own immune cells so that they attack your cancer. CAR T-cell therapy or other treatments actually may have a better chance at working than transplanting in this setting, Dr. Svoboda says.

Learn more about SurvivorNet's rigorous medical review process.

Dr. Jakub Svoboda is a medical oncologist at Penn Medicine, andassociate professor of medicine at the Hospital of the University of Pennsylvania. Read More

Dr. Jakub Svoboda Penn Medicine

Related: What is Autologous Stem Cell Transplant?

When people still have some metabolic activity within shrinking areas of cancer, they actually dont do well with the transplant, Dr. Svoboda says.

Learn more about SurvivorNet's rigorous medical review process.

Dr. Jakub Svoboda is a medical oncologist at Penn Medicine, andassociate professor of medicine at the Hospital of the University of Pennsylvania. Read More

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Could an Imaging Test Predict How Well Youll Respond to a Stem Cell Transplant? - SurvivorNet

Stem Cell and Regenerative Therapy Market Monitoring Growth Opportunities 2024 – Aerospace Journal

By adminOctober 31, 2020Stem Cell Treatment

The global stem cell and regenerative medicines market should grow from $21.8 billion in 2019 to reach $55.0 billion by 2024 at a compound annual growth rate (CAGR) of 20.4% for the period of 2019-2024.

Report Scope:

The scope of this report is broad and covers various type of product available in the stem cell and regenerative medicines market and potential application sectors across various industries. The current report offers a detailed analysis of the stem cell and regenerative medicines market.

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The report highlights the current and future market potential of stem cell and regenerative medicines and provides a detailed analysis of the competitive environment, recent development, merger and acquisition, drivers, restraints, and technology background in the market. The report also covers market projections through 2024.

The report details market shares of stem cell and regenerative medicines based on products, application, and geography. Based on product the market is segmented into therapeutic products, cell banking, tools and reagents. The therapeutics products segments include cell therapy, tissue engineering and gene therapy. By application, the market is segmented into oncology, cardiovascular disorders, dermatology, orthopedic applications, central nervous system disorders, diabetes, others

The market is segmented by geography into the following regions: North America, Europe, Asia-Pacific, South America, and the Middle East and Africa. The report presents detailed analyses of major countries such as the U.S., Canada, Mexico, Germany, the U.K. France, Japan, China and India. For market estimates, data is provided for 2018 as the base year, with forecasts for 2019 through 2024. Estimated values are based on product manufacturers total revenues. Projected and forecasted revenue values are in constant U.S. dollars, unadjusted for inflation.

Report Includes:

28 data tables An overview of global markets for stem cell and regenerative medicines Analyses of global market trends, with data from 2018, estimates for 2019, and projections of compound annual growth rates (CAGRs) through 2024 Details of historic background and description of embryonic and adult stem cells Information on stem cell banking and stem cell research A look at the growing research & development activities in regenerative medicine Coverage of ethical issues in stem cell research & regulatory constraints on biopharmaceuticals Comprehensive company profiles of key players in the market, including Aldagen Inc., Caladrius Biosciences Inc., Daiichi Sankyo Co. Ltd., Gamida Cell Ltd. and Novartis AG

Summary

The global market for stem cell and regenerative medicines was valued at REDACTED billion in 2018. The market is expected to grow at a compound annual growth rate (CAGR) of REDACTED to reach approximately REDACTED billion by 2024. Growth of the global market is attributed to the factors such as growingprevalence of cancer, technological advancement in product, growing adoption of novel therapeuticssuch as cell therapy, gene therapy in treatment of chronic diseases and increasing investment fromprivate players in cell-based therapies.

In the global market, North America held the highest market share in 2018. The Asia-Pacific region is anticipated to grow at the highest CAGR during the forecast period. The growing government funding for regenerative medicines in research institutes along with the growing number of clinical trials based on cell-based therapy and investment in R&D activities is expected to supplement the growth of the stem cell and regenerative market in Asia-Pacific region during the forecast period.

Reasons for Doing This Study

Global stem cell and regenerative medicines market comprises of various products for novel therapeutics that are adopted across various applications. New advancement and product launches have influenced the stem cell and regenerative medicines market and it is expected to grow in the near future. The biopharmaceutical companies are investing significantly in cell-based therapeutics. The government organizations are funding research and development activities related to stem cell research. These factors are impacting the stem cell and regenerative medicines market positively and augmenting the demand of stem cell and regenerative therapy among different application segments. The market is impacted through adoption of stem cell therapy. The key players in the market are investing in development of innovative products. The stem cell therapy market is likely to grow during the forecast period owing to growing investment from private companies, increasing in regulatory approval of stem cell-based therapeutics for treatment of chronic diseases and growth in commercial applications of regenerative medicine.

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Products based on stem cells do not yet form an established market, but unlike some other potential applications of bioscience, stem cell technology has already produced many significant products in important therapeutic areas. The potential scope of the stem cell market is now becoming clear, and it is appropriate to review the technology, see its current practical applications, evaluate the participating companies and look to its future.

The report provides the reader with a background on stem cell and regenerative therapy, analyzes the current factors influencing the market, provides decision-makers the tools that inform decisions about expansion and penetration in this market.

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Stem Cell and Regenerative Therapy Market Monitoring Growth Opportunities 2024 - Aerospace Journal

Animal Stem Cell Therapy Market 2020 Size, Share, Trends Analysis Report by Application, Region (North America, South America, Asia, and Europe) and…

By adminOctober 31, 2020Stem Cell Treatment

Research Organizations

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The content of the study subjects, includes a total of 15 chapters:

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Table of Contents of Animal Stem Cell Therapy Market:

1 Market Overview

1.1 Animal Stem Cell Therapy Introduction

1.2 Market Analysis by Type

1.2.1 Type 1

1.2.2 Type 2

1.3 Market Analysis by Applications

1.3.1 Application 1

1.3.2 Application 2

1.4 Market Analysis by Regions

1.4.1 North America (United States, Canada and Mexico)

1.4.2 Europe (Germany, France, UK, Russia and Italy)

1.4.3 Asia-Pacific (China, Japan, Korea, India and Southeast Asia)

1.4.4 South America, Middle East and Africa

1.4.4.5 Turkey Market States and Outlook (2014-2024)

1.5 Market Dynamics

1.5.1 Market Opportunities

1.5.2 Market Risk

1.5.3 Market Driving Force

2 Manufacturers Profiles

2.1 Manufacture

2.1.1 Business Overview

2.1.2 Animal Stem Cell Therapy Type and Applications

2.1.2.1 Product A

2.1.2.2 Product B

2.1.3 Manufacture Animal Stem Cell Therapy Sales, Price, Revenue, Gross Margin and Market Share (2019-2019)

3 Global Animal Stem Cell Therapy Sales, Revenue, Market Share and Competition by Manufacturer (2019-2019)

3.1 Global Animal Stem Cell Therapy Sales and Market Share by Manufacturer (2028-2019)

3.2 Global Animal Stem Cell Therapy Revenue and Market Share by Manufacturer (2018-2019)

3.3 Market Concentration Rate

3.3.1 Top 3 Animal Stem Cell Therapy Manufacturer Market Share in 2019

3.3.2 Top 6 Animal Stem Cell Therapy Manufacturer Market Share in 2019

3.4 Market Competition Trend

13 Sales Channel, Distributors, Traders and Dealers

13.1 Sales Channel

13.1.1 Direct Marketing

13.1.2 Indirect Marketing

13.1.3 Marketing Channel Future Trend

13.2 Distributors, Traders and Dealers

14 Research Findings and Conclusion

15 Appendix

15.1 Methodology

15.2 Data Source

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Animal Stem Cell Therapy Market 2020 Size, Share, Trends Analysis Report by Application, Region (North America, South America, Asia, and Europe) and...

Canine Stem Cell Therapy Market: Market Growth Factors, Applications, Regional Analysis, Key Players and Forecasts by 2026 – PRnews Leader

By adminOctober 31, 2020Stem Cell Treatment

AllTheResearchs published a research report on the Canine Stem Cell Therapy market, which represents a study for the period from 2020 to 2026. The research provides a near look at the market scenario and dynamics impacting its growth. This report highlights the crucial developments along with other events happening in the market which are marking on the growth and opening doors for future growth in the coming years. Additionally, the report is built based on the macro- and micro-economic factors and historical data that can influence the growth.

The global Canine Stem Cell Therapy market was valued at US$ 118.5 Mn in 2018 and is expected to reach US$ 240.7 Mn in 2026, growing at a CAGR of 9.3% during the forecast period.

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Key Players:

The global Canine Stem Cell Therapy market has been comprehensively analyzed and the different companies that occupy a large percentage of the market share in the regions mentioned have been listed out in the report. Industry trends that are popular and are causing a resurgence in the market growth are identified. A strategic profile of the companies is also carried out to identify the various subsidiaries that they own in the different regions and who are responsible for daily operations in these regions.

The Key Players Covered in Canine Stem Cell Therapy Market Study are:

How Report will help you to make decisions for business:

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Canine Stem Cell Therapy Market Segmentation

Canine Stem Cell Therapy market is split by Type and by Application. For the period 2015-2026, the growth among segments provide accurate calculations and forecasts for sales by Type and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.

Market Segmentation by Type:

Market Segmentation by Applications:

COVID-19 Impact on Canine Stem Cell Therapy Market:

The outbreak of COVID-19 has brought along a global recession, which has impacted several industries. Along with this impact COVID Pandemic has also generated few new business opportunities for Canine Stem Cell Therapy Market. Overall competitive landscape and market dynamics of Canine Stem Cell Therapy has been disrupted due to this pandemic. All these disruptions and impacts has been analysed quantifiably in this report, which is backed by market trends, events and revenue shift analysis. COVID impact analysis also covers strategic adjustments for Tier 1, 2 and 3 players of Canine Stem Cell Therapy Market.

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Research objectives:

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AllTheResearch was formed with the aim of making market research a significant tool for managing breakthroughs in the industry. As a leading market research provider, the firm empowers its global clients with business-critical research solutions. The outcome of our study of numerous companies that rely on market research and consulting data for their decision-making made us realise, that its not just sheer data-points, but the right analysis that creates a difference.While some clients were unhappy with the inconsistencies and inaccuracies of data, others expressed concerns over the experience in dealing with the research-firm. Also, same-data-for-all-business roles was making research redundant. We identified these gaps and built AllTheResearch to raise the standards of research support.

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Canine Stem Cell Therapy Market: Market Growth Factors, Applications, Regional Analysis, Key Players and Forecasts by 2026 - PRnews Leader

What Are the Treatment Options When Lymphoma Returns? – SurvivorNet

By adminOctober 31, 2020Stem Cell Treatment

Dr. Stephen Schuster Penn Medicine

Finally entering into remission after youve gone through several weeks or months worth of treatment for non-Hodgkin lymphoma can feel like a huge victory. Sometimes remissions are long lasting, but in a certain percentage of people, the cancer can eventually return. If your cancer does stage a comeback, your doctor will be ready with another round of treatment that oncologists call second-line therapy.

What tools do we have for the second line? Well, the standard right now is the high-dose chemotherapy with autologous stem cell rescue approach, Dr. Stephen Schuster, medical oncologist at Penn Medicine, tells SurvivorNet. An autologous stem cell transplant gives you an infusion of your own stem cells the preliminary cells that will eventually grow into new blood cells to replace the ones chemotherapy destroys. It allows your doctor to give you very high doses of chemo to treat your cancer.

In the late 1980s and 1990s, stem cell therapy worked pretty well in about one-third of people who received it. But as doctors improved upon the first-line treatment in the early 2000s by combining chemotherapy with the monoclonal antibody rituximab (Rituxan) into a drug cocktail called R-CHOP, stem cell therapy no longer worked as well in the second line. The hunt was on for a new way to treat relapsed non-Hodgkin lymphoma.

Fortunately, several new and improved cancer treatments have been introduced, and other novel therapies are under investigation. It took us from the 1970s to the late 90s to improve on the four drug combination CHOP, which is still the standard, adding rituximab to that, Dr. Schuster says. Today, not only have the treatments gotten better, but the pace of new drug development has sped up, he says. Several new immunotherapies have come out, just in the last few years.

One new therapeutic option if your cancer has returned is immunotherapy harnessing the power of your immune system to go after your cancer. [Immunotherapy is] frequently discussed in the popular scientific literature, Dr. Schuster says. Some of it sounds like science fiction. Its very cool stuff.

One group of immunotherapy drugs, collectively known as the monoclonal antibodies, use a protein called an antibody to home in on a target on the surface of cancer cells. Rituxan is one such drug.

A few new immunotherapy drugs have been approved for non-Hodgkin lymphoma in recent years:

Chimeric antigen receptor (CAR) T-cell therapy is one of the newest high-tech cancer treatments. During this therapy, your treatment team will take your own immune cells, called T cells, and genetically modify and multiply them in a lab so that they attach to proteins on the surface of your lymphoma cells and attack them.

These treatments each work in a slightly different way. And they can be effective for people whove tried and failed at two previous treatments.

Were coming up with the best approaches for people who were not successfully treated by first- or second-line approaches, Dr. Schuster says.There are currently two FDA-approved CAR T products for people with diffuse large B-cell lymphoma who have failed two prior lines of treatment.

Say youve tried three separate treatments and your cancer has come back again. It can be frustrating to face yet another round of treatment, but here again, innovation is your friend.

Soon, another therapy called bispecific antibodies or bispecific T-cell engagers (BiTEs),is likely to be added to the mix, says Dr. Schuster. Unlike monoclonal antibodies, which attach to only one target, bispecific antibodies bind to two targets at once. They essentially pull together your immune cells and cancer cells to help your immune system more effectively treat your cancer.

With so many non-Hodgkin lymphoma therapies available, theres a much better chance that your doctor will eventually find something that works for your cancer. If youve been through several rounds of treatment without success, you can always consider enrolling in a clinical trial of a new and as-yet unapproved drug that be more effective than anything youve already tried.

Learn more about SurvivorNet's rigorous medical review process.

Dr. Stephen Schuster is a medical oncologist and director of the Lymphoma Program at Penn Medicine. He is also theRobert and Margarita Louis-Dreyfus Professor in Chronic Lymphocytic Leukemia and Lymphoma Clinical Care and Research. Read More

Dr. Stephen Schuster Penn Medicine

One group of immunotherapy drugs, collectively known as the monoclonal antibodies, use a protein called an antibody to home in on a target on the surface of cancer cells. Rituxan is one such drug.

A few new immunotherapy drugs have been approved for non-Hodgkin lymphoma in recent years:

These treatments each work in a slightly different way. And they can be effective for people whove tried and failed at two previous treatments.

Say youve tried three separate treatments and your cancer has come back again. It can be frustrating to face yet another round of treatment, but here again, innovation is your friend.

Learn more about SurvivorNet's rigorous medical review process.

Excerpt from:
What Are the Treatment Options When Lymphoma Returns? - SurvivorNet