Stem Cell Clinic

5 Recent Tech Innovations Disrupting the Medical and Healthcare Industry – HealthTechZone

Technology is at our fingertips. Think of all the health monitors or wearable fitness trackers that people are using today. Virtual healthcare practices have changed our attitude towards the medical and healthcare industry. While there are loyalists as well as dissenters who rue the lack of personal connection with the doctor and quality care, tech innovations are breaking barriers meanwhile.

Technology in Healthcare

It could be as simple as information sharing between doctors and patients, or something as profound as robotic aid in a high-risk surgery. Better still, make it a remote surgery where the patient and doctor are separated by miles in between them! Clearly, recent tech advancements are disrupting the medical and healthcare industry with its dynamic applications.

It started with the online consultations and took off from there.

Telemedicine or virtual consultations are a thing of the past now. Even when they started, the dramatic impact it had on traditional healthcare roles has changed our collective attitude towards the industry. As these technologies develop further, more applications for professionals and patients stand to promote the overall wellness. Today, apps on the phone track our exercise and calorie intake, check obesity development, and monitor heart health.

Here are 5 recent tech innovations that have disrupted the industry for the long haul:

1. Virtual Reality or AR/MR/VR in Healthcare

Both medical professionals and patients stand to benefit from the multi-sensory, immersive experience that VR provides.

Think of realistic and low-risk simulated environment for training surgeons. On the other hand, in the arena of pain management or mental health, immersion in virtual worlds can produce better results. VRs therapeutic potential and rehabilitation chances in acute pain and anxiety disorder cases are far-reaching.

2. Nanomedicine

This is the stuff of sci-fi genres. Nanotechnology and nanodevices are arming the healthcare industry with control on the molecular level. Nanopharmaceuticals are aiming at smaller drugs and more precise delivery systems. For instance, delivering chemotherapy to targeted tumours rather than poisoning the whole body.

3. 3D Printing

Creating medical tools from buildable materials ranging from plastic to stem-cells, 3D printing has revolutionised the medical industry. Aided by the custom-friendly aspect of 3D printing, organ transplants and tissue repair, prosthetics and braces, even layered stem-cell organoids are possible today. Faster prototypes at a fraction of the traditional cost is a huge leg-up in the healthcare scene. The most dazzling innovation through this method is the poly-pill that holds several drugs for multiple illnesses with different release times!

4. Internet of Medical Things or IoT

Connected devices, cloud-computing, and the internet have allowed a larger the exchange of data, convenience, and automation. The IoT is significantly changing how healthcare professionals can manage patient records, control inventory, monitor and provide preventative care. In a way, this could be the most significant disruptive technology as a lot of other tech advancements have been possible only through this.

5. Precision Medicine

Diagnosis, treatment, and preventive care based on an individuals environment, lifestyle, and genetic makeup is a big shift from the all-purpose generic approach. Precision medicine is suggested based on diagnostic and molecular genetic testing processes such as genome sequencing and DNA mutation investigations. This will revolutionise preventive measures reducing treatment time and expenditure as well as healthcare requirement.

As healthcare and technological advancements grow together, the industry becomes more optimised providing quality care. It is evident in the cosmetic health industry where non-surgical procedures have advanced significantly. You can get Botox in Perth with breakthrough serums and great aftercare with minimal or no recovery time.

In fact, tech innovations have disrupted the healthcare industry so significantly, it is impossible to see it survive without them.

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5 Recent Tech Innovations Disrupting the Medical and Healthcare Industry - HealthTechZone

A New FMI Report Forecasts the Impact of COVID-19 Pandemic on Stem Cell Therapies Market Growth Post 2020 – The Scarlet

With 1000+ market research reports and 1 billion+ data points, Future Market Insights (FMI) serves each and every requirement of the clients operating in the global healthcare, pharmaceuticals, and medical device industries. FMI deploys digital intelligence solutions to offer compelling insights to report buyers that help them in overcoming market challenges, especially at the time of a crisis. Our dedicated team of professionals performs an extensive survey for gathering accurate information associated with the market.

FMI, in its upcoming business report, elaborates the historical and current scenario of the Stem Cell Therapies in terms of production, consumption, volume, and value. The report scrutinizes the market into various segments, regions and players on the basis of demand pattern and growth prospects.

Crucial information and forecast statistics covered in the Stem Cell Therapies report will arm both existing and emerging market players with necessary insights to craft long-term strategies as well as maintain business continuity during a crisis such as the ongoing COVID-19 pandemic.

COVID-19 Impact Analysis on Stem Cell Therapies

The recent outbreak of the COVID-19 has turned the spotlight on the healthcare industry, and subsequently impacted the Stem Cell Therapies. Severe shortages of critical medical supplies and a rapid rise in number of COVID-19 cases have resulted into a revolution rather than evolution in the healthcare ecosystems. Consequently, the impact is noticeable in the Stem Cell Therapies.

Following governments measures, particularly social distancing norms and stay-at-home orders, doctors are delaying or postponing elective surgeries unless critical to prevent the spread of the virus to individuals with comorbidities or chronic conditions. Additionally, movement restrictions and supply chain disruptions have created a logistical nightmare for market players, leading to severe product shortages in the global marketplace.

The FMIs report includes an interesting chapter on preliminary impact of the COVID-19 on the Stem Cell Therapies. This allows both leading and emerging market players to understand the market scenario during a crisis and aids them in making sound decisions to gain a distinct competitive edge.

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Stem Cell Therapies market: segmentation

To analyze the Marketing Stem Cell Therapies effectively and efficiently, the information has been segregated into key segments and sub-segments.

On the basis of treatment:

On the basis of application:

Stem Cell Therapies: Competition Analysis

The FMIs study presents a comprehensive analysis of global, regional, and country-level players active in the Stem Cell Therapies. Competitive information detailed in the Stem Cell Therapies report has been based on innovative product launches, distribution channels, local networks, industrial penetration, production methods, and revenue generation of each market player. Furthermore, growth strategies and mergers & acquisitions (M&A) activities associated with the players are enclosed in the Stem Cell Therapies report.

Key players covered in the report include:

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Important Questions Answered in the Stem Cell Therapies Report

Key Offerings of the Report

About Us Future Market Insights (FMI) is a leading market intelligence and consulting firm. We deliver syndicated research reports, custom research reports and consulting services which are personalized in nature. FMI delivers a complete packaged solution, which combines current market intelligence, statistical anecdotes, technology inputs, valuable growth insights and an aerial view of the competitive framework and future market trends.

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A New FMI Report Forecasts the Impact of COVID-19 Pandemic on Stem Cell Therapies Market Growth Post 2020 - The Scarlet

Cell Harvesting Market 2018 Analysis Of Production, Future Demand, Sales And Consumption Research Report To 2023 – The Scarlet

The global market for cell harvesting should grow from $885 million in 2018 to reach $1.5 billion by 2023 at a compound annual growth rate (CAGR) of 11.3% for the period of 2018-2023.

Report Scope:

The scope of the report encompasses the major types of cell harvesting that have been used and the cell harvesting technologies that are being developed by industry, government agencies and nonprofits. It analyzes current market status, examines drivers on future markets and presents forecasts of growth over the next five years.

The report provides a summary of the market, including a market snapshot and profiles of key players in the cell harvesting market. It provides an exhaustive segmentation analysis of the market with in-depth information about each segment. The overview section of the report provides a description of market trends and market dynamics, including drivers, restraints and opportunities. it provides information about market developments and future trends that can be useful for organizations, including wholesalers and exporters. It provides market positionings of key players using yardsticks of revenue, product portfolio, and recent activities. It further includes strategies adopted by emerging market players with strategic recommendations for new market entrants. Readers will also find historical and current market sizes and a discussion of the markets future potential. The report will help market players and new entrants make informed decisions about the production and exports of goods and services.

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Report Includes:

41 data tables and 22 additional tables Description of segments and dynamics of the cell harvesting market Analyses of global market trends with data from 2017, 2018, and projections of compound annual growth rates (CAGRs) through 2023 Characterization and quantification of market potential for cell harvesting by type of harvesting, procedure, end user, component/equipment and region A brief study and intact information about the market development, and future trends that can be useful for the organizations involved in Elaboration on the influence of government regulations, current technology, and the economic factors that will shape the future marketplace Key patents analysis and new product developments in cell harvesting market Detailed profiles of major companies of the industry, including Becton, Dickinson and Co., Corning, Inc., Fluidigm Corp., General Electric Co., Perkinelmer, Inc., and Thermo Fisher Scientific, Inc.

Summary

Stem cells are unspecialized cells that have the ability to divide indefinitely and produce specialized cells. The appropriate physiological and experimental conditions provided to the unspecialized cells give rise to certain specialized cells, including nerve cells, heart muscle cells and blood cells. Stem cells can divide and renew themselves over long periods of time. These cells are extensively found in multicellular organisms, wherein mammals, there are two types of stem cells embryonic stem cells and adult stemcells. Embryonic stem cells are derived from a human embryo four or five days old that is in the blastocyst phase of development. Adult stem cells grow after the development of the embryo and are found in tissues such as bone marrow, brain, blood vessels, blood, skin, skeletal muscles and liver. Stemcell culture is the process of harvesting the exosomes and molecules released by the stem cells for the development of therapeutics for chronic diseases such as cancer and diabetes. The process is widely used in biomedical applications such as therapy, diagnosis and biological drug production. The global cell harvesting market is likely to witness a growth rate of REDACTED during the forecast period of 2018-2023.The value of global cell harvesting market was REDACTED in 2017 and is projected to reach REDACTED by 2023. Market growth is attributed to factors such as increasing R&D spending in cell-based research,the introduction of 3D cell culture technology, increasing government funding, and the growing prevalence of chronic diseases such as cancer and diabetes.

The growing incidence and prevalence of cancer is seen as one of the major factors contributing to the growth of the global cell harvesting market. According to the World Health Organization (WHO), cancer is the second-leading cause of mortality globally and was responsible for an estimated 9.6 million deaths in 2018. Therefore, there is an increasing need for effective cancer treatment solutions globally. Cell harvesting is the preferred method used in cancer cell-related studies including cancer cell databases (cancer cell lines), and other analyses and drug discovery in a microenvironment. The rising prevalence of such chronic diseases has led governments to provide R&D funding to research institutes and biotechnology companies to develop advanced therapeutics. Various 3D cell culture technologies have been developed by researchers and biotechnology companies such as Lonza Group and Thermo Fischer Scientific for research applications such as cancer drug discovery. The application of cell culture in cancer research is leading to more predictive models for research, drug discovery and regenerative medicine applications.

Platelet-rich plasma (PRP) therapy, a new biotechnology solution that has a heightened interest among researchers in tissue engineering and cell-based therapies, has various applications in the treatment of tissue healing in tendinopathy, osteoarthritis and muscle injury. It has been conventionally employed in orthopedics, maxillofacial surgery, periodontal therapy and sports medicines. PRP therapy can be used in the treatment of fat grafting, acne scars, and hair regrowth.

Major factors driving market growth include increasing healthcare costs and the high rate of adoption for modern medicines in emerging economies such as China and India. It has been estimated that India will witness a CAGR of REDACTED in the cell harvesting market during the forecast period. The active participation of foreign pharmaceutical companies has tapped the Indian healthcare sector with a series of partnerships and mergers and acquisitions, which in turn is positively impacting the growth of the market in this region. Consistent development and clinical trials for stem cell therapies, plus contribution from the government and private sectors through investments and cohesive reimbursement policies in the development of cancer biomarkers, is further fueling market growth. InSweden, a research team at Lund University has developed a device to collect fluid and harvest stem mesenchymal stem cells (MSCs). The device is developed with 3D-printed bio-inert plastics which, when used by doctors, can result in the safe extraction of fluids (medical waste) from the patients body. The liquid is then passed through a gauze filter for purifying thoroughly and MSCs are separated from the fluid by centrifugation and are grown in culture.

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Cell Harvesting Market 2018 Analysis Of Production, Future Demand, Sales And Consumption Research Report To 2023 - The Scarlet

Sophie (5) lit up a room and was a little inspiration – New Ross Standard

Sophie Walsh, who left this world on Tuesday (18th) aged five, was a ray of sunshine who brightened up the lives of everyone who was fortunate enough to meet her.

Sophie, like most children her age, was due to start school this week. After a long, courageous battle with cancer, she succumbed to the illness that afflicted her over three years at Crumlin Children's Hospital on Tuesday.

Born a perfectly healthy child on July 3, 2015, into a loving home, her parents Sandra and Thomas were overjoyed to bring her back to her freshly decorated room in Lacken Valley.

Sophie met all her milestones but just before her second birthday, Thomas and Sandra sensed there was something wrong.

'She was going off her food. We went to doctors, hospitals a couple of times, both in Waterford and Wexford. Then back to the GP and CareDoc. They were all putting it down as a viral thing that would run its course but nothing seemed to be getting any better,' Thomas said.

They brought Sophie to CareDoc one Sunday evening and a doctor noticed a lump which was examined at University Hospital Waterford and the next day Sophie, Thomas and Sandra left for Crumlin, the first of many visits.

'Our lives changed overnight,' Sandra said. 'Our consultant sat us down and laid out a treatment plan which was going to be up to two years. The doctors said it was going to be an intensive time.'

Sophie was diagnosed with neuroblastoma, a cancer of the central nervous system.

The prognosis was 50/50 as Sophie had an amplified version of the illness which made it harder to treat. Thankfully Sophie responded very well to treatment and after a few weeks her energy levels started improving.

'She was back to being normal, except without the hair. She completed ten rounds of chemotherapy and had a break over Christmas and had surgery for her tumour, from which she recovered well. She had her own stem cell transplant in March,' Thomas said.

Throughout, Sandra and Thomas were staying in the Ronald McDonald House near Crumlin on and off, their every waking moment by her side as Sophie recovered from the transplant and had 14 rounds of radiotherapy in St Luke's, being administered a general anaesthetic every day.

She recovered from her treatment and had five rounds, once a month of immune-therapy.

'She finished that in January 2019 and then she was finished. There was no evidence of disease.'

Throughout Sophie couldn't enjoy the social interactions other children take for granted.

'She couldn't have a normal childhood as she was susceptible to infections. She could have cousins and friends around (sometimes). When we could, we did. She was in isolation for 100 days after her bone marrow transplant. Sophie made loads of friends at Crumlin. There were families from throughout Ireland we met up there and became good friends with. She was in Tir na ng playschool (when she could). She was looking forward to starting school.'

Throughout the spring of 2019 Sophie was in great health. 'Everything was going good. She loved her dolls. She loved watching Youtube. Watching kids playing with toys. She loved to play. When she was feeling up to it she wanted to play and when she wasn't she watched TV.'

Recalling a really happy child, an old soul in a child's body, her parents said she was ahead of her years in terms of her conversations and speech. 'She was around adults a lot between nurses and doctors. She had a great imagination. She could pick up a book and even if she couldn't understand the words she'd make up a story from the pictures.'

Sandra said: 'She was very witty; very quick off the mark. She was stubborn as well. If she didn't want to do anything you couldn't change her mind; it was set and that was it.

'We often said she was an old person wrapped up in a small person's body.'

Sophie enjoyed a magical trip to Disneyland with her parents, revelling in meeting Mickey Mouse and all the Disney characters she had seen on TV.

'She loved it!' they said.

Having enjoyed great health all spring of last year, something showed up in a routine scan midway during the summer.

'It was very small and they couldn't be 100 per cent. We had to wait and see what happened. She did a biopsy in September which confirmed she had relapsed and, at that stage, we knew she would have a very poor prognosis of five or six per cent. But we didn't give up hope because she had such a good response the first time around so we thought she could do it again. She had a tough road.'

Due to the location of the cancer within the femur and her tender age, the bone broke the day after the biopsy.

Undeterred Sophie went around in her buggy to trick or treat that Hallowe'en, totally embracing the chance to get dressed up.

'She adapted so well to every challenge. She had a nice Christmas.'

Sophie continued getting treatments after Christmas. 'The treatment she was on wasn't working as well as they liked and there was more progression on it. They switched her onto a different treatment again in February. We were running out of options at this stage.'

Sophie's condition was being kept at bay with the chemotherapy. She still had a good quality of life, but less energy.

'We had been told that the chemo would only work for so long and the cancer can find ways around it and gets used to it. We were always hoping for a miracle and that something would come along.'

Sophie enjoyed a great fifth birthday with friends and family in the garden.

A few weeks later, Aoibhinn's Pink Tie charity staff arranged a princess party at the Horse & Hound for her.

'She had wanted to meet Elsa and Anna. She had her cousins and there was face painting. That was her last good day.'

That evening Sophie started complaining of pain and her leg became more and more swollen.

She was admitted to University Hospital Waterford the following week and a CT scan showed quick progression of the tumour.

Sophie was transferred to Crumlin to help her pain management.

She died on Tuesday, August 18.

'It happened so suddenly. She was tired from treatment. There was one of us with her at all times; we took it in turns.'

Both Thomas and Sandra, who have been out of work since the diagnosis to care for Sophie, said: 'Everything changed so quickly and with the diagnosis and the prognosis we didn't want to wait a second. We didn't want to be looking back in five or ten years time that we had missed out. We had three amazing years. It was just the three of us, especially during lockdown it was nice just to have that time, the three of us.'

They praised the nursing staff of the hospitals Sophie as cared in.

Thomas said: 'Throughout, the whole community were amazing; especially neighbours and local businesses. Even just in terms of support. She was treated like a mini celebrity in The Bakehouse and O'Briens. Everywhere she went on the town everybody knew her and was so good to her. She was a little character as well. Every day she'd say something that made you laugh. She wasn't always in good form but she could change so quick. She would never dwell on things and never left her illness define her; she just kinda got on with it and never talked about it.'

Some of the nurses attended Sophie's funeral, as did staff members from McDonald's in Waterford, a favourite destination for Sophie.

'The nurses left off balloons outside for her. They were so good to her. If she wanted a dance party they held a dance party, copying her moves. The Dunbrody ship was lit up gold for Sophie, ahead of cancer awareness month in September. She would have been starting school this week. We had picked a school and she was looking forward to starting big school.'

Sandra and Thomas left the house on Friday morning for their daughter's funeral.

'All of the neighbours were lined up on either side of the road. We had a garda escort down. Fr Tom Orr gave a lovely, personal eulogy. He was excellent to us and even called to Crumlin to see her. Members of the United Striders stood as guards of honour, as did Urban Gym and Tr na Ng staff.'

'You Are My Sunshine' rang out from the speakers at her funeral Mass, where not a dry eye could be found.

Sophie was laid to rest in St Stephen's Cemetery, not far from her home.

The family want to thank everyone involved in sharing their love of Sophie on Friday, from the guards of honour to their neighbours and the wider community.

Sandra and Thomas said the Ronald McDonald House and Aoibhinn's Pink Tie charities were tremendously supportive throughout the three years.

'When a diagnosis comes, it's rushed and people arrive at John's Ward [in Crumlin] with just the clothes on their back. Even to have a toothpaste and brush.'

They recall in hushed tones, five years of happy memories with Sophie. 'Just being so happy; a family - the three of us. She could just light up a room; she had a presence about her. She would make anybody laugh and left a lasting impression on people who were just drawn to her. She could come out with anything. She told it as it was.'

They spoke of a child who inspired them to have a positive outlook on life and cherish each day as it comes, no matter what.

'For a five-year-old she was so happy go lucky. She inspired us. One day in the hospital she was colouring for the nurses and started colouring squiggles. I said why aren't you doing it properly and she said "life is too boring to just stay between the lines". There is a lot you can learn from a five-year-old, about outlook on life and how to deal with adversity. If Sophie spiked a temperature it means a few days in hospital and there was never any complaining.'

Sophie is dearly missed by Thomas and Sandra, her grandfathers Pat and Billy, aunts, uncles, cousins, extended family and friends.

New Ross Standard

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Sophie (5) lit up a room and was a little inspiration - New Ross Standard

Rare group of HIV patients don’t need drugs to suppress virus due to way it integrates in their DNA – Brinkwire

A woman diagnosed with HIV almost 30 years ago may have been cured of the virus without taking drugs or having a bone marrow transplant.

Scientists have studied Loreen Willenberg for decades, with the 66-year-old insisting she has never taken medication to keep the virus at bay. Doctors say her body fights the infection naturally.

But now academics claim she can be added to the list of cured HIV patients, next to theBerlin patient Timothy Ray Brown and the London patientAdam Castillejo.

Both Mr Brown, 54, and Mr Castillejo, 40, had cancer and were given a bone marrow transplant from adonor with HIV-resistant genes to wipe out their disease and the AIDS-causing virus in one fell swoop.

Ms Willenberg who was diagnosed in 1992 and is considered an elite controller because she possesses the rare ability to suppress the virus by itself never had the risky treatment.

Researchers at the Ragon Institute of MGH, MIT and Harvard found no traces of HIV in the Californian woman through standard tests.

Advanced technology that analysed 1.5billion of Ms Willenbergs blood cells found tiny quantities of the virus, meaning she isnt HIV-free. But the doctors revealed her immune system had rendered the leftover traces incapable of reproducing.

Dr Sharon Lewin, director of The Peter Doherty Institute for Infection and Immunity in Australia, told the New York Times: She could be added to the list of what I think is a cure, through a very different path.

Another 63 patients not on anti-retroviral drugs were also found to have traces of HIV that were unable to reproduce.

The team, whose work was published in the journal Nature, say the findings provide evidence that these people have achieved a functional cure.

Elite controllers are only believed to account for 0.5 per cent of the 37million people living with HIV across the world.

Researchers found that, because of where these patients have the virus encoded in their DNA, the pathogen is unable to make copies of itself. Thiskeeps the virus below detectable levels, which makes it untransmissible.

Once a person contracts HIV, the virus sets about attacking and destroying immune cells that normally protect the body from infection.

In the last decade, doctors have gained a much improved understanding of how to control HIV. The rate of deaths from the disease has plummeted since the peak of the AIDS epidemic in the early 1980s.

It is treatable and doctors recommend taking a combination or cocktail of drugs known as antiretroviral therapy, or ART.

Within six months of taking the medication once a day, a persons viral load will be virtually undetectable, but the body wont be completely rid of it.

This is because the virus hides in the body by integrating its genetic material into DNA and forming whats known as a latent reservoir.

But ART which can cause nausea, diarrhoea, headaches and fatigue isnt able to destroy these reservoirs but if an HIV patient ceases taking the cocktail, the virus can start making copies of itself again.

Elite controllers have latent reservoirs, but they dont need to take drugs to stop the virus from spreading throughout the body.

They naturally maintain what other people need ART to do, co-author Dr Mathias Lichterfeld, an infectious disease physician at Ragon, told HealthDay.

For the study, the team looked at blood samples from 64 elite controllers and 41 HIV patients taking ART.

Results showed that, in elite controllers, HIV genetic material was found in so-called gene deserts of the DNA. These are where there is little gene activity so the virus is unable to make copies of itself and instead remain in a blocked and locked state.

Lead author Dr Xu Yu, an associate professor of medicine at Harvard Medical School, said: This positioning of viral genomes in elite controllers is highly atypical.

In the vast majority of people living with HIV-1, HIV is located in the active human genes where viruses can be readily produced.

Dr Yu calls this a functional cure, which occurs when a virus is still in the body but can be controlled without medication.

The researchers believe this is because, in the early days of infection, the immune systems of elite controllers killed the virus after it integrated into DNA regions with a great deal of gene activity.

The team says the findings could lead to a cure, either by creating drugs that replicate the phenomenon of elite controllers or that eliminate HIV thats integrated in parts of the DNA that have substantial gene activity.

Elite controllers carry a mutation of CCR5, which prevents it from expressing, which essentially blocks the gene altogether. Experts say the genetic quirk has descended from northern Europeans.

The study comes after a Brazilian man in his mid-30s with HIV went into long-term remission after treatment with drugs and vitamin B3.

Doctors last month revealed the case of the Sao Paolo patient, who is understood to be the first HIV patient in the world to go into remission following pharmaceutical treatment.

And scientists last year revealed that a third HIV-positive patient in Germany may be free of the virus after undergoing the risky bone-marrow transplant.

But neither the Sao Paolo patient orthe Dsseldorf patient had been free of the virus for long enough to be considered cured.

For example, cancer patients have to be in remission for five years before they are labelled as cured.

Unfortunately, the Berlin and London patients cases do not change the reality much for the millions of people living with HIV.

The treatment is unlikely to have potential on a wider scale because both Mr Castillejo and Mr Ray Brown were given stem cells to treat cancer, not HIV.

Stem cell and bone marrow transplants are life-threatening operations with huge risks. Dangers lie in the patient suffering a fatal reaction if substitute immune cells dont take.

Mr Ray Brown, who is from Seattle but was treated in Germany, has been HIV-free for 12 years without medication.

But Mr Castillejo, whose mental health had spiralled drastically over the years and even led him to consider ending his life, was only treated in 2016.

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Rare group of HIV patients don't need drugs to suppress virus due to way it integrates in their DNA - Brinkwire