Stem Cell Clinic

‘We wanted a chance’: Sask. family left with $1M medical bill after 4-year-old’s potentially life-saving treatment – CTV News Saskatoon

By adminSeptember 10, 2020Stem Cell Treatment

SASKATOON -- The family of a four-year-old Saskatoon boy who is now recovering in a Minneapolis hospital after receiving a potentially life-saving treatment hopes their experience will ultimately help others in Saskatchewan.

In June, Conner Finn was diagnosed with cerebral adrenoleukodystrophy (ALD), a rare and sometimes fatal disease that attacks the membrane which insulates nerve cells the brain.

His father Craig Finn said the family quickly learned that the window of opportunity to treat the disease, which affects one in 18,000 people, was a narrow one and Saskatchewan did not offer the procedure that was Conner's best hope a blood stem cell transplant,

The procedure halts the degeneration in the body including brain deterioration which can cause hearing loss, losing the ability to walk and even death, Finn said.

He says tests showed they caught Conners level of degeneration at a lower stage, around three or four out of 10 which was positive news.

We knew we had to move quickly if we wanted a chance to stop this, Finn told CTV News.

Finn said the Government of Saskatchewan gave him the option of having the transplant done in Winnipeg or Toronto, but did not provide a definite timeline or confirm if there was an ALD specialist to treat him.

After learning the process could take months and cut into the window to effectively treat Conner, the Finns took matters into their own hands.

(A) doctor in Minneapolis said they had a plan in motion immediately to find a donor," Finn said.

The family drove to Minnesota on July 7. With a letter from the specialist, they crossed the border with relative ease despite COVID-19 restrictions after a phone call was made by border security to the ALD Leukodystrophy Centre in Minneapolis where Conner would receive treatment.

The procedure came with a hefty price tag, a cost of around CAD $1 million, according to Finn.

Finn said he was still in conversation with the province trying to get some funding for the medical costs involved.

I told the government 'This is serious with his brain deteriorating every day and you guys are still bouncing around ideas of hospitals while the doctor in the States has found a perfect match and has a plan.'"

He said he is planning on further appeals to the government to have the costs covered.

In an emailed statement, the Ministry of Health said while it does cover the cost of some elective medical services outside of the country, the coverage must have prior approval.

"One of the key requirements outlined in legislation is that the specialist must confirm that all care options in Saskatchewan and Canada have been explored and exhausted. That is, the services being requested are not obtainable within Canada," the statement said.

Conner is recovering in hospital, where he's expected to stay until well into November.

According to his dad, the family has been told that in two months, doctors will be able to determine if any more brain deterioration has occurred and if Conner's ALD will be fixed in the long term.

A GoFundMe page has been set up by a family friend to help with some of their expenses.

Finn said he will continue to push the province to pay for the procedure and if they do agree to cover the bill, he will donate all of the GoFundMe money to the doctors research at the ALD centre.

Currently, just over $87,000 of the $100,000 goal has been raised.

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'We wanted a chance': Sask. family left with $1M medical bill after 4-year-old's potentially life-saving treatment - CTV News Saskatoon

Innovative treatments for heart failure – Open Access Government

By adminSeptember 10, 2020Stem Cell Treatment

Concerning heart failure (HF), the current COVID-19 pandemic is having a dramatic effect on the daily life of each individual, ranging from social distancing measures applied in most countries to getting severely diseased due to the virus. Cardiovascular Disease (CVD) is among the most common conditions in people that die of the infection. The burden of CVD accounts for over 60 million people in the EU alone, therefore, it is the leading cause of death in the world.

Although COVID-19 shows us the direct impact of a potential treatment for peoples health, CVD is a stealthy pandemic killer. HF is a chronic disease condition in which the heart is not able to fill properly or efficiently pump blood throughout your body, caused by different stress conditions including myocardial infarction, atherosclerosis, diabetes and high blood pressure. Several measures are commonly used to treat heart disease, such as lifestyle changes and medications like beta-blockers and ACE inhibitors, yet these typically only slow down the progression of the disease.

Biomedical research is exploring new avenues by combining scientific insights with new technologies to overcome chronic diseases like HF. Among the most appealing and promising technologies are the use of cardiac tissue engineering and extracellular vesicles-mediated repair strategies.

Upon an initial cell loss post-infarction, it is appealing to replace this massive loss in contractile cells for new cells and thereby not treating patients symptoms, but repairing the cause of the disease. Cardiac cell therapy has been pursued for many years with variable results in small initial trials upon injection into patients. Different cell types have been used to help the myocardium in need, but the most promising approaches aim to use induced pluripotent cells (iPS) from reprogrammed cells from the patient themselves that can be directed towards contractile myocardial cells. These cells in combination with natural materials, in which the cells are embedded in the heart, can be used for tissue engineering strategies (1). Together with different international partners, Sluijters team are trying to develop strategies to use these iPS-derived contractile cells for myocardial repair via direct myocardial injection (H2020-Technobeat-66724) or to make a scaffold that can be used as a personalised biological ventricular assist device (H2020-BRAV-874827). A combination of engineering and biology to mimic the native myocardium aims to replace the chronically ill tissue for healthy and well-coupled heart tissue that can enhance the contractile performance of the heart.

Recently, a Dutch national programme started, called RegMedXB, in which the reparative treatment of the heart is aimed to be performed outside the patients body. During the time the heart is outside the body; the patient is connected to the heart-lung machine, and after restoring function, it will be re-implanted. The so-called Cardiovascular Moonshot aims to create a therapy that best suits the individual patient, by having their heart beating in a bioreactor, outside the body. Although it sounds very futuristic, many small lessons will be learned to feet novel therapeutic insights.

The initial injection of stem cells did result in a nice improvement of myocardial performance. We have now learned that rather than these delivered cells helping the heart themselves, the release of small lipid carriers called extracellular vesicles (EVs) (2) from these cells occur. These EVs carry different biological molecules, including nucleotides, proteins and lipids, and are considered to be the bodies nanosized messengers for communication. The use of stem cell-derived EVs are now being explored as a powerful means to change the course of the disease. Via these small messengers, natural biologics are delivered to diseased cells and thereby help them to overcome the stressful circumstances. EVs carry reparative signals that can be transferred to the diseased heart and thereby change the course of heart disease in some patients.

Within the EVICARE program (3) (H2020-ERC-725229), Sluijters team are using stem cell-derived EVs to change the response of the heart to injury. Also, to understand which heart cells and processes are being affected, they use materials to facilitate a slow release of biomaterials over an extended period rather than a single dose, which is probably essential for a chronic disease like HF. For now, improved blood flow is the main aim but the team have seen other effects as well, such as cardiovascular cell proliferation (4) by which the heart cells themselves start to repair the organ.

The use of EVs basically aims to enhance the endogenous repair mechanisms of the heart. These natural carriers can be mimicked with synthetic materials, or used as a hybrid of the two, thereby creating an engineered nanoparticle, that is superior in the intracellular delivery of genetic materials. The possibility of loading different biological materials allows a further tuning of its effectiveness and use in different disease conditions, creating a new off-the-shelf delivery system for nanomedicine to treat cancer and CVD (H2020-Expert-825828).

As is true of the current COVID-19 pandemic, HF is also a growing chronic disease that affects millions of people worldwide. The chronic damaged myocardium needs reparative strategies in the future to lower the social burden for patients, but also to keep the economic consequences affordable. New scientific insights with cutting edge technological developments will help to address these needs of CVD patients and their families.

References

(1) Madonna R, Van Laake LW, Botker HE, Davidson SM, De Caterina R, Engel FB, Eschenhagen T, Fernandez-Aviles F, Hausenloy DJ, Hulot JS, Lecour S, Leor J, Menasch P, Pesce M, Perrino C, Prunier F, Van Linthout S, Ytrehus K, Zimmermann WH, Ferdinandy P, Sluijter JPG. ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure. Cardiovasc Res. 2019 Mar 1;115(3):488-500.

(2) Sluijter JPG, Davidson SM, Boulanger, CM, Buzs EI, de Kleijn DPV, Engel FB, Giricz Z, Hausenloy DJ, Kishore R, Lecour S, Leor J, Madonna R, Perrino C, Prunier F, Sahoo S, Schiffelers RM, Schulz R, Van Laake LW, Ytrehus K, Ferdinandy P. Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res. 2018 Jan 1;114(1):19-34.

(3) https://www.sluijterlab.com/extracellular-vesicle-inspired-ther

(4) Maring JA, Lodder K, Mol E, Verhage V, Wiesmeijer KC, Dingenouts CKE, Moerkamp AT, Deddens JC, Vader P, Smits, AM, Sluijter JPG, Goumans MJ. Cardiac Progenitor Cell-Derived Extracellular Vesicles Reduce Infarct Size and Associate with Increased Cardiovascular Cell Proliferation. J Cardiovasc Transl Res. 2019 Feb;12(1):5-17.

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Innovative treatments for heart failure - Open Access Government

Reasons Industries to Thrive Post-Pandemic! Stem Cell Therapy for Osteoarthritis Market Report xyz Answers it Analysis by Key Companies Mesoblast,…

By adminSeptember 10, 2020Stem Cell Treatment

Global Coronavirus pandemic has impacted all industries across the globe, Stem Cell Therapy for Osteoarthritis market being no exception. As the global economy heads towards major recession post-2009 crisis, Cognitive Market Research has published a recent study which meticulously studies the impact of this crisis on Global Stem Cell Therapy for Osteoarthritis market and suggests possible measures to curtail them. This press release is a snapshot of the research study and further information can be gathered by accessing complete report.To Contact Research Advisor Mail us @ [emailprotected] or call us on +1-312-376-8303. As per the ongoing market, research finding says Stem Cell Therapy for Osteoarthritis Market is growing at a High CAGR during the forecast period 2020-2027. The increasing interest of the investors in the said market industry is one of the prominent reason for the growth and expansion of this market

The Stem Cell Therapy for Osteoarthritis Market research report 2020 give a detailed analysis of market and industry revenue (USD Mn) as well as volume (units) for year 2015-2027. The report provides updated information on market as well as future analysis regarding growth. Furthermore, Stem Cell Therapy for Osteoarthritis report quantifies the market share held by the significant players of the industry and gives an in-depth view of the competitive landscape.

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Major Key Players mentioned in the report are: Mesoblast, Regeneus, U.S. Stem Cell, Anterogen, Asterias Biotherapeutics

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Reasons Industries to Thrive Post-Pandemic! Stem Cell Therapy for Osteoarthritis Market Report xyz Answers it Analysis by Key Companies Mesoblast,...

Animal Stem Cell Therapy Market likely to touch new heights by end of forecast – News by aeresearch

By adminSeptember 10, 2020Stem Cell Treatment

N95 Respirator Mask Industry Market Competitive Landscape Analysis, Major Regions, Report 2020-2025 By Market Study Report

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Male Pattern Baldness gets longer effect QR678 therapy, more effective than Platelet-Rich Plasma (PRP): Journal of Cosmetic Dermatology Published…

By adminSeptember 8, 2020Platelet Rich Plasma Injections

(Eds: Disclaimer: The following content is a press release. PTI takes no editorial responsibility for the same.) Mumbai, 8th September 2020: QR 678, a patented treatment for hair regrowth therapy for men and women, has proven to be more effective than PRP as a hair loss treatment. This study was published in an iconic and much respected American Journal called the Journal of Cosmetic Dermatology. It showed that as compared to the Platelet Rich Plasma (PRP) therapy, QR 678showed significant improvement in hair regrowth with almost 100% reduction in hair fall. QR 678 was invented by Dr.Debraj Shome and Dr.Rinky Kapoor, celebrity cosmetic surgeons from India. They observed that male pattern baldness, known as Androgenic Alopecia characterised by progressive hair loss in men growing at a rampant rate of 58% in males aged 30-50 years which initiated their urge to research and find a solution to this cosmetic issue leading to the invention of QR 678. The therapy curbs hair fall and increases the thickness, the number and density of existing hair follicles, offering greaterhair coverage to the ones with alopecia.The formulation has received patents in the United States and in India. Dr.Debraj Shome, Cosmetic Surgeon and Director, at The Esthetic Clinics, said, The hair-regrowth treatments available currently have many limitations; they cannot revive hair beyond a certain stage. QR678 is a process where growth factors are injected in the hair follicles, which not only arrests hair fall but also stimulates hair growth. QR678 is a non-surgical, pain-free and non-invasive procedure for the hair regrowth treatment which has shown very good results in over 10,000 patients. Practicing from the Esthetics Clinics, Dr Shome says that, from my experience as a cosmetic surgeon dealing with hair loss patients on a daily basis the treatment has responded very well, especially in India. QR 678 has had a success rate of 90% in India and this is the highest success rate achieved by any hair fall treatment in a shortest treatment time of 6-8 sessions. Comparing the two treatments in question, Dr. Rinky Kapoor partner to Dr Shome and one of leading Dermatologists in India adds, PRP is used by all Dermatologists and plastic surgeons for hair growth. PRP involves extracting platelets from human blood and injecting it into the scalp to cause hair growth. But, the truth of the matter is that this therapy is more based on hope than actual science. There has never been a randomised controlled trial showing that PRP actually causes hair growth. That is why we conducted a comparative trial between the QR678 and PRP treatments and no surprises that the QR678 treatment caused almost 300% better results than the PRP". The trial was a split head trial, comparing the PRP treatment efficacy with the QR678 treatments. While PRP is supposed to have growth factors for hair growth, the QR 678 treatment is a bioengineered, first in class hair therapy, with six hair growth factors and biomimetic peptides, administered to the scalp via mesotherapy. With Alopecia and hair loss becoming more and more common and affecting more than 40% males and 30% Females over the age of 30 globally, having a new age, proven therapy is very important for the world. More than 12000 patients have already experienced amazing results with the QR 678 treatment, which has an USA and an Indian patent and is now being exported to multiple countries from India. Dr. Kapoor says, "We, as Doctors need to decide whether the treatments we offer are indeed backed by science or not. Just because hair loss is so common and we didn''t have too many solutions prior to the QR678 doesn''t mean that we use treatments like the PRP which have no strong evidence based data for hair growth. Ultimately, science must win!" The acceptance of the Journal of Cosmetic Dermatology of the QR678 hair growth treatment will change the execution and delivery of hair loss treatment, as PRP was rampantly and randomly used by dermatologists, plastic surgeons and cosmetic surgeons alike, in India and globally. India through the ''Made in India'' top class hair innovation the QR678, may have pioneered a way forward for cosmetology at an international level. Dr.Debraj Shome has been a global pioneer in developing new techniques and solutions for facial plastic surgery and facial cosmetic surgery for more than a decade, he is amongst the few super specialists India has in this area of cosmetology. Dr. Shome is also a celebrated, best-selling, and internationally acclaimed author of Dear People, With Love & Care, Your Doctors. Maintained its position as a bestseller for weeks in a row this book is an anthology of short stories based on the real-life doctor-patient relationship. He has written more than 50 peer-reviewed international papers in top International research journals. Dr. Shome is also the patent holder for the invention of the QR678 hair growth factor injections. This hair growth formulation has received patents in multiple locations, including the USA and India. Dr.Rinky Kapoor is one of the best dermatologists in India today. She is also an expert in the field of non-invasive and non-surgical skin rejuvenation treatments. She has a unique ability to use a mixture of treatments for correct results making her the one of the finest dermatologist in India.What sets Dr Rinky Kapoor apart is the fact that she uses the world''s best and latest technological advances to give the most natural looking results. She says, Its the joy of seeing the look of wonder and contentment on the faces of my patients and this is what keeps me going daily. About The Esthetic Clinics: (https://www.theestheticclinic.com/) The Esthetic Clinics is a group of world-class centresdedicated to plastic surgery & skin care. They are currently located at Mumbai, New Delhi, Ahmedabad, Hyderabad, Bangalore and Kolkata in India. The Esthetic Clinics practice evidence-based medicine and perform cosmetic surgery for beauty, plastic surgery for birth abnormalities; plastic surgery for fractures, trauma & cancer induced facial deformities. They also provide laser surgery & many cosmetic solutions for many skin diseases. The Esthetic Clinicswas voted as the Most Promising & Innovative Cosmetic Clinics 2016 at the Pharma Leaders Summit & Awards 2016. The Esthetic Clinics was rated by the Times Health Survey 2019 as being one of the Top Clinics in Plastic Surgery & Cosmetic Surgery, Dermatology & Trichology, in Mumbai, India. PWR PWR Disclaimer :- This story has not been edited by Outlook staff and is auto-generated from news agency feeds. Source: PTI More from Outlook Magazine

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Male Pattern Baldness gets longer effect QR678 therapy, more effective than Platelet-Rich Plasma (PRP): Journal of Cosmetic Dermatology Published...

Transcriptional Regulation in Embryonic Stem Cells …

By adminSeptember 8, 2020Embryonic Stem Cells

Abstract

Transcriptional regulation is a pivotal process that confers cellular identity and modulates the biological activities within a cell. In embryonic stem cells (ESCs), the intricate interplay between transcription factors and their targets on the genomic template serves as building blocks for the transcriptional network that governs self-renewal and pluripotency. At the heart of this complex network is the transcription factor trio, Oct4, Sox2 and Nanog, which constitute the ESC transcriptional core. Regulatory mechanisms such as autoregulatory and feedforward loops support the ESC transcriptional framework and serve as homeostatic control for ESC maintenance. Large-scale studies such as loss of function RNAi screens and transcriptome analysis have led to the identification of more players that support pluripotency. In addition, genome-wide localization studies of transcription factors have further unraveled the interconnectivity within the ESC transcriptional circuitry. Transcription factors also work in concert with epigenetic factors and together, this crosstalk between transcriptional and epigenetic regulation maintains the homeostasis of ESC. This chapter provides an overview of the significance of transcriptional regulation in ESC and traces the recent advances made in dissecting the ESC transcriptional regulatory network.

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Araki R, Fukumura R, Sasaki N et al. More than 40,000 transcripts, including novel and noncoding transcripts, in mouse embryonic stem cells. Stem Cells 2006; 24:25228.

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Sharov AA, Piao Y, Matoba R et al. Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol 2003; 1:E74.

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Nagalakshmi U, Wang Z, Waern K et al. The transcriptional landscape of the yeast genome defined by RNA sequencing. Science 2008; 320:13449.

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Global Cell Isolation Market Report Promising Growth of CAGR of 17.91% , Analysis of Top companies and their Share, Size,Scope and Current Trends -…

By adminSeptember 8, 2020Embryonic Stem Cells

GlobalCell Isolation Marketreport would come in handy to understand your competitors and give you an insight into sales; volumes, revenues in the Cell Isolation industry, assists in making strategic decisions. Cell Isolation Market is expected to grow at a CAGR of 17.91% from 2020 to 2023 and explains why and how it is going to achieve this growth.It provides vital information on every parameter which is required for making strategic decisions and development of every business in the industry.

Request a Sample Copy of the Report For COVID-19 Impact Analysis onCell Isolation Market

About Cell Isolation Market The rise in demand for clinical diagnosis is one of the key factors anticipated to drive the cell isolation market growth during the forecast period. To effectively treat various diseases using genetic engineering tools, early diagnosis is essential. Genetic engineering tools provide diagnostic enzymes such as cholesterol oxidase and xylitol oxidase. These diagnostic enzymes identify specific cells like cells with high levels of cholesterol. When blood levels of these particular enzymes increase significantly, it indicates a probable site for tissue damage, which releases these enzymes in the blood. These enzymes are used in assays using samples of serum or urine. The isolation of these enzymes can provide the required enzymes for clinical diagnosis. Thus, genetic engineering tools are useful, precise, and economical for researchers and healthcare providers to diagnose patients. Research analysts have predicted that the cell isolation market will register a CAGR of almost 19% by 2023.

TheTop Manufacturers/playersincluding:-

Agilent Technologies Inc., Becton Dickinson and Co., Merck KGaA, QIAGEN NV, Thermo Fisher Scientific Inc.

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Market Segment of Cell Isolation Industry:

Market Overview

Competitive Landscape

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Cell Isolation Market Report provides comprehensive analysis of-

Key Summary of Cell Isolation Market Growth Report:

In our market size and forecast determination efforts, in-depth secondary research was initially completed to realize an honest perspective of the market in each region. Extensive primary research was also administered by interviewing key executives from the industry. These interviews helped us to fill-in the info gaps after secondary research. Several secondary sources like encyclopedia, directories, and databases are wont to identify and collect information useful for this extensive techno-commercial study.

Key Questions Answered in ROY Cell Isolation Market Report:

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In the end, the Cell Isolation Market report makes some important proposals for a new project of the Cell Isolation Industry before evaluating its feasibility. Overall, the report provides an in-depth insight of Global Cell Isolation Industry covering all important parameters.

Table of Contents included in Cell Isolation Market ROY Report

PART 01: Executive summary

PART 02: Scope of the report

PART 03: Research Methodology

PART 04: Introduction

PART 05: Market landscape

PART 06: Market segmentation by end-user industry

PART 07: Market segmentation by application

PART 08: Geographical Segmentation

PART 09: A Decision framework

PART 10: Impact of drivers and challengesAnd Many More Parts Covered.

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Global Cell Isolation Market Report Promising Growth of CAGR of 17.91% , Analysis of Top companies and their Share, Size,Scope and Current Trends -...

Menkes SyndromeIndustry 2020 With Covid-19 Impact on Market Research by Size, Top Leading Countries, Companies, Consumption, Drivers, Trends, Forces…

By adminSeptember 8, 2020Gene Therapy Clinics

Data Bridge Market Research recently introducedGlobal Menkes Syndrome Market Size, Industry Share, Growth, Industry Trends and Forecast To 2020study with in-depth overview, describing about the Product / Industry Scope and elaborates market outlook and status to 2020.Menkes Syndrome Industry 2020 GlobalMarket Research report 2020 covers a detailed study of the Menkes Syndrome Market size, growth, and share, trends, consumption, segments, application and Forecast 2020. The study objective of this report is to analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market. The market type, organization size, availability on-premises, end-users organization type, and the availability in areas such as North America, South America, Europe, Asia-Pacific and Middle East & Africa are kept into focus while creating this global Menkes Syndrome market report. The growth of the Menkes Syndrome market was mainly driven by the increasing R&D spending across the world, howeverlatest COVID scenarioand economic slowdown have changed complete market dynamics.

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KNOW YOUR OPTIONS IN THE FIGHT AGAINST COVID-19

The COVID-19 Pandemic has created bottlenecks across industry pipelines, sales funnels, and supply chain activities. This has created unprecedented budget pressure on company spending for industry leaders. This has increased requirement for opportunity analysis, price trend knowledge and competitive outcomes. Use the DBMR team to create new sales channels and capture new markets previously unknown. DBMR helps its clients to grow in these uncertain markets.

Prominent Players Operating In The Market Include:-Fortress Biotech, Teva Pharmaceutical Industries Ltd, Amerigen Pharmaceuticals Limited, Mylan N.V., Bausch Health, H. Lundbeck A/S and others.

The Menkes Syndrome market accounted to USD 17.26 Billion in 2016 growing at a CAGR of 8.1% during the forecast period of 2019 to 2024.

Market Definition: Menkes Syndrome Market-Menkes syndrome is also known as steely hair disease is a rare, X-linked genetic disorder of copper metabolism caused by gene mutations of copper transporter ATP7A.Because of the mutation in copper transport gene, copper is unavailable to reach to the various cells where it is essential for the structure and function of various enzymes. It is characterized by sparse, kinky hair, failure to thrive and progressive deterioration of the nervous system.

According to the statistics published by National Organization for Rare Disorders, Inc, an estimated population of Menkes syndrome is about 1 in 100,000-250,000 live birth. Presence of refined healthcare infrastructure and emerging new market are the key factors for growth of this market.

Market Drivers

Market Restraints

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ThisMenkes Syndrome Marketreport provides details of new recent developments, trade regulations, import export analysis, production analysis, value chain optimization, market share, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market.

Browse 60 Market Data Tables and 220 Figures spread through 320 Pages and in-depth TOC on Menkes Syndrome Market .

Menkes Syndrome Marketis highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of Menkes Syndrome Market for global, Europe, North America, Asia Pacific, South America and Middle East & Africa.

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Global Menkes Syndrome Market Segmented ByType (Neurodegenerative Disease, X-linked Copper Malabsorption)

Global Menkes Syndrome Market Segmented byDistribution Channel (Hospital Pharmacies, Retail Pharmacies)

Global Menkes Syndrome Market SegmentedBy Therapy Type (Gene Therapy, Copper Injection Therapy), Drugs (Penicillamine, Droxidopa and Others),

Global Menkes Syndrome Market Segmented ByRoute of Administration (Oral, Injectable), End- Users (Hospitals, Homecare, Specialty Clinics and Others)

Some Of The Major Players Operating In The Menkes Syndrome Market AreFortress Biotech, Teva Pharmaceutical Industries Ltd, Amerigen Pharmaceuticals Limited, Mylan N.V., Bausch Health, H. Lundbeck A/S and others.

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The Menkes Syndrome report has been produced with the systematic gathering and analysis of information about individuals or organizations conducted through social and opinion research. With the studies, insights and analysis mentioned in the report, you get comprehensible idea about the marketplace with which you can take business decisions quickly and easily. The worldwide Menkes Syndrome advertise report comprises of all the organization profiles of the key players and brands. Market definition covered in this Menkes Syndrome report studies the market drivers and market restraints with which businesses can get idea of whether to increase or decrease the production of a particular product.

Detailed TOC of Menkes Syndrome Market Research Report: Table of Contents

1 Introduction

2Market Segmentation

3 Market Overview

4 Executive Summaries

5 Premium Insights

6 Regulatory Procedure

7 Menkes Syndrome Market, By Type

8 Menkes Syndrome Market, by disease type

9 Menkes Syndrome Market, By Deployment

10 Menkes Syndrome Market, By End User

11 Menkes Syndrome Market, By Distribution Channel

12 Menkes Syndrome Market, By Geography

13 Menkes Syndrome Market, Company Landscape

14 Company Profile

Continued!!!

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Menkes SyndromeIndustry 2020 With Covid-19 Impact on Market Research by Size, Top Leading Countries, Companies, Consumption, Drivers, Trends, Forces...

Global Organoids and Spheroids Market Is Expected to Reach USD 2794.79 Million by 2027 : Fior Markets – GlobeNewswire

By adminSeptember 8, 2020Stem Cell Medicine

September 08, 2020 16:00 ET | Source: Fior Markets

Newark, NJ, Sept. 08, 2020 (GLOBE NEWSWIRE) -- As per the report published by Fior Markets, the global organoids and spheroids market is expected to grow from USD 502.92 million in 2019 and to reach USD 2794.79 million by 2027, growing at a CAGR of 23.91 % during the forecast period 2020-2027.

The growing prevalence of chronic disorders in recent times has increased the demand for effective drugs. The organoids and spheroids model is increasingly becoming popular as they provide a better perspective for human developmental biology research. The organoids model reveals the effects of covid-19 on several intestinal cells. Thus, these models are playing a significant role in the vaccine development process. The rise in demand for diagnostics and therapeutics solutions for these chronic diseases is fuelling market growth.

The organoids and spheroids are the three-dimensional structures that replicate the condition of different tissues present in the human body. The organoids model works as an in-vitro model for the study of biological development. The organoids can be established for organs such as kidney, retina, brain, liver, small and large intestine, lungs, etc. The organoids can be derived from a single adult stem cell or the embryonic stem cell. On the other hand, spheroids consist of a cluster of cells. These are derived from both the single-cell type and multi-cellular stems. The organoids and spheroids differ in the driving force required for the development. The organoids are formed by internal development processes and spheroids forms by adhesion of cells to each other. These also differ in the time duration for which the 3D culture can be maintained.

The human organoids have helped in the analysis of many tissues, which helps in a better understanding of the working of the organs. The 3D models of human organs have opened up opportunities for conducting various studies and experiments to analyze the effects of drugs on different organs. It also has provided potential ways of organ transplantation. Further, the growing technological advancements in the spheroid and organoid 3D models are fuelling the market growth. Apart from this, the major players operating in the market are also focusing on facilitating cell activities by taking control of the microenvironment of the culture.

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Key players operating in the organoids and spheroids market are 3D Biotek LLC, 3D Biomatrix, ATCC, Cellesce Ltd., Hubrecht Organoid Technology (HUB), Merck KGaA, STEMCELL Technologies Inc., Corning Incorporated, AMS Biotechnology Limited, Perkin Elmer, Kuraray, Thermo Fisher Scientific, Inc., Greiner Bio-One, Prellis Biologics, Lonza and others. The major players in the organoids and spheroids market are focusing on expansionary strategies such as mergers & acquisitions, recent developments, joint ventures, collaborations, product innovations and partnerships. These strategies would extract higher market shares for the players and thus strengthen their position in the global market. Thermo Fisher Scientific and Corning Incorporated are some of the biggest manufacturers and suppliers of organoids and spheroids in the global market.

Spheroids segment dominated the market and held the largest market share of 54.92% in the year 2019

On the basis of type segment, the global organoids and spheroids market includes organoids and spheroids. The organoids are segmented into product type, techniques and source. The product type of organoids includes neural organoids, intestinal organoids, hepatic organoids and others. The techniques include crypt organoid culture techniques, general submerged technique, clonal organoid from Lgr5+ cells, air-liquid interface (ALI) method and brain and retina organoid formation protocol. The sources segment includes primary tissues and stem cells. The spheroids are also segmented into product type, techniques and source. The product type of spheroids includes mammospheres, neurospheres, embryoid bodies, multi-cellular tumor spheroids and hepatospheres. The techniques segment includes hanging drop method, micropatterned plates, low cell attachment plates and others. The source of spheroid includes primary cells, cell line and iPSCs derived cells. Spheroids dominated the market and held the largest market share of 54.92% in the year 2019. The spheroids are in high demand owing to its increased application in cancer research and drug discovery. The spheroids can be cultured to produce cells of consistent shape, which can be used for thorough analysis. Further, the organoids segment is projected to register an impressive growth rate as these are used as in-vitro models in the process of drug discovery. The segment is expected to be driven by the intestinal organoids type owing to the increased application is cell biology and disease modeling.

Developmental biology segment dominated the market and held the largest market share of 28.65% in the year 2019

On the basis of the application segment, the global organoids and spheroids market includes personalized medicine, developmental biology, drug toxicity and efficacy testing, disease pathology testing and regenerative medicine. Developmental biology dominated the market and held the largest market share of 28.65% in the year 2019. The organoids which are derived from induced pluripotent stem cells and embryonic stem cells are useful in human developmental biology. The spheroids and organoids have been increasingly used in the development biology study of the pancreas, kidney, stomach, liver, etc. for the purpose of embryonic development, tissue homeostasis and lineage specification.

Biotechnology and pharmaceutical companies segment dominated the market and held the largest market share of 39.82% in the year 2019

The end-user segment includes academic and research institutes, hospitals and diagnostic centers and biotechnology and pharmaceutical companies. Biotechnology and pharmaceutical companies segment dominated the market and held the largest market share of 39.82% in the year 2019. The organoids and spheroids are mainly used in clinical applications owing to the vast scope of the experiment. Thus, the biotechnology and pharmaceutical companies are using these increasingly in the drug discovery processes.

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Regional Segment Analysis of the Organoids and Spheroids Market

On the basis of geography, the global organoids and spheroids market is classified into North America, Europe, South America, Asia Pacific, and the Middle East and Africa. North America region accounted for a significant market share of 43.02% in the year 2019. The region has been lately, investing in the organoid and spheroids based research models. Further, the growing technological advancements provides a platform for extensive research on 3D models of human tissue structure for the development of personalized and regenerative medicines. However, Asia-Pacific is expected to register the highest growth rate during the forecast period. The growing patient population owing to the prevalence of chronic diseases has led to the development of the market in the region. Further, the growth of stem cell research has increased the demand for organoids and spheroids.

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The global organoids and spheroids market is analyzed on the basis of value (USD Million). All the segments have been analyzed on global, regional and country basis. The study includes an analysis of more than 30 countries for each segment. The report offers in-depth analysis of driving factors, opportunities, restraints, and challenges for gaining the key insight of the market. The study includes porter's five forces model, attractiveness analysis, raw material analysis, and competitor position grid analysis.

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School of Science grows by 10 – MIT News

By adminSeptember 8, 2020Stem Cell Medicine

Despite the upheaval caused by the coronavirus pandemic, 10 new faculty members have joined MIT in the departments of Biology; Chemistry; Earth, Atmospheric and Planetary Sciences; Mathematics; and Physics. The School of Science welcomes these new faculty, most of whom began their appointment July 1, amidst efforts to update education and research plans for the fall semester. They bring exciting and valuable new areas of strength and expertise to the Institute.

Camilla Cattania is an earthquake scientist. She uses continuum mechanics, numerical simulations, and statistics to study fault mechanics and earthquake physics at different scales, from small repeating events to fault interaction on regional and global scales. The models she has developed can help forecast earthquake sequences caused by seismic or aseismic events, such as aftershocks and swarms induced by forcing mechanisms like magma moving under the Earths surface. She has also developed theoretical models to explain why certain faults rupture in predictable patterns while others do not. Cattanias research plans include widening her focus to other tectonic settings and geometrically complex fault structures.

Cattania earned her bachelors and masters degrees from Cambridge University in experimental and theoretical physics in 2011, after which she completed a PhD in Germany at the GFZ German Research Center for Geosciences and the University of Potsdam in 2015. Subsequently, she spent a few months as a researcher at Woods Hole Oceanographic Institution and as a postdoc at Stanford University and her doctoral institution. She joins the Department of Earth, Atmospheric and Planetary Sciences as an assistant professor.

Richard Fletcher researches quantum physics using atomic vapors one-millionth the density of air and one-millionth the temperature of deep space. By manipulating the gas with intricately sculpted laser beams and magnetic fields, he can engineer custom-made quantum worlds, which provide both a powerful test bed for theory and a wonderful playground for discovering new phenomena. The goal is to understand how interesting collective behaviors emerge from the underlying microscopic complexity of many interacting particles. Fletchers interests include superfluidity in two-dimensional gases, methods to probe the correlations between individual atoms, and how the interplay of interactions and magnetic fields leads to novel physics.

Fletcher is a graduate of Cambridge University, where he completed his bachelor's in 2010. Before returning to Cambridge University to earn his PhD in 2015, he was a research fellow at Harvard University. He originally came to MIT as a postdoc in 2016 and now joins the Department of Physics as an assistant professor. Fletcher is a member of the MIT-Harvard Center for Ultracold Atoms.

William Frank investigates deformation of the Earths crust. He combines seismology and geodesy to explore the physical mechanisms that control the broad continuum of rupture modes and fault instabilities within the Earth. His research has illuminated the cascading rupture dynamics of slow fault slip and how the aftershocks that follow a large earthquake can reveal the underlying behavior of the host fault. Frank considers shallow shifts that cause earthquakes down to deep creep that is all-but-invisible at the surface. His insights work to improve estimates of seismic hazards induced by tectonic dynamics, volcanic processes, and human activity, which can then inform risk prediction and mitigation.

Frank holds a bachelors degree from the University of Michigan in earth systems science, which he received in 2009. The Institut de Physique du Globe de Paris awarded him a masters degree in geophysics in 2011 and a PhD in 2014. He first joined MIT as a postdoc in 2015 before moving to the University of Southern California as an assistant professor in 2018. He now returns as an assistant professor in the Department of Earth, Atmospheric and Planetary Sciences.

Ronald Fernando Garcia Ruizadvances research on fundamental physics and nuclear structure largely through the development of novel laser spectroscopy techniques. He investigates the properties of subatomic particles using atoms and molecules made up of short-lived radioactive nuclei. Garcia Ruizs experimental work provides unique information about the fundamental forces of nature and offers new opportunities in the search beyond the Standard Model of particle physics. His previous research at CERN focused on the study of the emergence of nuclear phenomena and the properties of nuclear matter at the limits of existence.

Garcia Ruizs bachelors degree in physics was achieved in 2009 at Universidad Nacional de Colombia. After earning a masters in physics in 2011 at Universidad Nacional Autnoma de Mxico, he completed a doctoral degree in radiation and nuclear physics at KU Leuven in 2015. Prior to joining MIT, he was first a research associate at the University of Manchester from 2016-17 and then a research fellow at CERN. Garcia Ruiz has now joined the Department of Physics as an assistant professor. He began his appointment Jan. 1. He is also affiliated with the Laboratory for Nuclear Science.

Ruth Lehmann studies germ cells. The only cells in the body capable of producing an entire organism on their own, germ cells pass genomic information from one generation to the next via egg cells. By analyzing the organization of their informational material as well as the mechanics they regulate, such as the production of eggs and sperm, Lehmann hopes to expose germ cells unique ability to enable procreation. Her work in cellular and developmental biology is renowned for identifying how germ cells migrate and lead to the continuation of life. An advocate for fundamental research in science, Lehmann studies fruit flies as a model to unveil vital aspects of early embryonic development that have important implications for stem cell research, lipid biology, and DNA repair.

Lehmann earned her bachelors degree in biology from the University of Tubingen in Germany. She took an interlude from her education to carry out research at the University of Washington in the United States before returning to Germany. There, she earned a masters equivalent from the University of Freiburg and a PhD from the University of Tubingen. Lehmann was subsequently a postdoc at the Medical Research Council Laboratory of Molecular Biology in the UK, after which she joined MIT. A faculty member and Whitehead Institute for Biomedical Research member from 1988 to 1996, she now returns after 23 years at New York University. Lehmann joins as a full professor in the Department of Biology and is the new director of the Whitehead Institute forBiomedical Research.

As an astrochemist, Brett McGuire is interested in the chemical origins of life and its evolution. He combines physical chemistry experiments and analyses with molecular spectroscopy in a lab, the results of which he then compares against astrophysics observation. His work ties together questions about the formation of planets and a planets ability to host and create life. McGuire does this by investigating the generation, presence, and fate of new molecules in space, which is vast and mostly empty, providing unique physical challenges on top of chemical specifications that can impact molecular formation. He has discovered several complex molecules already, including benzonitrile, a marker of carbon-based reactions occurring in an interstellar medium.

McGuires BS degree was awarded by the University of Illinois at Urbana-Champaign in 2009. He completed a masters in physical chemistry in 2011 at Emory University and a PhD in 2015 at Caltech. He then pursued a postdoc at the National Radio Astronomy Observatory and the Harvard-Smithsonian Center for Astrophysics. He joins the Department of Chemistry as an assistant professor.

Dor Minzer works in the fields of mathematics and theoretical computer science. His interests revolve around computational complexity theory, or more explicitly probabilistically checkable proofs, Boolean function analysis, and combinatorics. With collaborators, he has proved the 2-to-2 Games Conjecture, a central problem in complexity theory closely related to the Unique-Games Conjecture. This work significantly advances our understanding of approximation problems and, in particular, our ability to draw the border between computationally feasible and infeasible approximation problems.

Minzer is not new to online education. After earning his bachelors degree in mathematics in 2014 and a PhD in 2018, both from Tel-Aviv University, he became a postdoc at the Institute for Advanced Study in Princeton, New Jersey. He joins the Department of Mathematics as an assistant professor.

Lisa Piccirillo is a mathematician specializing in the study of three- and four-dimensional spaces. Her work in four-manifold topology has surprising applications to the study of mathematical knots. Perhaps most notably, Piccirillo proved that the Conway knot is not "slice." For all other small knots, "sliceness" is readily determined, but this particular knot had remained a mystery since John Conway presented it in the mid-1900s. After hearing about the problem at a conference, Piccirillo took only a week to formulate a proof. She is broadly interested in low-dimensional topology and knot theory, and employs constructive techniques in four-manifolds.

Piccirillo earned her BS in mathematics in 2013 from Boston College. Her PhD in mathematics was earned from the University of Texas at Austin in 2019, and from 2019-20 she was a postdoc at Brandeis University. She joins the Department of Mathematics as an assistant professor.

Jonathan Weissmans research interest is protein folding and structure, an integral function of life. His purview encompasses the expression of human genes and the lineage of cells, as well as protein misfolding, which can cause diseases and other physiological issues. He has made discoveries surrounding protein folding mechanisms, the development of CRISPR gene-editing tools, and other new therapeutics and drugs, and in the process generated innovative experimental and analytical methods and technologies. One of his novel methods is the ribosome profiling approach, which allows researchers to observe in vivo molecular translation, the process by which a protein is created according to code provided by RNA, a major advancement for health care.

Weissman earned a bachelors degree in physics from Harvard University in 1998 and a PhD from MIT in 1993. After completing his doctoral degree, he left MIT to become a postdoc at Yale University for three years, and then a faculty member at the University of California at San Francisco in 1996. He returns to MIT to join the Department of Biology as a full professor and a member of the Whitehead Institute for Biomedical Research. He is also a Howard Hughes Medical Institute investigator.

Yukiko Yamashita, a stem cell biologist, delves into the origins of multicellular organisms, asking questions about how genetic information is passed from one generation to the next, essentially in perpetuity, via germ cells (eggs and sperm), and how a single cell (fertilized egg) becomes an organism containing many different types of cells. The results of her work on stem cell division and gene transmission has implications for medicine and long-term human health. Using fruit flies as a model in the lab, she has revealed new areas of knowledge. For example, Yamashita has identified the mechanisms that enable a stem cell to produce two daughter cells with distinct fates, one a stem cell and one a differentiating cell, as well as the functions of satellite DNA, which she found to be crucial, unlike the waste they were previously thought to be.

Yamashita received her bachelors degree in biology in 1994 and her PhD in biophysics in 1999, both from Kyoto University. After being a postdoc at Stanford University for five years, she was appointed a faculty member at the University of Michigan in 2007. She joined the Department of Biology as a full professor with a July 1 start. She also became a member of the Whitehead Institute of Biomedical Research and is a standing investigator at the Howard Hughes Medical Institute.

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School of Science grows by 10 - MIT News