Stem Cell Clinic

Celebrities and Astronauts to "Show up for Science" at the NYSCF Gala & Science Fair – PRNewswire

NEW YORK, Oct. 23, 2020 /PRNewswire/ --Hosted by CNN Chief Medical Correspondent Sanjay Gupta, MD and featuring appearances from world-renowned cellist Yo-Yo Ma, former New York Mayor Michael Bloomberg, Whoopi Goldberg, Martha Stewart, actors Annaleigh Ashford, Lilli Cooper, Jesse Tyler Ferguson, Santino Fontana, Victor Garber, Jane Krakowski, Kelli O'Hara, Billy Porter, Seth Rogen, and John Slattery, among others, The New York Stem Cell Foundation Research Institute's first-ever virtual gala is streaming online on the evening of October 27th. Open to the public and free for all who would like to watch, guests can register at http://www.nyscf.org/gala.

Under the theme "Show Up for Science," the program will re-imagine the Science Fair, a signature element of NYSCF's traditional gala at which guests meet and talk with NYSCF Research Institute scientists, turning it into an online experience as special celebrity guests like Garber, Krakowski, andFerguson interview scientists and learn about the latest updates and breakthroughs in stem cell research. The Gala will bring the world of the NYSCF Research Institute laboratories to life, this year in a multi-platform digital experience produced by Broadway Director Scott Ellis with Music by Tree Adams and Andrew Schuyler.

The Gala also honors the three 2020 NYSCF Stem Cell Heroes: internationally renowned architect Frank Gehry; bioethicist and patient advocate Brooke Ellison, PhD, and award-winning architect and designer David Rockwell.

The 2020 NYSCF Research Institute Gala and Science Fair experience will also include NASA astronauts Serena Aun-Chancellor, MD, PhD, and Peggy Whitson, PhD, talking about stem cell research in space and about what this can mean for stem cell research. In Garber's segment, he will talk with NYSCF Senior Vice President of Research Scott Noggle, PhD, on how stem cells can help find a cure for diabetes, while Krakowski will discuss the basics of stem cells and how they are being used to study and fight COVID-19 with NYSCF Vice President, Automation Systems & Stem Cell Biology Daniel Paull, PhD.

The program will also include Ferguson speaking with NYSCF Principal Investigator Laura Andres-Martin, PhD, about NYSCF's new cutting-edge research on women's reproductive cancers, and NYSCF scientists Howard Kim, PhD, and Cecile Terrenoire, PhD will also share an update on NYSCF's macular degeneration stem cell therapy.

The 75-minute program will focus on education about science, using entertainment as a means to help viewers understand scientific concepts. It will also feature a short performance in honor of Frank Gehry by cellist Yo-Yo Ma, and a comedy skit by Fontana and Ashford.

Frank Gehry is perhaps the world's most celebrated living architect, known for his designs of landmark buildings including the Guggenheim Museum in Bilbao, Spain; Walt Disney Concert Hall in Los Angeles; and Fondation Louis Vuitton in Paris. The Los Angeles-based architect, whose buildings are known for the sweeping shapes and dramatic silhouettes, has won the Pritzker Prize, long considered the architecture profession's equivalent of the Nobel, as well as the Praemium Imperiale in Japan and the Gold Medal of the American Institute of Architects and the Gold Medal of the Royal Institute of British Architects. Frank has also dedicated himself to philanthropic work throughout his long career with numerous pro bono design projects in the arts, and he has had a longstanding engagement with medical research. NYSCF is honored to count Frank as a steadfast supporter of its mission to accelerate better treatments and cures for the most devastating diseases of our time through stem cell research.

David Rockwell is the founder and President of the Rockwell Group, an interdisciplinary and innovative architecture and design firm based in New York with offices in Los Angeles and Madrid, with work that ranges from restaurant and hotel design to cultural and educational institutions, theaters, and stage sets, to self-initiated pro bono projects supporting New York City during times of crisis. Ten years ago, David conceptualized the first Science Fair at a NYSCF Gala, and for many years he designed the environment that simulates the NYSCF Research Institute Laboratories and allows benefit guests to meet and mingle with NYSCF scientists. He has received numerous awards and recognition for his groundbreaking work, including a Tony Award in 2016 for set design, and NYSCF is honored to recognize his dedication, creativity, and talent for making cutting-edge science come alive each fall.

Brooke Ellison, PhD, is an Associate Professor at Stony Brook University, and the Director of Education and Ethics at the Stony Brook Stem Cell Facility. An expert in stem cell research policy and ethics, and longtime patient and disability advocate, Brooke has dedicated her professional career to changing the perception of life-saving science. Paralyzed from the neck down and dependent on a ventilator since age eleven following an accident, Brook has surmounted innumerable hurdles to achieve her goals, including serving on the Empire State Stem Cell Board, which designed New York State's stem cell policy. NYSCF is proud to recognize Brooke's tireless efforts to bring the promise of stem cell research to fruition, and for her advocacy for people in need of better solutions.

"Scientific research is more important than ever, particularly now in the midst of a global pandemic," stated NYSCF Research Institute CEO and Founder Susan L. Solomon. "I am thrilled that we are able to bring our research to life through this digital medium, and to honor our three incredible stem cell heroes. Private philanthropy is the fuel that drives our scientific success, and the Gala and Science Fair celebration highlight both the importance of our work and the promise of stem cell research around the world."

About The New York Stem Cell Foundation Research Institute

The New York Stem Cell Foundation (NYSCF) Research Institute is an independent non-profit organization accelerating cures and better treatments for patients through stem cell research. The NYSCF global community includes over 190 researchers at leading institutions worldwide, including the NYSCF Druckenmiller Fellows, the NYSCF Robertson Investigators, the NYSCF Robertson Stem Cell Prize Recipients, and NYSCF Research Institute scientists and engineers. The NYSCF Research Institute is an acknowledged world leader in stem cell research and in developing pioneering stem cell technologies, including the NYSCF Global Stem Cell Array and in manufacturing stem cells for scientists around the globe. NYSCF focuses on translational research in an accelerator model designed to overcome barriers that slow discovery and replace silos with collaboration. For more information, visitwww.nyscf.org.

David McKeon 212-365-7440 [emailprotected]

SOURCE The New York Stem Cell Foundation

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Celebrities and Astronauts to "Show up for Science" at the NYSCF Gala & Science Fair - PRNewswire

Mystery Solved: How Do Tips of Plants Stay Virus-Free in Face of Intensive Infection? – SciTechDaily

WUSCHEL proteins resist the viral invasion by inhibiting the protein assembly line of the plant stem cell. Credit: LIANG Yan, CHEN Lei

Plants are able to keep growing indefinitely because they have tissues made of meristems plant stem cells which have the unique ability to transform themselves into the various specialized cells that make up the plant, dividing whenever appropriate and producing new cells of whatever type as needed. Meristems exist at the tips of all plants, allowing them to grow new stems or new roots, and, in trees, also in the trunk, where they add extra girth.

It has been known since the 1950s that the meristems at the tips of plants, or shoot apical meristems (SAM), have the remarkable ability to remain virus-free as they give birth to their specialized daughter cells, even if the rest of the plant is thoroughly infected by a virus. This happens not just for one or even a few viruses, but a very wide range of them.

This virus-beating ability in perhaps the most important part of a plant has been exploited by scientists and farmers since then in order to cultivate new plants from donor plants that are infected, but without passing on the virus. They simply snip a tiny part of the tip, raise it for a time in a test tube or petri dish, and repeat it several times, the plant cutting typically grows pathogen-free.

Researchers at the University of Science and Technology of China (USTC) have offered new insights into this incredible ability in a new study published on October 8, 2020, in Science.

Stem cells at the tips of plants have been known to keep viruses away from this region, even as an infection ravages the rest of the plant. Quite how this happens has long been something of a mystery to scientists. Until now. Researchers at the University of Science and Technology of China (USTC) have offered new insights into this incredible ability in a new study published on Oct 8th in Science. They found surprisingly that the WUSCHEL proteins worked to inhibit production of viral proteins. The researchers are interested in seeing whether this strategy can be applied in breeding to obtain broad-spectrum antiviral crop varieties in the future says Zhong Zhao, paper author and a professor from the School of Life Science at USTC. Credit: News Center of University of Science and Technology of China

The research team inoculated a thale cress plant (Arabidopsis thaliana, related to cabbage and mustard, often used in botanical research as a model organism) with Cucumber Mosaic Virus and watched what happened.

As the virus spread towards the SAM, they noticed that it halted just before it got to a region called the WUSCHEL-expression domain. Taking a very close look at the distribution of the WUSCHEL regulator proteins here, they noticed more had appeared where the virus had tried to establish itself upon inoculation. WUSCHEL is an extremely important protein that plays a key, regulating role in determining stem cell fate, at the early stages of the development of a plant embryo, and also oversees the meristems, maintaining them in an undifferentiated state and specifying what sort of daughter cells they will produce.

Then they inoculated virus directly into the cresss stem cell and just below it, and found that the virus only spread in the latter region. Theres a chemical called dexamethasone that can induce production of these WUSCHEL proteins in our tested plants, said Zhong Zhao, paper author and a professor from the School of Life Science at USTC, so next, we inoculated more cress with the virus and then gave some of the plants dexamethasone treatment, and some we just left alone. Some 89 percent of the plants without the treatment were infected with the virus, but 90 percent of those with the treatment were free from virus invasion.

How does WUSCHEL beat viruses? They found surprisingly that the WUSCHEL proteins worked to inhibit production of viral proteins.

Viruses cant make their own proteins, but rather hijack the protein assembly line of an organism and make it produce copies of the virus. The WUSCHEL proteins, which do so much to regulate the SAM, had in essence frozen all protein production whether by the plant for itself or when hijacked by the virus thus preventing the viruses from replicating.

Genes similar to those that direct production of WUSCHEL proteins in the thale cress are very widespread across the plant kingdom, so the researchers are interested in seeing whether this strategy can be applied in breeding to obtain broad-spectrum antiviral crop varieties in the future says Zhao.

Reference: WUSCHEL triggers innate antiviral immunity in plant stem cells by Haijun Wu, Xiaoya Qu, Zhicheng Dong, Linjie Luo, Chen Shao, Joachim Forner, Jan U. Lohmann, Meng Su, Mengchu Xu, Xiaobin Liu, Lei Zhu, Jian Zeng, Sumei Liu, Zhaoxia Tian and Zhong Zhao, 9 October 2020, Science. DOI: 10.1126/science.abb7360

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Mystery Solved: How Do Tips of Plants Stay Virus-Free in Face of Intensive Infection? - SciTechDaily

Scientists grow mini-lungs in lab, infect them with coronavirus and watch battle in real time – The Indian Express

Written by Kabir Firaque | New Delhi | October 24, 2020 2:17:37 pm Medical workers check a X-ray photo of a lung of a patient suffering of Covid-19 in the Nouvel Hopital Civil of Strasbourg, eastern France, Thursday, Oct.22, 2020. (AP Photo: Jean-Francois Badias, File)

The novel coronavirus is known to attack primarily the lungs, but how the attack unfolds is still a subject of research. Now, two studies have thrown light on these processes by using the same approach. Scientists have developed lung models in the lab, infected these with SARS-CoV-2, and watched the battle between the lung cells and the virus.

Both papers are published in the journal Cell Stem Press. One study is by South Korean and UK researchers, including from the University of Cambridge; the other is by researchers from Duke University and University of North Carolina.

In both studies, scientists observed how the virus damages the alveoli in the lungs. Alveoli are balloon-like air sacs that take up the oxygen we breathe and release the carbon dioxide we exhale. Damage to alveoli causes pneumonia and acute respiratory distress the leading cause of death in Covid-19.

Both teams developed the model using mini-lungs or lung organoids. The organoids were grown from the stem cells that repair the deepest portions of the lungs where SARS-CoV-2 attacks. These are called AT2 cells. Follow Express Explained on Telegram

The UK and South Korean team reprogramed the AT2 cells back to their earlier stem cell stage. They grew self-organising, alveolar-like 3D structures that mimic the behaviour of key lung tissue. When the 3D models were exposed to SARS-CoV-2, the virus began to replicate rapidly.

In six hours, cells began to produce interferonsproteins that act as warning signals to neighbouring cells. After 48 hours, the cells started fighting back. And after 60 hours from infection, some of the alveolar cells began to disintegrate, leading to cell death and damage to the tissue.

In the other study, led by Duke University cell biologist Purushothama Rao Tata, the team got a single lung cell to multiply into thousands of copies and create a structure that resembles breathing tissues of the human lung. Once infected with the virus, the model showed an inflammatory response.

The team also witnessed the cytokine storm the hyper reaction of immune molecules the lungs launch to fight the infection.

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Scientists grow mini-lungs in lab, infect them with coronavirus and watch battle in real time - The Indian Express

Platelet Rich Plasma & Stem Cell Alopecia Treatment Market 2020: Reporting and Evaluation of Recent Industry Developments – Eurowire

The report provides study at global and regional level to provide comprehensive value market analysis for the years (2017 & 2018 Historic Years, 2019 Base Year and 2020-2027 Forecast Period). The Platelet Rich Plasma & Stem Cell Alopecia Treatment Market research report is a wide-ranging study of current trends, market growth drivers, and restraints. Each market segment is broadly analyzed at a powdered level by region (North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America) to provide thorough information on the global and regional level.

Some of the key players in this market include

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Stem Cell Therapy Market Revenue, Key Players, Supply-Demand, Investment Feasibility and Forecast 2026 – The Think Curiouser

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Adipose Tissue-Derived Mesenchymal SCs Bone Marrow-Derived Mesenchymal SCs Embryonic SCs Other Sources

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Musculoskeletal Disorders Wounds & Injuries Cardiovascular Diseases Gastrointestinal Diseases Immune System Diseases Other Applications

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Stem Cell Therapy Market Revenue, Key Players, Supply-Demand, Investment Feasibility and Forecast 2026 - The Think Curiouser