Boise State engineers given the opportunity to send stem cell research into space – Boise State University The Arbiter Online

Boise State engineers have been awarded $315,000 from the National Science Foundation (NSF) to launch stem cell research into space.

Alexander Regner, masters student in materials science engineering, has been working on stem cell research for nearly three years. Through Regners research, he has studied the health and maintenance of bone and bone marrow.

As you exercise and move, your bone marrow stimulates cells, which is a vital part of maintaining health, according to Regner.

Thats why exercise is so good for you. We know all of this contributes to health and maintenance, but we dont actually know what it looks like mechanically to these cells, Regner said.

Regner and his associates Gunes Uzer, assistant professor of mechanical and biomedical engineering, and Aykut Satici, assistant professor of mechanical and biomedical engineering, have created a model to mimic the bone marrow mechanical environment and analyze what kind of mechanical environment is causing the cells to react in certain ways.

Regner uses a computer simulation that matches a 3D printed physical sample. This allows Regner to understand what the mechanical environment looks like so they can correlate the mechanical environment to the cellular response.

Through this research, Regner asks the big question, is there a different mechanical environment generated due to changes in bone architecture?

Gunes and Satici looked at Regners research and wanted to bring it to a bigger audience. Their new goal was to determine how stem cell research can benefit Earth. According to Gunes, space travel tends to produce tissue types and cell behavior that is similar to aging. This aging happens over a matter of weeks in space, as opposed to a matter of years on Earth.

We take one of these bone cells and we age them for a year or two. But obviously, these bones have a shelf life, Gunes said. Maybe we can do that in space in three weeks and do the experiment in space. Maybe we can learn more about how the bone mechanical environment contributes to the aging process. Thats really the project, take Alexs work and send it to space.

Saticis contribution to this research is from a different perspective, robotics. According to Satici, there needs to be mechanical vibrations applied to particular cells. To accomplish this, there needs to be a robotic mechanism to perform that motion in a consistent matter.

Center for the Advancement of Science in Space (CASIS) holds a subcontract with the International Space Station along with the National Science Foundation (NSF). Each year, they ask the question, what type of research can we perform in space that can teach us something about Earth and improve advanced science on Earth?

Regner, Gunes and Satici argued that they cannot properly age experiments on Earth, and proposed that space could be a good platform for their research. They wrote a grant proposal for their research, what they have done in the past, what they plan to do and who is a part of the research team.

Regner, Gunes and Satici also work closely with the University of Texas, Rensselaer Polytechnic Institute and Space Tango to complete this research.

Through this extensive research, Regner, Satici and Gunes emphasize the importance of working hard to accomplish ones goals.

Just because its fun to do, doesnt mean you are going to learn it. You have to persevere and do the dirty work. Try to improve yourself with any resources you can get, Satici said.

Regner advocates for students to continuously work hard to help solve modern problems. There are a lot of job opportunities in the STEM field, and many jobs that may not require a STEM background at all, like politics.

A lot of our modern problems we are dealing with are multidisciplinary things. It requires the involvement of everyone. Space flight, for example, you need people to understand not only the mechanics but make sure were safe while were doing it, Regner said. [There are] a lot of problems we are facing in the middle age. If youre interested in helping solve them, there are so many different opportunities to get involved. If you want to go into politics, we need people to advocate for science in politics to make sure that we have adequate funding and focused goals for where we are going and what we are doing.

Gunes hopes students who want to get involved and achieve their goals will start with volunteer work.

Go to a lab youre interested in and say Hey, I want to do volunteering involving research. Before you know it you start getting your masters, your Ph.D., and then you become a scientist. If youre interested in [science] then stop thinking about it and do it, Gunes said.

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Boise State engineers given the opportunity to send stem cell research into space - Boise State University The Arbiter Online

Stem Cell and Progenitor Cell-based Therapeutics Market Market Size, Share, Industry Report by Growt – PharmiWeb.com

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Stem Cell and Progenitor Cell-based Therapeutics Market Market Size, Share, Industry Report by Growt - PharmiWeb.com

Thinking It Through: Only two of 12 statewide propositions should be approved – VVdailypress.com

By Richard Reeb | For the Victorville Daily Press

California is one of 24 states that authorize citizens to vote directly on legislation or constitutional amendments that are proposed either by the initiative of the voters, the legislature or referendum. After some lean ballots in recent years, we face a dozen measures come Nov. 3 on a variety of subjects, including health, civil rights, property taxes, voting rights, rent control, parole and bail, and consumer privacy.

An initiative statute that would authorize $5.5 billion in state bonds to fund stem cell research, which, with interest, would climb to $7.8 billion. Proponents claim that it dedicates $1.6 billion to brain research but say nothing about whether, as in its original form, it includes embryonic stem cells. Opponents suspect that is the case, condemning their destruction as unethical. I would add, as the less scrupulous Chinese Communist regime discovered, their cherished multifaceted character leads to wildly unpredictable results in human beings. Vote no.

An initiative constitutional amendment at least equally malicious as 14, as it aims to undercut the historic property tax reform effected by a famous initiative passed in 1978 that cut property taxes for all property owners, both residential and commercial. It does this by striking at what proponents believe is its alleged privileging of large commercial interests. But opponents not only believe the measure is unfair to small commercial properties, but predict that residential property owners are next if the measure passes. Vote no.

An especially obnoxious measure, a constitutional amendment proposed by the state legislature to overturn a 1996 amendment that put an end to racial discrimination under the guise of diversity in state hiring, contracting and college admissions. Despite covert efforts to ignore the ban of official violation of civil rights, the existing provision has generally succeeded. The claim of systemic racism is as bogus now as it was 24 years ago. Vote no.

This legislative constitutional amendment, is cut from the same cloth as 16 in that it gives preferential treatment, here by permitting convicts to obtain voting rights before they have completed their parole. Their debt to society is not paid on the day they leave their prison cell as they are still under the supervision of persons with the authority to revoke it. It does not matter, as proponents claim, that other states have taken this step. It still trivializes the voting privilege. Vote no.

This is equally ill-conceived, a legislative constitutional amendment extending voting rights to children months before their 18th birthday by allowing them to vote in the primary election if they qualify for the general election. Proponents thrill at adolescents participating in politics, ignoring the opponents valid counterargument that voting is a big responsibility that should be reserved for persons who actually have responsibilities. Vote no.

Yet another legislative constitutional amendment that attacks property inheritances by persons 55 and over as not deserving of the same tax-saving protections as other transfers. Proponents anticipate increased tax revenues but opponents see that as unfair to parents seeking to help their children. Vote no.

An initiative statute limiting access to parole for such crimes as misdemeanor shoplifting with actual jail time for the offenders. The current absurd policy permits perps to steal as much as $950 worth three times! before they face serious consequences. Besides ending this madness, the measure would expand DNA collection in cases of rape and murder. Critics fear excess confinement that would overload the prisons, which supporters discount. Vote yes.

An initiative statute that would allow hundreds of our local governments to impose rent control on residential properties over 15 years old. Proponents call this a useful tool against homelessness, but opponents say it undermines the existing state rent control and would drive up the cost of housing, thereby doing nothing to increase supply. Vote no.

An initiative statute aimed at freeing app-based transportation and delivery companies from Assembly Bill 5 that requires all contract job holders to be redefined as regular employees so that they are provided the benefits and costs, as well as possible unionization. Uber, Lyft and DoorDash qualified this measure and pay for advertisements. They tried to escape the confines of this law through court action but failed. The measure provides some employee benefits but opponents reject it root and branch. Vote yes.

An initiative statute that would require a medical professional on site for dialysis treatment. Proponents claim it combats poor hygiene but opponents argue that it would force many clinics to shut down. Would the passage of this measure lead to a similar requirement for blood work or x-rays? Vote no.

An initiative statute that aims to protect consumer privacy but it is so convoluted that critics fear it would have the opposite result. Proponents say it will check Big Techs data collection but opponents say that consumers ability to restrict them would take far too long.Vote no.

A referendum that would replace existing law that requires bail for persons accused of crime with a system based on public safety and flight risk, purportedly enabling poor defendants to avoid heavy financial burdens that well-to-do suspects easily bear. Proponents promise a fairer and safer process as well, but opponents are skeptical of its dependence on computer-generated profiling. Vote no.

Richard Reeb taught political science, philosophy and journalism at Barstow College from 1970 to 2003. He is the author of Taking Journalism Seriously: Objectivity as a Partisan Cause (University Press of America, 1999). He can be contacted at rhreeb@verizon.net.

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Thinking It Through: Only two of 12 statewide propositions should be approved - VVdailypress.com

Oakland University researchers acquire flow cytometry cell sorter with NSF grant – 2020 – College of Arts and Sciences – News – OU Magazine – News at…

A grant from the National Science Foundation recently helped researchers at Oakland University acquire a flow cytometry cell sorter, a scientific instrument which will allow for hands-on collaborative research in the areas of amphibian biology, plant genomics, and stem cell biology.

A flow cytometry cell sorter is an instrument that is used to perform fluorescent activated cell sorting, which means it can separate or sort small particles, such as cells, chemical compounds, beads, and proteins that are suspended in a stream of fluid, said Dr. Luis Villa-Diaz, an assistant professor in the Biological Sciences and Bioengineering departments at OU.

It does this based on fluorescent signals coming from the particle after it has been stimulated by lasers in the instrument, Villa-Diaz said. If the laser signal makes the particle glow, then a computer will detect that signal and quantify it, and also will direct that particle to a particular container to be collected. Then we can recover the desired particles after theyre sorted and use them for other experiments or purposes.

The flow cytometry cell sorter was obtained using a Major Research Instrumentation (MRI) grant provided by the National Science Foundation. Under the terms of the grant, the NSF covered 70 percent of the cost approximately $544,073 while a collaboration between the Office of the Provost, the College of Arts and Sciences, the Department of Biological Sciences, the Department of Chemistry, the Eye Research Institute, and the Center for Biomedical Research provided the remaining 30 percent ($233,174).

Villa-Diaz will serve as principal investigator on the grant, while Dr. Shailesh Lal, a professor of Biological Sciences and chair of the Bioengineering Department; Dr. Thomas Raffel, an associate professor of Biological Sciences; and Dr. Gerard Madlambayan, an associate professor of Biological Sciences, will serve as co-principal investigators.

I will be using the flow cell sorter to separate different populations of stem cells based on the expression of proteins at their cell membrane, Villa-Diaz said. After sorting and enrichment of the desired cells, we will be able to use and compare the different cell populations using other experimental conditions.

The flow cytometry cell sorter can also be used for a variety of other projects, including the determination of basic biological functions and signaling directed by cell surface proteins in stem cells, the role of endothelial cells on anti-apoptotic pathways, the regulation of pre-mRNA processing in plants, the effects of temperature in amphibian immunology, the development of tubular organs, and basic understanding of DNA repair mechanisms.

The instrument will be available for use by all investigators at OU and investigators from neighboring educational institutions, as well as by users coming from other industries, although there will be a fee involved, Villa-Diaz said. The instrument will also be used for educational purposes in multiple classes, including biology, chemistry and bioengineering.

For more information regarding the use of the instrument, contact Kathie Lesich at lesich@oakland.edu or Suraj Timilsina at surajtimilsina@oakland.edu.

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Oakland University researchers acquire flow cytometry cell sorter with NSF grant - 2020 - College of Arts and Sciences - News - OU Magazine - News at...

California propositions: What you should know before voting – The Mercury News

The vote for president may be the item on the ballot that is drawing the most attention, but California voters are faced with another slate of propositions.

Of the 12 measures on this years ballot, some may feel very familiar. Others are all new.

Its a lot to consider. And now that ballots have been mailed to Californians, its a good time to find out what each proposition is about.

Heres a primer:

Vote yes for this and state taxpayers will be on the hook for $5.5 billion in bonds aimed at reviving the California Institute for Regenerative Medicine (CIRM), a program created in 2004 to boost stem cell research.

A vote against it would save money, but it might kill CIRM. The 16-year-old program ran out of its initial funding last year and it hasnt taken on new research since last summer, according to the state.

Stem cells, if youre wondering, are used in medical research on everything from nerve disorders and blindness to tooth decay.

Read our recommendation on how to votehere.

A yes vote would essentially create two distinct tracks (split roll) for state property taxes one for most commercial buildings and another for residential dwellings.

Under Prop. 15, the tax rate on most commercial and industrial properties would be based on the buildings market value, not its original purchase price. Exceptions would be made for buildings used in agriculture and for buildings owned by individuals or companies with less than $3 million in other assets. Overall, the state estimates it would generate up to $12.5 billion a year in new taxes from the owners of commercial properties.

A no vote would leave Californias Prop. 13 tax rules intact. All residential structures in California would continue to be taxed as they are now, with annual tax hikes jumping no more than the rate of inflation or 2%, whichever is lower.

Read our recommendation on how to votehere.

A yes vote on Prop. 16 would make it legal to consider race and gender, among other things, as potentially favorable factors when it comes to making decisions about public employment, public education and public contracting.

Technically, Prop. 16 is a constitutional amendment to repeal Prop. 209, a 1996 constitutional amendment approved by voters that ended the use of affirmative action in California.

Thus, a no vote would uphold Prop. 209.

Read our recommendation on how to votehere.

A yes vote for Prop. 17 would make it legal for people to vote while on parole for a felony conviction. Right now, in California, felons cant vote until after theyve served both their prison sentence and any parole. So were clear, Prop. 17 does not propose letting felons vote while in prison.

Read our recommendation on how to votehere.

A yes vote would allow 17-year-olds to vote in any primary or special election if they will turn 18 by the following general election

Read our recommendation on how to votehere.

This complicatedgrab bag of a proposal would allow older homeowners (those 55 and older), as well as disabled people and anyone who lost properties in a natural disaster, to take some of their property tax base with them when they sell a home and buy a new one.

It also would make it harder to keep a low property tax rate while transferring properties between generations.

And, finally, some of the new money generated by these changes would be used to help pay for firefighting.

Read our recommendation on how to votehere.

A yes vote for Prop. 20 would add to the states list of wobbler crimes, violations that currently are misdemeanors but, under this proposal, could be charged as felonies in some circumstances. Such crimes include organized petty theft, credit card scams and stealing a firearm, among others.

Prop. 20 also would create stiffer penalties for people who violate terms of their parole three times and make it tougher for those convicted of certain crimes including domestic violence to be considered for early parole. Finally, Prop. 20 would require that DNA samples be taken from people convicted of some misdemeanors.

Read our recommendation on how to votehere.

A yes vote on Prop. 21 would let cities write new rent control laws for older housing (15 years and older) or expand any rent control rules they already have on the books.

The proposal carves out an exception for single-family homes owned by landlords with no more than two properties. And, while Prop. 21 would wipe out the Costa-Hawkins Rental Housing Act (Costa-Hawkins) of 1995, it would not change the 7% rent hike limit set by state lawmakers last year.

Read our recommendation on how to votehere.

A yes vote on Prop. 22 would make an employee of gig-based companies such as Lyft or Uber an independent contractor same as before the passage of AB 5, which took effect in September 2019.

Under Prop. 22, rideshare and delivery companies that depend on such workers would not have to pay standard wage and hour restrictions, though they would have to provide an earnings floor and some money to purchase health insurance and mileage, among other things.

A no vote on Prop. 22 means existing law including AB 5 will apply to gig workers.

Its important to note that Prop. 22 is about people who use their own cars and cell phones as keys to their trade.

Read our recommendation on how to vote here.

A yes vote on Prop. 23 would mean at least one physician would have to be on site at an operating dialysis clinic. It also would require clinics to report on infections and get health department approval to close. And it would prohibit clinics from discriminating against patients based on how they pay for the clinics services.

Read our recommendation on how to votehere.

A yes vote on Prop. 24 would expand and add to Californias 2-year-old law on consumer data privacy and its reuse. Consumers could prohibit companies from sharing their personal information for any reason and shorten the period companies currently are given to fix the problem.

Prop. 24 also would create a Privacy Protection Agency to enforce the new rules.

Read our recommendation on how to votehere.

A no vote on Prop. 25 would maintain the cash bail system, letting people stay or leave jail while awaiting trial based largely on their ability to pay.

Read our recommendation on how to votehere.

Southern California News Group writer Andre Mouchard contributed to this story.

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California propositions: What you should know before voting - The Mercury News

Cell Culture Market Research Report by Product, by Application – Global Forecast to 2025 – Cumulative Impact of COVID-19 – Yahoo Finance UK

Cell Culture Market Research Report by Product (Consumables and Equipment), by Application (Biopharmaceutical Production, Cell Banking, Diagnostics, Drug Screening & Development, and Stem Cell Research) - Global Forecast to 2025 - Cumulative Impact of COVID-19

New York, Oct. 08, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Cell Culture Market Research Report by Product, by Application - Global Forecast to 2025 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p05940079/?utm_source=GNW

The Global Cell Culture Market is expected to grow from USD 16,371.34 Million in 2019 to USD 33,826.78 Million by the end of 2025 at a Compound Annual Growth Rate (CAGR) of 12.85%.

Market Segmentation & Coverage: This research report categorizes the Cell Culture to forecast the revenues and analyze the trends in each of the following sub-markets:

Based on Product, the Cell Culture Market studied across Consumables and Equipment. The Consumables further studied across Bioreactor Accessories, Sera, Media, and Reagents, and Vessels. The Equipment further studied across Bioreactors, Storage Equipment, and Supporting Equipment.

Based on Application , the Cell Culture Market studied across Biopharmaceutical Production, Cell Banking, Diagnostics, Drug Screening & Development, Stem Cell Research, and Tissue Engineering & Regenerative Medicine.

Based on Geography, the Cell Culture Market studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas region surveyed across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific region surveyed across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa region surveyed across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom.

Company Usability Profiles: The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Cell Culture Market including CellGenix GmbH, Corning Incorporated, Danaher Corporation, Eppendorf AG, Fujifilm Irvine Scientific, GE Healthcare, Hi-Media Laboratories, Invivogen, Lonza Group AG, Merck KGaA, Miltenyi Biotec, Promocell, Sartorius AG, and Thermo Fisher Scientific Inc..

FPNV Positioning Matrix: The FPNV Positioning Matrix evaluates and categorizes the vendors in the Cell Culture Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

Competitive Strategic Window: The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth.

Cumulative Impact of COVID-19: COVID-19 is an incomparable global public health emergency that has affected almost every industry, so for and, the long-term effects projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlaying COVID-19 issues and potential paths forward. The report is delivering insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecast, considering the COVID-19 impact on the market.

The report provides insights on the following pointers: 1. Market Penetration: Provides comprehensive information on the market offered by the key players 2. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets 3. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments 4. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players 5. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments

The report answers questions such as: 1. What is the market size and forecast of the Global Cell Culture Market? 2. What are the inhibiting factors and impact of COVID-19 shaping the Global Cell Culture Market during the forecast period? 3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Cell Culture Market? 4. What is the competitive strategic window for opportunities in the Global Cell Culture Market? 5. What are the technology trends and regulatory frameworks in the Global Cell Culture Market? 6. What are the modes and strategic moves considered suitable for entering the Global Cell Culture Market? Read the full report: https://www.reportlinker.com/p05940079/?utm_source=GNW

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Cell Culture Market Research Report by Product, by Application - Global Forecast to 2025 - Cumulative Impact of COVID-19 - Yahoo Finance UK

U of T’s Medicine by Design invests $1 million to advance new ideas in regenerative medicine – News@UofT

Patients with cystic fibrosis experience recurrent lung infections that eventually destroy their airways, shortening their average life expectancy to 50 years in Canada. Current drug treatments, which target a malfunctioning pathway in cells that causes the infections, are costly and have varying effectiveness.

Now, with funding from Medicine by Design, a researcher at the Hospital for Sick Children (SickKids) is combining stem cells, gene editing and computational modelling to try to hijack an alternative cell pathway in the hopes of restoring lung function in these patients.

If successful, our study will be the first to provide proof-of-concept that this alternative approach to treating cystic fibrosis is effective, saysAmy Wong, a scientist working in developmental and stem cell biology at SickKids who is also an assistant professor in the department of laboratory medicine and pathobiology in the University of Torontos Temerty Faculty of Medicine.

Wongs project is one of seven across U of T and its affiliated hospitals that have been awarded 2020New Ideas AwardsandSeed Fundawards from Medicine by Design. Through a $1 million investment, Medicine by Design is supporting research aimed at advancing new concepts expected to be important to regenerative medicine in the coming years. The funded projects will have potential impacts in diseases and conditions such as vision loss, amyotrophic lateral sclerosis (ALS), intestinal disease in premature babies and more.

Supporting novel strategies and approaches is crucial to moving regenerative medicine into the future, saysMichael Sefton, executive director of Medicine by Designand a University Professor at U of Ts Institute of Biomedical Engineeringand thedepartment of chemical engineering & applied chemistry in the Faculty of Applied Science & Engineering.

Our 2020 New Ideas project portfolio integrates mathematical modelling, physics and computational biology with stem cell biology and biomedical engineering, and strengthens engagement with clinicians who are key to translating our research into patient impact. We are particularly delighted this year to support so many outstanding early-career researchers, who will ensure Toronto remains a global leader in regenerative medicine for years to come.

Wong is one of three investigators to receive a 2020 New Ideas Award, which is valued at $100,000 per year for up to two years. Four additional projects were selected for Seed Fund Awards of $100,000 each for one year to further develop their potential.

Medicine by Design selected the funded projects from among 36 short-listed proposals, which were evaluated and ranked through an external peer review process. Applications were submitted by clinicians and researchers at U of T and its affiliated hospitals from a wide range of disciplines including biochemistry, biomedical engineering, developmental and stem cell biology, immunology, neuroscience and surgery.

Medicine by Design builds on decades of made-in-Canada excellence in regenerative medicine dating back to the discovery of stem cells in the early 1960s by Toronto researchers James Till and Ernest McCulloch. Regenerative medicine uses stem cells to replace diseased tissues and organs, creating therapies in which cells are the biological product. It can also mean triggering stem cells that are already present in the human body to repair damaged tissues or to modulate immune responses. Increasingly, regenerative medicine researchers are using a stem cell lens to identify critical interactions or defects that prepare the ground for disease, paving the way for new approaches to preventing disease before it starts. Medicine by Design is made possible thanks in part to a $114-million grant from theCanada First Research Excellence Fund.

Current cystic fibrosis drug treatments target a genetic mutation that causes epithelial cells, which line the airway and act as a barrier against viruses, to function improperly. The mutation affects the function of an important ion channel in cells, called CFTR, which helps to maintain the right balance of fluid in the airways. Poor function causes mucosal obstructions in the airways and prevents clearance of foreign pathogens, which leads to chronic infections and ultimately destroys airway tissue.

In her project, Wong will explore an alternative ion channel in the epithelial cells to determine if it can be hijacked and used to compensate for the lack of function caused by the mutant CFTR. The research will be conducted using a combination of stem cell-derived lung models, gene editing and computational modelling.

Wongs project builds on decades of cystic fibrosis research at SickKids, where the cystic fibrosis gene was first identified 30 years ago.

To date, more than 2,000 mutations in the cystic fibrosis gene have been identified, says Wong. SickKids scientists and U of T researchers have become the epicentre of incredible cystic fibrosis research to understand how this disease works at the genetic and molecular level.

Wong says that, while the idea of targeting an alternative pathway is not necessarily ground-breaking on its own, its the array of tools now available that makes the idea a potential game changer.

We have access to an incredible resource of primary cells and stem cells from more than 100 individuals with cystic fibrosis harbouring various mutations. Wong says.Our lab has developed human lung models from stem cells that can be used to model lung disease such as cystic fibrosis. And with new advanced tools in single-cell genomics and gene-editing, coupled with key collaborations for computational modelling, we are poised to find new therapeutic targets for cystic fibrosis.

Leo Chou, an assistant professor at the Institute of Biomedical Engineering, andHyun Kate Lee, an assistant professor in the department of biochemistry in the Temerty Faculty of Medicineboth Medicine by Design New Investigators are also leading 2020 New Ideas projects.

Chou, along with co-investigatorsJulie Lefebvre, a scientist at SickKids and U of T assistant professor of molecular genetics, andValerie Wallace, a senior scientist at the Krembil Research Institute, University Health Network and a U of T professor of laboratory medicine and pathobiology and ophthalmology, will focus on cell transplantation in the retina, a process that has demonstrated encouraging pre-clinical results such as partial vision restoration in several animal disease models.

Recent research had demonstrated that this restoration is a result of the transfer of proteins complex molecules required for the structure, function and regulation of the bodys tissues between host tissue and donor cells. But the scope of that transfer process is not well understood. Chous project will develop an imaging approach to detect the transfer of mRNA molecules between host and donor cells. The outcomes from this project will inform the future design of cell transplantation therapies and lead to novel methods to deliver therapeutics. This project could improve therapies for retinal diseases and visual impairments, and inform strategies for other degenerative disorders.

Lee and co-investigatorPenney Gilbert,an associate professor at the Institute of Biomedical Engineering, will look at a common but not well-understood structure called the neuromuscular junction (NMJ), which mediates communication between neurons and muscles throughout the body. Defects in NMJ integrity and function underlie fatal diseases such as ALS. NMJ diseases, which affect more than 500,000 people globally, lack effective treatments. This project will use stem cells derived from reprogrammed skin cells of healthy people to develop NMJs in culture. Through high-resolution imaging, the healthy human NMJs will be studied both on their own and along with NMJs built from ALS patient cells. Through this work, the research team aims to identify genes to target to improve the health of NMJs, which could eventually help prevent or delay NMJ degeneration and even promote regeneration.

Michael Garton, an assistant professor at the Institute of Biomedical Engineering, has received a Seed Fund award to tackle the challenge of translating the genetic tools of synthetic biology an area of research that aims to create or redesign biological components using engineering methods into effective medical therapies against a number of diseases.

But they are difficult to translate into human therapies, Garton says, because the bodys T-cells immune cells that detect and destroy cells containing foreign material will identify these tools as foreign and destroy them.

Instead of switching off the T-cells, Gartons goal is to use computational modelling and high-throughput screening to selectively turn off the bodys foreign antigen display system so the immune system will still respond to foreign invaders when necessary, but allow cells containing synthetic tools to survive. If successful, this approach could enable a new generation of synthetic biology-enhanced cell therapies for a range of diseases.

Medicine by Design funding will help to facilitate the integration of synthetic biology and regenerative medicine and aid the development of cell-based therapies that perform better than nature, says Garton.

Other Seed Fund projects will encompass research in repairing the heart after paediatric cardiac surgery, treating an intestinal emergency in premature babies and creating a database for cell lineage paths.

John Parkinson, a senior scientist at SickKids and a U of T professor of biochemistry and molecular genetics, along with co-investigatorsJason Maynes, Wasser Chair in Anesthesia and Pain Medicine at SickKids and a U of Tassociate professor of anesthesiology and biochemistry, andWilliam Navarre, an associate professor in the department of molecular genetics, will investigate manipulating the microbiome, or community of microorganisms in the gut, to improve cardiac repair in post-operative treatment of a congenital heart disorder. Through a process that will identify prebiotics in breast milk that help enhance the production of molecules that research has shown can aid cardiac repair, the team will organize both observational (how disease alters the microbiome) and interventional (how the microbiome alters the disease) multi-site trials, which will provide the opportunity to immediately translate findings into changes in patient care regimens and improve outcomes.

CliniciansAgostino Pierro, a surgeon at the Division of General and Thoracic Surgery at SickKids and a U of T professor of surgery and physiology, and Philip Sherman, a senior scientist and gastroenterologist at the Division of Gastroenterology, Hepatology and Nutrition at SickKids and U of T professor of dentistry, pediatrics and laboratory medicine and pathobiology, have proposed a novel way of enhancing gut repair for a common intestinal emergency in premature babies, called necrotizing enterocolitis (NEC). A leading cause of death for these infants, NEC causes complications such as blindness, intellectual disability, repeat hospitalizations and gut damage even in those that survive. This project will look at whether intestinal organoids organ-like structures grown in the laboratory from stem cells that mimic some of the functions of native intestines can potentially stimulate repair of the gut and recovery from NEC. The project will define how to best transplant organoids, identify how the organoids protect the intestine from injury and assess if organoid transplantation is a valid new treatment for NEC.

Lincoln Stein, who is head of adaptive oncology at the Ontario Institute for Cancer Research and a professor in the department of molecular genetics at U of T, has received seed funding to build a database called Cytomics Reactome, which will be freely available to Canadian and international researchers. The database will build on recent technologies that open the door to the possibility of deciphering cell lineage paths the series of steps that lead a young, undifferentiated cell into a specialized one at single-cell resolution. To accelerate the path from basic research to clinical application, the database will systematically organize pre-existing knowledge of cell lineage paths into a comprehensive, interactive and easily accessible map that can serve as a framework for interpretation and integration of the latest experimental findings.

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U of T's Medicine by Design invests $1 million to advance new ideas in regenerative medicine - News@UofT

AIVITA Biomedical’s Stem Cell Therapeutic in Vision Loss Published in Investigative Ophthalmology & Vision Science – PRNewswire

IRVINE, Calif., Oct. 9, 2020 /PRNewswire/ --AIVITA Biomedical, Inc., a private biotechnology company developing personalized vaccines for the treatment of cancer and COVID-19, announced today the publication of the peer-reviewed manuscript, "Retina organoid transplants develop photoreceptors and improve visual function in RCS rats with RPE dysfunction,"in the journal Investigative Ophthalmology & Visual Science. The study, led by researchers at AIVITA Biomedical and the Sue & Bill Gross Stem Cell Research Center of the University of California, Irvine, used 3D-retina organoids generated from human stem cells developed by AIVITA to provide insight into the potential use of transplanted retina organoids as a therapeutic option for blinding diseases.

In the study, transplanted retina organoid sheets were examined to determine if human stem cell-derived photoreceptors coulddevelop, survive and function in vivo without the support of healthy retina pigment epithelium (RPE). Visual function was examined through a variety of tests, including optokinetic testing (OKT), electroretinogram (ERG), and superior colliculus (SC) brain recording. These tests concluded that retina organoid transplantations demonstrated significant improvement in visual function compared to non-surgery and sham surgery controls, supporting the application of AIVITA's stem cell technologies in visual disease therapeutics.

"Leveraging our expertise in stem cell growth and differentiation, I'm excited to see the promise of our technology platform in potential therapeutics for vision loss," said Hans Keirstead, Ph.D., chief executive officer of AIVITA and a contributing author to the paper. "To our knowledge, this study is the first to show that it's possible for photoreceptors derived from stem cells to survive and function after transplantation when a host has a dysfunctional RPE."

This work is supported by funding from the California Institute for Regenerative Medicine (CIRM) and National Institutes of Health (NIH).

About AIVITA Biomedical AIVITA Biomedical is a privately held company engaged in the advancement of commercial and clinical-stage programs utilizing curative and regenerative medicines. Founded in 2016 by pioneers in the stem cell industry, AIVITA Biomedical utilizes its expertise in stem cell growth and directed, high-purity differentiation to enable safe, efficient and economical manufacturing systems which support its therapeutic pipeline and commercial line of skin care products. All proceeds from the sale of AIVITA's skin care products support the treatment of people with cancer.

SOURCE AIVITA Biomedical, Inc.

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AIVITA Biomedical's Stem Cell Therapeutic in Vision Loss Published in Investigative Ophthalmology & Vision Science - PRNewswire

Proposition 14 would authorize state to borrow $5.5 billon for stem cell research – KESQ

California voters are once again considering the issue of stem cell research.

After approving spending $3 billion on the work in 2004, taxpayers are being asked for another $5.5 billion under Proposition 14.

Some of the initial funding was used to create the California Institute for Regenerative Medicine which would get more money if the measure passes.

"Prop 14 is targeted at treating and curing curable diseases that we all care about," said Dr. Larry Goldstein, a professor at UC San Diego, and the Scientific Director for the Sanford Consortium for Regenerative Medicine.

He a supporter of Prop 14, along with the California Democratic Party and the UC Board of Regents.

He says the funding is necessary to save lives.

"We lose family members prematurely to terrible diseases like cancer and Alzheimer's Disease," said Goldstein.

Proposition 14's total cost to tax payers, including interest on the general obligation bonds, is $7.8 billion according to the state legislate analyst.

That breaks down to $280 million a year over 30 years, with the money coming from the state general fund.

The highest profile opponent of Prop 14 points to what they call a "lack of legislative oversight" of the California Institute for Regenerative Medicine.

They also say the state budget deficit is already too high.

That opponent is the Oakland-based "Center for Genetics and Society".

Another opponent has close ties to the California Institute for Regenerative Medicine.

Jeff Sheehy is a member of the agency's Citizen's Oversight Committee.

"We have a lot of needs that are more pressing than stem cell research which is well funded by the federal government," said Sheehy.

Sheehy contends state funding for scientific research should be up to the state legislature.

"You don't vernally pay for programs like this with debt," said Sheehy.

ANALYSIS OF PROPOSITION 21 FROM BALLOTPEDIA:

https://ballotpedia.org/California_Proposition_14,_Stem_Cell_Research_Institute_Bond_Initiative_(2020)

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Proposition 14 would authorize state to borrow $5.5 billon for stem cell research - KESQ

Regenerative Medicine Market | Increasing Prevalence of Chronic Diseases to Boost the Market Growth | Technavio – Business Wire

LONDON--(BUSINESS WIRE)--The global regenerative medicine market size is poised to grow by USD 9.55 billion during 2020-2024, progressing at a CAGR of over 20% throughout the forecast period, according to the latest report by Technavio. The report offers an up-to-date analysis regarding the current market scenario, latest trends and drivers, and the overall market environment. The report also provides the market impact and new opportunities created due to the COVID-19 pandemic. Download a Free Sample of REPORT with COVID-19 Crisis and Recovery Analysis.

The increasing prevalence of various chronic diseases is one of the primary factors which will drive regenerative medicine market growth during the forecast period. The incidence of many musculoskeletal disorders and bone injuries such as arthritis, osteoporosis, and severe limb trauma injuries requiring hospitalization is also increasing. Regenerative medicine opens the possibility of overcoming previously untreatable diseases using new treatment methods like processed cells for reconstructing tissues. It has the unique capability of altering the fundamental mechanisms of disease and also helps in reducing healthcare costs by eliminating the need for long-term hospitalization or drug regimes. This is leading to the increased adoption of regenerative medicine for the treatment of chronic diseases.

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Increasing Number of Clinical Trials will be a Key Market Trend

One of the most significant regenerative medicine market trends is the growing number of clinical trials. The rise in the number of clinical trials is primarily attributed to the increasing initiatives and support from various international and national public and private organizations. There are many regenerative medicine products at different stages of clinical trials ranging from discovery, pre-clinical phase to mid-stage and late-stage period. The increasing number of products completing clinical trials and receiving product approval will drive the regenerative medicine market to grow during the forecast period.

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Regenerative Medicine Market 2020-2024: Key Highlights

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Executive Summary

Market Landscape

Market Sizing

Five Forces Analysis

Market Segmentation by Technology

Customer landscape

Geographic Landscape

Drivers, Challenges, and Trends

Vendor Landscape

Vendor Analysis

Appendix

About Us

Technavio is a leading global technology research and advisory company. Their research and analysis focuses on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavios report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavios comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.

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Regenerative Medicine Market | Increasing Prevalence of Chronic Diseases to Boost the Market Growth | Technavio - Business Wire