Researchers at City of Hope combine oncolytic virus with a CAR-T to eradicate solid tumors in mice – Endpoints News

A new combination of existing cancer treatments is showing early signs of potentially cracking open a new approach to treating solid tumors.

In preclinical research published by City of Hope, a California-based non-profit, scientists effectively blended CAR-T therapy with an oncolytic virus to eradicate solid tumors in mice. The virus is genetically engineered to enter the tumors and force them to express the CD19 protein, allowing the CAR-T cells to attack.

We came up with the idea based on the compatible expertise and essentially with several investigators at City of Hope, Saul Priceman, senior author of the paper, told Endpoints News. It was almost an idea to overcome the challenges associated with treating solid tumors with CAR-T cell therapy the challenge being what tumor antigen to go after in solid tumors and also what we call the immunosuppressive microenvironment.

The researchers are expecting to move into human trials within the next year and a half. Priceman added he likes to describe the method as mark and kill, where the virus marks the tumor with a recognizable target for the CAR-T cells that then go in for the kill.

Normally used to treat blood cancers like B cell lymphomas and acute lymphoblastic leukemia, CAR-T therapy has made significant headway since netting its first FDA approval back in late 2017. The success seen in these cancers hasnt translated into solid tumors as of yet given that finding receptors on the surfaces of those cells is much more challenging and can lead to unwanted toxicities.

By combining CAR-T with a virus that essentially compels the tumors into expressing a receptor like CD19, however, Priceman hopes this concept can be a game-changer. Specifically in the mouse trials, Priceman and his team showed the virus was able to express CD19 in triple-negative breast cancer, as well as in pancreatic, prostate, ovarian, and head and neck cancer, as well as brain tumor cells.

Oncolytic viruses have had markedly less success when used on their own to treat cancers, according to paper co-author Anthony Park, largely because the immune system can develop a resistance. Theyve also never been tested clinically, but with CAR-Ts safety profile already well-known, the team is expecting positive results.

When used alone, the oncolytic virus will induce an endogenous immune response, which could be beneficial for targeting tumors, but it can also be detrimental to the virus activity because the immune system can recognize the virus to not only show the tumor cells but also get rid of the virus, Park said.

City of Hopes results have already impressed some outside experts, namely Ezra Cohen, the chief of UC San Diegos hematology-oncology division. Cohen, who himself is researching a similar combination using ROR1-targeting CAR-T cells, said City of Hope used a clever approach and found an added bonus in the study when the virus propagated into other tumor cells after the originally-infected cells died off.

That could suggest widespread efficacy even if the oncolytic virus doesnt manage to infect every single tumor cell.

Youve got this hammer, which has been successful in hematological diseases, but you cant use it for all the patients with solid tumors because you cant see the nail, Cohen said. But what City of Hope did is they put the nail into cells that they wanted, and now all of a sudden you can use that hammer and it becomes effective.

The biggest challenge moving forward will be how well the experiments in mice can translate into humans. Some experimental CAR-T therapies have failed at this stage before, Cohen said, as getting the treatment to hone in on the tumor when its not directly injected into its cells something thats not always possible in humans with metastatic cancers is immensely difficult.

But Priceman is confident in the expertise of the City of Hope team, noting that the institution has 13 active Phase I clinical trials with CAR-T cells in a range of diseases.

One of the beauties of City of Hope is weve done this a number of times, Priceman said. Clinical translation of a CAR-T cell is something we have a wide expertise in, and weve also growing expertise in oncolytic viruses.

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Researchers at City of Hope combine oncolytic virus with a CAR-T to eradicate solid tumors in mice - Endpoints News

Game change: A frontrunner in the cell therapy 2.0 field offers a first look at their lead therapy. And it’s a doozy – Endpoints News

Two Bay Area upstarts with close connections are joining forces today in the hunt for cell therapy 2.0. And the deal is bonding some brash new players with one of the best connected biotech execs in San Francisco.

Theres no money mentioned in the deal announcement, but both Orca Bio and Lyell Immunopharma have had no trouble raising hundreds of millions of dollars in the past year or so.

This is a match made in biotech heaven with plans to take on some devilish killers. Orca brings its T cell purification platform to the table, while Lyell has deep ranks of experts in T cell biology. Together, they think they can make curative strides in solid tumors, ranging beyond the first victories over blood cancer.

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Game change: A frontrunner in the cell therapy 2.0 field offers a first look at their lead therapy. And it's a doozy - Endpoints News

Global Canine Stem Cell Therapy Market 2020 to Witness Huge Growth by 2026 | Top Key Players; VETSTEM BIOPHARMA, Cell Therapy Sciences, Regeneus,…

The report mainly focuses on the Canine Stem Cell Therapy Market size, recent trends and development status, as well as investment opportunities, market dynamics such as driving factors, restraining factors, and opportunity, also industry news like mergers, acquisitions, and investments. Along with that, this research report provides detailed information regarding technological innovation and advancement which will further optimize the performance of the product, making it more widely used in downstream applications.

Download Sample Copy of Canine Stem Cell Therapy Market Report Study 2019-2026 At: https://www.innovateinsights.com/report/global-canine-stem-cell-therapy-market-by-type/325678/#requestsample

Global Canine Stem Cell Therapy Market: Analysis and Insights To study the global Canine Stem Cell Therapy market size, with its sub-segments. Detailed information about drivers, opportunities, and restraints of the Canine Stem Cell Therapy market. Report provides detailed information related to the major key players, essential regions/countries, products and application, background information. SWOT analysis for all key players mentioned in the research report. This report also analyses the impact of Coronavirus COVID-19 on the global Canine Stem Cell Therapy market. To analyze the amount and value of the global Canine Stem Cell Therapy Market, depending on key regions. To study the global Canine Stem Cell Therapy market current trends, prospects and also their participation in the entire sector.

The Major players profiled in this report include:

In addition, global Canine Stem Cell Therapy research report offers the Porters Five Forces Analysis, Product Life Cycle, manufacturing process, and supply chain analysis.All the information in the research report is collected through primary and secondary research. Primary research collected by using various methods such as interviews, surveys and observation of analysts and secondary research grabbed by using well known paid sources, trade journals, and industry databases. The report also utilizes qualitative and quantitative methods for analyzing data gathering from various industry analysts and market players.

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Global Canine Stem Cell Therapy market report covers the various geographical regions such as North America, Asia-Pacific, Europe, Southeast Asia, South America, Middle East & Africa, and other regions. Also, various countries included are Canada, U.K., France, the U.S., Russia, China, India, and Germany and so on.

Global Canine Stem Cell Therapy Market Split by Product Type and Applications:

Global Canine Stem Cell Therapy Market Segmentation By Type:

Global Canine Stem Cell Therapy Market Segmentation By Applications:

Impact of COVID-19: There is hardly any place in the world that has remained unaffected by the brutality of the Covid-19 pandemic; almost every company is suffering from ruthless Novel Coronavirus Disease. To encompass the pandemic, many nations and Governments around the world has imposed a lockdown, restricting the gatherings and the movement of people. Lockdown has multiple consequences, which further stretch the troubles for various sector like reverse migration, disruption of supply chains, manufacturing industries, machinery and equipment industry, healthcare industry, agriculture industry, medical and pharmaceutical industry, construction sector, food industry sector, chemical industry, Cosmetics and Personal Care industry and so on.

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Chapters Define in TOC (Table of Content) of the Report: Chapter 1: Market Overview, Drivers, Restraints and Opportunities, Segmentation overview Chapter 2: Market Competition by Manufacturers Chapter 3: Production by Regions Chapter 4: Consumption by Regions Chapter 5: Production, By Types, Revenue and Market share by Types Chapter 6: Consumption, By Applications, Market share (%) and Growth Rate by Applications Chapter 7: Complete profiling and analysis of Manufacturers Chapter 8: Manufacturing cost analysis, Raw materials analysis, Region-wise manufacturing expenses. Chapter 9: Industrial Chain, Sourcing Strategy and Downstream Buyers Chapter 10: Marketing Strategy Analysis, Distributors/Traders Chapter 11: Market Effect Factors Analysis Chapter 12: Market Forecast Chapter 13: Canine Stem Cell Therapy Research Findings and Conclusion, Appendix, methodology and data source.

A separate analysis of the current trends in the parent market by using macro and microenvironment indicators is represented in the report. By showing all these things users easily analyze the major segments over the forecast period.

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Global Canine Stem Cell Therapy Market 2020 to Witness Huge Growth by 2026 | Top Key Players; VETSTEM BIOPHARMA, Cell Therapy Sciences, Regeneus,...

FDA Approves First Maintenance Therapy for AML – Medscape

The US Food and Drug Administration (FDA) has approved an oral form of azacitidine (Onureg) for use as maintenance therapy for patients with acute myeloid leukemia (AML) who have achieved a first complete remission.

The approval extends to patients who have achieved complete remission with incomplete blood count recovery following intensive induction chemotherapy and who are unable to complete intensive curative therapy.

The approval was based on data from the QUAZAR AML-001 trial, which showed that oral azacitidine significantly improved overall survival when compared to placebo.

"It's not too hard to get these patients into remission," Harry P. Erba, MD, PhD, director of the Leukemia Program at the Duke Cancer Institute, Durham, North Carolina, told Medscape Medical News last year, when these results were first presented at the 2019 annual meeting of the American Society of Hematology. "The problem comes in keeping them in remission."

Despite various attempts, there has been no success over the past 30 years in defining maintenance treatment for these patients, Andrew H. Wei, MBBS, PhD, from the Alfred Hospital in Melbourne, Australia, said.

"Oral azacitidine represents a new therapeutic standard for patients with AML in remission," he said.

Azacitidine is a hypomethylating agent that incorporates into DNA and RNA. It has long been used as an injectable therapy for the treatment of myelodysplastic syndromes.

The approval of the new oral formulation for the new indication of AML "is the culmination of over a decade of research and 13 preclinical and clinical trials," said Giovanni Caforio, M.D., chairman and chief executive officer of Bristol-Myers Squibb, in a statement.

The QUAZAR AML-001 trial was a phase 3, international study involving 472 patients with AML who were within achieving a first complete remission or remission with incomplete blood recovery. All patients has received intensive induction chemotherapy with or without consolidation treatment, per investigator preference prior to study entry, and were not candidates for hematopoietic stem cell transplant at the time of screening.

Patients were randomly assigned to receive either oral azacitidine 200 mg daily on days 1 to 14 of a repeat 28-day cycle (n = 278) or matching placebo (n = 274). Treatment was continued indefinitely until blast count was more than 15% or patients experienced unacceptable toxicity or underwent transplant.

At a median follow-up of over 41.2 months, the median overall survival was significantly longer for patients who received oral azacitidine, at 24.7 monthsvs 14.8 months for those who received placebo (P < .0009; hazard ratio [HR], 0.69).

Relapse-free survival was also significantly prolonged to 10.2 months for patients who received oral azacitidinevs 4.8 months for those who received placebo (HR, 0.65; P < .0001).

Serious adverse reactions occurred in 15% of patients who received azacitidine. Events that occurred in 2% of patients include pneumonia (8%) and febrile neutropenia (7%). There was one fatal event.

The most common adverse reactions were nausea (65%, 24%), vomiting (60%, 10%), diarrhea (50%, 21%), fatigue/asthenia (44%, 25%), constipation (39%, 24%), pneumonia (27%, 17%), abdominal pain (22%, 13%) arthralgia (14%, 10%), decreased appetite (13%, 6%), febrile neutropenia (12%, 8%), dizziness (11%, 9%) and pain in extremity (11%, 5%). Permanent discontinuation because of an adverse reaction occurred in 8% of patients.

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FDA Approves First Maintenance Therapy for AML - Medscape

Expert Panel Points to Central Role of Endothelial Injury and Lectin Pathway Activation in Critically Ill COVID-19 Patients – Business Wire

SEATTLE--(BUSINESS WIRE)--Omeros Corporation (Nasdaq: OMER) today announced that the Demy-Colton Virtual Salon Series featured an expert discussion of developments in the treatment of severe COVID-19. The panel session, entitled Lessons from Bergamo: Discoveries in Treating Critically-ill COVID-19 Patients, was held on September 2, 2020 and included international experts in hematology, oncology and complement science. The panel was moderated by Sara Jane Demy, founder and chief executive officer of Demy-Colton. A replay of the panel can be viewed here (free registration required).

The panel discussed the emerging evidence that endothelial injury and the activation of the lectin pathway of complement are central drivers of the acute respiratory distress syndrome (ARDS) and thrombosis seen in critically ill COVID-19 patients. Narsoplimab, Omeros investigational human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the key effector of the lectin pathway of complement, was identified as a potentially highly effective therapy to treat critically ill COVID-19 patients.

Omeros previously announced positive results from the treatment with narsoplimab of six critically ill COVID-19 patients under a compassionate use protocol. All patients initially required mechanical ventilation and, following treatment with narsoplimab, all recovered, survived and were discharged from the hospital.

About Narsoplimab

Narsoplimab, also known as OMS721, is an investigational human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), a novel pro-inflammatory protein target and the effector enzyme of the lectin pathway of complement. Importantly, inhibition of MASP-2 does not appear to interfere with the antibody-dependent classical complement activation pathway, which is a critical component of the acquired immune response to infection. Omeros controls the worldwide rights to MASP-2 and all therapeutics targeting MASP-2.

Phase 3 clinical programs are in progress for narsoplimab in hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA), in immunoglobulin A (IgA) nephropathy, and in atypical hemolytic uremic syndrome (aHUS). The FDA has granted narsoplimab breakthrough therapy designations for HSCT-TMA and for IgA nephropathy; orphan drug status for the prevention (inhibition) of complement-mediated thrombotic microangiopathies, for the treatment of HSCT-TMA and for the treatment of IgA nephropathy; and fast track designation for the treatment of patients with aHUS. The European Medicines Agency has granted orphan drug designation to narsoplimab for treatment in HSCT and for treatment of primary IgA nephropathy.

About Omeros Corporation

Omeros is a commercial-stage biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, complement-mediated diseases, disorders of the central nervous system and immune-related diseases, including cancers. In addition to its commercial product OMIDRIA (phenylephrine and ketorolac intraocular solution) 1%/0.3%, Omeros has multiple late-stage clinical development programs focused on complement-mediated disorders, including COVID-19, and substance abuse. A rolling biologics license application for narsoplimab, the companys lead MASP-2 inhibitor, in hematopoietic stem cell transplant-associated thrombotic microangiopathy is being completed for submission to the U.S. FDA. Omeros also has a diverse group of preclinical programs including GPR174, a novel target in immuno-oncology that modulates a new cancer immunity axis recently discovered by Omeros. Small-molecule inhibitors of GPR174 are part of Omeros proprietary G protein-coupled receptor (GPCR) platform through which it controls 54 new GPCR drug targets and their corresponding compounds. The company also exclusively possesses a novel antibody-generating platform.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, which are subject to the safe harbor created by those sections for such statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as anticipate, believe, can, could, estimate, expect, goal, intend, likely, look forward to, may, on track, plan, potential, predict, project, prospects, scheduled, should, slated, targeting, will, would and similar expressions and variations thereof. Forward-looking statements, including statements regarding anticipated regulatory submissions, the timing and results of ongoing or anticipated clinical trials, and the therapeutic application of Omeros investigational product, are based on managements beliefs and assumptions and on information available to management only as of the date of this press release. Omeros actual results could differ materially from those anticipated in these forward-looking statements for many reasons, including, without limitation, availability and timing of data from clinical trials and the results of such trials, unproven preclinical and clinical development activities, regulatory oversight, intellectual property claims, competitive developments, litigation, and the risks, uncertainties and other factors described under the heading Risk Factors in the companys Annual Report on Form 10-K for the year ended December 31, 2019, filed with the Securities and Exchange Commission (SEC) on March 2, 2020, as supplemented by its Quarterly Report on Form 10-Q filed with the SEC on August 10, 2020 and subsequent filings with the SEC. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and the company assumes no obligation to update these forward-looking statements, whether as a result of any new information, future events or otherwise, except as required by applicable law.

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Expert Panel Points to Central Role of Endothelial Injury and Lectin Pathway Activation in Critically Ill COVID-19 Patients - Business Wire

SoftWave Tissue Regeneration Technologies Receives FDA Clearance for the Treatment of Burn Wounds – PRNewswire

ATLANTA, Sept. 1, 2020 /PRNewswire/ --SoftWave Tissue Regeneration Technologies, a disruptive bio-medical device company, was cleared by the FDA on Friday, Aug. 28, 2020, for the treatment of superficial, partial-thickness, second-degree burns in adults (FDA 510k letter number K200926). SoftWave also has clearance for the treatment of Diabetic Foot Ulcers (DFU's), making it the only ESWT company to have two clearances for both acute (burns) and chronic wounds (DFU's). SoftWave therapy gives physicians, who treat burn patients, another option in healing burn wounds.

Each year, in the United States, approximately 450,000 patients receive medical attention, at emergency rooms, for burn related injuries. Most superficial wounds heal in two weeks; however, patients who suffer severe burns must endure intense physical and psychological pain during the burn injury treatment phase. There are over 3,400 burn injury deaths, including 1,100 children every year. The CDC estimates that $7.5 billion dollars are spent each year for burn related injuries. After the treatment phase is over and wounds are healed, scarring and disfigurement may interfere with movement, mobility, and daily life functions, resulting in a lifetime of physical and emotional burdens.

SoftWave's technology uses an unfocused extracorporeal shock wave (uESWT) to promote both a physical and biological response in order to improve wound healing. In a prospective randomized trial conducted by Dr. Christian Ottomann, published in the Annals of Surgery, significant accelerated epithelialization was demonstrated in the patients who had undergone uESWT (9.6 1.7 days) as compared to the patients who did not undergo uESWT (12.5 2.2 days); a statistically significant reduction in the days required for healing (3). This change is a substantial factor for any burn patient. The SoftWave biological response for wound healing is associated with neovascularization, and an increase in oxygenation and perfusion, ultimately resulting in angiogenesis. The hypothesized mechanisms of action for accelerated wound healing include stem cell activation and recruitment, and a reduction in the inflammation as proven in our published TLR3 model.

About SoftWave Tissue Regeneration Technologies

SoftWave TRT is a bio-medical device company that has proprietary patented technology, using unfocused acoustic waves, to treat a variety of conditions. The OrthoGold was first cleared in 2018 for the activation of connective tissue and registered for pain reduction and increased blood flow. Our second clearance, in 2019, was for the treatment of Diabetic Foot Ulcers. SoftWave TRT has over thirty patents for a variety of indications, including the following: stem cell activation, cellulite reduction, numerous indications involving the heart, and wound healing. SoftWave TRT plans to pursue FDA clearance, for all ESWT therapies, targeted by other publicly traded shockwave companies including Sanuwave (SNWV), Soliton (SOLY) and Shockwave Medical (SWAV). SoftWave believes our patented "softwaves" have superior benefits compared to traditional ESWT, and we are conducting multiple clinical trials to demonstrate the effectiveness over current available therapies.

Contact Us: [emailprotected] or call us at (888) 862-6162

Twitter: @SoftwaveTRT

Source: SoftWave Tissue Regeneration Technologies

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SoftWave Tissue Regeneration Technologies Receives FDA Clearance for the Treatment of Burn Wounds - PRNewswire

Mesoblast (ASX:MSB) granted ethics approval to treat COVID-19 patients in Australia – The Market Herald

Stem cell researcher Mesoblast (MSB) has been granted ethics approval for a trial of its remestemcel-L therapy in Australian COVID-19 patients.

Participating hospitals in Melbourne and Sydney will join 17 other facilities across the U.S. in the phase three trial in ventilator-dependent COVID-19 patients with acute respiratory distress syndrome (ARDS).

ARDS is the leading cause of death associated with COVID-19. It occurs when the body's immune response gets caught in a runaway feedback loop which can cause organ and tissue damage.

Mesoblast's stem cell treatment has shown positive indications of reducing the inflammatory response in COVID-19 patients.

If the phase three trial is successful, remestemcel-L will be a step closer to being added to the growing arsenal medical practitioners have at their disposal to combat the disease.

Mesoblast CEO, Dr Silviu Itescu says it's important to gather as much data as possible as the pandemic continues unabated.

"As an Australian company developing a potential treatment for COVID-19 ARDS, the primary cause of death in patients infected with COVID-19, we have a responsibility to evaluate remestemcel-L in Australian patients as the country continues to grapple with COVID-19," Dr Itescu said.

The phase three trial was given the go-ahead based on results from a pilot study using remestemcel-L in patients under emergency compassionate care at Mt Sinai Hospital in New York.

Nine of the 12 patients with moderate-to-severe ARDS were successfully taken off a ventilator and discharged from hospital within a median of 10 days.

The new trial will test the treatment in ventilator-dependent patients in intensive care units with moderate-to-severe COVID-19 ARDS.

The trial will be randomised meaning some patients will receive a placebo instead of the remestemcel-L therapy. The results will consider mortality from all causes 30 days after the beginning of treatment.

The number of patients taken off ventilators in the trial period will also be considered in assessing the treatment's efficacy.

The independent Data Safety Monitoring Board (DSMB) plans to complete an interim analysis this month in the trials first 90 patients in the U.S. after they have completed 30 days of follow up.

Once that analysis is complete, the DSMB will make recommendations as to whether the trial should continue as planned or stop early.

Mesoblast is trading 0.38 per cent lower at $5.22 per share as at 12:27 pm AEST.

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Mesoblast (ASX:MSB) granted ethics approval to treat COVID-19 patients in Australia - The Market Herald

Global Animal Stem Cell Therapy Market Size, Share, Technology, Included Features, Cost, Revenue, Manufacturers, Region, Applications and Forecast to…

Animal Stem Cell Therapy Market Data and Acquisition Research Study with Trends and Opportunities 2019-2024,The study of Animal Stem Cell Therapy market is a compilation of the market of Animal Stem Cell Therapy broken down into its entirety on the basis of types, application, trends and opportunities, mergers and acquisitions, drivers and restraints, and a global outreach. The detailed study also offers a board interpretation of the Animal Stem Cell Therapy industry from a variety of data points that are collected through reputable and verified sources. Furthermore, the study sheds a lights on a market interpretations on a global scale which is further distributed through distribution channels, generated incomes sources and a marginalized market space where most trade occurs.

Along with a generalized market study, the report also consists of the risks that are often neglected when it comes to the Animal Stem Cell Therapy industry in a comprehensive manner. The study is also divided in an analytical space where the forecast is predicted through a primary and secondary research methodologies along with an in-house model.

Download PDF Sample of Animal Stem Cell Therapy Market report @ https://hongchunresearch.com/request-a-sample/74090

Key players in the global Animal Stem Cell Therapy market covered in Chapter 4:,ANIMAL CELL THERAPIES,Celavet,Animacel,VETSTEM BIOPHARMA,Cell Therapy Sciences,Magellan Stem Cells,Cells Power Japan,Animal Care Stem,Aratana Therapeutics,VetCell Therapeutics,MediVet Biologic,U.S. Stem Cell,J-ARM

In Chapter 11 and 13.3, on the basis of types, the Animal Stem Cell Therapy market from 2015 to 2026 is primarily split into:,Dogs,Horses,Others

In Chapter 12 and 13.4, on the basis of applications, the Animal Stem Cell Therapy market from 2015 to 2026 covers:,Veterinary Hospitals,Research Organizations

Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historic and forecast (2015-2026) of the following regions are covered in Chapter 5, 6, 7, 8, 9, 10, 13:,North America (Covered in Chapter 6 and 13),United States,Canada,Mexico,Europe (Covered in Chapter 7 and 13),Germany,UK,France,Italy,Spain,Russia,Others,Asia-Pacific (Covered in Chapter 8 and 13),China,Japan,South Korea,Australia,India,Southeast Asia,Others,Middle East and Africa (Covered in Chapter 9 and 13),Saudi Arabia,UAE,Egypt,Nigeria,South Africa,Others,South America (Covered in Chapter 10 and 13),Brazil,Argentina,Columbia,Chile,Others

For a global outreach, the Animal Stem Cell Therapy study also classifies the market into a global distribution where key market demographics are established based on the majority of the market share. The following markets that are often considered for establishing a global outreach are North America, Europe, Asia, and the Rest of the World. Depending on the study, the following markets are often interchanged, added, or excluded as certain markets only adhere to certain products and needs.

Here is a short glance at what the study actually encompasses:,Study includes strategic developments, latest product launches, regional growth markers and mergers & acquisitions,Revenue, cost price, capacity & utilizations, import/export rates and market share,Forecast predictions are generated from analytical data sources and calculated through a series of in-house processes.

However, based on requirements, this report could be customized for specific regions and countries.

Brief about Animal Stem Cell Therapy Market Report with [emailprotected] https://hongchunresearch.com/report/animal-stem-cell-therapy-market-size-2020-74090

Some Point of Table of Content:

Chapter One: Report Overview

Chapter Two: Global Market Growth Trends

Chapter Three: Value Chain of Animal Stem Cell Therapy Market

Chapter Four: Players Profiles

Chapter Five: Global Animal Stem Cell Therapy Market Analysis by Regions

Chapter Six: North America Animal Stem Cell Therapy Market Analysis by Countries

Chapter Seven: Europe Animal Stem Cell Therapy Market Analysis by Countries

Chapter Eight: Asia-Pacific Animal Stem Cell Therapy Market Analysis by Countries

Chapter Nine: Middle East and Africa Animal Stem Cell Therapy Market Analysis by Countries

Chapter Ten: South America Animal Stem Cell Therapy Market Analysis by Countries

Chapter Eleven: Global Animal Stem Cell Therapy Market Segment by Types

Chapter Twelve: Global Animal Stem Cell Therapy Market Segment by Applications 12.1 Global Animal Stem Cell Therapy Sales, Revenue and Market Share by Applications (2015-2020) 12.1.1 Global Animal Stem Cell Therapy Sales and Market Share by Applications (2015-2020) 12.1.2 Global Animal Stem Cell Therapy Revenue and Market Share by Applications (2015-2020) 12.2 Veterinary Hospitals Sales, Revenue and Growth Rate (2015-2020) 12.3 Research Organizations Sales, Revenue and Growth Rate (2015-2020)

Chapter Thirteen: Animal Stem Cell Therapy Market Forecast by Regions (2020-2026) continued

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List of tables List of Tables and Figures Table Global Animal Stem Cell Therapy Market Size Growth Rate by Type (2020-2026) Figure Global Animal Stem Cell Therapy Market Share by Type in 2019 & 2026 Figure Dogs Features Figure Horses Features Figure Others Features Table Global Animal Stem Cell Therapy Market Size Growth by Application (2020-2026) Figure Global Animal Stem Cell Therapy Market Share by Application in 2019 & 2026 Figure Veterinary Hospitals Description Figure Research Organizations Description Figure Global COVID-19 Status Overview Table Influence of COVID-19 Outbreak on Animal Stem Cell Therapy Industry Development Table SWOT Analysis Figure Porters Five Forces Analysis Figure Global Animal Stem Cell Therapy Market Size and Growth Rate 2015-2026 Table Industry News Table Industry Policies Figure Value Chain Status of Animal Stem Cell Therapy Figure Production Process of Animal Stem Cell Therapy Figure Manufacturing Cost Structure of Animal Stem Cell Therapy Figure Major Company Analysis (by Business Distribution Base, by Product Type) Table Downstream Major Customer Analysis (by Region) Table ANIMAL CELL THERAPIES Profile Table ANIMAL CELL THERAPIES Production, Value, Price, Gross Margin 2015-2020 Table Celavet Profile Table Celavet Production, Value, Price, Gross Margin 2015-2020 Table Animacel Profile Table Animacel Production, Value, Price, Gross Margin 2015-2020 Table VETSTEM BIOPHARMA Profile Table VETSTEM BIOPHARMA Production, Value, Price, Gross Margin 2015-2020 Table Cell Therapy Sciences Profile Table Cell Therapy Sciences Production, Value, Price, Gross Margin 2015-2020 Table Magellan Stem Cells Profile Table Magellan Stem Cells Production, Value, Price, Gross Margin 2015-2020 Table Cells Power Japan Profile Table Cells Power Japan Production, Value, Price, Gross Margin 2015-2020 Table Animal Care Stem Profile Table Animal Care Stem Production, Value, Price, Gross Margin 2015-2020 Table Aratana Therapeutics Profile Table Aratana Therapeutics Production, Value, Price, Gross Margin 2015-2020 Table VetCell Therapeutics Profile Table VetCell Therapeutics Production, Value, Price, Gross Margin 2015-2020 Table MediVet Biologic Profile Table MediVet Biologic Production, Value, Price, Gross Margin 2015-2020 Table U.S. Stem Cell Profile Table U.S. Stem Cell Production, Value, Price, Gross Margin 2015-2020 Table J-ARM Profile Table J-ARM Production, Value, Price, Gross Margin 2015-2020 Figure Global Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Global Animal Stem Cell Therapy Revenue ($) and Growth (2015-2020) Table Global Animal Stem Cell Therapy Sales by Regions (2015-2020) Table Global Animal Stem Cell Therapy Sales Market Share by Regions (2015-2020) Table Global Animal Stem Cell Therapy Revenue ($) by Regions (2015-2020) Table Global Animal Stem Cell Therapy Revenue Market Share by Regions (2015-2020) Table Global Animal Stem Cell Therapy Revenue Market Share by Regions in 2015 Table Global Animal Stem Cell Therapy Revenue Market Share by Regions in 2019 Figure North America Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Europe Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Asia-Pacific Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Middle East and Africa Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure South America Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure North America Animal Stem Cell Therapy Revenue ($) and Growth (2015-2020) Table North America Animal Stem Cell Therapy Sales by Countries (2015-2020) Table North America Animal Stem Cell Therapy Sales Market Share by Countries (2015-2020) Figure North America Animal Stem Cell Therapy Sales Market Share by Countries in 2015 Figure North America Animal Stem Cell Therapy Sales Market Share by Countries in 2019 Table North America Animal Stem Cell Therapy Revenue ($) by Countries (2015-2020) Table North America Animal Stem Cell Therapy Revenue Market Share by Countries (2015-2020) Figure North America Animal Stem Cell Therapy Revenue Market Share by Countries in 2015 Figure North America Animal Stem Cell Therapy Revenue Market Share by Countries in 2019 Figure United States Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Canada Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Mexico Animal Stem Cell Therapy Sales and Growth (2015-2020) Figure Europe Animal Stem Cell Therapy Revenue ($) Growth (2015-2020) Table Europe Animal Stem Cell Therapy Sales by Countries (2015-2020) Table Europe Animal Stem Cell Therapy Sales Market Share by Countries (2015-2020) Figure Europe Animal Stem Cell Therapy Sales Market Share by Countries in 2015 Figure Europe Animal Stem Cell Therapy Sales Market Share by Countries in 2019 Table Europe Animal Stem Cell Therapy Revenue ($) by Countries (2015-2020) Table Europe Animal Stem Cell Therapy Revenue Market Share by Countries (2015-2020) Figure Europe Animal Stem Cell Therapy Revenue Market Share by Countries in 2015 Figure Europe Animal Stem Cell Therapy Revenue Market Share by Countries in 2019 Figure Germany Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure UK Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure France Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Italy Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Spain Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Russia Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Asia-Pacific Animal Stem Cell Therapy Revenue ($) and Growth (2015-2020) Table Asia-Pacific Animal Stem Cell Therapy Sales by Countries (2015-2020) Table Asia-Pacific Animal Stem Cell Therapy Sales Market Share by Countries (2015-2020) Figure Asia-Pacific Animal Stem Cell Therapy Sales Market Share by Countries in 2015 Figure Asia-Pacific Animal Stem Cell Therapy Sales Market Share by Countries in 2019 Table Asia-Pacific Animal Stem Cell Therapy Revenue ($) by Countries (2015-2020) Table Asia-Pacific Animal Stem Cell Therapy Revenue Market Share by Countries (2015-2020) Figure Asia-Pacific Animal Stem Cell Therapy Revenue Market Share by Countries in 2015 Figure Asia-Pacific Animal Stem Cell Therapy Revenue Market Share by Countries in 2019 Figure China Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Japan Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure South Korea Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Australia Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure India Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Southeast Asia Animal Stem Cell Therapy Sales and Growth Rate (2015-2020) Figure Middle East and Africa Animal Stem Cell Therapy Revenue ($) and Growth (2015-2020) continued

About HongChun Research: HongChun Research main aim is to assist our clients in order to give a detailed perspective on the current market trends and build long-lasting connections with our clientele. Our studies are designed to provide solid quantitative facts combined with strategic industrial insights that are acquired from proprietary sources and an in-house model.

Contact Details: Jennifer Gray Manager Global Sales + 852 8170 0792 [emailprotected]

NOTE: Our report does take into account the impact of coronavirus pandemic and dedicates qualitative as well as quantitative sections of information within the report that emphasizes the impact of COVID-19.

As this pandemic is ongoing and leading to dynamic shifts in stocks and businesses worldwide, we take into account the current condition and forecast the market data taking into consideration the micro and macroeconomic factors that will be affected by the pandemic.

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Global Animal Stem Cell Therapy Market Size, Share, Technology, Included Features, Cost, Revenue, Manufacturers, Region, Applications and Forecast to...

Keeping kids and adults alike healthy with Colostrum – North Coast Courier

Did you know that your childs immune system isnt fully developed until the age of 7 or 8 years, and that they are exposed to thousands of germs each and every day?

Kids will be kids, and who we cannot keep them wrapped in bubble wrap but there are ways to strengthen their immune response.

Key to doing this is to maintain and strengthen your childs gut health.

Ballito based New Image International consultant, Prema Naidoo recommends the Alpha Lipid Dinotabs a Colostrum-based product in the form of a tablet which children can take daily from the age of 12 months and upwards.

Containing Bovine Colostrum, these strawberry flavoured tablets provide important immune factors antibodies which may help your child to cope with the constant challenges they may face with their immune health.

Bovine Colostrum is a milky fluid which comes from the udders of cows during the first few days after giving birth (before true milk appears) this is filled with proteins, carbohydrates, fats, vitamins, minerals and specific kinds of proteins called antibodies, which help fight bacteria and viruses.

Taken daily, Colostrum supports digestion by providing nutrients to your child which nourishes a healthy digestive tract.

Dinotabs also improves bone and dental health.

And while youre busy running after your child, you may need something to aid with replenishing, rejuvenating and revitalising your own bodys natural cellular repair process. This can be done by taking Alpha Lipid Colostem, which supports stem cell nutrition.

Colostrum has stem cell releasing properties. Stem cells have the ability to develop into many different cell types, which can range from muscle cells to brain cells.

Acting as a universal repair system while also maintaining the regeneration of cells throughout the body, adult stem cells divide to replenish dying cells.

Alpha Lipid Colostem supports this natural process, adding antioxidants and nutrients to boost your immunity and leave your body feeling restored, healthy and protected.

For more information, contact Prema Naidoo at 079 694 7893.

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Keeping kids and adults alike healthy with Colostrum - North Coast Courier

Newly discovered molecule could play key role in treating osteoarthritis – Irish Examiner

A newly discovered molecule has the potential to play a role in treating osteoarthritis, after researchers found it provided long-lasting regeneration of bone and cartilage defects in animals.

Osteoarthritis is a condition that causes joints to become painful and stiff and is the most common type of arthritis in the UK, affecting nearly 9 million people.

Cartilage, which overlies bones to enable frictionless movement in joints, often fails to repair after injury which leads to further cartilage loss and osteoarthritis.

There is no cure for arthritis, with treatments only helping to slow it down.

A team of researchers, led by Queen Mary University of London in England, studied the effects of a molecule called agrin on animals and discovered that it repairs cartilage by recruiting and activating adult stem cells present in the joint.

Scientists explained that these mechanisms were the same as those used by a body first developing a skeleton in the embryo.

Their study, published in Science Translational Medicine journal, suggests that supporting such mechanisms is an effective way to help heal injuries that are too big to heal in normal conditions.

Researchers injected mice with a gel containing agrin into joint surface defects and after eight weeks found it caused long-lasting regeneration of bone and cartilage more than a control group that received the gel without agrin.

Testing the agrin-containing gel on sheep also found cartilage and bone repair was better after six months, when compared to a control group.

Researchers said the sheep spent more time playing and less time resting during the study, suggesting the repair improvement was associated with improved function.

Dr Suzanne Eldridge, from Queen Mary University of London, said osteoarthritis costs the UK 13 billion a year when factoring in indirect costs such as carers and being out of employment.

She explained the condition leaves people severely disabled and there is no cure.

Many are unable to do basic things, including bathing, getting dressed, cooking or shopping, she said.

This week's new issue of Science Translational Medicine has arrive! https://t.co/UcX7IPgRNN pic.twitter.com/raEEs3AES8

Dr Eldridge added: If we could intervene at an early stage once an injury has occurred, and repair the damage, the likelihood of patients going on to develop osteoarthritis is much slimmer.

Our ultimate aim is to transform osteoarthritis from a disease that requires surgery, to one that just requires an injection.

Professor Francesco DellAccio, also from Queen Mary University of London, said: Weve shown that its possible to repair joint defects, for the moment at least in animals, not just in the bone but also in the cartilage.

One single administration of this molecule is sufficient to trigger a cascade of events in the joints, which, once started, are then self-maintained.

Not only does it achieve structural repair, but weve shown that it gives symptomatic relief in animals extremely rapidly.

Researchers are now working towards applying their findings safely in humans but predict clinical trials are several years away.

The study was funded by the Medical Research Council, charity Versus Arthritis, Reumafond, a Dutch arthritis foundation, and private medical research charity The Rosetrees Trust.

It also involved researchers from Scotland's University of Aberdeen and England's University of Cambridge.

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Newly discovered molecule could play key role in treating osteoarthritis - Irish Examiner