Stem Cell Clinic

Potential Combination Therapy Discovered for Treating Head and Neck Squamous Cell Carcinoma – Genetic Engineering & Biotechnology News

By Stem Cell Treatment

Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat. It is an aggressive life-threatening disease associated with high mortality rates, and accounts for more than 90% of the cancers of the head and neck.

PD1 blockade-based combination therapy has been approved as a first-line treatment for HNSCC. However, the response rate remains relatively low, and patients with HNSCC eventually relapse. Now scientists at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry have revealed a potential new combination therapy to treat advanced head and neck squamous cell carcinoma. Using a mouse model, researchers found that using an anti-PD1 immunotherapy drug in combination with PTC209, an inhibitor that targets the protein BMI1, successfully stopped the growth and spread of the cancer, prevented reoccurrences, and eliminated cancer stem cells.

Their findings, BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse, is published in Cell Stem Cell.

PD1 blockade combined with chemotherapy has been approved for recurrent or metastatic head and neck cancer. However, response rates remain low and response duration is suggesting that this type of cancer might be resistant to PD1 blockade.

The researchers sought to overcome the resistance and had been studying the role of cancer stem cells and the protein BMI1. BMI1, a polycomb group (PcG) protein, plays a critical role in epigenetic regulation of cell differentiation and proliferation, and cancer stem cell self-renewal.

The researchers used a mouse model of HNSCC that mimicked human cancer development and metastasis, allowing them to perform lineage tracing of BMI1-positive cancer stem cells in an undisturbed tumor immune microenvironment. Then they tested whether BMI1 cancer stem cells could be eliminated by PD1 blockade-based combination therapy using both pharmacological and genetic inhibition of BMI1.

Here, we show that the combination treatment of anti-PD1 and cisplatin enriched BMI1+ CSCs in HNSCC while inhibiting HNSCC growth. In contrast, the pharmacological and genetic inhibition of BMI1 eliminated BMI1+ CSCs and enabled PD1 blockade therapy, resulting in the inhibition of metastatic HNSCC and prevention of HNSCC relapses, the researchers wrote.

BMI1 inhibition induced tumor cell-intrinsic immune responses by recruiting and activating CD8+ T cells along with eliminating BMI1 and cancer stem cells.

This is the first preclinical study to provide evidence that targeting BMI1 proteins enhances immunotherapy and eliminates cancer stem cells by activating antitumor immunity. This discovery holds promise for those with advanced head and neck cancers who are treated with PD1 blockade, but later become resistant to therapy.

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Potential Combination Therapy Discovered for Treating Head and Neck Squamous Cell Carcinoma - Genetic Engineering & Biotechnology News

Eikonoklastes Therapeutics Closes Oversubscribed Seed Financing to Advance Next-Generation Tissue Factor (TF) Immunotherapies With Initial Focus on…

By Stem Cell Treatment

CINCINNATI--(BUSINESS WIRE)-- Eikonoklastes Therapeutics, a preclinical stage biopharmaceutical company developing next-generation tissue factor (TF) immunotherapies for triple-negative breast cancer (TNBC) and several other diseases with unmet clinical need, today announced closing of an oversubscribed seed financing. Working with The Ohio State University Corporate Engagement Office and seed investor CincyTech, the company was formed to advance technology discovered and engineered in the lab of Dr. Zhiwei Hu, MD, PhD, and licensed from the Ohio State Innovation Foundation. CincyTech led the financing.

Eikonoklastes is developing novel immunotherapies that target tissue factor, a cell surface receptor that is prevalent in certain pathological cells-- but not healthy cells-- including a broad range of cancers with high unmet clinical need and high morbidity. The lead indication is triple- negative breast cancer, an aggressive cancer which accounts for 15% of all breast cancers, with an average mortality of ~18 months post diagnosis.

There is an urgent and critical need for a novel approach, said Bruce Halpryn, PhD, co-founder and CEO of Eikonoklastes. Eikonoklastes platform technology is designed for maximum efficacy and a superior safety profile, using targeted killing without the need for a toxic payload. This is a tremendous opportunity to treat numerous diseases.

Eikonoklastes L-ICON3 immune conjugate platform was discovered and engineered by scientific founder, Zhiwei Hu, MD, PhD, an early pioneer of tissue factor physiology, who has worked to leverage tissue factor as a highly specific and highly selective target for therapy. In his lab at Ohio State, Dr Hu has engineered molecules which attack three key components of the tumor microenvironment: the tumor cells, the disease neovasculature and tumor stem cells; activating the bodys natural immune reaction. These novel and proprietary molecules are the third generation of technology that Dr. Hu initially designed while at Yale University.

Dr. Hu has worked on several iterations of the technology that Eikonoklastes has licensed. We are grateful for his partnership and his dedication to discovery and innovation, said Scott Osborne, vice president of economic and corporate engagement at Ohio State.

The seed round will enable the company to complete a confirmatory in vivo I.V. efficacy study, to study I.V. pharmacokinetics, and to initiate manufacturing scaleup. The company will be headquartered in Cincinnati, OH.

We are impressed with the breadth of the opportunity, which has the potential to address critical needs for patient populations across a broad range of cancers and other diseases, said John Rice, PhD, Managing Director at CincyTech. We are also pleased to invest in the Eikonoklastes team, led by a seasoned and successful entrepreneur in Bruce Halpryn, with whom we had worked previously on Myonexus Therapeutics.

Halpryn and Chief Scientific/Medical Officer Mark Dato, MD, PhD, are both drug development industry veterans who worked together at P&G Pharmaceuticals. More recently Halpryn was COO of Myonexus Therapeutics, a gene therapy company also backed by CincyTech that was acquired by Sarepta Therapeutics in 2019. Halpryn then approached CincyTech about his next venture, co-founding Eikonoklastes with Sam Lee, MD, MBA, MPH, who will serve as Chief Business Officer. Details of the financing are undisclosed.

ABOUT EIKONOKLASTES THERAPEUTICS Eikonoklastes Therapeutics is advancing a new generation of tissue factor (TF) immunotherapies for the treatment of triple-negative breast cancer and other cancers and diseases with high morbidity and unmet clinical needs. Eikonoklastes proprietary molecules are engineered for maximum efficacy and a superior safety profile.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200722005443/en/

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Eikonoklastes Therapeutics Closes Oversubscribed Seed Financing to Advance Next-Generation Tissue Factor (TF) Immunotherapies With Initial Focus on...

Longevity And Anti-Senescence Therapy Market Analysis, Trends, and Forecasts size- COVID-19 2023 – Cole of Duty

By Stell Cell Research

Theglobal longevity and anti-senescence therapies marketshould grow from $329.8 million in 2018 to $644.4 million by 2023 with a compound annual growth rate (CAGR) of 14.3% during 2018-2023.

Report Scope:

The scope of this report is broad and covers various therapies currently under trials in the global longevity and anti-senescence therapy market. The market estimation has been performed with consideration for revenue generation in the forecast years 2018-2023 after the expected availability of products in the market by 2023. The global longevity and anti-senescence therapy market has been segmented by the following therapies: Senolytic drug therapy, Gene therapy, Immunotherapy and Other therapies which includes stem cell-based therapies, etc.

Revenue forecasts from 2028 to 2023 are given for each therapy and application, with estimated values derived from the expected revenue generation in the first year of launch.

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The report also includes a discussion of the major players performing research or the potential players across each regional longevity and anti-senescence therapy market. Further, it explains the major drivers and regional dynamics of the global longevity and anti-senescence therapy market and current trends within the industry.

The report concludes with a special focus on the vendor landscape and includes detailed profiles of the major vendors and potential entrants in the global longevity and anti-senescence therapy market.

Report Includes:

71 data tables and 40 additional tables An overview of the global longevity and anti-senescence therapy market Analyses of global market trends, with data from 2017 and 2018, and projections of compound annual growth rates (CAGRs) through 2023 Country specific data and analysis for the United States, Canada, Japan, China, India, U.K., France, Germany, Spain, Australia, Middle East and Africa Detailed description of various anti-senescence therapies, such as senolytic drug therapy, gene therapy, immunotherapy and other stem cell therapies, and their influence in slowing down aging or reverse aging process

Coverage of various therapeutic drugs, devices and technologies and information on compounds used for the development of anti-ageing therapeutics A look at the clinical trials and expected launch of anti-senescence products Detailed profiles of the market leading companies and potential entrants in the global longevity and anti-senescence therapy market, including AgeX Therapeutics, CohBar Inc., PowerVision Inc., T.A. Sciences and Unity Biotechnology

Summary

Global longevity and anti-senescence therapy market deals in the adoption of different therapies and treatment options used to extend human longevity and lifespan. Human longevity is typically used to describe the length of an individuals lifetime and is sometimes used as a synonym for life expectancy in the demography. Anti-senescence is the process by which cells stop dividing irreversibly and enter a stage of permanent growth arrest, eliminating cell death. Anti-senescence therapy is used in the treatment of senescence induced through unrepaired DNA damage or other cellular stresses.

Global longevity and anti-senescence market will witness rapid growth over the forecast period (2018-2023) owing to an increasing emphasis on Stem Cell Research and an increasing demand for cell-based assays in research and development.

An increasing geriatric population across the globe and a rising awareness of antiaging products among generation Y and later generations are the major factors expected to promote the growth of global longevity and anti-senescence market. Factors such as a surging level of disposable income and increasing advancements in anti-senescence technologies are also providing traction to the global longevity and anti-senescence market growth over the forecast period (2018-2023).

According to the National Institutes of Health (NIH), the total geriatric population across the globe in 2016 was over REDACTED. By 2022, the global geriatric population (65 years and above) is anticipated to reach over REDACTED. An increasing geriatric population across the globe will generate huge growth prospectus to the market.

Senolytics, placenta stem cells and blood transfusions are some of the hot technologies picking up pace in the longevity and anti-anti-senescence market. Companies and start-ups across the globe such as Unity Biotechnology, Human Longevity Inc., Calico Life Sciences, Acorda Therapeutics, etc. are working extensively in this field for the extension of human longevity by focusing on study of genomics, microbiome, bioinformatics and stem cell therapies, etc. These factors are poised to drive market growth over the forecast period.

Global longevity and anti-senescence market is projected to rise at a CAGR of REDACTED during the forecast period of 2018 through 2023. In 2023, total revenues are expected to reach REDACTED, registering REDACTED in growth from REDACTED in 2018.

The report provides analysis based on each market segment including therapies and application. The therapies segment is further sub-segmented into Senolytic drug therapy, Gene therapy, Immunotherapy and Others. Senolytic drug therapy held the largest market revenue share of REDACTED in 2017. By 2023, total revenue from senolytic drug therapy is expected to reach REDACTED. Gene therapy segment is estimated to rise at the highest CAGR of REDACTED till 2023. The fastest growth of the gene therapy segment is due to the Large investments in genomics. For Instance; The National Human Genome Research Institute (U.S.) had a budget grant of REDACTED for REDACTED research projects in 2015, thus increasing funding to REDACTED for approximately REDACTED projects in 2016.

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Longevity And Anti-Senescence Therapy Market Analysis, Trends, and Forecasts size- COVID-19 2023 - Cole of Duty

Pioneering Surgical Approach Could be Used as Treatment for Progressive Blindness – Technology Networks

By Stell Cell Research

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Dry age-related macular degeneration (dry AMD) poses a significant clinical challenge. It is one of the leading causes of progressive blindness, robbing millions of people over the age of 65 of their central vision, and it often hinders patients abilities to read books, drive and discern the faces of their loved ones. Although vitamin-based supplements may slow progression, no treatments currently exist. A team of physicians and scientists at the USC Dr. Allen and Charlotte Ginsburg Institute for Biomedical Therapeutics (Ginsburg Institute) saw in this situation an opportunity to innovate and pioneer a novel treatment approach for dry AMD patients. Theirs has been a feat of scientific and surgical prowess, and over a decade of their diligence and ingenuity has resulted in what may become the first FDA-approved treatment to transform the prospects of regaining vision for millions of patients.

The Ginsburg Institute team, led by vitreoretinal surgeons Amir Kashani, MD, PhD, associate professor of ophthalmology at the Keck School of Medicine, and Mark Humayun, MD, PhD, director of the Ginsburg Institute and co-director of the USC Roski Eye Institute, developed a stem cell-based retinal implant and accompanying surgical procedure to help restore vision to dry AMD patients. Their innovative approach and insights from their phase 1/2a clinical trial are described in the latest print issue of the American Academy of Ophthalmologys journal Ophthalmology Retina.

In practice, being able to get underneath the retina, which is only about a quarter of a millimeter thick, to physically replace the RPE cell layer is a challenging task, explains Kashani, who is lead author of the publication. Normally we dont operate underneath the retina. Its a place you generally try to avoid during surgery, so that has been a very novel, challenging aspect of delivering these stem cells.

There are very few tools for performing surgery within the subretinal space. Most available tools were designed 30 to 40 years ago, are relatively bulky and are generally meant to remove scar tissue or other lesions rather than insert anything into the subretinal space. The Ginsburg Institute team decided that the most promising option was to start fresh and design a brand-new tool to fit their purpose.

The surgeons worked with materials and design engineers at the Ginsburg Institute to create single-use forceps with an internal compartment to encapsulate the implant and a roller-style thumbwheel to deploy it. The implant itself is shaped much like a champagne bottle, and the forceps grab onto the narrow end. Rolling the implant into the devices compartment causes it to fold into a curved shape, and the surgeon can ultimately release it to lay flat inside the eye.

In pre-clinical models, creating a bleb alone proved insufficient; the surgeons had to innovate again and ultimately used water pressure to dissect one cell layer from another in a process called targeted hydrodissection. To monitor progress during surgery and prevent complications, the team utilized an advanced imaging technique called optical coherence tomography (OCT) to visualize the dissection at the cellular level. One part of our job was to make this a very doable surgery and I think we have achieved that with this study, Kashani says.

Without tools like OCT, it would be very difficult to visualize the damage we need to treat, Kashani explains. He emphasizes that in addition to using OCT intraoperatively, he sees a promising role for the technology to be used in earlier-stage AMD patients to monitor the progression of their geographic atrophy. Its not a standard of practice to use OCT and other diagnostic methods to detect early and subtle disease changes, but that may prove to be really important for classifying disease and treating it in the future.

Kashani adds that one of the most rewarding aspects of the entire clinical trial process has been working with his patients and witnessing their commitment to making this translation from research lab to clinical practice possible. None of this is happening by magic. Patients are volunteering, and theyre taking a chance for the sake of advancing medicine and potentially helping countless other patients down the road. We always appreciate that effort and we thank the patients and their families, too.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Pioneering Surgical Approach Could be Used as Treatment for Progressive Blindness - Technology Networks

Global Cart Cell Therapy Market To Grow At A CAGR of 29.4% With The Emergence Of Immunotherapies In Medical Treatment – GlobeNewswire

By Stem Cell Medical Center

July 22, 2020 08:41 ET | Source: Quince Market Insights

Pune, India, July 22, 2020 (GLOBE NEWSWIRE) -- The global cart cell therapy market size was valued at USD 355.1 million in 2018 and is anticipated to grow at a CAGR of 29.4% during the forecast period. For years, the foundations of cancer treatment were chemotherapy, surgery, and radiation therapy. With the development of targeted therapies like trastuzumab (Herceptin) and imatinib (Gleevec), drugs that target cancer cells have cemented themselves as standard treatments for many types of cancers.

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But in recent years, immunotherapy has emerged as the "fifth pillar" of cancer treatment. The use of CAR T-cell clinical trials has captured the attention of researchers and the public alike because of the remarkable responses they have produced in both children and adults. Studies of CAR T-cell therapy in other blood cancers and treatment of solid tumors is also underway, researchers are exploring the application of CAR T-cell therapy.

The COVID-19 Impact on the Global Cart Cell Therapy Market

CAR-T and TCR-T therapies have revolutionized blood cancer treatment. Scientists at Duke-NUS Medical School are studying the potential of turning this approach for the treatment of COVID-19 patients.

Researchers suggest these immunotherapies might also be useful in treating SARS-CoV-2, the virus causing the current pandemic. Several organizations are also working on cell therapies for COVID-19. AlloVir and Baylor College of Medicine have partnered to develop an off-the-shelf therapy to target and treat the novel coronavirus.

The battle against COVID-19 is taking place across thousands of fronts in the U.S., from underfunded rural regional hospitals to the steel and glass high-rises of well-endowed university centers. What becomes clear when speaking with clinicians across the nation is that the effect of the pandemic on the delivery of CAR T-cell therapy depends on the type of center that provides it, as well as its location.

There were some initial delays providing CAR T-cell treatments at Mayo Clinic in Rochester, Minnesota, but they were short-lived and imposed in the name of patient safety as the institution looked to acquire an accurate diagnostic test to determine which patients had COVID-19.

CD19 to Lead the Target Antigen Segment of the Cart Cell Therapy Market

As per the current market scenario in 2018, the CD19 segment has covered the largest cart cell therapy market share and is projected to register a higher CAGR during the forecast period.

Besides, the growing need for integrated healthcare systems is responsible for the high demand for CD19 in the global cart cell therapy market.

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Cart Cell Therapy to Benefit Treatment of Blood Cancer Propelling the Growth of the Market

The application for the generation of revenues in the global cart cell therapy market is acute lymphoblastic leukemia, diffuse large b-cell lymphoma, and others. The acute lymphoblastic leukemia segment is predicted to account for the largest share. Cart Cell Therapy provides alternative therapeutic options for patients who failed to respond to conventional treatment or relapse for acute lymphoblastic leukemia which is a type of blood cancer.

Increasing Research Studies and Clinical Trials to Fuel the Growth of the Healthcare Segment

In 2018, healthcare accounted for the largest share of the end-user segment. As cart cell therapy improves clinical outcomes by helping to improve disease management. This will result in a shorter duration of hospitalization and overall physician observation hours.

North America Held a Major Market Share of the Global Cart Cell Therapy Market

North America holds a dominant position in the global cart cell therapy market. The region's dominance is attributable to favorable government policies for the prevention of disease and HCIT adoption, increasing funding for population health management, raising prevalence of chronic diseases, and the presence of well-developed healthcare infrastructure. For Instance, in 2010, the U.S. government implemented the Patient Protection and Affordable Care Act which encourages a high quality of care and reduces costs. The act has encouraged the creation of Accountable Care Organizations (ACOs), including the Medicare Shared Savings Program (MSSP).

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Companies Collaborate & Promote R&D along with Product Development

Cart Cell Therapy Market vendors are making substantial efforts in adopting advanced technologies essentially by allying and partnering that will help to facilitate the demand for Cart Cell Therapy.

Key participants include operating in the market include Bellicum Pharmaceuticals, Kite Pharma, Novartis AG, Mustang Bio, CARsgen Therapeutics, Sorrento Therapeutics, Autolus Therapeutics, Cellectis, Pfizer Inc., Legend Biotech, and others.

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About US

Quince Market Insights is a global market research and consulting company publishing syndicate studies as well as consulting assignments pertaining to markets that promise high growth opportunities in strategic future. We are dedicated team of analysts with strong base in technical expertise as well as thorough understanding of the market dynamics. Some of key areas expertise includes chemicals, advanced materials, construction, mining, food & agriculture, automotive, machines & equipment, and others. We analyze emerging trends in relatively nascent markets that promise high growth opportunities in future. We focus towards precision research practices that provide accurate market estimations and forecasts. This helps our clients to make proper estimations with regards to demand analysis, regional growth, major competitors, and dynamics of the market.

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Global Cart Cell Therapy Market To Grow At A CAGR of 29.4% With The Emergence Of Immunotherapies In Medical Treatment - GlobeNewswire

Takeaways from the As loss to the Giants: why is the offense cold? – The Mercury News

By Platelet Rich Plasma Injections

The Oakland As traveled across the Bay Bridge to play the second of a two-game exhibition series against the San Francisco Giants, losing 4-2.

This short and semi-sweet summer is over, and the As are clearly shaking off some rust heading into Opening Day at home against the Los Angeles Angels at the Oakland Coliseum.

Here are some takeaways from the last exhibition game of 2020.

As offense goes cold

The As scored all of four runs in these two losses. Stephen Piscotty hit a home run on Monday, and Chad Pinder hit a two-run double off the deep centerfield bricks at Oracle Park on Tuesday that the naked eye tells us was actually a home run.

Manager Bob Melvin challenged it, and the base hit call was upheld with very little explanation.

That the As faced 18 different pitchers in 18 innings probably didnt help ignite the offensive momentum. But, rare high points and a handful of competitive at bats aside, the As put together some rough plate appearances in these exhibition games.

We would have like to have better offense here the last couple games, just didnt happen, manager Bob Melvin said. We have a good offensive team, so its not concerning. Just didnt do a whole lot.

The As struck out eight times on Monday, 12 times on Tuesday. Through these two games, theyve collected six hits and eight walks.

If the As want to avoid a slow star thats plagued them in recent years, the sluggish offense theyve displayed certainly isnt promising.

Whos on second?

For all the hullabaloo surrounding second base during Spring Training 1.0 will it be Jorge Mateo? Tony Kemp? Franklin Barreto? Vimael Machin? Will there be a platoon? Will one player play the lions share? theres a chance Pinder could be the starting second baseman against Angels left-handed starter Andrew Heaney, Melvin said.

If not at second, expect Pinder somewhere in the lineup.

Pinder has been a standout at the plate during this camp, and hes had success against left-handed pitching: slashing .252/.313/.436 with a .748 OPS and 112 wRC+ against them.

If Pinder starts at second base, what does this mean for Barreto? He had one at bat in Tuesdays game, resulting in a strikeout. None on Monday.

Barreto also caught the teams attention at camp, where he hit two quick home runs off Frankie Montas and Liam Hendriks. Coaches have said that Barreto is in need of consistent at bats to show that his high ceiling he demonstrated in the minor leagues power at the plate, speed on the bases can translate to the big leagues.

Having too much talent at one position is a good problem to have. But, somehow the second base picture got a little more fuzzy. Maybe thats OK.

Fiers got the start at Oracle Park on Tuesday, allowing two home runs to Mike Yastrzemski to lead off the first inning and Alex Dickerson in the second inning on 67 pitches in 3.1 innings. He walked Pablo Sandoval before his exit in the fourth, and Sandoval scored on a sac fly off of Joakim Soria for Fiers third earned run.

The right-handed pitchers command was a tad off and he fumbled a few signs with catcher Austin Allen.

Allen, who was named to the 30-man roster as the backup catcher, is still adjusting to Fiers unpredictability and backwards pitching style.

I made it tough on myself, Fiers said after his start. I was just wild. Wasnt throwing the ball exactly where I wanted to. Just a little erratic.

Got another five days before games actually start, for me at least.

Fiers first meaningful start should come on Sunday, where hell go head-to-head with Angels phenom Shohei Ohtani. Fiers missed the first few days of camp taking extra precautions due to exposure to Jess Luzardo, who tested positive for the coronavirus prior to report day.

Because Fiers threw bullpens during the hiatus, he wasnt too far behind his fellow rotation mates. Even if this start left a sour taste in his mouth, Fiers curveball looked season ready.

Remember, Fiers curveball had one of the best vertical drops in baseball in 2019. His 70.7 vertical drop is 7.7 inches over the league average which ranks eighth in all of baseball.

Chris Bassitt looks ready to roll

Bassitt was a step behind the rest of the starters heading into camp. He hadnt faced live hitting during the hiatus like the others had.

He caught up quickly, and looked rotation ready dealing four innings with five strikeouts in Tuesdays game. His fastball hit 95 mph and he had command of his changeup and curveball.

Hell pitch fourth out of the rotation, on Monday against the Angels.

A.J. Puk and Jess Luzardo update

Puk traveled to Los Angeles to meet with Dr. Neal ElAttrache on Monday and received platelet-rich plasma and cortisone injections in his strained left shoulder, As manager Bob Melvin said Tuesday.

Puk is likely to be sidelined for two weeks, at least, and is resting for the next 48 hours.

The left-handed pitcher was slotted to start the season in the fifth spot of Oaklands rotation, but was placed on the 10-day IL. Right-handed pitcher Daniel Mengden will fill in for him in the rotation until Puks return from injury.

Jess Luzardo is slated to pitch in either the first or second game of the regular season, Melvin announced. Luzardo, who missed the first two weeks of camp after testing positive for coronavirus, is expected to come out of the bullpen and build his arm up to pitching three innings until he can be slotted into the rotation.

Luzardo pitched to Ramn Laureano in live batting practice prior to Mondays game against the San Francisco Giants.

Other notes

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Takeaways from the As loss to the Giants: why is the offense cold? - The Mercury News

Global Stem Cell Assay Market to Witness Heightened Growth During the Period 2017 2025 – 3rd Watch News

By Embryonic Stem Cells

The undifferentiated biological cells that can differentiate into specialized cells are called as stem cells. In the human body during early life and growth phase, stem cells have the potential to develop into other different cell types. Stem cells can differ from other types of cells in the body. There are two types of stem cells namely the embryonic stem cells and adult stem cells. Adult stem cells comprise of hematopoietic, mammary, intestinal, neural, mesenchymal stem cells, etc. All stem cells have general properties such as capability to divide and renew themselves for long period.

Stem cells are unspecialized and can form specialized cell types. The quantitative or qualitative evaluation of a stem cells for various characteristics can be done by a technique called as stem cell assay. The identification and properties of stem cells can be illustrated by using Stem Cell Assay. The new developments in the field of stem cell assay research related to the claim of stem cell plasticity have caused controversies related to technical issues. In the study of stem cell assay, most conflicting results arise when cells express stem cell characteristics in one assay but not in another. The most important factor is that the true potential of stem cells can only be assessed retrospectively. The retrospective approach refers to back drop analysis which provides quantitative or qualitative evaluation of stem cells. The development in embryonic & adult stem cells assay will be beneficial to the global stem cell assay market.

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Stem cell assays find applications in pharmaceutical & biotechnology companies, academic & research institutes, government healthcare institutions, contract research organizations (CROs) and others. The influential factors like chronic diseases, increased investment in research related activities, and technological advancements in pharmaceutical & biotech industry is anticipated to drive the growth of the global stem cell assay market during the forecast period. The cost of stem cell based therapies could be one of the major limiting factor for the growth of the global stem cell assay market.

The global stem cell assay market has been segmented on the basis of kit type, application, end user and region. The global stem cell assay market can be differentiated on the basis of kit type into human embryonic stem cell kits and adult stem cell kits. The adult stem cell kit includes hematopoietic stem cell kits, mesenchymal stem cell kits, induced pluripotent stem cell kits (IPSCs), and neuronal stem cell kits. The adult stem cell kits are projected to witness the highest CAGR during the forecast period due to the ease of use, cost & effectiveness of this type of kit in stem cell analysis.

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Based on application global stem cell assay market is based on drug discovery and development, therapeutics and clinical research. The therapeutics segment includes oncology, dermatology, cardiovascular treatment, orthopedic & musculoskeletal spine treatment, central nervous system, diabetes and others.

Depending on geographic segmentation, the global stem cell assay market is segmented into five key regions: Asia Pacific, North America, Europe, Latin America, and Middle East & Africa. North America is expected to contribute significant share to the global stem cell assay market. The stem cell assay market in Europe, has gained impetus from the government & industrial initiatives for stem cell based research and the market in Europe is expected to grow at a remarkable pace during the forecast period.

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The major players in the global stem cell assay market include

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Global Stem Cell Assay Market to Witness Heightened Growth During the Period 2017 2025 - 3rd Watch News

Kidney Detox Market 2020 to Witness Lucrative Growth in Coming Years with Top Key Players- Becton, Danaher Corporation, Merck Millipore – Cole of Duty

By Embryonic Stem Cells

Kidney Detox Industry Report focuses on Market Influence Factors, Growth Drivers, Restraints, Trends and Opportunities so that Market Players can face any challenges and take advantage of Lucrative Prospects available in the Global Kidney Detox market.

The kidney detox market is segmented on the basis of product, technology, application and end user. Based on technology, the market is segmented as fluorescence-based droplet kidney detox, magnetic-activated kidney detox (MACS), micro-electromechanical systems (MEMS) microfluidics. On the basis of product, the market is categorized as cell sorters, kidney detox reagents and consumables, kidney detox services. On the basis of application, the market is categorized as research, clinical. On the basis of end user, the market is categorized as research institutes, pharmaceutical and biotechnology companies, medical schools, hospitals and clinical testing laboratories.

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Kidney DetoxMarket by COVID19 Impact Analysis and Top Manufacturers:

Some of the key players profiled in the study areBecton, Dickinson and Company, Bio-Rad Laboratories, Danaher Corporation, Merck Millipore, pluriSelect Life Science UG & Co. KG, STEMCELL Technologies Inc., Sysmex Partec GmbH, Terumo BCT, Inc., Thermo Fisher Scientific, Union Biometrica, Inc., etc.

Kidney detox is a technique to purify cell populations based on the presence or absence of specific physical characteristics. Kidney detox allows the separation of cells based on their intra- or extracellular properties, including DNA, RNA, and protein interactions, size, and surface protein expression. This is a unique attribute of many stem cell populations, including hematopoietic, embryonic, and cancer stem cells.

The kidney detox market is driving due to the growing prevalence of chronic diseases and cancer and the increasing demand for cell therapies for the treatment of these diseases. However, the high cost of devices, stringent regulations, and lack of skilled personnel with sound technical know-how is likely to restraint the market growth during the forecast period. Moreover, the rise in government initiatives to enhance health care facilities, focus on research and increase in research funding contribute to the growth of the market for kidney detox.

Key Benefits

The report profiles the key players in the industry, along with a detailed analysis of their individual positions against the global landscape. The study conducts SWOT analysis to evaluate strengths and weaknesses of the key players in the Kidney Detox market. The researcher provides an extensive analysis of the Kidney Detox market size, share, trends, overall earnings, gross revenue, and profit margin to accurately draw a forecast and provide expert insights to investors to keep them updated with the trends in the market.

Competitive scenario:

The study assesses factors such as segmentation, description, and applications of Kidney Detox industries. It derives accurate insights to give a holistic view of the dynamic features of the business, including shares, profit generation, thereby directing focus on the critical aspects of the business.

Scope of the Report

The research on the Kidney Detox market focuses on mining out valuable data on investment pockets, growth opportunities, and major market vendors to help clients understand their competitors methodologies. The research also segments the Kidney Detox market on the basis of end user, product type, application, and demography for the forecast period 20212027. Comprehensive analysis of critical aspects such as impacting factors and competitive landscape are showcased with the help of vital resources, such as charts, tables, and infographics.

Promising Regions & Countries Mentioned in The Kidney Detox Market Report:

Major highlights of the report:

All-inclusive evaluation of the parent market

Evolution of significant market aspects

Industry-wide investigation of market segments

Assessment of market value and volume in past, present, and forecast years

Evaluation of market share

Study of niche industrial sectors

Tactical approaches of market leaders

Lucrative strategies to help companies strengthen their position in the market

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Thanks for reading this article; you can also customize this report to get select chapters or region-wise coverage with regions such as Asia, North America, and Europe.

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Kidney Detox Market 2020 to Witness Lucrative Growth in Coming Years with Top Key Players- Becton, Danaher Corporation, Merck Millipore - Cole of Duty

Cell Culture Market 2019 | Industry Size, Trends, Global Growth, Insights and Forecast Research Report 2025 – Cole of Duty

By Stell Cell Research

Up Market Research (UMR), one of the worlds prominent market research firms has announced a novel report on Global Cell Culture Market. The report contains vital insights on the market which will support the clients to make the right business decisions. This research will help both existing and new aspirants for Cell Culture market to figure out and study the market needs, market size, and competition. The report incorporates data regarding the supply and demand situation, the competitive scenario, and the challenges for market growth, market opportunities, and the threats faced by key players during the forecast period of 2020-2026.

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Impact of COVID-19 on Cell Culture Market

The report also includes the impact of ongoing global crisis i.e. COVID-19 on the Cell Culture market and what the future holds for it. It provides an analysis of the effects of the pandemic on the global economy. The outbreak has directly disturbed the demand and supply chain. The report also analyzes the financial impact on firms and financial markets. Up Market Research (UMR) has gathered insights from several delegates of the industry and got involved in the primary and secondary research to provide the clients with data and strategies to combat the market challenges during and after COVID-19 pandemic.

Benefits of buying the report:

Industry experts and research analysts have worked extensively to prepare the research report which will help you to give that extra edge in the competitive market. The market research report can be customized according to you to your needs. This means that Up Market Research (UMR) can cover a particular product, application, or can provide a detailed analysis in the report. You can also purchase a separate report for a specific region.

You can buy the complete report @ https://www.upmarketresearch.com/buy/cell-culture-market-research-2019

Some of the major companies that are covered in this report:

Thermo Fisher Merck Millipore Corning GE Healthcare BD Takara Lonza HiMedia CellGenix PromoCell

*Note: Additional companies can be included on request

The market scenario is likely to be fairly competitive. To analyze any market with simplicity the market is fragmented into the following segments:

By Application:

Biopharmaceutical Manufacturing Tissue Culture & Engineering Gene Therapy Other

By Type:

Classical Media & Salts Serum-free Media Stem Cell Media Others

By Geographical Regions

Asia Pacific: China, Japan, India, and Rest of Asia Pacific Europe: Germany, the UK, France, and Rest of Europe North America: The US, Mexico, and Canada Latin America: Brazil and Rest of Latin America Middle East & Africa: GCC Countries and Rest of Middle East & Africa

Segmenting the market into smaller components helps in analyzing the dynamics of the market with more clarity. Another key component that is included in the report is the regional analysis to assess the global presence of the Cell Culture market. You can also opt for a yearly subscription of all the updates on the Cell Culture market.

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Below is the TOC of the report:

Executive Summary

Assumptions and Acronyms Used

Research Methodology

Cell Culture Market Overview

Cell Culture Supply Chain Analysis

Cell Culture Pricing Analysis

Global Cell Culture Market Analysis and Forecast by Type

Global Cell Culture Market Analysis and Forecast by Application

Global Cell Culture Market Analysis and Forecast by Sales Channel

Global Cell Culture Market Analysis and Forecast by Region

North America Cell Culture Market Analysis and Forecast

Latin America Cell Culture Market Analysis and Forecast

Europe Cell Culture Market Analysis and Forecast

Asia Pacific Cell Culture Market Analysis and Forecast

Middle East & Africa Cell Culture Market Analysis and Forecast

Competition Landscape

If you have any questions on this report, feel free to reach us! @ https://www.upmarketresearch.com/home/enquiry_before_buying/67793

About Up Market Research (UMR):

Up Market Research (UMR) has a vast experience in making customized market research reports in various industry verticals. Our motto is to provide complete client satisfaction. We cover in-depth market analysis, which consists of stipulating lucrative business strategies, especially for the new entrants and the emerging players of the market. We make sure that each report goes through intensive primary, secondary research, interviews, and consumer surveys before final dispatch.

We invest in our analysts to ensure that we have a full roster of experience and expertise in any field we cover. Our team members are selected for stellar academic records, specializations in technical fields, and exceptional analytical and communication skills. We also provide ongoing training and knowledge sharing to keep our analysts tapped into industry best practices and loaded with information.

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Cell Culture Market 2019 | Industry Size, Trends, Global Growth, Insights and Forecast Research Report 2025 - Cole of Duty

Adipose Derived Stem Cell Therapy Market Driven by Growing Research into Medical Applications of cel – PharmiWeb.com

By Stem Cell Treatment

Adipose-derived stem cells (ADSCs) are a part of stem cells that are derived from adipocytes and can differentiate into a variety of cell types. They have multipotency like bone marrow mesenchymal stem cells, therefore they are also considered as a substitute for bone marrow as a source of stem cells.

Adipose stem cells (ASCs) can be extracted from adipose by manual as well as automatic stem cell separation technique and flow cytometry is the most common method employed to isolate ADSCs from other stem cells within a cell solution.

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Adipose-derived stem cells are gaining demand as a new cell source in regenerative medicine therapies as they can be differentiated into a variety of different cell lineages. Moreover, these stem cells also have anti-inflammatory, immunomodulatory, anti-apoptotic, pro-angiogenic, and anti-scarring properties, which improve their effectiveness and expand their application.

Adipose-Derived Stem Cell Therapy Market Drivers

Growing demand for adipose-derived stem cell therapy across medical and biotechnology fields owing to its effectiveness along with a rising number of research and development in activities by the various organizations is projected to foster the market growth of adipose-derived stem cell therapy over the forecast period. Adipose-derived stem cells (ADSCs) have expanded to various applications in medical and biomedical science field such as treatment of diabetes; regeneration of tissues partially in osteogenic, adipogenic, chondrogenic, and cardiovascular areas of medicine; bone regeneration; fat reconstruction; and myocardial and cardiovascular regeneration; among others

For instance, in November 2018, a peer-reviewed case study conducted using a stem cell processed by Celltex Therapeutics Corporation showed the improvement in disease findings following systemic administration of autologous adipose-derived mesenchymal stem cells (MSCs).

Browse Global Strategic Business Report: https://www.coherentmarketinsights.com/ongoing-insight/adipose-derived-stem-cell-therapy-market-2357

Adipose-Derived Stem Cell Therapy Market Regional Analysis

North America is projected to hold a dominant position in the global adipose-derived stem cell therapy market and account the largest market share during the forecast period, and this can be attributed to strong presence of key players in the region, which are actively engaged in research & development activities and implementing inorganic growth strategies such as acquisition and collaboration to increase its market share.

For instance, in December 2017, Mesoblast Limited made exclusive license agreement with TiGenix NV, through which Mesoblast granted TiGenix exclusive access to certain of its patents to support global commercialization of Cx601, adipose-derived mesenchymal stem cell product, for the local treatment of fistulae.

Adipose-Derived Stem Cell Therapy Market Restraint

On the other side, high costs associated with stem cell processing, lack of skilled professionals for managing, preserving, and monitoring of stem cell lines are expected to restrain the market growth of adipose-derived stem cell therapy market during the forecast period.

For instance, Bioinformant a research firm engaged in stem cell research released a data on November 2018, on the cost of stem cell therapy and various key factors impacting the cost of stem cell therapy including types of stem cells used within the procedure, number of treatment, and the site of the clinic. The study findings reveal the cost of stem cell therapy ranges between US$ 5,000-8,000 per patient, in some cases, it may raise as much as US$ 25,000 or more depending on the complexity of the procedure.

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Adipose-Derived Stem Cell Therapy Market Key Players

Key players operating in the global adipose-derived stem cell therapy market include BioRestorative Therapies, Inc., Celltex Therapeutics Corporation, Antria, Inc., Cytori Therapeutics Inc., Intrexon Corporation, Mesoblast Ltd., iXCells Biotechnologies, Pluristem Therapeutics, Inc., Thermo Fisher Scientific, Inc., Tissue Genesis, Inc., Cyagen US Inc., Celprogen, Inc., and Lonza Group, among others.

Adipose-Derived Stem Cell Therapy Market Taxonomy:

The global adipose-derived stem cell therapy market is segmented based on cell type, product type, application, end-user, and region.

By Cell Type

By Product Type

By Application

By End-User

By Region

About Us:

Coherent Market Insights is a global market intelligence and consulting organization focused on assisting our plethora of clients achieve transformational growth by helping them make critical business decisions. We are headquartered in India, having office at global financial capital in the U.S. and sales consultants in United Kingdom and Japan. Our client base includes players from across various business verticals in over 150 countries worldwide. We pride ourselves in catering to clients across the length and width of the horizon, from Fortune 500 enlisted companies, to not-for-profit organization, and startups looking to establish a foothold in the market. We excel in offering unmatched actionable market intelligence across various industry verticals, including chemicals and materials, healthcare, and food & beverages, consumer goods, packaging, semiconductors, software and services, Telecom, and Automotive. We offer syndicated market intelligence reports, customized research solutions, and consulting services.

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