Stem Cell Clinic

Insights on the Human Microbiome Immunology Therapeutics Global Market to 2025 – Featuring Finch Therapeutics, MaaT Pharma & Merck Among Others -…

By adminSeptember 3, 2020Stell Cell Research

September 02, 2020 04:49 ET | Source: Research and Markets

Dublin, Sept. 02, 2020 (GLOBE NEWSWIRE) -- The "Global Human Microbiome Immunology Therapeutics Market & Clinical Trial Insight 2025" clinical trials has been added to ResearchAndMarkets.com's offering.

The scale and scope of microbiome research activity has now become one of the fastest growing areas in biology. The relevance that it has shown for the welfare of the society and pharmaceutical industry has led to the development of a transdisciplinary environment that is however conducive to innovation with a mission to abolish the limitations in the pharmaceutical industry through excellence in microbiome research, awareness and outreach. Over the years now, gut microbiome is estimated to implicate success for the various immunotherapies.

Microbiome's role in immunology practices is to transform world-class treatment into the medicine of today and tomorrow. It is highly recognizable that the healthcare issues that mankind is facing today is now bigger than any one solution. The treatment of certain diseases requires multiple options for the treatment and ultimately prevention. Therefore, the amalgamation of two different treatment paradigms i.e. microbiome and immunology are apparently delivering some medical benefits that millions of patients were in need for long period of time. The ways in which microbiome is understood and manipulated to serve the immunological aspects has given great interest to all the researchers.

The essential and usual concept of immunology depicts targeting the immune system of the body to provoke an immune response with huge impact but then the unsuccessful implication of immunology therapies driven treatments led to an exploration of several other basic concepts that could play an important role in boosting the immune system when combined. Looking forward, the microbiome community in the gut represented beneficial patterns with respect to further research. The area of microbiome research and its combination with immunological aspect for the disease treatment has produced a real excitement in the area of medical research and specifically microbiome research.

All over the world, the amalgamation of the two has been well accepted and appreciated by the patients, physicians and the clinicians. Investigation of all the working sides of microbiome and how it plays an important role in boosting the manipulated immune cells have recently started in large numbers as the technology available in the medical field allows to capture it accurately. To facilitate the microbiome and immunology community in order to extract the best and trending opportunities that are stemmed into the microbiome research, the experts from both the relevant disciplines are analyzing it through clinical researches and surveys. Further, the area is getting supported by 86 different clinical trials getting conducted in different countries.

The Global Human Microbiome Immunology Therapeutics Market & Clinical Trial Insight 2025 report summarizes the view of the wider opportunities that are associated microbiome community for the advancement of the scientific information regarding immunology. The science that is related to microbiome has high interdisciplinary and various opportunities that somehow have remained hidden in the medical world. It is believed that the opportunities and all the desirable tangible benefits microbiome is capable of delivering when combined with immunology is large and needs coordinated and constructive approach. The call to the two different sectors i.e. microbiology and immunology is estimated to unlock the potential and promising benefits of microbiome. The approach leading to the extraction of advantages if properly embedded in the microbiome and immunology research, the future benefits will be huge

Report Highlights:

Key Topics Covered:

1. Overview of Microbiome 1.1 Introduction to Microbiome 1.2 History & Evolution of Microbiome

2. Role of Microbiome in Human Body

3. Microbiome: Various Forms 3.1 Gut Microbiome 3.2 Lung Microbiome 3.3 Skin Microbiome 3.4 Microbiome in Other Parts of the Body

4. Mechanism of Microbiome Activity 4.1 Nature of Immune Response 4.1.1 Immunosuppressive Activity 4.1.2 Immunostimulatory Activity 4.2 Messengers Involves in Microbiome Mechanism 4.2.1 MAMPs/PAMPs 4.2.2 Microbial Metabolites As Messengers 4.2.3 Host Cytokines As Messengers 4.2.4 Immune Cells As Messengers

5. Technological Requirement for Microbiota 5.1 Technologies Used 5.1.1 iChip 5.1.2 Simulator of the Human Intestinal Microbial Ecosystem (SHIME) 5.1.3 Gut-on-a-Chip System 5.1.4 Colonic Stem Cell Construction 5.2 Harnessing & Engineering the Microbiome 5.2.1 Additive Approaches 5.2.2 Subtractive Approaches

6. Need for Microbiome Immunology

7. Therapeutic Applications of Microbiome Immunology 7.1 Microbiome Therapy 7.2 Precision Medicine 7.3 Drug discovery 7.4 Biomarkers & Therapy Optimization

8. Human Microbiota in Infectious Diseases 8.1 Infection with Clostridium Difficile 8.2 Infection with Helicobacter Pylori 8.3 Bacterial Vaginosis 8.4 Infection with HIV

9. The Human Microbiota & Liver Diseases 9.1 Non-Alcoholic Fatty Liver Disease (NAFLD) 9.2 Alcoholic Liver Diseases (ALD) 9.3 Liver Fibrosis & Cirrhosis

10. The Human Microbiota & Metabolic Disorders 10.1 Obesity 10.2 Type 2 Diabetes

11. The Human Microbiota & Other Diseases 11.1 Microbiota & Allergic Diseases 11.2 Microbiota & Psychiatric Diseases

12. Microbiome in Immuno Oncology 12.1 Role of Microbiome in Immuno Oncology 12.2 Microbiome Mechanism in Oncogenesis & Tumor Suppression

13. Microbiome Application by Cancer Types 13.1 Gastric Cancer 13.2 Colorectal Cancer 13.3 Esophageal Cancer 13.4 Hepatocellular Carcinoma 13.5 Melanoma 13.6 Solid Tumors

14. Industrial Approaches of Microbiome Therapy in Oncology 14.1 Bacterial Approaches 14.1.1 Fecal Microbiota Transplantation (FMT) 14.1.2 Synthetic Bacteria 14.1.3 Microbial Culture 14.2 Microbiome as Vaccine 14.3 Microbiome as Small Molecules 14.4 Microbiome Therapy using Phage Virus

15. Global Human Microbiome Market Analysis 15.1 Overview 15.2 Human Microbiome Market Segmentation 15.2.1 Regional Segmentation 15.2.2 Disease Based Segmentation 15.2.3 Segmentation by Application

16. Clinical Pipeline of Microbiome Based Therapy 16.1 Microbiome Modulators in Clinical Trial 16.2 Cancer Related Clinical Trials 16.2.1 Preclinical & Discovery Phase 16.2.2 Active Clinical Trials 16.3 Clinical Trial Related To FMT 16.3.1 Clinical Trial for Recurrent C. difficile 16.3.2 Clinical Trial for Inflammatory Bowel Disease (IBD) 16.3.3 Other FMT Related Clinical Trials

17. Global Microbiome Modulators Clinical Pipeline By Company, Indication & Phase 17.1 Research 17.2 Preclinical 17.3 Clinical 17.4 Phase-I 17.5 Phase-I/II 17.6 Phase-II 17.7 Phase-II/III 17.8 Phase-III

18. Marketed Microbiome Modulators Clinical Insight 18.1 Sodium Oligomannurarate - Shanghai Green Valley Pharmaceutical 18.2 Miya-BM

19. Global Microbiome Immunology Therapeutics Market Growth Drivers

20. Microbiome Technology - Investments, Acquisitions & Collaborations by Leading Microbiome Companies

21. Blockades in the Microbiome Immunology Market 21.1 Stable Engraftment 21.2 Development of Clinically Relevant Sensors 21.3 Robustness and Evolutionary Stability of Genetic Circuits 21.4 Regulation, Safety and Biocontainment

22. Global Microbiome Immunology Market Future Panorama

23. Competitive Landscape 23.1 4D Pharma 23.2 AbbVie 23.3 AstraZeneca plc 23.4 Biocodex 23.5 Bristol Mayer Squibb 23.6 Corebiome/Diversigen 23.7 Elogi Bioscience 23.8 Enterome 23.9 Ferring Pharmaceuticals 23.10 Finch Therapeutics 23.11 Maat Pharma 23.12 Merck 23.13 Microbiome Therapeutics 23.14 Novartis 23.15 OpenBiome 23.16 Pfizer 23.17 Rebiotix 23.18 Second Genome 23.19 Seres Therapeutics 23.20 Symberix 23.21 Takeda Pharmaceuticals 23.22 Vedanta Bioscience

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Insights on the Human Microbiome Immunology Therapeutics Global Market to 2025 - Featuring Finch Therapeutics, MaaT Pharma & Merck Among Others -...

Global Rheumatoid Arthritis Stem Cell Therapy Market Dynamics, Forecast, Analysis and Supply Demand 2018 to 2028 – Scientect

By adminSeptember 3, 2020Stem Cell Clinics

The globalRheumatoid Arthritis Stem Cell Therapymarketstudy presents an all in all compilation of the historical, current and future outlook of the market as well as the factors responsible for such a growth. With SWOT analysis, the business study highlights the strengths, weaknesses, opportunities and threats of each Rheumatoid Arthritis Stem Cell Therapy market player in a comprehensive way. Further, the Rheumatoid Arthritis Stem Cell Therapy market report emphasizes the adoption pattern of the Rheumatoid Arthritis Stem Cell Therapy across various industries. Request Sample Reporthttps://www.factmr.com/connectus/sample?flag=S&rep_id=1001 The Rheumatoid Arthritis Stem Cell Therapy market report highlights the following players:The global market for rheumatoid arthritis stem cell therapy is highly fragmented. Examples of some of the key players operating in the global rheumatoid arthritis stem cell therapy market include Mesoblast Ltd., Roslin Cells, Regeneus Ltd, ReNeuron Group plc, International Stem Cell Corporation, TiGenix and others.

The Rheumatoid Arthritis Stem Cell Therapy market report examines the operating pattern of each player new product launches, partnerships, and acquisitions has been examined in detail. Important regions covered in the Rheumatoid Arthritis Stem Cell Therapy market report include:

North America (U.S., Canada) Latin America (Mexico, Brazil) Western Europe (Germany, Italy, U.K., Spain, France, Nordic countries, BENELUX) Eastern Europe (Russia, Poland, Rest Of Eastern Europe) Asia Pacific Excluding Japan (China, India, Australia & New Zealand) Japan Middle East and Africa (GCC, S. Africa, Rest Of MEA)

The Rheumatoid Arthritis Stem Cell Therapy market report takes into consideration the following segments by treatment type:

Allogeneic Mesenchymal stem cells Bone marrow Transplant Adipose Tissue Stem Cells

The Rheumatoid Arthritis Stem Cell Therapy market report contain the following distribution channel:

Hospitals Ambulatory Surgical Centers Specialty Clinics Have Any Query? Ask our Industry Experts-https://www.factmr.com/connectus/sample?flag=AE&rep_id=1001

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The Rheumatoid Arthritis Stem Cell Therapy market report offers a plethora of insights which include:

Changing consumption pattern among individuals globally. Historical and future progress of the global Rheumatoid Arthritis Stem Cell Therapy market. Region-wise and country-wise segmentation of the Rheumatoid Arthritis Stem Cell Therapy market to understand the revenue, and growth lookout in these areas. Accurate Year-on-Year growth of the global Rheumatoid Arthritis Stem Cell Therapy market. Important trends, including proprietary technologies, ecological conservation, and globalization affecting the global Rheumatoid Arthritis Stem Cell Therapy market.

The Rheumatoid Arthritis Stem Cell Therapy market report answers important questions which include:

Which regulatory authorities have granted approval to the application of Rheumatoid Arthritis Stem Cell Therapy in Health industry? How will the global Rheumatoid Arthritis Stem Cell Therapy market grow over the forecast period? Which end use industry is set to become the leading consumer of Rheumatoid Arthritis Stem Cell Therapy by 2028? What manufacturing techniques are involved in the production of the Rheumatoid Arthritis Stem Cell Therapy? Which regions are the Rheumatoid Arthritis Stem Cell Therapy market players targeting to channelize their production portfolio? Get Full Access of the Report @https://www.factmr.com/report/1001/rheumatoid-arthritis-stem-cell-therapy-market

Pertinent aspects this study on the Rheumatoid Arthritis Stem Cell Therapy market tries to answer exhaustively are:

What is the forecast size (revenue/volumes) of the most lucrative regional market? What is the share of the dominant product/technology segment in the Rheumatoid Arthritis Stem Cell Therapy market? What regions are likely to witness sizable investments in research and development funding? What are Covid 19 implication on Rheumatoid Arthritis Stem Cell Therapy market and learn how businesses can respond, manage and mitigate the risks? Which countries will be the next destination for industry leaders in order to tap new revenue streams? Which new regulations might cause disruption in industry sentiments in near future? Which is the share of the dominant end user? Which region is expected to rise at the most dominant growth rate? Which technologies will have massive impact of new avenues in the Rheumatoid Arthritis Stem Cell Therapy market? Which key end-use industry trends are expected to shape the growth prospects of the Rheumatoid Arthritis Stem Cell Therapy market? What factors will promote new entrants in the Rheumatoid Arthritis Stem Cell Therapy market? What is the degree of fragmentation in the Rheumatoid Arthritis Stem Cell Therapy market, and will it increase in coming years? Why Choose Fact.MR?

Fact.MR follows a multi- disciplinary approach to extract information about various industries. Our analysts perform thorough primary and secondary research to gather data associated with the market. With modern industrial and digitalization tools, we provide avant-garde business ideas to our clients. We address clients living in across parts of the world with our 24/7 service availability.

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Global Rheumatoid Arthritis Stem Cell Therapy Market Dynamics, Forecast, Analysis and Supply Demand 2018 to 2028 - Scientect

Gaining clarity on the ethical issues of a possible COVID-19 vaccine – Pursuit

By adminSeptember 3, 2020Embryonic Stem Cells

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All republished articles must be attributed in the following way and contain links to both the site and original article: This article was first published on Pursuit. Read the original article.

Dr Christopher Gyngell, Dr Michelle Taylor-Sands and Professor Megan Munsie

On 20 August 2020, three prominent religious leaders in Australia wrote to the Prime Minister to express concerns about the ethical dilemma associated with calls to make vaccination for COVID-19 mandatory.

This followed the announcement that the Australian Government had signed a letter of intent to secure supply of the AstraZeneca/Oxford University COVID-19 vaccine should the current clinical trials prove successful.

The central concern is that the production of the vaccine uses a cell line HEK-293 that is cultured from electively aborted human foetus and that the Australian Government should support supply of an alternative uncontroversial vaccine if mandatory vaccination for COVID-19 is to be introduced.

Given the implications for potential take-up of a vaccine, its important to unpack this concern as well as the general ethical concerns from using human cell lines.

Manufacturing of the Oxford vaccine involves human kidney cells. These cells are used as factories to make the component of the vaccine that carries genes from the SARS-CoV-2 virus with the aim of triggering an immune response to protect the recipient when injected.

The type of cells used are descendants of cells first obtained in the early 1970s, from a foetus which was probably electively aborted (although records have now been lost).

These cells were cultured in the laboratory to produce what is called a cell line, a population of cells that have adapted to grow continuously in culture while retaining uniform characteristics.

Once created, cell lines are usually shared with researchers in different laboratories and referred to by a simple reference code. In the case of this foetal cell line it was called HEK-293.

Even though the descendants of foetal cells are used to produce the vaccine, the actual vaccination does not contain any foetal cells, or pieces of foetal DNA.

This cell line, and others like it, are commonly used in medical research. Indeed of the six COVID-19 vaccine candidates in development across the globe use human foetal cell lines.

Foetal cells derived from elective terminations of pregnancy have been commonly used in scientific research since the 1960s.

Their unique properties, such as an ability to be grown easily in the lab into cell lines, and the extensive knowledge about these cells gathered over decades of research, has seen them used to manufacture many vaccines, including those commonly used against rubella, chickenpox, hepatitis A, and shingles.

Again like in the production of the Oxford vaccine, there is no residual foetal cells or DNA in the actual vaccines.

Foetal cells have also been used to make approved drugs against diseases including haemophilia, rheumatoid arthritis, and cystic fibrosis and to study infectious diseases like Zika and HIV.

It is important to clarify that while foetal cells are sometimes referred to as embryonic cell lines, this should not be confused with the use of human embryos or creation of embryonic stem cells.

Foetal cells are obtained from donated tissue following termination of pregnancy or spontaneous miscarriage, while embryonic stem cells are obtained from donated human embryos originally created in the course of infertility treatment at an IVF clinic.

The term embryonic can refer to a stage of development both before and after a pregnancy is established.

HEK-293 cell line may be correctly described as being from embryonic kidney cells but is quite different to the use of human embryos to make an embryonic stem cell line that could be used in research to understand kidney disease or how kidneys develop.

The use of human embryos in research is highly regulated in Australia and elsewhere across the globe. While advances in stem cell research have reduced the need for foetal cells in certain areas of research, there remains a clear need for foetal tissue research.

The letter to the Prime Minister cites concerns that using products from the HEK-293 line amounts to benefiting from an elective termination, and therefore makes one complicit in a moral wrong.

This is only a concern for people who believe terminating a pregnancy is a moral wrong. This position would have far-ranging implications for public health, beyond the use of the Oxford vaccine.

Many currently available vaccines, and some other COVID-19 vaccine candidates, are produced using foetal cell lines.

More fundamentally the use of foetal cells lines is a ubiquitous part of medical research, leading to many techniques and drugs that are commonly used in medicine and have contributed to advances that have saved many lives.

Even those who have no moral objection to elective termination of pregnancy may have other concerns about the use of human or animal cell lines.

Ethical standards have improved greatly in the last few decades, and we need to confront some ethically suspect practices of the past. But one way we should respond to past bad practices is to learn from them and improve our standards.

In Australia, research using foetal tissue is subject to careful oversight under the National Statement on Ethical Conduct in Human Research (National Statement), which exemplifies the values of respect, research merit and integrity, justice, and beneficence.

The National Statement acknowledges that human research carries a potential risk of harm, discomfort and/or inconvenience for participants and/or others and therefore requires that the potential benefits of the research justify any risks involved.

It also requires that those who conscientiously object to being involved in conducting research with foetal tissue are not compelled to participate or put at a disadvantage because of their objection. This concession reflects the value of respect for human life and the beliefs of those involved in research.

While one of the letters authors, Sydneys Archbishop Anthony Fisher, has subsequently stressed that he does not think that it would be unethical to use this vaccine if there is no alternative available, and that he wont be critical of anyone who uses the vaccine.

His call for ethically untainted alternative might be difficult to meet given the long and deep role that foetal tissue has played in medical research.

Its unlikely that any COVID-19 vaccine will be entirely free from the use foetal cell lines, as some knowledge gained from those cell lines will go into any vaccine that is created.

While this issue may not be easily resolved, it is important to continue discussing ethical issues as we race to develop safe and effective treatments and/or vaccines for COVID-19.

As acknowledged in the National Statement, the risks and benefits of human research must always be considered to promote ethically good research.

The development of a safe and effective vaccine for COVID-19 carries significant benefit for the community, thereby promoting the values of research merit and integrity and beneficence.

Another core value in the National Statement is justice, which includes procedural justice (fair treatment in the recruitment of participants and the review of research) and distributive justice (fair distribution of the benefits and burdens of research).

As new vaccines are developed, it will therefore be important to uphold rigorous ethical standards in both laboratory and clinical research and ensure equitable distribution of the vaccine on a global scale.

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Gaining clarity on the ethical issues of a possible COVID-19 vaccine - Pursuit

Stem Cells Market is Expected to Thrive at Impressive CAGR by 2025 – Scientect

By adminSeptember 3, 2020Embryonic Stem Cells

This report studies the Stem Cells market size (value and volume) by players, regions, product types and end industries, history data 2013-2017 and forecast data 2018-2025; This report also studies the global market competition landscape, market drivers and trends, opportunities and challenges, risks and entry barriers, sales channels, distributors and Porters Five Forces Analysis.

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Stem cells are a class of undifferentiated cells that are able to differentiate into specialized cell types. Commonly, stem cells come from two main sources: Embryos formed during the blastocyst phase of embryological development (embryonic stem cells) and Adult tissue (adult stem cells).

Both types are generally characterized by their potency, or potential to differentiate into different cell types (such as skin, muscle, bone, etc.).

Stem Cells market, by technology, is Cell Acquisition, Cell Production, Cryopreservation, Expansion, and Sub-Culture. Stem Cell Therapy in China is not mature, so in this report we mainly cover Stem Cell Banking market.

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Geographically, this report is segmented into several key regions, with sales, revenue, market share and growth Rate of Stem Cells in these regions, from 2013 to 2025, covering

North America (United States, Canada and Mexico)

Europe (Germany, UK, France, Italy, Russia and Turkey etc.)

Asia-Pacific (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Malaysia and Vietnam)

South America (Brazil etc.)

Middle East and Africa (Egypt and GCC Countries)

The various contributors involved in the value chain of the product include manufacturers, suppliers, distributors, intermediaries, and customers. The key manufacturers in this market include

CCBC

Vcanbio

Boyalife

Beikebiotech

By the product type, the market is primarily split into

Umbilical Cord Blood Stem Cell

Embryonic Stem Cell

Adult Stem Cell

Other

By the end users/application, this report covers the following segments

Diseases Therapy

Healthcare

We can also provide the customized separate regional or country-level reports, for the following regions:

North America

United States

Canada

Mexico

Asia-Pacific

China

India

Japan

South Korea

Australia

Indonesia

Singapore

Malaysia

Philippines

Thailand

Vietnam

Rest of Asia-Pacific

Europe

Germany

France

Italy

Spain

Russia

Rest of Europe

Central & South America

Brazil

Rest of Central & South America

Middle East & Africa

GCC Countries

Turkey

Egypt

South Africa

Rest of Middle East & Africa

The study objectives of this report are:

To study and analyze the global Stem Cells market size (value & volume) by company, key regions/countries, products and application, history data from 2013 to 2017, and forecast to 2025.

To understand the structure of Stem Cells market by identifying its various subsegments.

To share detailed information about the key factors influencing the growth of the market (growth potential, opportunities, drivers, industry-specific challenges and risks).

Focuses on the key global Stem Cells manufacturers, to define, describe and analyze the sales volume, value, market share, market competition landscape, SWOT analysis and development plans in next few years.

To analyze the Stem Cells with respect to individual growth trends, future prospects, and their contribution to the total market.

To project the value and volume of Stem Cells submarkets, with respect to key regions (along with their respective key countries).

To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market.

To strategically profile the key players and comprehensively analyze their growth strategies.

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Stem Cells Market is Expected to Thrive at Impressive CAGR by 2025 - Scientect

Study reveals genetic mutations may be linked to infertility, early menopause – Sify News

By adminSeptember 3, 2020Embryonic Stem Cells

The study appears in the journal of Science Advances. The human gene -- called nuclear envelope membrane protein 1 (NEMP1) -- is not widely studied. In animals, mutations in the equivalent gene had been linked to impaired eye development in frogs. When the gene is missing in fruit flies, roundworms, zebrafish and mice, the animals are infertile or lose their fertility unusually early but appear otherwise healthy. The researchers who made the new discovery were not trying to study fertility at all. Rather, they were using genetic techniques to find genes involved with eye development in the early embryos of fruit flies. "We blocked some gene expression in fruit flies but found that their eyes were fine," said senior author Helen McNeill, PhD, the Larry J. Shapiro and Carol-Ann Uetake-Shapiro Professor and a BJC Investigator at the School of Medicine. "So, we started trying to figure out what other problems these animals might have. They appeared healthy, but to our surprise, it turned out they were completely sterile. We found they had substantially defective reproductive organs." Though it varied a bit by species, males and females both had fertility problems when missing this gene. And in females, the researchers found that the envelope that contains the egg's nucleus -- the vital compartment that holds half of an organism's chromosomes -- looked like a floppy balloon. "This gene is expressed throughout the body, but we didn't see this floppy balloon structure in the nuclei of any other cells," said McNeill, also a professor of developmental biology. "That was a hint we'd stumbled across a gene that has a specific role in fertility. We saw the impact first in flies, but we knew the proteins are shared across species. With a group of wonderful collaborators, we also knocked this gene out in worms, zebrafish and mice. It's so exciting to see that this protein that is present in many cells throughout the body has such a specific role in fertility. It's not a huge leap to suspect it has a role in people as well." To study this floppy balloon-like nuclear envelope, the researchers used a technique called atomic force microscopy to poke a needle into the cells, first penetrating the outer membrane and then the nucleus's membrane. The amount of force required to penetrate the membranes gives scientists a measure of their stiffness. While the outer membrane was of normal stiffness, the nucleus's membrane was much softer. "It's interesting to ask whether stiffness of the nuclear envelope of the egg is also important for fertility in people," McNeill said. "We know there are variants in this gene associated with early menopause. And when we studied this defect in mice, we see that their ovaries have lost the pool of egg cells that they're born with, which determines fertility over the lifespan. So, this finding provides a potential explanation for why women with mutations in this gene might have early menopause. When you lose your stock of eggs, you go into menopause." McNeill and her colleagues suspect that the nuclear envelope has to find a balance between being pliant enough to allow the chromosomes to align as they should for reproductive purposes but stiff enough to protect them from the ovary's stressful environment. With age, ovaries develop strands of collagen with the potential to create mechanical stress not present in embryonic ovaries. "If you have a softer nucleus, maybe it can't handle that environment," McNeill said. "This could be the cue that triggers the death of eggs. We don't know yet, but we're planning studies to address this question." Over the course of these studies, McNeill said they found only one other problem with the mice missing this specific gene: They were anaemic, meaning they lacked red blood cells. "Normal adult red blood cells lack a nucleus," McNeill said. "There's a stage when the nuclear envelope has to condense and get expelled from the young red blood cell as it develops in the bone marrow. The red blood cells in these mice aren't doing this properly and die at this stage. With a floppy nuclear envelope, we think young red blood cells are not surviving in another mechanically stressful situation." The researchers would like to investigate whether women with fertility problems have mutations in NEMP1. To help establish whether such a link is causal, they have developed human embryonic stem cells that, using CRISPR gene-editing technology, were given specific mutations in NEMP1 listed in genetic databases as associated with infertility. "We can direct these stem cells to become eggs and see what effect these mutations have on the nuclear envelope," McNeill said. "It's possible there are perfectly healthy women walking around who lack the NEMP protein. If this proves to cause infertility, at the very least this knowledge could offer an explanation. If it turns out that women who lack NEMP are infertile, more research must be done before we could start asking if there are ways to fix these mutations -- restore NEMP, for example, or find some other way to support nuclear envelope stiffness." (ANI)

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Study reveals genetic mutations may be linked to infertility, early menopause - Sify News

Strategic Analysis to Understand the Competitive Outlook of Cell Therapy Manufacturing Market – The News Brok

By adminSeptember 3, 2020Somatic Stem Cells

Prophecy Market Insights Cell Therapy Manufacturing market research report provides a comprehensive, 360-degree analysis of the targeted market which helps stakeholders to identify the opportunities as well as challenges. The research report study offers keen competitive landscape analysis including key development trends, accurate quantitative and in-depth commentary insights, market dynamics, and key regional development status forecast 2020-2029. It incorporates market evolution study, involving the current scenario, growth rate, and capacity inflation prospects, based on Porters Five Forces and DROT analyses.

Get Free Sample Copy of This Report @ https://www.prophecymarketinsights.com/market_insight/Insight/request-sample/21

An executive summary provides the markets definition, application, overview, classifications, product specifications, manufacturing processes; raw materials, and cost structures.

Market Dynamics offers drivers, restraints, challenges, trends, and opportunities of the Cell Therapy Manufacturing market

Segment Level Analysis in terms of types, product, geography, demography, etc. along with market size forecast

Regional and Country- level Analysis different geographical areas are studied deeply and an economical scenario has been offered to support new entrants, leading market players, and investors to regulate emerging economies. The top producers and consumers focus on production, product capacity, value, consumption, growth opportunity, and market share in these key regions, covering

The comprehensive list of Key Market Players along with their market overview, product protocol, key highlights, key financial issues, SWOT analysis, and business strategies. The report dedicatedly offers helpful solutions for players to increase their clients on a global scale and expand their favour significantly over the forecast period. The report also serves strategic decision-making solutions for the clients.

Competitive landscape Analysis provides mergers and acquisitions, collaborations along with new product launches, heat map analysis, and market presence and specificity analysis.

Segmentation Overview:

Cell Therapy ManufacturingMarket Key Companies:

harmicell, Merck Group, Dickinson and Company, Thermo Fisher, Lonza Group, Miltenyi Biotec GmBH, Takara Bio Group, STEMCELL Technologies, Cellular Dynamics International, Becton, Osiris Therapeutics, Bio-Rad Laboratories, Inc., Anterogen, MEDIPOST, Holostem Terapie Avanazate, Pluristem Therapeutics, Brammer Bio, CELLforCURE, Gene Therapy Catapult EUFETS, MaSTherCell, PharmaCell, Cognate BioServices and WuXi AppTec.

The Cell Therapy Manufacturing research study comprises 100+ market data Tables, Graphs & Figures, Pie Chat to understand detailed analysis of the market. The predictions estimated in the market report have been resulted in using proven research techniques, methodologies, and assumptions. This Cell Therapy Manufacturing market report states the market overview, historical data along with size, growth, share, demand, and revenue of the global industry.

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The study analyses the manufacturing and processing requirements, project funding, project cost, project economics, profit margins, predicted returns on investment, etc. This report is a must-read for investors, entrepreneurs, consultants, researchers, business strategists, and all those who have any kind of stake or are planning to foray into the Cell Therapy Manufacturing industry in any manner.

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Strategic Analysis to Understand the Competitive Outlook of Cell Therapy Manufacturing Market - The News Brok

Gene therapy research for HIV awarded $14.6 million NIH grant – USC News

By adminSeptember 3, 2020Stem Cell Treatment

Paula Cannon. (USC Photo/Richard Carrasco)

An HIV research program led by scientists at USC and the Fred Hutchinson Cancer Research Center in Seattle has received a five-year, $14.6million grant from the National Institutes of Health. The team is advancing a gene therapy approach to control the virus without the need for daily medicines.

The programs co-directors are Paula Cannon, PhD, Distinguished Professor of Molecular Microbiology and Immunology at the Keck School of Medicine of USC, and Hans-Peter Kiem, MD, PhD, the Stephanus Family Endowed Chair for Cell and Gene Therapy at Fred Hutch. Other key partners are David Scadden, MD, a professor at Harvard University, and the biotechnology company Magenta Therapeutics.

The NIH award will support preclinical studies that combine gene editing against HIV with technologies for safer and more effective hematopoietic stem cell transplants. Such transplants, also known as bone marrow transplants, are currently used for severe blood cancers. They renew a patients immune system, which can be damaged by cancer therapies, by infusing healthy donor blood stem cells that can grow into any type of blood or immune cell.

The researchers goal is to build a therapy that prepares patients for a stem cell transplantation using their own cells with little to no toxicity, engineers their own stem cells to fight HIV and stimulates those cells to quickly produce new and engineered immune cells once theyre reintroduced into the patient.

This grant funds a team with an overarching goal of developing what our perfect HIV gene therapy would look like, Cannon said. All of these pieces could happen separately, but the fact that the NIH has funded us as a team means that the sum will be so much bigger than the parts.

Halting HIV without daily drugs

About 38million people worldwide are living with HIV, the virus that causes AIDS. HIV is manageable with daily antiretroviral drugs, but the research team seeks a more durable solution.

Their strategy is inspired by the three cases where patients seem to have been cured of HIV. All had aggressive leukemia and received blood stem cell transplants from donors who also carried a mutation that confers immunity to HIV. The mutation was in the CCR5 gene, which encodes a receptor that HIV uses to infect immune cells and is present in about 1 percent of the population.

Timothy Ray Brown, famously nicknamed the Berlin patient, received such a transplant in 2007; he has been off antiretroviral drugs since then, and the virus remains undetectable in his system. In recent years, patients in London and Dusseldorf have shown similar results.

I think of the Berlin patient as proof of principle that replacing the immune system with one thats HIV-resistant by removing CCR5 is a possible way to treat somebody, Cannon said.

However, the rigors of the blood stem cell transplant process, combined with the difficulty in finding tissue-matched CCR5-negative donors, make it highly unlikely that this will provide more than a very rare treatment.

Three for one gene therapy

The research team will tackle these two major problems. First, to get around the lack of CCR5-negative donors, Cannon has already helped pioneer the use of gene editing to remove CCR5 from a patients own stem cells. This is now an investigational treatment for HIV in a clinical trial at City of Hope in Duarte, California.

She will now combine CCR5 disruption with additional genetic changes, so that the progeny of engineered stem cells will release antibodies and antibody-like molecules that block HIV.

Our engineered cells will be good neighbors, Cannon said. They secrete these protective molecules so that other cells, even if they arent engineered to be CCR5-negative, have some chance of being protected.

Meanwhile, Kiems group is providing a third approach by adapting an emerging cancer treatment called CAR T cell therapy. This re-engineers T cells of the immune system with chimeric antigen receptors (CARs), which are customized to recognize cancer cells.

In this project, Kiem and colleagues will create stem cells whose T cell descendants can instead hunt down HIV-infected cells.

A gentler blood stem cell transplant

The grant also supports two other components that relate to the blood stem cell transplant.

Magenta Therapeutics is developing less-toxic protocols for conditioningpreparing a patients bone marrow to receive a transplant. Traditionally, mild chemotherapy or radiotherapy is needed to make room for newly infused stem cells and to help them re-engraft.

The company is instead using antibody-drug conjugates to deliver this conditioning much more narrowly and to reduce the side effects that occur with systemic chemo or radiation.

Meanwhile, Scadden and his team are addressing another drawback of stem cell transplants and conditioning, the delay before infused stem cells generate new immune cells in sufficient numbers. In cancer patients, this delay leaves them highly susceptible to infection.

Scadden is approaching this using an injectable gel that biochemically resembles the bone marrow environment, to quickly repopulate the immune system with HIV-fighting cells.

With success, the teams research may free HIV patients from the need for daily medication and the expense and potential side effects that come with it. Their work may also improve other therapies based on blood stem cells, for conditions such as cancer, sickle cell disease and autoimmune disorders.

A home run would be that we completely cure people of HIV, Cannon said. What Id be fine with is the idea that somebody no longer needs to take anti-HIV drugs every day because their immune system is keeping the virus under control, so that it no longer causes health problems and, importantly, they cant transmit it to anybody else.

By Wayne Lewis

Making Headway in the Quest for COVID-19 Cell Therapies – Technology Networks

By adminSeptember 3, 2020Stem Cell Treatment

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With the SARS-CoV-2 virus now widespread around the globe, scientists across many disciplines are racing to develop therapies for COVID-19 a disease which has disrupted our world. Vaccine research continues, and a wide range of potential treatments are being explored, including the repurposing of small molecules and de novo design of drugs and peptides. Interest in cell-based therapies has escalated over recent decades, largely driven by a growing appreciation for the inter-individual variation that exists for many diseases and the subsequent shift towards personalized medicine. This trend has been supported by increasing technical and manufacturing capabilities and has continued in 2020. In June, a director from the US Food and Drug Administration (FDA) said their clinical team was stretched trying to deal with the COVID-19-related growth. In the same month there were more than 1000 cell therapies in the pipeline, 25 of which were available in the market. Increasing commercial investment suggests expectations of the industry are high, and it is hoped cell therapies will be available to treat a wide range of diseases in the near future. Faced with a global pandemic, we explore the following questions: can cell therapies help alleviate the symptoms of COVID-19? What strategies are being employed?

Table 1. Examples and rationale of cell therapy approaches for COVID-19

Michele Wilson is a freelance science writer for Choice Science Writing.

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Making Headway in the Quest for COVID-19 Cell Therapies - Technology Networks

Global Cord Blood Banking Market 2020 with Analysis of 44 Industry Players – PRNewswire

By adminSeptember 3, 2020Stem Cell Treatment

DUBLIN, Sept. 2, 2020 /PRNewswire/ -- The "Global Cord Blood Banking Industry Report 2020" report has been added to ResearchAndMarkets.com's offering.

This report presents the number of cord blood units stored in inventory by the largest cord blood banks worldwide and the number of cord blood units (CBUs) released by registries across the world for hematopoietic stem cell (HSC) transplantation. Although cord blood is now used to treat more than 80 different diseases, this number could substantially expand if applications related to regenerative medicine start receiving approvals in major healthcare markets worldwide.

From the early 1900s through the mid-2000s, the global cord blood banking industry expanded rapidly, with companies opening for business in all major markets worldwide. From 2005 to 2010, the market reached saturation and stabilized.

Then, from 2010 to 2020, the market began to aggressively consolidate. This has created both serious threats and unique opportunities within the industry.

Serious threats to the industry include low rates of utilization for stored cord blood, expensive cord blood transplantation procedures, difficulty educating obstetricians about cellular therapies, and an increasing trend toward industry consolidation. There are also emerging opportunities for the industry, such as accelerated regulatory pathways for cell therapies in leading healthcare markets worldwide and expanding applications for cell-based therapies. In particular, MSCs from cord tissue (and other sources) are showing intriguing promise in the treatment and management of COVID-19.

Cord Blood Industry Trends

Within recent years, new themes have been impacting the industry, including the pairing of stem cell storage services with genetic and genomic testing services, as well as reproductive health services. Cord blood banks are diversifying into new types of stem cell storage, including umbilical cord tissue storage, placental blood and tissue, amniotic fluid and tissue, and dental pulp. Cord blood banks are also investigating means of becoming integrated therapeutic companies. With hundreds of companies offering cord blood banking services worldwide, maturation of the market means that each company is fighting harder for market share.

Growing numbers of investors are also entering the marketplace, with M&A activity accelerating in the U.S. and abroad. Holding companies are emerging as a global theme, allowing for increased operational efficiency and economy of scale. Cryoholdco has established itself as the market leader within Latin America. Created in 2015, Cryoholdco is a holding company that will control nearly 270,000 stem cell units by the end of 2020. It now owns a half dozen cord blood banks, as well as a dental stem cell storage company.

Globally, networks of cord blood banks have become commonplace, with Sanpower Group establishing its dominance in Asia. Although Sanpower has been quiet about its operations, it holds 4 licenses out of only 7 issued provincial-level cord blood bank licenses in China. It has reserved over 900,000 cord blood samples in China, and its reserves amount to over 1.2 million units when Cordlife' reserves within Southeast Asian countries are included. This positions Sanpower Group and it's subsidiary Nanjing Cenbest as the world's largest cord blood banking operator not only in China and Southeast Asia but in the world.

The number of cord blood banks in Europe has dropped by more than one-third over the past ten years, from approximately 150 to under 100. The industry leaders in this market segment include FamiCord Group, who has executed a dozen M&A transactions, and Vita34, who has executed approximately a half dozen. Stemlab, the largest cord blood bank in Portugal, also executed three acquisition deals prior to being acquired by FamiCord. FamiCord is now the leading stem cell bank in Europe and one of the largest worldwide.

Cord Blood Expansion Technologies

Because cord blood utilization is largely limited to use in pediatric patients, growing investment is flowing into ex vivo cord blood expansion technologies. If successful, this technology could greatly expand the market potential for cord blood, encouraging its use within new markets, such as regenerative medicine, aging, and augmented immunity.

Key strategies being explored for this purpose include:

Currently, Gamida Cell, Nohla Therapeutics, Excellthera, and Magenta Therapeutics have ex vivo cord blood expansion products proceeding through clinical trials. Growing numbers of investors have also entered the cord blood banking marketplace, led by groups such as GI Partners, ABS Capital Partners & HLM Management, KKR & Company, Bay City Capital, GTCR, LLC, and Excalibur.

Cord Blood Banking by Region

Within the United States, most of the market share is controlled by three major players: Cord Blood Registry (CBR), Cryo-Cell, and ViaCord. CBR has been traded twice, once in 2015 to AMAG Pharmaceuticals for $700 million and again in 2018 to GI Partners for $530 million. CBR also bought Natera's Evercord Cord Blood Banking business in September 2019. In total, CBR controls over 900,000 cord blood and tissue samples, making it one of the largest cord blood banks worldwide.

In China, the government controls the industry by authorizing only one cord blood bank to operate within each province, and official government support, authorization, and permits are required. Importantly, the Chinese government announced in late 2019 that it will be issuing new licenses for the first time, expanding from the current 7 licensed regions for cord blood banking to up to 19 regions, including Beijing.

In Italy and France, it is illegal to privately store one's cord blood, which has fully eliminated the potential for a private market to exist within the region. In Ecuador, the government created the first public cord blood bank and instituted laws such that private cord blood banks cannot approach women about private cord blood banking options during the first six months of pregnancy. This created a crisis for private banks, forcing most out of business.

Recently, India's Central Drugs Standard Control Organization (CDSCO) restricted commercial banking of stem cells from most biological materials, including cord tissue, placenta, and dental pulp stem cells - leaving only umbilical cord blood banking as permitted and licensed within the country.

While market factors vary by geography, it is crucial to have a global understanding of the industry, because research advances, clinical trial findings, and technology advances do not know international boundaries. The cord blood market is global in nature and understanding dynamics within your region is not sufficient for making strategic, informed, and profitable decisions.

Overall, the report provides the reader with the following details and answers the following questions:

1. Number of cord blood units cryopreserved in public and private cord blood banks globally 2. Number of hematopoietic stem cell transplants (HSCTs) globally using cord blood cells 3. Utilization of cord blood cells in clinical trials for developing regenerative medicines 4. The decline of the utilization of cord blood cells in HSC transplantations since 2005 5. Emerging technologies to influence the financial sustainability of public cord blood banks 6. The future scope for companion products from cord blood 7. The changing landscape of cord blood cell banking market 8. Extension of services by cord blood banks 9. Types of cord blood banks 10. The economic model of public cord blood banks 11. Cost analysis for public cord blood banks 12. The economic model of private cord blood banks 13. Cost analysis for private cord blood banks 14. Profit margins for private cord blood banks 15. Pricing for processing and storage in private banks 16. Rate per cord blood unit in the U.S. and Europe 17. Indications for the use of cord blood-derived HSCs for transplantations 18. Diseases targeted by cord blood-derived MSCs in regenerative medicine 19. Cord blood processing technologies 20. Number of clinical trials, number of published scientific papers and NIH funding for cord blood research 21. Transplantation data from different cord blood registries

Key questions answered in this report are:

1. What are the strategies being considered for improving the financial stability of public cord blood banks? 2. What are the companion products proposed to be developed from cord blood? 3. How much is being spent on processing and storing a unit of cord blood? 4. How much does a unit of cryopreserved cord blood unit fetch on release? 5. Why do most public cord blood banks incur a loss? 6. What is the net profit margin for a private cord blood bank? 7. What are the prices for processing and storage of cord blood in private cord blood banks? 8. What are the rates per cord blood units in the U.S. and Europe? 9. What are the revenues from cord blood sales for major cord blood banks? 10. Which are the different accreditation systems for cord blood banks? 11. What are the comparative merits of the various cord blood processing technologies? 12. What is to be done to increase the rate of utilization of cord blood cells in transplantations? 13. Which TNC counts are preferred for transplantation? 14. What is the number of registered clinical trials using cord blood and cord tissue? 15. How many clinical trials are involved in studying the expansion of cord blood cells in the laboratory? 16. How many matching and mismatching transplantations using cord blood units are performed on an annual basis? 17. What is the share of cord blood cells used for transplantation from 2000 to 2020? 18. What is the likelihood of finding a matching allogeneic cord blood unit by ethnicity? 19. Which are the top ten countries for donating cord blood? 20. What are the diseases targeted by cord blood-derived MSCs within clinical trials?

Key Topics Covered

1. REPORT OVERVIEW 1.1 Statement of the Report 1.2 Executive Summary 1.3 Introduction 1.3.1 Cord Blood: An Alternative Source for HPSCs 1.3.2 Utilization of Cord Blood Cells in Clinical Trials 1.3.3 The Struggle of Cord Blood Banks 1.3.4 Emerging Technologies to Influence Financial Sustainability of Banks 1.3.4.1 Other Opportunities to Improve Financial Stability 1.3.4.2 Scope for Companion Products 1.3.5 Changing Landscape of Cord Blood Cell Banking Market 1.3.6 Extension of Services by Cord Blood Banks

2. CORD BLOOD & CORD BLOOD BANKING: AN OVERVIEW 2.1 Cord Blood Banking (Stem Cell Banking) 2.1.1 Public Cord Blood Banks 2.1.1.1 Economic Model of Public Cord Blood Banks 2.1.1.2 Cost Analysis for Public Banks 2.1.1.3 Relationship between Costs and Release Rates 2.1.2 Private Cord Blood Banks 2.1.2.1 Cost Analysis for Private Cord Blood Banks 2.1.2.2 Economic Model of Private Banks 2.1.3 Hybrid Cord Blood Banks 2.2 Globally Known Cord Blood Banks 2.2.1 Comparing Cord Blood Banks 2.2.2 Cord Blood Banks in the U.S. 2.2.3 Proportion of Public, Private and Hybrid Banks 2.3 Percent Share of Parents of Newborns Storing Cord Blood by Country/Region 2.4 Pricing for Processing and Storage in Commercial Banks 2.4.1 Rate per Cord Blood Unit in the U.S. and Europe 2.5 Cord Blood Revenues for Major Cord Blood Banks

3. CORD BLOOD BANK ACCREDITATIONS 3.1 American Association of Blood Banks (AABB) 3.2 Foundation for the Accreditation of Cellular Therapy (FACT) 3.3 FDA Registration 3.4 FDA Biologics License Application (BLA) License 3.5 Investigational New Drug (IND) for Cord Blood 3.6 Human Tissue Authority (HTA) 3.7 Therapeutic Goods Act (TGA) in Australia 3.8 International NetCord Foundation 3.9 AABB Accredited Cord Blood Facilities 3.10 FACT Accreditation for Cord Blood Banks

4. APPLICATIONS OF CORD BLOOD CELLS 4.1 Hematopoietic Stem Cell Transplantations with Cord Blood Cells 4.2 Cord Cells in Regenerative Medicine

5. CORD BLOOD PROCESSING TECHNOLOGIES 5.1 The Process of Separation 5.1.1 PrepaCyte-CB 5.1.2 Advantages of PrepaCyte-CB 5.1.3 Treatment Outcomes with PrepaCyte-CB 5.1.4 Hetastarch (HES) 5.1.5 AutoXpress (AXP) 5.1.6 SEPAX 5.1.7 Plasma Depletion Method (MaxCell Process) 5.1.8 Density Gradient Method 5.2 Comparative Merits of Different Processing Methods 5.2.1 Early Stage HSC Recovery by Technologies 5.2.2 Mid Stage HSC (CD34+/CD133+) Recovery from Cord Blood 5.2.3 Late Stage Recovery of HSCs from Cord Blood 5.3 HSC (CD45+) Recovery 5.4 Days to Neutrophil Engraftment by Technology 5.5 Anticoagulants used in Cord Blood Processing 5.5.1 Type of Anticoagulant and Cell Recovery Volume 5.5.2 Percent Cell Recovery by Sample Size 5.5.3 TNC Viability by Time Taken for Transport and Type of Anticoagulant 5.6 Cryopreservation of Cord Blood Cells 5.7 Bioprocessing of Umbilical Cord Tissue (UCT) 5.8 A Proposal to Improve the Utilization Rate of Banked Cord Blood

6. CORD BLOOD CLINICAL TRIALS, SCIENTIFIC PUBLICATIONS & NIH FUNDING 6.1 Cord Blood Cells for Research 6.2 Cord Blood Cells for Clinical Trials 6.2.1 Number of Clinical Trials involving Cord Blood Cells 6.2.2 Number of Clinical Trials using Cord Blood Cells by Geography 6.2.3 Number of Clinical Trials by Study Type 6.2.4 Number of Clinical Trials by Study Phase 6.2.5 Number of Clinical Trials by Funder Type 6.2.6 Clinical Trials Addressing Indications in Children 6.2.7 Select Three Clinical Trials Involving Children 6.2.7.1 Sensorineural Hearing Loss (NCT02038972) 6.2.7.2 Autism Spectrum (NCT02847182) 6.2.7.3 Cerebral Palsy (NCT01147653) 6.2.8 Clinical Trials for Neurological Diseases using Cord Blood and Cord Tissue 6.2.9 UCB for Diabetes 6.2.10 UCB in Cardiovascular Clinical Trials 6.2.11 Cord Blood Cells for Auto-Immune Diseases in Clinical Trials 6.2.12 Cord Tissue Cells for Orthopedic Disorders in Clinical Trials 6.2.13 Cord Blood Cells for Other Indications in Clinical Trials 6.3 Major Diseases Addressed by Cord Blood Cells in Clinical Trials 6.4 Clinical Trials using Cord Tissue-Derived MSCs 6.5 Ongoing Clinical Trials using Cord Tissue 6.5.1 Cord Tissue-Based Clinical Trials by Geography 6.5.2 Cord Tissue-Based Clinical Trials by Phase 6.5.3 Cord Tissue-Based Clinical Trials by Sponsor Types 6.5.4 Companies Sponsoring in Trials using Cord Tissue-Derived MSCs 6.6 Wharton's Jelly-Derived MSCs in Clinical Trials 6.6.1 Wharton's Jelly-Based Clinical Trials by Phase 6.6.2 Companies Sponsoring Wharton's Jelly-Based Clinical Trials 6.7 Clinical Trials Involving Cord Blood Expansion Studies 6.7.1 Safe and Feasible Expansion Protocols 6.7.2 List of Clinical Trials involved in the Expansion of Cord Blood HSCs 6.7.3 Expansion Technologies 6.8 Scientific Publications on Cord Blood 6.9 Scientific Publications on Cord Tissue 6.10 Scientific Publications on Wharton's Jelly-Derived MSCs 6.11 Published Scientific Papers on Cord Blood Cell Expansion 6.12 NIH Funding for Cord Blood Research

7. PARENT'S AWARENESS AND ATTITUDE TOWARDS CORD BLOOD BANKING 7.1 Undecided Expectant Parents 7.2 The Familiar Cord Blood Banks Known by the Expectant Parents 7.3 Factors Influencing the Choice of a Cord Blood Bank

8. CORD BLOOD: AS A TRANSPLANTATION MEDICINE 8.1 Comparisons of Cord Blood to other Allograft Sources 8.1.1 Major Indications for HCTs in the U.S. 8.1.2 Trend in Allogeneic HCT in the U.S. by Recipient Age 8.1.3 Trends in Autologous HCT in the U.S. by Recipient Age 8.2 HCTs by Cell Source in Adult Patients 8.2.1 Transplants by Cell Source in Pediatric Patients 8.3 Allogeneic HCTs by Cell Source 8.3.1 Unrelated Donor Allogeneic HCTs in Patients &lessThan;18 Years 8.4 Likelihood of Finding an Unrelated Cord Blood Unit by Ethnicity 8.4.1 Likelihood of Finding an Unrelated Cord Blood Unit for Patients &lessThan;20 Years 8.5 Odds of using a Baby's Cord Blood 8.6 Cord Blood Utilization Trends 8.7 Number of Cord Blood Donors Worldwide 8.7.1 Number of CBUs Stored Worldwide 8.7.2 Cord Blood Donors by Geography 8.7.2.1 Cord Blood Units Stored in Different Geographies 8.7.2.2 Number of Donors by HLA Typing 8.7.3 Searches Made by Transplant Patients for Donors/CBUs 8.7.4 Types of CBU Shipments (Single/Double/Multi) 8.7.5 TNC Count of CBUs Shipped for Children and Adult Patients 8.7.6 Shipment of Multiple CBUs 8.7.7 Percent Supply of CBUs for National and International Patients 8.7.8 Decreasing Number of CBU Utilization 8.8 Top Ten Countries in Cord Blood Donation 8.8.1 HLA Typed CBUs by Continent 8.8.2 Percentage TNC of Banked CBUs 8.8.3 Total Number of CBUs, HLA-Typed Units by Country 8.9 Cord Blood Export/Import by the E.U. Member States 8.9.1 Number of Donors and CBUs in Europe 8.9.2 Number of Exports/Imports of CBUs in E.U. 8.10 Global Exchange of Cord Blood Units

9. CORD BLOOD CELLS AS THERAPEUTIC CELL PRODUCTS IN CELL THERAPY 9.1 MSCs from Cord Blood and Cord Tissue 9.1.1 Potential Neurological Applications of Cord Blood-Derived Cells 9.1.2 Cord Tissue-Derived MSCs for Therapeutic use 9.1.2.1 Indications Targeted by UCT-MSCs in Clinical Trials 9.2 Current Consumption of Cord Blood Units by Clinical Trials 9.3 Select Cord Blood Stem Cell Treatments in Clinical Trials 9.3.1 Acquired Hearing Loss (NCT02038972) 9.3.2 Autism (NCT02847182) 9.3.3 Cerebral Palsy (NCT03087110) 9.3.4 Hypoplastic Left Heart Syndrome (NCT01856049) 9.3.5 Type 1 Diabetes (NCT00989547) 9.3.6 Psoriasis (NCT03765957) 9.3.7 Parkinson's Disease (NCT03550183) 9.3.8 Signs of Aging (NCT04174898) 9.3.9 Stroke (NCT02433509) 9.3.10 Traumatic Brain Injury (NCT01451528)

10. MARKET ANALYSIS 10.1 Public vs. Private Cord Blood Banking Market 10.2 Cord Blood Banking Market by Indication

11. PROFILES OF SELECT CORD BLOOD BANKS 11.1 AllCells 11.1.1 Whole Blood 11.1.2 Leukopak 11.1.3 Mobilized Leukopak 11.1.4 Bone Marrow 11.1.5 Cord Blood 11.2 AlphaCord LLC 11.2.1 NextGen Collection System 11.3 Americord Registry, Inc. 11.3.1 Cord Blood 2.0 11.3.2 Cord Tissue 11.3.3 Placental Tissue 2.0 11.4 Be The Match 11.4.1 Hub of Transplant Network 11.4.2 Partners of Be The Match 11.4.3 Allogeneic Cell Sources in Be The Match Registry 11.4.4 Likelihood of a Matched Donor on Be The Match by Ethnic Background 11.5 Biocell Center Corporation 11.5.1 Chorionic villi after Delivery 11.5.2 Amniotic Fluid and Chorionic Villi during Pregnancy 11.6 BioEden Group, Inc. 11.6.1 Differences between Tooth Cells and Umbilical Cord Cells 11.7 Biovault Family 11.7.1 Personalized Cord Blood Processing 11.8 Cell Care 11.9 Cells4Life Group, LLP 11.9.1 Cells4Life's pricing 11.9.2 TotiCyte Technology 11.9.3 Cord Blood Releases 11.10 Cell-Save 11.11 Center for International Blood and Marrow Transplant Research (CIBMTR) 11.11.1 Global Collaboration 11.11.2 Scientific Working Committees 11.11.3 Medicare Clinical Trials and Studies 11.11.4 Cellular Therapy 11.12 Crio-Cell International, Inc. 11.12.1 Advanced Collection Kit 11.12.2 Prepacyte-CB 11.12.3 Crio-Cell International's Pricing 11.12.4 Revenue for Crio-Cell International 11.13 Cord Blood Center Group 11.13.1 Cord Blood Units Released 11.14 Cordlife Group, Ltd. 11.14.1 Cordlife's Cord Blood Release Track Record 11.15 Core23 Biobank 11.16 Cord Blood Registry (CBR) 11.17 CordVida 11.18 Crioestaminal 11.18.1 Cord Blood Transplantation in Portugal 11.19 Cryo-Cell International, Inc. 11.19.1 Processing Method 11.19.2 Financial Results of the Company 11.20 CryoHoldco 11.21 Cryoviva Biotech Pvt. Ltd 11.22 European Society for Blood and Bone Marrow Transplantation (EBMT) 11.22.1 EBMT Transplant Activity 11.23 FamiCord Group 11.24 GeneCell International 11.25 Global Cord Blood Corporation 11.25.1 The Company's Business 11.26 HealthBaby Hong Kong 11.26.1 BioArchive System Service Plan 11.26.2 MVE Liquid Nitrogen System 11.27 HEMAFUND 11.28 Insception Lifebank 11.29 LifebankUSA 11.29.1 Placental Banking 11.30 LifeCell International Pvt. Ltd. 11.31 MiracleCord, Inc. 11.32 Maze Cord Blood Laboratories 11.33 New England Cord Blood Bank, Inc. 11.34 New York Cord Blood Center (NYBC) 11.34.1 Products 11.34.2 Laboratory Services 11.35 PacifiCord 11.35.1 FDA-Approved Sterile Collection Bags 11.35.2 AXP Processing System 11.35.3 BioArchive System 11.36 ReeLabs Pvt. Ltd. 11.37 Smart Cells International, Ltd. 11.38 Stem Cell Cryobank 11.39 StemCyte, Inc. 11.39.1 StemCyte Sponsored Clinical Trials 11.39.1.1 Spinal Cord Injury Phase II 11.39.1.2 Other Trials 11.40 Transcell Biolife 11.40.1 ScellCare 11.40.2 ToothScell 11.41 ViaCord 11.42 Vita 34 AG 11.43 World Marrow Donor Association (WMDA) 11.43.1 Search & Match Service 11.44 Worldwide Network for Blood & Marrow Transplantation (WBMT)

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Global Cord Blood Banking Market 2020 with Analysis of 44 Industry Players - PRNewswire

What is Wharton’s Jelly? – PRNewswire

By adminSeptember 3, 2020Stem Cell Treatment

CLEARWATER, Fla., Sept. 2, 2020 /PRNewswire/ --Wharton's jellyis at the forefront of current medical research. Its name dates back to the 17th century when the English anatomist Thomas Wharton first identified the jellylike substance that surrounds vital parts inside the umbilical cord. Today, it has become a distinct source of stem cells and, therefore, Advanced Medical Integration considers it a critical element in the advancement ofmedical treatments for everything from wound care to surgical procedures.

Found within Wharton's jellyare several distinct stem cell genes. With this raw material, biomedical firms can create stem cell lines that, among other things, aid recuperation via the regeneration of tissue that has been lost or damaged.

This is because stem cells are, basically, the core building blocks of all human cells. When retrieved from sources like Wharton's jelly, stem cells are not dedicated to any specific bodily function. But their power is that they have the ability, when introduced to other parts of the body, to adapt and grow into other, more "mature" types of cells (known as potency).

Stem cells are unspecialized cells of the human body. They are able to differentiate into any cell of an organism and have the ability of self-renewal. Stem cells exist both in embryos and adult cells. There are several steps of specialization.

Current research is focused on growing a wide range of new tissue from stem cells, including muscle, blood, brain, and cartilage cells. It is an intricate field with remarkable potential.

There are currently four ways of sourcing stem cells.Each is now a distinct area of study and research, with the relative strengths and weaknesses of each methodology being probed and perfected:

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