Covid-19 roundup: CureVac beefs up its unicorn IPO dreams as billionaire owner takes this Covid-19 mRNA player on a forced march to Nasdaq; Kodak’s…

Almost exactly 4 years ago, Seres Therapeutics $MCRB experienced one of those soul-crunching failures that can raise big questions about a biotechs future. Out front in their pursuit of a gut punch to C. difficile infection (CDI), the Phase II test was a flat failure, and investors wiped out a billion dollars of equity value that never returned in the years that followed.

Seres, though, pressed ahead, changing out CEOs a year ago bidding Merck vet Roger Pomerantz farewell from the C suite and pushing through a Phase III, hoping that amping up the dosage would make the key difference. And this morning, they unveiled a claim that they had aced the Phase III and positioned themselves for a run at a landmark FDA OK.

Unlock this story instantly and join 86,800+ biopharma pros reading Endpoints daily and it's free.

SUBSCRIBE SIGN IN

Original post:
Covid-19 roundup: CureVac beefs up its unicorn IPO dreams as billionaire owner takes this Covid-19 mRNA player on a forced march to Nasdaq; Kodak's...

How Close Are We To Making Babies from Bone Marrow? – Discover Magazine

(Credit: MakeStory Studio/Shutterstock)

Sign up for our email newsletter for the latest science news

In 2007, a group of researchers reported a startling discovery: They had created sperm-like cells out of stem cells taken from the bone marrow of human men. Two years later, however, the study was retracted due to charges of plagiarism. Thirteen years later, the ability to create functional human sperm out of stem cells remains elusive.

Scientists have been trying to figure out how to create functioning human gametes eggs and sperm from stem cells for 20 or 30 years, says Vittorio Sebastiano, a stem cell biologist at Stanford University whose research focuses on reproductive biology. Doing so would help people struggling with infertility have children and help scientists unlock the secrets of human development. Since 2007, scientists have made considerable progress on this front, creating healthy mouse pups from stem cell-generated gametes and even immature human egg cells. But there is still a long road ahead before scientists will be able to convert skin or bone marrow into babies.

We are trying to really find ways to efficiently, robustly generate germ cells that can be, in the short term, used to understand the biology of these concepts, but in the long term [used to be] able to restore fertility, says Sebastiano.

When the first baby conceived via in vitro fertilization (IVF) was born in 1978, it was a major step forward for reproductive science and a precursor to the stem cell research conducted by Sebastiano and others today, he says. But IVF is not an option for every individual or couple trying to have a biological child, including those who are born without gametes or who receive aggressive cancer treatments at a young age. This scientific technique would offer these individuals a new shot at reproduction.

The next major step came in the 2000s, with the creation of induced pluripotent stem cells (iPSCs). These cells are taken from blood or skin cells and reprogrammed to behave like embryonic cells, which have the ability to develop into any type of cell in the body. Since then, researchers have been trying to figure out how to turn these embryonic-like cells into functional sperm and eggs.

A colony of induced pluripotent stem cells used to treat the rare genetic disorder Fanconi anemia. (Credit: Juan Carlos Izpisua Belmonte, Salk Institute for Biological Studies)

Part of what has made this work so challenging is that scientists havent been able to fully grasp what happens in a human embryo during normal development, says Sebastiano. Scientists understand this process in mice because the rodents are easy to study in the lab. But ethical restrictions and technical factors (like having access to the embryos at just the right point in time) make this phenomenon hard to study in people, he says.

Despite the roadblocks, scientists have made significant progress in the last 10 years. In 2012, a group of researchers in Japan created fertile mouse eggs from iPSCs and used those eggs to breed healthy mouse pups. In [the] mouse, the whole circle has already been completed, says Sebastiano. Now it has been shown by a couple of groups in the UK and in Japan that you can generate embryonic-like cells from mice and then you can actually push these cells to become eggs or sperm, fully functional.

In 2018, the same group of Japanese scientists made another major breakthrough. Using human blood cells and the pluripotent stem cell technique, they managed to produce immature human eggs.

Similar efforts to create sperm are not as far along, says Sebastiano. Several efforts over the years have purported to create sperm-like cells, including the 2007 blood marrow study. A much-heralded study published in 2014 also made major news, but Sebastiano says the development of the cells in that study didnt go far beyond the earliest stages of differentiation.

But, we are actively working on it, says Sebastiano. Probably in the next few years we will be able to generate fully functional sperm and fully functional oocytes. Then, the question will be how do scientists test the quality of these gametes, he says.

The only way to fully assess the quality and functionality of a sperm or egg is to use it to, well, try to fertilize another gamete and produce a baby. Thats why this work has to be approached with the utmost care, says Sebastiano. He hypothesizes that once scientists have developed techniques that they think produce mature human oocytes and sperm, the next step will be testing these techniques in primates. That way, researchers can follow the entire life of individual animals produced from this technique to see if any unexpected problems develop, he says.

Sebastiano has no doubt that one day, these stem cells could help individuals struggling with infertility to produce healthy children. This, along with a fascination with biological development, is what drives Sebastianos work. There are also, of course, significant ethical considerations that have to be carefully considered. This technique has the potential to affect human life on a generational level, he notes. And many people also raise concerns about other future consequences, like the ability to create designer babies or produce offspring from hairs stolen from unsuspecting celebrities. Bioethics experts have written about the need to start working through the medical and legal issues around this technique now, before it is viable.

There is a need actually to develop this, but since we are really dealing with a very unique cell type we need to be cautious, says Sebastiano.

Read more:
How Close Are We To Making Babies from Bone Marrow? - Discover Magazine

Stem Cell Equipment Market by global COVID-19 impact analysis, industry trends, business strategies, opportunities and forecast to 2024 discussed in a…

The Stem Cell Equipment Market report has been recently added by Report Ocean to its vast repository. This intelligence report includes investigations based on Historical records, Current scenarios, and future predictions. It presents the 360-degree overview of the competitive landscape of the industries. SWOT analysis has been used to understand the Strength, Weaknesses, Opportunities, and threats in front of the businesses. Stem Cell Equipment Market is showing steady growth and CAGR is expected to improve during the forecast period.

The Stem Cell Equipment Market Research Report categorizes the Stem Cell Equipment Market by key players, product type, applications, and regions, etc. The report also covers the latest industry data, key players analysis, market share, growth rate, opportunities and trends, investment strategy for your reference in analyzing the Stem Cell Equipment Market.

COVID- 19 Impact on Stem Cell Equipment Market

As companies move from reacting to mitigating the impact of the COVID-19 outbreak, they are keenly focusing on strategies that may result in emerging as strong market player. This market research report included the detailed study related to impact of COVID-19 on the supply chain based on both downstream and upstream markets. The report also includes the future development in the Stem Cell Equipment Market in relation with the impact of COVID-19 on the market.

Request Free Sample Report athttps://www.reportocean.com/industry-verticals/sample-request?report_id=bis64912

Competitive Landscape:

This section of the report has mainly focused on Key Strategies adopted by leading players in Stem Cell Equipment Market. These companies are selected based on revenue, innovations, strength of product portfolio, regional presence, investment capacity and similar other factors.

Chart Worthington Industries Cesca Therapeutics Shengjie Cryogenic Equipment Sichuan Mountain Vertical Qingdao Beol

Market Segmentation:

The segmentation is used to decide the target market into smaller sections or segments like product type, application, and geographical regions to optimize marketing strategies, advertising technique and global as well as regional sales efforts of Stem Cell Equipment Market.

Product Type Segmentation Stem Cell Cryopreservation Equipment Stem Cell Separation Equipment

Industry Segmentation Cord Blood Stem Cells Cryopreservation Other Stem Cells Cryopreservation

Channel (Direct Sales, Distributor) Segmentation

Region Segmentation:

Each region is exhaustively researched about so that players can use the analysis to tap into unexplored markets and plan powerful strategies to gain a foothold in Stem Cell Equipment Market. The regional analysis section of the report offers an extensive analysis of the Stem Cell Equipment Market based on region. The Stem Cell Equipment Market will showcase a steady CAGR in the forecast year.

Unravelling the geographical landscape of the Stem Cell Equipment Market:

Americas (United States, Canada, Mexico, Brazil)

APAC (China, Japan, Korea, Southeast Asia, India, Australia)

Europe (Germany, France, UK, Italy, Russia, Spain)

Middle East & Africa (Egypt, South Africa, Israel, Turkey, GCC Countries)

Some of the Points cover in Stem Cell Equipment Market Research Report are:

Chapter 1: Overview of Stem Cell Equipment Market

Definition

Specifications

Classification

Applications

Regions

Chapter 2: Market Competition by Players/Suppliers

Manufacturing Cost Structure

Raw Material and Suppliers

Manufacturing Process

Industry Chain Structure

Chapter 3: Sales (Volume) and Revenue (Value) by Region

Sales

Revenue and market share

Chapter 4, 5 and 6: Stem Cell Equipment Market by Type, Application & Players/Suppliers Profiles

Market Share by Type & Application

Growth Rate by Type & Application

Drivers and Opportunities

Company Basic Information

Continued

Note: Regional Breakdown & Sectional purchase Available We provide Pie chats Best Customize Reports As per Requirements.

For more information and discount on this report, ask your query at:https://www.reportocean.com/industry-verticals/sample-request?report_id=bis64912

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe, and Asia.

Contact Us: +1 888 212 3539 (US) +91-9997112116 (Outside US) Contact Person: Tom Email:[emailprotected]

Read more from the original source:
Stem Cell Equipment Market by global COVID-19 impact analysis, industry trends, business strategies, opportunities and forecast to 2024 discussed in a...

Stem Cell Source Market 2020 Size by Product Analysis, Application, End-Users, Regional Outlook, Competitive Strategies and Forecast to 2027 – Owned

New Jersey, United States,- The most recent Stem Cell Source Market Research study includes some significant activities of the current market size for the worldwide Stem Cell Source market. It presents a point by point analysis dependent on the exhaustive research of the market elements like market size, development situation, potential opportunities, and operation landscape and trend analysis. This report centers around the Stem Cell Source business status, presents volume and worth, key market, product type, consumers, regions, and key players.

The COVID-19 pandemic has disrupted lives and is challenging the business landscape globally. Pre and Post COVID-19 market outlook is covered in this report. This is the most recent report, covering the current economic situation after the COVID-19 outbreak.

Key highlights from COVID-19 impact analysis:

Unveiling a brief about the Stem Cell Source market competitive scope:

The report includes pivotal details about the manufactured products, and in-depth company profile, remuneration, and other production patterns.

The research study encompasses information pertaining to the market share that every company holds, in tandem with the price pattern graph and the gross margins.

Stem Cell Source Market, By Type

Stem Cell Source Market, By Application

Other important inclusions in the Stem Cell Source market report:

A brief overview of the regional landscape:

Reasons To Buy:

About Us:

Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage, and more. These reports deliver an in-depth study of the market with industry analysis, the market value for regions and countries, and trends that are pertinent to the industry.

Contact Us:

Mr. Steven Fernandes

Market Research Intellect

New Jersey ( USA )

Tel: +1-650-781-4080

Our Trending Reports

Unplasticized Polyvinyl Chloride (UPVC) Windows Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

Urological Operating Tables Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

Urology Surgical Devices Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

Utility Cleaning Machines Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

UV LED Printers Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

See original here:
Stem Cell Source Market 2020 Size by Product Analysis, Application, End-Users, Regional Outlook, Competitive Strategies and Forecast to 2027 - Owned

Stem Cell Banking Storage Market 2020 Size by Product Analysis, Application, End-Users, Regional Outlook, Competitive Strategies and Forecast to 2027…

New Jersey, United States,- Market Research Intellect aggregates the latest research on Stem Cell Banking Storage Market to provide a concise overview of market valuation, industry size, SWOT analysis, revenue approximation, and regional outlook for this business vertical. The report accurately addresses the major opportunities and challenges faced by competitors in this industry and presents the existing competitive landscape and corporate strategies implemented by the Stem Cell Banking Storage market players.

The Stem Cell Banking Storage market report gathers together the key trends influencing the growth of the industry with respect to competitive scenarios and regions in which the business has been successful. In addition, the study analyzes the various limitations of the industry and uncovers opportunities to establish a growth process. In addition, the report also includes a comprehensive research on industry changes caused by the COVID-19 pandemic, helping investors and other stakeholders make informed decisions.

Key highlights from COVID-19 impact analysis:

Unveiling a brief about the Stem Cell Banking Storage market competitive scope:

The report includes pivotal details about the manufactured products, and in-depth company profile, remuneration, and other production patterns.

The research study encompasses information pertaining to the market share that every company holds, in tandem with the price pattern graph and the gross margins.

Stem Cell Banking Storage Market, By Type

Stem Cell Banking Storage Market, By Application

Other important inclusions in the Stem Cell Banking Storage market report:

A brief overview of the regional landscape:

Reasons To Buy:

About Us:

Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage, and more. These reports deliver an in-depth study of the market with industry analysis, the market value for regions and countries, and trends that are pertinent to the industry.

Contact Us:

Mr. Steven Fernandes

Market Research Intellect

New Jersey ( USA )

Tel: +1-650-781-4080

Our Trending Reports

Pear Preserves Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

Peptide and Anticoagulant Drugs Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

Peracetic Acid Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

Percutaneous Transluminal Coronary Angioplasty (PTCA) Products Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

Perfume Ingredients Chemicals Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

See original here:
Stem Cell Banking Storage Market 2020 Size by Product Analysis, Application, End-Users, Regional Outlook, Competitive Strategies and Forecast to 2027...

Cell Isolation Market In-Depth Survey and Future Outlook By 2027 | GE Healthcare, Merck KgaA, Miltenyi Biotec, etc. – Levee Report

Cell Isolation Market Report Forecast to 2027

Reports and Data has added a new research report titled Global Cell Isolation Market to its extensive database. The report thoroughly explains the market dynamics from vital industry data to accurate estimation in the forecast years. It comprises of all the crucial segments of the changing dynamics of the market. The information can be beneficial for readers to gain a robust footing in the global market.

The report mainly focuses on the types, applications, overview, and major players in the Cell Isolation market. The report provides historical data from 2017-2018 and industrial development trends and growth patterns for the forecast years 2020-2027. The report is updated with the latest economic scenario due to the global COVID-19 crisis. The pandemic has brought dynamic changes in the major segments of the market. The report covers the present and future impact of the COVID-19 crisis and the economic scenario post-COVID-19.

Get a sample of the report @ https://www.reportsanddata.com/sample-enquiry-form/2237

The report on the global Cell Isolation market consists of up-to-date financial data formulated by extensive research to provide accurate analysis. The report also consists of the evaluation of key market trends, in-depth analysis of segmentations, and sub-market categorization on a regional and global scale. The report also provides strategic recommendations to key market players and new entrants based on current emerging trends.

Key players of the market mentioned in the report are:

Thermo Fisher Scientific, Beckman Coulter, Becton, Dickinson and Company, GE Healthcare, Merck KgaA, Miltenyi Biotec, pluriSelect, STEMCELL Technologies Inc., Terumo BCT and Bio-Rad Laboratories Inc.

The report provides an in-depth analysis of production cost, market segmentation, end-use applications, and industry chain analysis. The report provides CAGR, value, volume, revenue, and other key factors related to the global Cell Isolation market. All the findings and data have been gathered through extensive primary and secondary research and are validated by industry experts and research analysts.

The report further studies the segmentation of the market based on product types offered in the market and their end-use/applications.

Product (Revenue in USD Billion, 2018 2026)

Cell Type (Revenue in USD Billion, 2018 2026)

Technique (Revenue in USD Billion, 2018 2026)

Application (Revenue in USD Billion, 2018 2026)

End Use (Revenue in USD Billion, 2018 2026)

Request customization of the report @ https://www.reportsanddata.com/request-customization-form/2237

Major geographical regions studied in this report include:

Request a discount on the report @ https://www.reportsanddata.com/discount-enquiry-form/2237

Key points covered in the report:

To get the Report Description and TOC, visit @ https://www.reportsanddata.com/report-detail/cell-isolation-market

Thank you for reading our report. Please get in touch with us if you wish to request a customization of the report. Our team will ensure you get a report well-suited for your needs.

David is an Experience Business writer who regularly contributes to the blog, He specializes in manufacturing news

Link:
Cell Isolation Market In-Depth Survey and Future Outlook By 2027 | GE Healthcare, Merck KgaA, Miltenyi Biotec, etc. - Levee Report

Cancer Stem Cell Therapeutics Market Report, History and Forecast 2020-2027, Data Breakdown by Manufacturers, Key Regions, Types and Application -…

Reports and Data has recently added a new research study on the Global Cancer Stem Cell Therapeutics Market to its ever-expanding database. The report is equipped with detailed information about the product types, applications, regions, and key players operating in the market. The report provides a comprehensive analysis of the emerging trends, key challenges, growth potential, drivers, competitive landscape, and industrial chain analysis of the Global Cancer Stem Cell Therapeutics industry.

The latest report is furnished with the impact analysis of the current COVID-19 pandemic on the market. The pandemic has drastically changed the dynamics of the market and has affected every aspect of life globally. The rapidly changing dynamics of the market and current and future growth potential of the market are covered in the report. The report offers crucial information about the initial and future assessment of the impact of the COVID-19 crisis on the overall market.

Get a sample of the report @ https://www.reportsanddata.com/sample-enquiry-form/1414

The report covers an exhaustive analysis of manufacturing processes, development policies, plans, product portfolio, and cost analysis. The data is represented in the form of tables, charts, graphs, diagrams, and figures.

Furthermore, the report includes an in-depth analysis of the competitive landscape. The segment offers a comprehensive overview of the company profiles along with the product profiles, production capacities, products/services, pricing analysis, profit margins, and manufacturing process developments. The report also covers strategic business measures undertaken by the companies to gain substantial market share. The report provides insightful information about recent mergers and acquisitions, product launches, collaborations, joint ventures, partnerships, agreements, and government deals.

The report provides an in-depth analysis of the competitive landscape and covers profiles of key players, along with their product portfolios and business strategies.

Key players of the market mentioned in the report are:

Merck KGA, LONZA Group AG, Novartis, Osiris Therapeutics, Pfizer, Pfizer, Stemline Therapeutics Inc., STEMCELL Technologies, and Thermo Fischer Scientific Inc., Others

The report analyzes various product types and applications, along with manufacturing and process analysis and cost analysis. The data is further validated via extensive primary and secondary research verified by industry experts and professionals of the profiled companies.

Treatment Type: (Revenue, USD Million; 20162026)

Disease Type: (Revenue, USD Million; 20162026)

Application: (Revenue, USD Million; 20162026)

End Use: (Revenue, USD Million; 20162026)

Request a discount on the report @ https://www.reportsanddata.com/discount-enquiry-form/1414

Highlights of the Cancer Stem Cell Therapeutics Report:

The report covers historical revenue and sales volume, and the data is validated to provide a forecast market estimation of the market size and sales numbers for key regions along with types and end-user applications. Moreover, the report also includes macroeconomic factors and regulatory policies pertaining to the Cancer Stem Cell Therapeutics industry for evaluation and predictive analysis.

Additionally, the report provides beneficial data about distribution, production, consumption patterns, export/import, and demand and supply ratio. The report covers the latest trends, product portfolio, demographics, regional segmentation, and regulatory framework of the Cancer Stem Cell Therapeutics industry.

Based on the geographical spread, the Cancer Stem Cell Therapeutics industry is segmented into North America, Latin America, Europe, Asia-Pacific, and the Middle East & Africa.

Request customization of the report @ https://www.reportsanddata.com/request-customization-form/1414

Highlights of the TOC of the Cancer Stem Cell Therapeutics Market Report:

Global Cancer Stem Cell Therapeutics Market Overview

Global Cancer Stem Cell Therapeutics Market Size and Share by Types

Global Cancer Stem Cell Therapeutics Market Size and Share by Applications

Global Cancer Stem Cell Therapeutics Market Sales and Growth Rate

Global Cancer Stem Cell Therapeutics Market Competitive Landscape

Global Cancer Stem Cell Therapeutics Market Regional Analysis

Global Cancer Stem Cell Therapeutics Market Forecast Estimation (2020-2027)

Global Cancer Stem Cell Therapeutics Market Trends, Drivers, Challenges, Risks, and Opportunities

Global Cancer Stem Cell Therapeutics Market Revenue, Price, and Gross Margin for Each Segment

Global Cancer Stem Cell Therapeutics Market Industrial Chain Analysis

Read more about the TOC in the full report.

To get the Report Description and TOC, visit @ https://www.reportsanddata.com/report-detail/cancer-stem-cell-therapeutics-market

Thank you for reading our report. Customization of this report is available on chapter wise section or region wise. Kindly get in touch with us to know more about the report, and our team will provide the report suited to your needs.

Link:
Cancer Stem Cell Therapeutics Market Report, History and Forecast 2020-2027, Data Breakdown by Manufacturers, Key Regions, Types and Application -...

FDA warns businesses to stop claiming to prevent, treat and diagnose COVID-19 – wtkr.com

HAMPTON ROADS, Va. - The FDA is warning that companies are preying on the fears people have about COVID-19 and producing products that they say help prevent, treat, diagnose and cure COVID-19.

The FDA says the claims are false and not scientifically proven.

The FDA says as of August 10, 102 warning letters have been sent to businesses stating that if they dont make changes to the false claims within 48 hours, they will be subject to legal action.

The products include pills, sprays, essential oils, stem cell products and even home COVID-19 kits.

I think this is a moment where they're rising to the challenge and they're doing quite a good job in terms of tracking down businesses that are making non evidence-based claims, selling products that are not approved by the FDA and issuing letters, said Associate Professor at University of Minnesota Leigh Turner. He praised the FDA for taking action.

He recently wrote a journal article called, Preying on Public Fears and Anxieties in a Pandemic: Businesses Selling Unproven and Unlicensed Stem Cell Treatments for COVID-19 in Cell Stem Cell.

These are basically companies that are entering the marketplace, charging thousands or tens of thousands of dollars for products where there's not a credible basis for the claims that are being made. When you go on the websites and see what sorts of statements are being made, they're misleading they are deceptive, theyre persuasive and they're not backed by any kind of credible scientific reality, said Tuner.

FDA said theyre working to find a vaccine and drugs that will prevent and treat COVID-19 as quickly as possible and offered some tips on how to identify false or misleading claims.

They said be suspicious of products that claim to treat a wide range of diseases and said personal testimonials are no substitute for scientific evidence.

They said few diseases or conditions can be treated quickly, so be suspicious of a quick fix," and miracle cures, which claim scientific breakthroughs or contain secret ingredients, are likely a hoax.

Turner said many products are just a waste of money and useless, however some could potentially cause harm to humans.

The FDA wants you to report any suspicious products you find online click here to do that.

Consumer Update: Beware of Fraudulent Coronavirus Tests, Vaccines and Treatments

List of Warning Letters for Fraudulent Coronavirus Disease 2019 (COVID-19) Products

Read the rest here:
FDA warns businesses to stop claiming to prevent, treat and diagnose COVID-19 - wtkr.com

Perceptive fields SPAC #3 as another group of biotechs scoops up $364M in latest Nasdaq romp – Endpoints News

Theres no sign that the windfall of cash dropping biotechs way on Wall Street is abating. Three more biopharmas priced IPOs on Thursday and Friday morning, riding a historic boom with a $364 million payoff.

London-based biotech Freeline Therapeutics took home the lions share of the cash with $159 million after pricing 8,823,529 shares at $18 a pop. Checkmate Pharmaceuticals, of Cambridge, MA, raised $75 million with an offer of 5 million shares at $15 right at the midpoint of its range. And Arya Sciences Acquisition Corp III, the third in a series from Perceptive, priced 13,000,000 shares at $10 per share.

Drugmakers are securing big sums amid the pandemic boom, including AlloVir, which bagged $276 million from 16.3 million shares last week. Initially, the company had filed for a $100 million IPO.By June, all 23 newly public companies had priced above their midpoint or upsized their offering.

And theres more coming: Kymera Therapeutics announced plans to go public on Monday, when it filed for a $100 million IPO.

Checkmate initially filed for an IPO on July 17, then raised its maximum offering price to $92 million in an amended S-1 filing. The immuno-oncology biotech is investigating its drug CMP-001 across multiple cancers, including melanoma and head and neck squamous cell carcinoma (HNSCC), and says it will use the funds to advance clinical trials. BofA Securities, Jefferies Group and BMO Capital Markets are managing the deal.

CMP-001 uses the immune system to its advantage, directing activated anti-tumor T cells to attack both the injected tumor and tumors throughout the body. Its been tested on more than 200 melanoma patients to date, and based on clinical data, the company believes there is an opportunity for CMP-001 to be developed as a differentiated immuno-oncology therapy, according to the S-1 filing.

Freeline initially filed for a $100 million IPO, with JP Morgan Securities LLC, Morgan Stanley & Co. and Evercore Group as joint bookrunners. Its AAV gene-therapy treatments target hemophilia A and B, Fabry disease, and Type 1 Gaucher disease.

The biotechs lead candidate, FLT180a, is currently in a Phase I/II trial for hemophilia B. IPO funds will propel the companys pipeline, including Phase I/II trials for FLT180a and FLT190, a potential drug to treat Fabry disease.

SPACs (special purpose acquisition companies) are benefiting from the boom, too. Once rare in the biotech world, they now represent nearly 35% of listings, Nasdaqs Jay Heller told Endpoints lastmonth.

Perceptive Advisors blank check company Arya III filed for a $143.7 million IPO on July 21, and investors are betting on a profitable merger. In March, Arya I merged with biotech Immatics in a $252 million deal. Cerevel Therapeutics merged with Arya II in July, expecting to raise about $445 million to develop its pipeline.

Go here to read the rest:
Perceptive fields SPAC #3 as another group of biotechs scoops up $364M in latest Nasdaq romp - Endpoints News

California Sours On Trump, Including Some Of His Base – Los Angeles, CA Patch

LOS ANGELES, CA The presidential election is almost three months away, but Golden State voters are already fired up, according to a new poll out this week.

So what has the bluest of states so fired up? A chance to vote for Former Vice President Joe Biden? The two or three competitive congressional races (Districts 21, 25 and maybe 28)? Any of the 12 statewide ballot measures ranging from affirmative action to consumer privacy, property tax increases or voting rights for 17-year-olds and parolees?

According to a new poll from UC Berkeley's Institute of Governmental Studies, California voters are looking forward to voting against President Donald Trump in record numbers. He already holds the state record for a landslide loss in a presidential race having lost to Hillary Clinton in California by 30 percent. But he's poised to break his own record, according to the Berkeley poll. The poll has the president trailing Biden in California by 39 points, 28 percent to 67 percent. His dismal polling in California stems largely from declining approval ratings among independent voters and Republican voters.

"There was a question of whether his support was already so low in the state that it couldn't go lower," said Berkeley political scientist Eric Schickler, co-director of the Institute of Governmental Studies told the Los Angeles Times, adding the poll "shows the answer is no."

Schickler said it's notable that Trump is polling poorly with all racial groups in California.

"Biden's overwhelming support across all racial groups is striking. He leads by at least a two-to-one margin among white voters, Latinos, Black voters and Asian Americans," he said. "In many states, white voters are closely divided and there are big differences in the views of President Trump across racial groups. Not so in California."

According to the poll, Trump's standing with California voters has slipped notably in the past six months. Just 29% of registered voters now say they approve of the job Trump is doing as president while 71% disapprove. Among those who disapprove, 63% disapprove strongly, up 6 percentage points from January.

His approval rating is largely tied with attitudes about his handling of the coronavirus pandemic. Trump theoretically has just under three months to turn it around, but in reality, a significant proportion of California voters could be casting their mail-in ballots a full month before the election.

Due to the pandemic, all registered voters will receive mail-in ballots. Each county is required to start mailing out the ballots by Oct. 5, and some counties may send them out even sooner, according to the Secretary of State's office.

In addition to local elections, California voters will be choosing 53 of California's seats in the House of Representatives, 80 state assembly seats, 20 state senate seats, and 12 statewide ballot measures.

See the original post here:
California Sours On Trump, Including Some Of His Base - Los Angeles, CA Patch