Stem Cell Clinic

Post-doctoral Fellow in Computational Stem Cell Biology job with THE UNIVERSITY OF HONG KONG | 234737 – Times Higher Education (THE)

Work type:Full-time Department:School of Biomedical Sciences (22600) Categories:Academic-related Staff

Applications are invited for appointment asPost-doctoral Fellow in Computational Stem Cell Biology (several posts) in the School of Biomedical Sciences(Ref.:502657), to commence as soon as possible for one to three year(s), with the possibility of renewal subject to satisfactory performance.

The selected candidates will work in a company incorporated by the University of Hong Kong that was established to administer and support the Universitys innovation endeavors. They will conduct research in a computational lab and closely work with experimental lab(s).The specific project will be discussed and determined between each candidate and the Principal Investigator together.

Applicants should have a Ph.D. degree in Bioinformatics, Genetics, Computational Biology or other relevant quantitative disciplines, and in-depth experience in at least one of the programming languages for scientific computing, for example, Python, R, Perl, C/C++ and JAVA.Research experience in stem cells, regenerative medicine, cancer, heart disease, liver disease, immunology or drug screening would be an advantage.Preference will be given to those with expertise in bioinformatics and computational biology, and with strong interests in translational research utilizing next-generation sequencing and single-cell sequencing to study any of the above research areas.The ability to work independently, participate in highly collaborative projects, and contribute intellectually to research development are requisites.Applicants should also be highly motivated individuals with good verbal and written communication skills in English.

A competitive salary commensurate with qualifications and experience will be offered.

The University only accepts online applications for the above posts. Applicants should apply online and upload an up-to-date C.V.Review of applications will start from December 4, 2020 and continue untilDecember 30, 2020, or until the posts are filled, whichever is earlier.

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Post-doctoral Fellow in Computational Stem Cell Biology job with THE UNIVERSITY OF HONG KONG | 234737 - Times Higher Education (THE)

Circulating Tumor Cells and Cancer Stem Cells Market Research Report 2020 with Manufacturing Process Analysis and Market Concentration Rate till 2026…

The Circulating Tumor Cells and Cancer Stem Cells Market grew in 2019, as compared to 2018, according to our report, Circulating Tumor Cells and Cancer Stem Cells Market is likely to have subdued growth in 2020 due to weak demand on account of reduced industry spending post Covid-19 outbreak. Further, Circulating Tumor Cells and Cancer Stem Cells Market will begin picking up momentum gradually from 2021 onwards and grow at a healthy CAGR between 2021-2025

Deep analysis about market status (2016-2019), competition pattern, advantages and disadvantages of products, industry development trends (2019-2025), regional industrial layout characteristics and macroeconomic policies, industrial policy has also been included. From raw materials to downstream buyers of this industry have been analysed scientifically. This report will help you to establish comprehensive overview of the Circulating Tumor Cells and Cancer Stem Cells Market

Get a Sample Copy of the Report at: https://i2iresearch.com/report/global-circulating-tumor-cells-and-cancer-stem-cells-market-2020-market-size-share-growth-trends-forecast-2025/#download-sample

The Circulating Tumor Cells and Cancer Stem Cells Market is analysed based on product types, major applications and key players

Key product type: Cell Enrichment Detection CTC Analysis

Key applications: Hospital NSC Medical Research Institute

Key players or companies covered are: QIAGEN Hannover AVIVA Biosciences Epic Sciences ApoCell Cynvenio Biosystems Fluxion Biosciences Rarecells Janssen Diagnostics CellTraffix Silicon Biosystems Advanced Cell Diagnostics

The report provides analysis & data at a regional level (North America, Europe, Asia Pacific, Middle East & Africa , Rest of the world) & Country level (13 key countries The U.S, Canada, Germany, France, UK, Italy, China, Japan, India, Middle East, Africa, South America)

Inquire or share your questions, if any: https://i2iresearch.com/report/global-circulating-tumor-cells-and-cancer-stem-cells-market-2020-market-size-share-growth-trends-forecast-2025/

Key questions answered in the report: 1. What is the current size of the Circulating Tumor Cells and Cancer Stem Cells Market, at a global, regional & country level? 2. How is the market segmented, who are the key end user segments? 3. What are the key drivers, challenges & trends that is likely to impact businesses in the Circulating Tumor Cells and Cancer Stem Cells Market? 4. What is the likely market forecast & how will be Circulating Tumor Cells and Cancer Stem Cells Market impacted? 5. What is the competitive landscape, who are the key players? 6. What are some of the recent M&A, PE / VC deals that have happened in the Circulating Tumor Cells and Cancer Stem Cells Market?

The report also analysis the impact of COVID 19 based on a scenario-based modelling. This provides a clear view of how has COVID impacted the growth cycle & when is the likely recovery of the industry is expected to pre-covid levels.

Contact us: i2iResearch info to intelligence Locational Office: *India, *United States, *Germany Email: [emailprotected] Toll-free: +1-800-419-8865 | Phone: +91 98801 53667

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Circulating Tumor Cells and Cancer Stem Cells Market Research Report 2020 with Manufacturing Process Analysis and Market Concentration Rate till 2026...

Analyzing Impacts of Covid-19 on Global Cell Culture Media Market Effects, Aftermath and Forecast To 2025 – The Courier

The research report titled Analyzing Impacts of Covid-19 on Global Cell Culture Media Market Effects, Aftermath and Forecast To 2025 and published by Zion Market Research is an in-depth and dedicated scrutiny of the existing stats of the globalCell Culture Media Marketentailing the numerous facets pertinent to statistics and growth of the business. The report segregated into diverse sections to simplify the comprehension of the included data and thus, market dynamics. It encompasses all the major competitors and playersAnalytical Biological Services Inc., Atlanta BiologicalsInc., BD Biosciences, Cell EssentialsInc., ClonTech LaboratoriesInc., GE Healthcare, JR ScientificInc., Life Technologies, Lonza Bioscience, Merck Millipore, MP Biomedicals, Novozymes Biopharma US Inc., Quality BiologicalInc., SeraCare Life SciencesInc., Siam Bioscience Co. Ltd., Sigma-Aldrich, Stemcell Technologies Inc., and Thermo Fisher ScientificInc.involved in the global Cell Culture Media Market along with the various features relating to the market players like company profiles, supply chain value, product specifications, market shares, and so on. Also, the report entails the major strategic market developments, comprising R&D activities, collaborations, new product launch, agreements, joint ventures, partnerships, M&A, and presence & expansion extent of these prominent players on the global and regional scale. In addition, it comprises the systematic examination of business strategies for expansion of the prominent Cell Culture Media Market players.

Request Free Sample Report of Cell Culture Media Market Report @https://www.zionmarketresearch.com/sample/cell-culture-media-market

Some of the Major Market Players Are:

Analytical Biological Services Inc., Atlanta BiologicalsInc., BD Biosciences, Cell EssentialsInc., ClonTech LaboratoriesInc., GE Healthcare, JR ScientificInc., Life Technologies, Lonza Bioscience, Merck Millipore, MP Biomedicals, Novozymes Biopharma US Inc., Quality BiologicalInc., SeraCare Life SciencesInc., Siam Bioscience Co. Ltd., Sigma-Aldrich, Stemcell Technologies Inc., and Thermo Fisher ScientificInc.

The Cell Culture Media Market report encompasses the general idea of the global Cell Culture Media Market including definition, classifications, and applications. Further, it includes the all-inclusive comprehension of several factors such as drivers, constraints, and major micro markets. The report is a wide-ranging source of widespread facts and figures for business strategists as it offers the historical & futuristic data such as demand & supply data, cost, revenue, profit, supply chain value, and so on. Furthermore, it entails the key market features, comprising production, revenue, price, capacity, gross margin, market share, consumption, gross, production rate, demand/supply, cost, capacity utilization rate, export/import, and CAGR (compound annual growth rate). In addition the report encompasses global Cell Culture Media Market segmentation on the basis of diverse facets like product/service type, application, technology, end-users, and major geographic regionsLatin America, North America, Asia Pacific, Middle & East Africa, and Europe.Apart from this, the researcher market analyst and experts present their outlook or insights of product sales, market share, and value along with the possible opportunities to grow or tap into in these regions.

Promising Regions & Countries Mentioned In The Cell Culture Media Market Report:

The Cell Culture Media Market report also entails the vigorous evaluation about the growth plot and all opportunities & risk related to of global Cell Culture Media Market during the forecast period. In addition, the report comprises the key events and most recent innovations in the industry together with the prospective trends technological progresses within the global Cell Culture Media Market that can impact its expansion graph. Entailing the pivotal data on the markets statistics and dynamics, the report will serve as a valued asset in term of decision-making and guidance for the businesses and companies already active within industry or looking forward to enter into it.

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The Study Objectives of Cell Culture Media Market Report Are:

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Analyzing Impacts of Covid-19 on Global Cell Culture Media Market Effects, Aftermath and Forecast To 2025 - The Courier

Adipose Tissue-Derived Stem Cells (ADSCS) Market Expected to Witness High Growth over the Forecast 2027 – Cheshire Media

TheAdipose Tissue-Derived Stem Cells (ADSCS) MarketReport conveys the clean expounded structure of the Market including every single business-related data of the market at a worldwide level. The total scope of data identified with the Market is acquired through different sources and this got main part of data is orchestrated, handled, and spoken to by a gathering of authorities through the utilization of various methodological procedures and logical instruments, for example, SWOT analysis to produce an entire arrangement of exchange based examination in regards to the Adipose Tissue-Derived Stem Cells (ADSCS) Market.

Adipose Tissue-Derived Stem Cells (ADSCS) Market Insight:

Adipose tissue-derived stem cells (ADSCS) market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market to account grow at a CAGR of 6.1% in the above-mentioned forecast period. The accelerating application of adipose tissue-derived stem cells (ADSCS) in the regenerative medicines research, development of cell linage, tissue engendering, bone and cartilage regeneration are driving the exponential growth of adipose tissue-derived stem cells (ADSCS) market during the forecast period of 2020 to 2027.

Adipose Tissue-Derived Stem Cells (ADSCS) Market Presented byData Bridge Market Researchexamines the market ecosystem, adoption trends, key drivers, restraints, competitive outlook, key challenges, future growth potentials, and revenue chain analysis. Also, the report provides detailed exploration and upcoming trends of this market place for Adipose Tissue-Derived Stem Cells (ADSCS) .

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Adipose Tissue-Derived Stem Cells (ADSCS) Market competition by top manufacturers/players, with sales volume, Price (USD/Unit), Revenue (Million USD) and market share for each manufacturer/player; the top players including:

Antria Inc., CELGENE CORPORATION, pluristem, Tissue Genesis, Cytori Therapeutics Inc., PRECIGEN, Mesoblast Ltd, CORESTEM, Inc, among other domestic and global players.

The Objectives of the Adipose Tissue-Derived Stem Cells (ADSCS) Market Report:

Major Regions:

Geographically, this report split into several key Regions, with sales (MT), Revenue (Million USD), market share and growth rate of Adipose Tissue-Derived Stem Cells (ADSCS) for these regions, covering

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Major Points Covered in Adipose Tissue-Derived Stem Cells (ADSCS) Market Report:-

Reasons to Purchase this Report

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In conclusion, the Adipose Tissue-Derived Stem Cells (ADSCS) Market report is a reliable source for accessing the research data that is projected to exponentially accelerate your business. The report provides information such as economic scenarios, benefits, limits, trends, market growth rates, and figures. SWOT analysis is also incorporated in the report along with speculation attainability investigation and venture return investigation.

COVID-19 Impact Analysis:

The report seeks to track the evolution of the market growth pathways and publish a medical crisis in an exclusive section publishing an analysis of the impact of COVID-19 on the Adipose Tissue-Derived Stem Cells (ADSCS) market. The new analysis of the COVID-19 pandemic provides a clear assessment of the impact on the Adipose Tissue-Derived Stem Cells (ADSCS) market and the expected volatility of the market during the forecast period. Various factors that can affect the general dynamics of the Adipose Tissue-Derived Stem Cells (ADSCS) market during the forecast including current trends, growth opportunities, limiting factors, etc., are discussed in detail in this market research.

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Adipose Tissue-Derived Stem Cells (ADSCS) Market Expected to Witness High Growth over the Forecast 2027 - Cheshire Media

Accretion: Current and Future Business Analysis in Cell Expansion Market – PharmiWeb.com

Pune, New York, USA, November 25 2020 (Wiredrelease) Research Dive :The global cell expansion market is estimated to surpass $39,876.1 million by 2027, exhibiting a CAGR of 15.1% from 2020 to 2027.

The report aims to offer a clear picture of the current scenario and future growth of the global Cell Expansion Market market. The report provides scrupulous analysis of global market by thoroughly reviewing several factors of the market such as vital segments, regional market condition, market dynamics, investment suitability, and key players operating in the market. Besides, the report delivers sharp insights into present and forthcoming trends & developments in the global market.

The report articulates the key opportunities and factors propelling the global Cell Expansion Market market growth. Also, threats and limitations that have the possibility to hamper the market growth are outlined in the report. Further, Porters five forces analysis that explains the bargaining power of suppliers and consumers, competitive landscape, and development of substitutes in the market is also sketched in the report.

For More Detail Insights, Download Sample Copy of the Report at: https://www.researchdive.com/download-sample/1779

The report reveals various statistics such as predicted market size and forecast by analyzing the major factors and by assessing each segment of the global Cell Expansion Market market. Regional market analysis of these segments is also provided in the report. The report segments the global market into four main regions including Asia-Pacific, Europe, North America, and LAMEA. Moreover, these regions are sub-divided to offer an exhaustive landscape of the Cell Expansion Market market across key countries in respective regions. Furthermore, the report divulges some of the latest advances, trends, and upcoming opportunities in every region.

Furthermore, the report profiles top players active in the global Cell Expansion Market market. A comprehensive summary of 10 foremost players operating in the global market is delivered in the report to comprehend their position and footmark in the industry. The report highlights various data points such as short summary of the company, companys financial status and proceeds, chief company executives, key business strategies executed by company, initiatives undertaken & advanced developments by the company to thrust their position and grasp a significant position in the market.

RESEARCH METHODOLOGY

The research report is formed by collating different statistics and information concerning the Cell Expansion Market market. Long hours of deliberations and interviews have been performed with a group of investors and stakeholders, including upstream and downstream members. Primary research is the main part of the research efforts; however, it is reasonably supported by all-encompassing secondary research. Numerous product type literatures, company annual reports, market publications, and other such relevant documents of the leading market players have been studied, for better & broader understanding of market penetration. Furthermore, medical journals, trustworthy industry newsletters, government websites, and trade associations publications have also been evaluated for extracting vital industry insights.

Connect with Our Analyst to Contextualize Our Insights for Your Business:https://www.researchdive.com/connect-to-analyst/1779

KEY MARKET BENEFITS

This report is a compilation of qualitative assessment by industry analysts, detailed information & study, and valid inputs from industry participants & experts across the value chainAn in-depth analysis along with recent trends of the industry are provided in the report to identify & comprehend the prevailing opportunities and the tactical assessment of the global Cell Expansion Market market growthThe market size and forecasts are derived by scrutinizing market boomers and restraints, and key developments in the Cell Expansion Market marketThe report studies the market from 2019 to 2027 and maps the qualitative impact of several industry factors on market segments as well as geographiesThe development strategies implemented by the key industry players are conscripted in the report to understand the competitive scenario of the global Cell Expansion Market marketThe report also offers insights into foremost market players, Porters Five Analysis, and top winning business strategies

KEY MARKET SEGMENTS

The global Cell Expansion Market market is segmented on the basis of the following:

Global Cell Expansion Market Market By Product Type:

Consumables, Instruments, Bioreactors, Automated Cell Expansion Systems

Global Cell Expansion Market Market By Applications:

Regenerative Medicine and Stem Cell Research, Cancer and Cell-based Research, Other

Global Cell Expansion Market Market By Regions:

North America (U.S, Canada, and Mexico.)Europe (Germany, UK, France, Spain, Italy, Rest of Europe.)Asia-Pacific (Japan, China, India, Australia, South Korea, Rest of APAC.)LAMEA (Brazil, Argentina, Saudi Arabia, South Africa, UAE, Rest of LAMEA)

Top Leading key players stated in Global Cell Expansion Market Market report are:

Thermo Fisher Scientific Inc., Danaher, Becton, Dickinson and Company, Lonza, Corning Inc., Merck KGaA, Sartorius Stedim Biotech, Getinge AB, Terumo Corporation, Miltenyi Biotec

The report also summarizes other important aspects including financial performance, product portfolio, SWOT analysis, and recent strategic moves and developments of the leading players.

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Accretion: Current and Future Business Analysis in Cell Expansion Market - PharmiWeb.com

Stem Cell Market to Witness a Pronounce Growth During (2020-2026) Cheshire Media – Cheshire Media

United States (2020):- The Stem Cell Market report makes available the current and forthcoming technical and financial details of the industry. It is one of the most comprehensive and important additions to the Prudent Markets archive of market research studies. It offers detailed research and analysis of key aspects of the global Stem Cell market. This report explores all the key factors affecting the growth of the global Stem Cell market, including demand-supply scenario, pricing structure, profit margins, production, and value chain analysis.

The report concludes with the profiles of major players in the Stem Cell market are: CCBC, Vcanbio, Boyalife, Beikebiotech

Global Stem Cell Market research is an understanding report with meticulous efforts undertaken to study the right and important information offering an entire study of the Impact of COVID-19 on Stem Cell Market, Industry Outlook, Opportunities in Market, and Expansion By 2026 and also taking into consideration key factors like drivers, challenges, recent trends, opportunities, advancements, and competitive landscape. Research techniques like PESTLE and SWOT analysis are made available by the researchers.

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Type Segmentation: Diseases Therapy, Embryonic Stem Cell, Adult Stem Cell, Others

Industry Segmentation: Diseases Therapy, Healthcare

Stem Cell Market

Prudent Markets provides attractive discounts that fit your needs. Customization of the reports as per your requirement is also offered. Get in touch with our sales team, who will guarantee you a report that suits your needs.

Speak To Our Analyst For A Discussion On The Above Findings, And Ask For A Discount up to 40% On The Report @ https://www.prudentmarkets.com/discount-request/18806/

In this study, the years considered to estimate the market size of Stem Cell Market: History Year: 2015 2019 Base Year: 2019 Estimated Year: 2020 Forecast Year: 2020 2026

The report covers the competitive analysis of the market. As the demand is driven by a buyers paying capacity and the rate of item development, the report shows the important regions that will direct growth. This section exclusively shares insight into the budget reports of big-league members of the market helping key players and new entrants understand the potential of investments in the Global Stem Cell Market. It can be better employed by both traditional and new players in the industry for complete know-how of the market.

Regional Analysis for Stem Cell Market: North America (the USA and Canada) Europe (UK, Germany, France, Italy, Spain, Scandinavia and Rest of Europe) Asia Pacific (Japan, China, India, Australia, Southeast Asia and Rest of Asia Pacific) Latin America (Brazil, Mexico and Rest of Latin America) Middle East & Africa (South Africa, GCC and Rest of the Middle East & Africa)

The report provides insights on the following pointers: 1. Market Penetration: Comprehensive information on the product portfolios of the top players in the Stem Cell market. 2. Product Development/Innovation: Detailed insights on the upcoming technologies, R&D activities, and product launches in the market. 3. Competitive Assessment: In-depth assessment of the market strategies, geographic and business segments of the leading players in the market. 4. Market Development: Comprehensive information about emerging markets. This report analyzes the market for various segments across geographies. 5. Market Diversification: Exhaustive information about new products, untapped geographies, recent developments, and investments in the Stem Cell market.

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Free Customization on the basis of client requirements on Immediate purchase: 1- Free country-level breakdown of any 5 countries of your interest. 2- Competitive breakdown of segment revenue by market players.

Customization of the Report: This report can be customized to meet the clients requirements. Please connect with our sales team ([emailprotected]), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +91 835 605 0278 to share your research requirements.

Get ready to Recognize the pros and cons of the regulatory framework, local reforms, and its effect on the Industry. Understand how the Leaders in Intelligent Network are keeping themselves one stage forward with our most up-to-date survey analysis.

In conclusion, the Stem Cell Market report is a genuine source for accessing the research data which is projected to exponentially grow your business. The report provides information such as economic scenarios, benefits, limits, trends, market growth rates, and figures. SWOT analysis and PESTLE analysis is also incorporated in the report.

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Stem Cell Market to Witness a Pronounce Growth During (2020-2026) Cheshire Media - Cheshire Media

Demand with COVID-19 impact analysis on Cell Expansion Market – The Courier

The report aims to offer a clear picture of the current scenario and future growth of the global Cell Expansion Market market. The report provides scrupulous analysis of global market by thoroughly reviewing several factors of the market such as vital segments, regional market condition, market dynamics, investment suitability, and key players operating in the market. Besides, the report delivers sharp insights into present and forthcoming trends & developments in the global market.

The report articulates the key opportunities and factors propelling the global Cell Expansion Market market growth. Also, threats and limitations that have the possibility to hamper the market growth are outlined in the report. Further, Porters five forces analysis that explains the bargaining power of suppliers and consumers, competitive landscape, and development of substitutes in the market is also sketched in the report.

For More Detail Insights, Download Sample Copy of the Report at: https://www.researchdive.com/download-sample/1779

The report reveals various statistics such as predicted market size and forecast by analyzing the major factors and by assessing each segment of the global Cell Expansion Market market. Regional market analysis of these segments is also provided in the report. The report segments the global market into four main regions including Asia-Pacific, Europe, North America, and LAMEA. Moreover, these regions are sub-divided to offer an exhaustive landscape of the Cell Expansion Market market across key countries in respective regions. Furthermore, the report divulges some of the latest advances, trends, and upcoming opportunities in every region.

Furthermore, the report profiles top players active in the global Cell Expansion Market market. A comprehensive summary of 10 foremost players operating in the global market is delivered in the report to comprehend their position and footmark in the industry. The report highlights various data points such as short summary of the company, companys financial status and proceeds, chief company executives, key business strategies executed by company, initiatives undertaken & advanced developments by the company to thrust their position and grasp a significant position in the market.

RESEARCH METHODOLOGY

The research report is formed by collating different statistics and information concerning the Cell Expansion Market market. Long hours of deliberations and interviews have been performed with a group of investors and stakeholders, including upstream and downstream members. Primary research is the main part of the research efforts; however, it is reasonably supported by all-encompassing secondary research. Numerous product type literatures, company annual reports, market publications, and other such relevant documents of the leading market players have been studied, for better & broader understanding of market penetration. Furthermore, medical journals, trustworthy industry newsletters, government websites, and trade associations publications have also been evaluated for extracting vital industry insights.

Connect with Our Analyst to Contextualize Our Insights for Your Business:https://www.researchdive.com/connect-to-analyst/1779

KEY MARKET BENEFITS

KEY MARKET SEGMENTS

The global Cell Expansion Market market is segmented on the basis of the following:

Global Cell Expansion Market Market By Product Type:

Global Cell Expansion Market Market By Applications:

Global Cell Expansion Market Market By Regions:

Top Leading key players stated in Global Cell Expansion Market Market report are:

Thermo Fisher Scientific Inc., Danaher, Becton, Dickinson and Company, Lonza, Corning Inc., Merck KGaA, Sartorius Stedim Biotech, Getinge AB, Terumo Corporation, Miltenyi Biotec

The report also summarizes other important aspects including financial performance, product portfolio, SWOT analysis, and recent strategic moves and developments of the leading players.

Contact Us:

Mr. Abhishek Paliwal Research Dive 30 Wall St. 8th Floor, New York NY 10005 (P) + 91 (788) 802-9103 (India) +1 (917) 444-1262 (US) Toll Free : +1 -888-961-4454 Email:support@researchdive.com LinkedIn:https://www.linkedin.com/company/research-dive Twitter:https://twitter.com/ResearchDive Facebook:https://www.facebook.com/Research-Dive Blog:https://www.researchdive.com/blog Follow us on:https://covid-19-market-insights.blogspot.com

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Demand with COVID-19 impact analysis on Cell Expansion Market - The Courier

Approval of Phase I/II Clinical Trial of ATG-016 (Eltanexor), a Second Generation Selective Inhibitor of Nuclear Export (SINE), in Mainland China for…

SHANGHAI and HONG KONG, Nov. 25, 2020 /PRNewswire/ -- Antengene Corporation Limited ("Antengene", HKSE stock code: 6996.HK), a leading innovative biopharmaceutical company dedicated to discovering, developing and commercializing global first-in-class and/or best-inclass therapeutics in hematology and oncology, announced that the National Medical Products Administration (NMPA) has approved the clinical trial of ATG-016 (eltanexor) in patients with intermediate and higher risk myelodysplastic syndrome (MDS) according to the Revised International Prognostic Scoring System (IPSS-R) after the failure of hypomethylating agents (HMA) based therapy. The trial is a Phase I/II, single-arm, open-label clinical study, aiming to evaluate the pharmacokinetics, safety and efficacy of ATG-016 (eltanexor) monotherapy.

MDS is a heterogeneous group of clonal disorders of the bone marrow hematopoietic stem cells (HPSCs), characterized by ineffective hematopoiesis with peripheral blood cytopenia and a higher risk for developing acute myeloid leukemia (AML). Patients with high-risk MDS refractory to hypomethylating agents have a median overall survival (OS) of only 4 to 6 months with limited options for follow-up treatment. Pre-clinical studies have demonstrated that selective inhibitor of nuclear export (SINE) compounds are able to block the nuclear export of many tumor suppressor proteins (e.g. p53, IkB, p21) leading to their accumulation and activation in the nucleus thereby exerting anti-tumor effects. In addition, SINE compounds can also reduce the nuclear export and translation of many oncogenic mRNA (c-Myc, Bcl-2, Bcl-6, cyclin D) which are bound to elF4E and result in selective apoptosis of tumor cells. ATG-016 is a member of the latest-generation of SINE compounds. Compared to the first-generation nuclear export inhibitor, ATG-016 demonstrates minimal blood-brain barrier permeability and a broader therapeutic window. It has shown preliminary anti-cancer activity in high-risk MDS patients.

Dr. Jay Mei, the Founder, Chairman and CEO of Antengene expressed, "The approval of the ATG-016 clinical trial demonstrates the efficient execution of the Antengene R&D team and is also the first clinical trial approval obtained by Antengene in mainland China after its listing." He also mentioned, "Selinexor, the first-generation selective inhibitor of nuclear export, has shown extensive activity against hematological malignancies and solid tumors, and has been approved by the FDA for relapsed/refractory multiple myeloma and diffuse large B-cell lymphoma. As a second-generation orally available SINE compound, ATG-016 can reduce the blood-brain barrier penetration, thereby representing a broader therapeutic window with potentially less adverse events and better drug tolerability."

About ATG-016

ATG-016 (eltanexor) is a second-generation selective inhibitor of nuclear export compound. Compared to the first-generation SINE compound, ATG-016 has lower blood-brain barrier penetration and broader therapeutic window which allows more frequent dosing and a longer period of exposure at higher levels with better tolerability. Therefore, ATG-016 may be used to target a wider range of indications. We plan to conduct phase I/II clinical studies for MDS in China, and plan to further develop ATG-016 for cancers with high prevalence in the Asia-Pacific region (such as KRAS-mutant solid tumors) and virus infection related malignancies (such as nasopharyngeal carcinoma).

About Antengene

Antengene Corporation Limited ("Antengene", SEHK: 6996.HK) is a leading clinical-stage Asia-Pacific biopharmaceutical company focused on innovative oncology medicines. Antengene aims to provide the most advanced anti-cancer drugs to patients in China, the Asia Pacific Region and around the world. Since its establishment, Antengene has built a pipeline of 12 clinical and pre-clinical stage assets, obtained 10 investigational new drug (IND) approvals and has 9 ongoing cross-regional clinical trials in Asia Pacific. At Antengene, we focus on developing drug candidates with novel mechanisms of action (MoAs) and first-in-class/best-in-class potential to address significant unmet medical needs. The vision of Antengene is to "Treat Patients Beyond Borders" through research, development and commercialization of first-in-class/best-in-class therapeutics.

Forward-looking statements

The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development.

SOURCE Antengene Corporation Limited

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Approval of Phase I/II Clinical Trial of ATG-016 (Eltanexor), a Second Generation Selective Inhibitor of Nuclear Export (SINE), in Mainland China for...

Researchers grow first plant-based gel to help organoid development for biomedical applications – Microbioz India

Monash University researchers have created the worlds first bioactive plant-based nanocellulose hydrogel to support organoid growth and help significantly reduce the costs of studies into cancer and COVID-19.

This discovery by researchers at BioPRIA (Bioresource Processing Institute of Australia), Monash Universitys Department of Chemical Engineering and the Monash Biomedicine Discovery Institute will develop organoids cheaper, faster and more ethically.

The hydrogel can also improve drug screening and disease modelling for infectious diseases, like COVID-19; metabolic diseases, such as obesity and diabetes; and cancer.

The findings, published inAdvanced Science, emerge as a promising finding for growth of organoids for essential laboratory testing across the world. With additional testing, this hydrogel could be available to researchers and health professionals across the world in less than 12 months.

Nanocellulose gels cost just cents for every 10ml used, compared to $600 or more for the current gold standard.

Above all, nanocellulose gels are completely plant-based, preventing the harvesting of animal organs and unknown biomolecules for any advanced medical testing.

Professor Gil Garnier and Dr Rodrigo Curvello from BioPRIA within Monash Universitys Department of Chemical Engineering led the study.

Organoids provide a robust model for key applications in biomedicine, including drug screening and disease modelling. But current approaches remain expensive, biochemically variable and undefined.

Gil Garnier, Director of BioPRIA, Monash University

These are major obstacles for fundamental research studies and the translation of organoids to clinics. Alternative matrices able to sustain organoid systems are required to reduce costs drastically and to eliminate the unreliability of unknown biomolecules.

As nanocellulose hydrogel is animal-free, its composition is controlled perfectly and reproducible unlike the current progress and fully mimic the human body conditions.

Organoids are three-dimensional, miniaturised and simplified versions of organs produced in vitro that can replicate behaviours and functionalities of developed organs.

Commonly referred to as organs in a dish or mini-organs, organoids are an excellent tool to study basic biological processes. Through organoids, we can understand how cells interact in an organ, how diseases affect them and the effects of drugs in disease reduction.

Organoids are generated from embryonic, adult, pluripotent orinduced pluripotent stem cells, as well as from primary healthy or cancerous tissues.

For long-term use, organoids are commonly embedded within an Engelbreth-Holm Swarm (EHS) matrix derived from the reconstituted basement membrane of mouse sarcoma.

Currently, organoid culture is dependent of this expensive and undefined tumour-derived material that hinders its application in high-throughput screening, regenerative medicine and diagnostics.

Our study was essentially able to use an engineered plant-based nanocellulose hydrogel that can replicate the growth of small intestinal organoids derived from mice, Dr Curvello said.

It is essentially made from 99.9% water and only 0.1% solids, functionalised with a single cell adhesive peptide. Cellulose nanofibers are linked with salts that provide the microenvironment needed for small intestinal organoid growth and proliferation.

Engineered nanocellulose gel represents a sustainable alternative for the growth of organoids, contributing to reducing the costs of studies on diseases of global concern, particularly in developing countries.

Source:

Journal reference:

Curvello, R.,et al.(2020) Engineered PlantBased Nanocellulose Hydrogel for Small Intestinal Organoid Growth.Advanced Science.doi.org/10.1002/advs.202002135.

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Researchers grow first plant-based gel to help organoid development for biomedical applications - Microbioz India