Stem Cell Clinic

Lowrie to have injections for knee pain relief – MLB.com

By Platelet Rich Plasma Injections

NEW YORK -- Jed Lowrie's 18-month injury saga took another turn on Wednesday, when the team announced the infielder will undergo a series of platelet-rich plasma and stem cell injections. Lowries timeline to return to the Mets will depend upon the outcome of that treatment. Its almost like a progression

NEW YORK -- Jed Lowrie's 18-month injury saga took another turn on Wednesday, when the team announced the infielder will undergo a series of platelet-rich plasma and stem cell injections. Lowries timeline to return to the Mets will depend upon the outcome of that treatment.

Its almost like a progression of injections and well see how everything responds, and [if] the pain goes away and hes able to join us at some point this season, Mets manager Luis Rojas said. Thats the plan.

The injection regimen was presented to Lowrie as a course of therapy after examinations from both Mets physician Dr. David Altchek and an independent, third-party doctor. Lowrie has been unable to play due to PCL laxity, a loosening of a left knee ligament that causes him pain when he runs. Although Lowrie feels some relief from the pain when he wears a rehab brace on his knee, the brace is too large and restricting for him to wear in games.

Until Lowrie can play with a smaller, more mobile brace, he will not come off the 45-day injured list. He is not eligible to come off anyway until Sept. 3.

Lowrie, 36, has taken just eight plate appearances since signing a two-year, $20 million contract in Jan. 2019. He has spent the vast majority of his tenure on the IL due to left knee trouble and a right calf strain. Lowrie initially sustained a sprained left knee capsule in Feb. 2019, before the team revealed that he was also battling more general, undefined left side issues.

Only last month did the Mets announce the updated PCL laxity diagnosis for Lowrie. Rojas said he was unsure if Lowrie, who was unavailable for comment, considered surgery or only the injection regimen.

Even if Lowrie can make it back in September, he will find playing time hard to come by. The Mets feature a crowded middle infield with Amed Rosario, Andrs Gimnez, Robinson Can and others all jockeying for reps. J.D. Davis has become the starter at third base, one of Lowries primary positions, while Gimnez has developed into an early National League Rookie of the Year candidate at second and short. Given his physical issues, it seems unlikely Lowrie would contribute anywhere other than at designated hitter, which is Dominic Smiths primary position.

From the trainers room Starting pitcher Michael Wacha (right shoulder inflammation) restarted a throwing program Tuesday at Citi Field, playing catch at distances up to 75 feet. He felt better, according to Rojas, but he will miss at least two starts on the IL. For now, Robert Gsellman has taken Wachas rotation spot.

Can (left adductor strain) could return from the IL as soon as hes eligible on Friday. Can was scheduled to play in a simulated game Wednesday at the Mets alternate site in Brooklyn, which Rojas called another step ahead for the veteran second baseman. When Can returns, the Mets will have to be creative to find playing time for Gimnez.

Shortstop sidelined Rosario was out of the lineup for a second straight game on Wednesday due to the lingering effects of a stomach bug, though he was available off the bench. Gimnez filled in at shortstop.

Everyday Daz The key to Edwin Dazs recent run of success out of the bullpen? Pitching more often.

When the Mets removed Daz from the closers role last week, he requested that the team use him more frequently than once every four or five days. Rojas listened, deploying Daz five times in a 10-day stretch from Aug. 2-11, and the reliever responded with 10 strikeouts and one walk over five scoreless innings.

Now that Ive been pitching more consecutively and more often, I feel like my pitches are all sharp, Daz said through an interpreter. But in regards to closing, thats not my decision. Im open to pitching whatever inning they tell me to come in -- whether its the sixth, seventh, eighth -- it doesnt matter to me. As long as they put the ball in my hands, Ill be ready to help the team.

Since Dazs unofficial demotion, Rojas has exclusively turned to Seth Lugo in save situations. The team is taking a committee approach, however, making it possible for Daz to garner more save chances again if he keeps pitching well.

Anthony DiComo has covered the Mets for MLB.com since 2007. Follow him on Twitter @AnthonyDiComo, Instagram and Facebook.

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Lowrie to have injections for knee pain relief - MLB.com

PRP versus Hyaluronic Acid Injections for Knee OA: Cost-Effectiveness Analysis – DocWire News

By Platelet Rich Plasma Injections

A study compared the cost-effectiveness of a series of three intra-articular platelet-rich plasma (PRP) injections versus hyaluronic acid (HA) viscosupplementation to treat symptomatic osteoarthritis (OA) of the knee.

Level one outcome data on PRP or HA injections in symptomatic knee OA patients through 2015 were used to collect health utility values. Costs were calculated using typical charges incurred by symptomatic knee OA patients treated at a large private orthopedic practice with a series of either PRP or HA injections. The health utility values and costs were the basis for an expected-value decision analysis model.

Per the model, the cost per quality-adjusted life year (QALY) of a series of PRP injections was $8,635.23/QALY compared with $5,331.75/QALY for a series of HA injections. While the series of PRP injections had a higher initial cost than the HA injections seriesa $1,433.67 differencethe PRP injections series was more effective, yielding a higher utility value, compared with the HA injections series at one year (0.69 vs. 0.58, respectively; P=0.0062). Using PRP injections instead of HA injections was associated with an incremental cost-effectiveness ratio of $12,628.15/QALY.

While a series of either PRP ($8,635.23/QALY) or HA ($5,331.75/QALY) injections for the treatment of symptomatic knee osteoarthritis would be considered cost-effective (cost/QALY <$50,000), PRP injections were not more cost-effective than HA. However, PRP was significantly more effective at one year, and being associated with an Institute for Clinical and Economic Review of $12,628.15/QALY when compared with HA, a series of PRP injections should be considered a reasonable and acceptable alternative to HA injections for the treatment of symptomatic knee OA, the authors concluded.

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PRP versus Hyaluronic Acid Injections for Knee OA: Cost-Effectiveness Analysis - DocWire News

Yes, People Are Reportedly Losing Hair Due to Stress From the Pandemic – POPSUGAR

By Platelet Rich Plasma Injections

As the year progresses and the novel coronavirus continues to upend everyday life, there's still a lot more we're learning about the virus and its side effects. For example, recent research has shown that hair loss is common among those who have recovered from the virus even actress Alyssa Milano revealed via Twitter that her hair has been falling out in clumps following her experience with COVID-19 though it also appears to be a common experience among those who haven't contracted the virus but are affected by the stress of the pandemic directly.

"I'm based in California, so the reopening of our salons has been a slower process than most states," celebrity hairstylist Carrera Alvarez told POPSUGAR. "One thing I'm hearing from my clients is concern about hair loss from stress, which is very real. We're living in a superstressful time, and that can lead to [potentially] losing more hair."

This type of hair loss is known as telogen effluvium, which, as a previous POPSUGAR article says, is "caused by physiologic stress to the body following conditions like anemia, low iron, surgery, general anesthesia, changes in hormones, or others." It's essentially stress-related hair loss, and it happens when the hair is pushed into the resting phase but doesn't enter the growth phase following a highly stressful event. "Anything that your body deems a stress physical or psychological will cause a person to develop a telogen effluvium," dermatologist Sapna Palep, MD, told POPSUGAR.

Dr. Palep has experienced telogen effluvium five times so far; two of them occurred after giving birth, while the others happened after three separate stressful events. According to her, most stress-related hair loss can linger for up to six months following whatever triggered it and can take up to one full year for the hair to recover. The good news is that this type of hair loss is usually temporary and can be treated with topical products and in-office procedures.

"In my office, I treat patients with hair loss with PRP (platelet-rich plasma) therapy, which uses injections of a concentration of a patient's own platelets to restore and accelerate hair growth," Dr. Palep said. "Treatments are done once a month for three months and every six months thereafter for maintenance. It's highly effective, and I've undergone PRP therapy myself for my hair loss."

If PRP isn't as accessible for you, both Alvarez and Dr. Palep have alternative hair-loss treatments they'd recommend turning to. "My go-to is Nioxin. It's the number one brand for thinning hair and known globally as a trusted brand," Alvarez said. "I start [my clients] on a System Kit to create a solid foundation for healthy growing hair." Meanwhile, Dr. Palep is a big fan of Nutrafol and the results it's been proven to show.

"I think it has a unique grouping of ingredients compared to its competitors," she said. For topical therapy, though, Dr. Palep recommends using Midoxil. "It's available without a prescription as a two percent solution, a five percent solution, and a five percent foam," she said. "I typically recommend five percent because studies support that it has somewhat greater efficacy. It works by increasing the window of time that a hair follicle is in its anagen (growth) phase, shortening the window of the telogen (resting/nongrowing) phase, and enlarging miniaturized follicles."

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Yes, People Are Reportedly Losing Hair Due to Stress From the Pandemic - POPSUGAR

Advisory Body Backs MesoBlast Therapy for Transplant Complication – Xconomy

By Stem Cell Treatment

Xconomy New York

An FDA advisory committee Thursday voted 9-1 to recommend that the agency approve a stem cell therapy developed by MesoBlast as a treatment for acute graft-versus-host disease (aGVHD) in children. The panel weighed the need for a new way to address the potentially fatal condition against shortcomings of the clinical trial the Australian biotech conducted to evaluate the investigational cell therapy.

Shares in (NASDAQ: MESO), which fell more than 30 percent earlier in the week after the FDA released briefing documents ahead of the committees meeting, closed up 51 percent Friday at $17.88 apiece compared to $11.81 at market close Wednesday. (Trading was halted on Thursday.)

The MesoBlast cell therapy, remestemcel-L (Ryoncil), is made from mesenchymal cells taken from healthy donors. The properties of these cells, which dont prompt an immune reaction, allow them to be used as an off-the-shelf treatment without accompanying immunosuppressants that put patients at greater risk for infection, among other side effects.

Some patients with blood cancer are treated with a stem cell transplant, in which cells from a healthy donor are infused into their bloodstream with the intent that those cells will travel to the bone marrow and form new healthy blood cells. Frequently, however, when donors are unrelated, their cells identify the recipients as foreign, prompting them to attack organs and tissues. Treatment with systemic corticosteroids can help control the severity of the condition. But in up to 90 percent of aGVHD patients who dont respond to steroid treatment, the condition can prove fatal.

MesoBlasts submission was based on a clinical trial that enrolled 55 children age 2 months to 17 years who had received a transplant of bone marrow, peripheral blood stem cells, or cord blood, were diagnosed with aGVDH and werent responding to steroid therapy. The study tracked their responses to remestemcel on day 28. Overall, 70 percent of the patients responded, including 76 percent of the 25 patients whose condition was graded as most severe. On day 100, 74 percent of patients remained alive; on day 180, 69 percent.

However, the trial was neither randomized nor controlled, raising concerns of confounding factors and potential bias. MesoBlast said investigators werent willing to enroll children in such a trial. But the company said randomization and controlled design would be incorporated into a planned post-marketing study in adults.

In previous clinical trials in wider patient populations, the treatment missed the primary goal. Analyses of results from those earlier trials prompted MesoBlasts decision to focus the drugs further development to steroid-refractory pediatric patients. In its presentation to the advisory panel the company said the remestemcel manufacturing process has been improved since those trials in ways that have made the treatment more potent.

The panel voted on whether MesoBlast provided enough clinical data to show that its therapy was effective in treating aGVHD in this narrower group. Panelist Christian Hinrichs, a clinical researcher at the National Cancer Institute and physician by training, was the sole no vote. Nine panelists felt the available data did indicate efficacy. (The committee recorded the tally as 8-2, but a MesoBlast representative said one no vote was made in error.)

I do think that the two prior randomized trials convincingly show that the [earlier version of remestemcel], at least in the population that was being studied, which is similar but not the same, clearly did not have meaningful activity, Hinrichs said. So, you know, do we think that these tweaks to the manufacturing have suddenly made it highly effective, and the change in patient population has suddenly made it highly effective?

Jorge Garcia, division chief of solid tumor oncology at University Hospitals Seidman Cancer Center in Cleveland, however, said while it isnt clear how the treatment compares to other drugs used to treat patients with the condition, the data indicate it is safe and has shown some efficacy.

In May 2019 an Incyte (NASDAQ: INCY) treatment, ruxolitinib (Jakafi), became the first FDA-approved treatment for patients with aGVHD who didnt responded to steroid therapy. Ruxolitinib was OKd for patients starting at age 12. But no treatment is approved for those younger.

Although the FDA considers advisory panel recommendations during drug reviews, committee recommendations are not binding, and the agency doesnt always follow them. Its decision on remestemcel is anticipated by Septembers end.

Image: iStock/Yarygin

Sarah de Crescenzo is an Xconomy editor based in San Diego. You can reach her at sdecrescenzo@xconomy.com.

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Advisory Body Backs MesoBlast Therapy for Transplant Complication - Xconomy

Stem Cell Therapy: A Ray of Hope to End Global Pandemic of COVID-19 | Roots Analysis – Bulletin Line

By Stem Cell Treatment

I would never have thought that a mutant flu virus could create that big panic in people at each and every corner of the world. In fact, the past few days in quarantine have really made me realize where exactly the humanity is heading. For majority of us, our lives are on a temporary hold while the world is dealing with the global pandemic of COVID-19. In fact, past three months have served as something of an inflection for many countries and as the number of infected patients have surpassed one million, there is already a sense of worry looming across the industries.

Since Coronavirus is a newly identified pathogen, there is no known pre-existing immunity observed in humans and therefore everyone is assumed to be susceptible. While researchers all across the globe are putting efforts to develop immediate treatment, there are speculations, based on credible evidence, that infected patients treated with Stem Cell Therapy are more likely to survive the disease. Specifically, mesenchymal stem cells can be effectively used to improve patients resistance to the SARS-CoV-2 virus induced pneumonia as these cells have the potential to repair damaged tissues in the patients respiratory system leading to speedy recovery.

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Recent Trends

Recent trends across several social medial platform highlight the immense efforts put by several stakeholders validating the therapeutic potential of stem cells. Specifically, Id like to appreciate the efforts of Azidus Brasil, CAR-T (Shanghai) Biotechnology, Janssen Research & Development, Mesoblast, Millennium Pharmaceutical, Pfizer, Stem Cell Arabia, Tianhe Stem Cell Biotechnologies and Tuohua Biological Technology that have progressed significantly in-terms of development of stem cell-based therapies to defeat this global pandemic of COVID-19 infection.

Looking at the efforts made by different pharmaceutical companies, I felt assured and hopeful as many patients have successfully recovered, while others are at the verge of getting discharged by using these novel classes of regenerative medicines.

What are the Key Hubs for Stem Cell Research?

With the virus strengthening its foothold in several countries across the globe, the threat of pandemic has become real and the question is are we ready?

As per the recent study published by Roots Analysis, the efforts for development of stem cell therapies have been undertaken by players all across the globe, majority of the developers (45%) are based in Asia-Pacific regions; China, South Korea and Japan; followed by developed countries, such as the US, Germany, Belgium, Spain and the UK.

Roots Analysis, in its recent report, has captured the clinical and research landscape of stem cell therapy-based treatment. To know further, check out the report here

Expert Opinion

In fact. several industry stakeholders are quite optimistic about the future market potential of stem cell-based therapies.

Bottom Line: Stay Cautious, Stay Hopeful!!

In the midst of the anxiety, worry, and uncertainty surrounding the COVID-19 pandemic, each day seems to bring news thats worse than the day before. However, remember this is not for the first time any pandemic outbreak has taken place in the history of mankind. About 200,000 (~20%) patients have already been recovered from this disease. The sky is not falling and for sure, life would return to normal. Stay cautious, stay hopeful.

For further information, check out the report here

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About Roots Analysis

Roots Analysis is one of the fastest growing market research companies, sharing fresh and independent perspectives in the bio-pharmaceutical industry. The in-depth research, analysis and insights are driven by an experienced leadership team which has gained many years of significant experience in this sector. If youd like help with your growing business needs, get in touch at [emailprotected]

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Stem Cell Therapy: A Ray of Hope to End Global Pandemic of COVID-19 | Roots Analysis - Bulletin Line

Amniotic Fluid Stem Cell Therapy Market Forecasted To Surpass The Value Of US$ XX Mn/Bn By 2018 2026 – Scientect

By Stem Cell Treatment

Persistence Market Research recently published a market study that sheds light on the growth prospects of the global Amniotic Fluid Stem Cell Therapy market during the forecast period (20XX-20XX). In addition, the report also includes a detailed analysis of the impact of the novel COVID-19 pandemic on the future prospects of the Amniotic Fluid Stem Cell Therapy market. The report provides a thorough evaluation of the latest trends, market drivers, opportunities, and challenges within the global Amniotic Fluid Stem Cell Therapy market to assist our clients arrive at beneficial business decisions.

The recent published research report sheds light on critical aspects of the global Amniotic Fluid Stem Cell Therapy market such as vendor landscape, competitive strategies, market drivers and challenges along with the regional analysis. The report helps the readers to draw a suitable conclusion and clearly understand the current and future scenario and trends of global Amniotic Fluid Stem Cell Therapy market. The research study comes out as a compilation of useful guidelines for players to understand and define their strategies more efficiently in order to keep themselves ahead of their competitors. The report profiles leading companies of the global Amniotic Fluid Stem Cell Therapy market along with the emerging new ventures who are creating an impact on the global market with their latest innovations and technologies.

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The recent published study includes information on key segmentation of the global Amniotic Fluid Stem Cell Therapy market on the basis of type/product, application and geography (country/region). Each of the segments included in the report is studies in relations to different factors such as market size, market share, value, growth rate and other quantitate information.

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The company profile section of the report offers great insights such as market revenue and market share of global Amniotic Fluid Stem Cell Therapy market. Key companies listed in the report are:

key players operating in global amniotic fluid stem cell therapy market are Stem Shot, Provia Laboratories LLC, Thermo Fisher Scientific Inc. Mesoblast Ltd., Roslin Cells, Regeneus Ltd. etc. among others.

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Global Amniotic Fluid Stem Cell Therapy Market by Geography:

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Chapter 4: Amniotic Fluid Stem Cell Therapy Market, By Region

Chapter 5: Company Profile

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Amniotic Fluid Stem Cell Therapy Market Forecasted To Surpass The Value Of US$ XX Mn/Bn By 2018 2026 - Scientect

Stem Cell Therapy for Osteoarthritis Market 2019 By Demand Services, Developments, Advancements, Application, Platforms Types, Industry Growth Drivers…

By Stem Cell Treatment

New study Stem Cell Therapy for Osteoarthritis Market research report covering the current trend and effect on the business of COVID-19. The global Stem Cell Therapy for Osteoarthritis Market Report offers valuable data on this report with the aid of fragmenting the market into different segments. Various vital elements are covered in the global Stem Cell Therapy for Osteoarthritis Market research report, including regional industry perspectives, geographic developments, country-level assessment, competitive environment, market share analysis of companies, and top company proreports. The study on the Stem Cell Therapy for Osteoarthritis Market fine-tuns the variety of the key features for which companies are analyzed. The study utilizes various techniques such as surveys, interviews, and existing discussions with participants, end-users, and industry leaders to analyze the global specialty malt industry.

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The key players covered in this study Mesoblast Regeneus U.S. Stem Cell Anterogen Asterias Biotherapeutics

Market segment by Type, the product can be split into Monotherapy Combination Therapy

Market segment by Application, split into Osteoarthritis (unspecified) Knee Osteoarthritis Shoulder Osteoarthritis Hip Osteoarthritis

Market segment by Regions/Countries, this report covers United States Europe China Japan Southeast Asia India Central & South America

Factors and Stem Cell Therapy for Osteoarthritis Market execution are analyzed using quantitative and qualitative approaches to give a consistent picture of current and future trends in the boom. The study also allows for a detailed market analysis focused primarily on geographic locations. The Global Stem Cell Therapy for Osteoarthritis Market Report offers statistical graphs, estimates, and collateral that explain the state of specific trade within the local and global scenarios.

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The purpose of the Stem Cell Therapy for Osteoarthritis Market analysis is to provide a well-structured overview of significant innovations, discoveries coupled with the technological advancements that occur in the global industry. The study also provides descriptions of the impact these findings may have on the growth prospects of the Global Stem Cell Therapy for Osteoarthritis Market during the review period. In addition, our analysts provided a comprehensive overview of the macro as well as the micro indicators combined with the reports existing and expected industry developments. The report provides an insight into the aspects within this segment that may encourage or demote the expansion of the Global Stem Cell Therapy for Osteoarthritis Industry. The Stem Cell Therapy for Osteoarthritis report segment also helps the consumer understand the life cycle of the desired product, along with the application reach of the product across industries and the prominent technological developments that will assess the level of competition for the product around the world. In summary, the segment provides the current business position, thus retaining in the projection period 2020 as the beginning year and 2026 as the ending year.

The Stem Cell Therapy for Osteoarthritis report provides separate comprehensive analytics for North America, Europe, China, Japan, Middle East & Africa, India, South America, and Others. Annual estimates and forecasts are provided for the period 2015 through 2026. Market data and analytics are derived from primary and secondary research. This report analyzes the worldwide markets for Stem Cell Therapy for Osteoarthritis in US$ Million.

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History Year 2015-2019

Base Year 2020

Estimated Year 2020

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Stem Cell Therapy for Osteoarthritis Market 2019 By Demand Services, Developments, Advancements, Application, Platforms Types, Industry Growth Drivers...

MASCC/ISOO Updates Its Guidelines on Preventing, Treating Mucositis Associated With Cancer Therapy – Oncology Nurse Advisor

By Stem Cell Treatment

Clinical setting-specific guidance was provided in a recently updated version of the Multinational Association for Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO) clinical practice guidelines on the management of cancer treatment-related mucositis, and published in the journal Cancer.

Mucositis is a common adverse effect of cancer treatments, including chemotherapy, radiotherapy (RT), and chemoradiotherapy (chemoRT), and intensive conditioning therapy administered in the setting of hematopoietic stem cell transplantation (HSCT). It is characterized by inflammation and ulceration of the mucosal lining of the gastrointestinal tract and can be associated with substantial morbidity, as well as early interruption of cancer therapy and a higher rate of opioid use in patients with cancer.

Following a recently conducted, rigorous, systematic review of the related medical literature, the MASCC/ISOO Mucositis Study Group issued the fourth version of its guidelines on the prevention and treatment of mucositis secondary to chemotherapy, RT, chemoRT, or HSCT. MASCC/ISOO guidelines were first published in 2004.

Of note, although mucositis has also been identified as a potential adverse effect of some targeted therapies and immunotherapies used in the treatment of cancer, these guidelines do not address management of mucositis in those settings.

Although the guidelines cover both prevention and treatment, the emphasis of these updates was on interventions for preventing mucositis and its potentially serious complications in patients undergoing cancer therapy.

Some of the key recommendations issued by the Study Group regarding mucositis secondary to chemotherapy, RT, chemoRT, and/or HSCT include:

Regarding professional oral care for the prevention of mucositis in patients with cancer undergoing treatment and the use of misoprostol mouthwash in patients with head and neck cancer treated with RT, the Study Group noted that only limited, high-quality evidence exists in these areas, hence no related guideline recommendations were issued on those topics.

However, recommendations were issued against prophylactic use of both topical granulocyte macrophage colony-stimulating factor (GM-CSF) in patients undergoing HSCT and chlorhexidine rinses in those with head and neck cancer undergoing RT.

Regarding treatment of mucositis, the guidelines suggested topical 0.2% morphine mouthwash for patients with pain related to oral mucositis secondary to the treatment of head and neck cancer with chemoRT (Level III Evidence). However, a recommendation was made against using combined topical and systemic sucralfate to treat oral mucositis-related pain in those with head and neck cancer receiving RT and those with solid tumors treated with chemotherapy.

The ultimate goal of these guidelines is to improve the supportive care for patients with cancer and provide direction for future trials. As new research is conducted, new evidence will become available, the guideline authors noted in their concluding remarks. To this end, the MASCC/ISOO Mucositis Study Group plans to continue periodically updating its guidelines.

Disclosure: Multiple authors declared affiliations with industry. Please refer to the original article for a full list of disclosures.

Reference

Elad S, Cheng KKF, Lalla RV, et al; Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. Published online July 28, 2020. doi:10.1002/cncr.33100

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MASCC/ISOO Updates Its Guidelines on Preventing, Treating Mucositis Associated With Cancer Therapy - Oncology Nurse Advisor

A systematic literature review of the effects of immunoglobulin replacement therapy on the burden of secondary immunodeficiency diseases associated…

By Stem Cell Treatment

This article was originally published here

Expert Rev Clin Immunol. 2020 Aug 12. doi: 10.1080/1744666X.2020.1807328. Online ahead of print.

ABSTRACT

INTRODUCTION: Secondary immunodeficiency diseases (SID) caused by hematological malignancies (HMs), stem cell transplant (SCT), and associated therapies are mainly characterized by the presence of hypogammaglobulinemia or antibody production deficits.

AREAS COVERED: The authors summarized the scientific literature on disease burden of SIDs in patients who had HMs or SCT. Systematic searches were conducted to identify English-language articles from 1994-2020, reporting on clinical, humanistic, and economic burdens of SID due to HMs or SCT. Definitions of SID and serum immunoglobulin G thresholds varied across the 24 studies that met eligibility criteria. In most (n=16) studies, patients received immunoglobulin replacement therapy (IGRT). Several studies found IGRT was associated with significant reductions in rates of infection and antimicrobial use. However, 1 study found no statistically significant difference in antibiotic use with IGRT. Only 3 studies reported on quality of life, and no economic studies were identified.

EXPERT OPINION: Overall, the findings show several beneficial effects of IGRT on clinical outcomes and quality of life; however, disparate definitions, infrequent reporting of statistical significance, and scarcity of clinical trial data after the 1990s present areas for further investigation. This paucity indicates an unmet need of current evidence to assess the benefits of IGRT in SID.

PMID:32783541 | DOI:10.1080/1744666X.2020.1807328

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A systematic literature review of the effects of immunoglobulin replacement therapy on the burden of secondary immunodeficiency diseases associated...

Global Stem Cell Therapy Market Future Growth Analysis, Business Demand And 2025 Opportunities – Bulletin Line

By Stem Cell Treatment

A research report on the global Stem Cell Therapy market offers an in-depth analysis of the market scope and objective of the target market. The report also gives complete information regarding the major market players and segments. This research report provides a precise market prediction for the global and the local market. The Stem Cell Therapy report also sheds light on the market share and market growth rate on the basis of different regions involved in this market.

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Additionally, this report intensely studied the different strategies such as collaboration, expansion, mergers & acquisitions, key player analysis, manufacturing base, as well as share of the leading players. In addition, the Stem Cell Therapy research report also gives comprehensive information regarding the industry size by dividing the market into product, type, as well as application. Likewise, the research study contains the major players that are studied on the basis of their product portfolio, price, revenue, products, gross margin, sales, business, as well as other company data. Also, this study offers an in-depth analysis of the regional marketing, opportunities, challenges, market drivers, and supply chain for the correct forecast of the global Stem Cell Therapy market.

Key Segmentation:

Key Players: Anterogen Co., Ltd. (South Korea), MEDIPOST Co., Ltd. (South Korea), Osiris Therapeutics, Inc. (U.S.) and Pharmicell Co., Ltd.

Types: Based on cell source, the market has been segmented into,

Adipose Tissue-Derived Mesenchymal SCs Bone Marrow-Derived Mesenchymal SCs Embryonic SCs Other Sources

Key Applications: Based on therapeutic application, the market has been segmented into,

Musculoskeletal Disorders Wounds & Injuries Cardiovascular Diseases Gastrointestinal Diseases Immune System Diseases Other Applications

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The global Stem Cell Therapy market report delivers an appropriate analysis about the research & methodology approach, data sources, and authors of the target market study. Likewise, the Stem Cell Therapy research study also covers the complete details regarding the manufacturing data which may include gross profit, shipment, interview record, and business distribution that can help customer to know about the overall competitive landscape across the world. Similarly, the global Stem Cell Therapy market report also delivers all the regions and countries across the globe that shows a geographical growth status such as pricing structure, market size, as well as value and volume. The research report also covers a complete analysis of the target market segmentation and sub-segments. Additionally, this research study provides an appropriate analysis of the industry trends along with the precise data of market use cases and leading industry trends, and market size by regions.

Likewise, the study also analyzes numerous factors that are influencing the Stem Cell Therapy market from supply and demand side and further evaluates market dynamics that are impelling the market growth over the prediction period. In addition to this, the target market report provides inclusive analysis of the SWOT and PEST tools for all the major regions such as North America, Europe, Asia Pacific, and the Middle East and Africa. The report offers regional expansion of the industry with their product analysis, market share, and brand specifications. Furthermore, the Stem Cell Therapy market study offers an extensive analysis of the political, economic, and technological factors impelling the growth of the global Stem Cell Therapy market across these economies.

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https://www.adroitmarketresearch.com/industry-reports/stem-cell-therapy-market

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Global Stem Cell Therapy Market Future Growth Analysis, Business Demand And 2025 Opportunities - Bulletin Line

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