Tribute to Andra Campbell after five-year cancer battle | Romsey Advertiser – Romsey Advertiser

A MOTHER has paid tribute to her brave star who passed away this week after a five-year battle with cancer.

Andra Campbell was diagnosed with acute myeloid leukaemia after collapsing at her Roman Way home in August of 2015.

As reported in the Advertiser, a global search for a blood donor was later launched after it was discovered that she had rare blood cells due to her grandfathers St Lucian heritage.

Andra underwent a bone marrow transplant when her father, Paul, was found to be a suitable stem cell donor, and had been undergoing clinical trials at Oxford.

However, after the cancer returned for a third time she was told it was terminal. She died at the age of 33 on Saturday, July 4.

Andras mother, Beverley, has since paid tribute to her well-loved daughter and the legacy she leaves behind.

She was somebody who lived for life, said her mother, Beverley. She went all around the world, she travelled, she has friends all over. She was just the life and soul of the party.

Its incredible how many people she knew and how many people she touched. She was just a fun loving girl who touched a lot of hearts. And she fought hard. She had three lots of trying to get better, but it just didnt work for her.

The familys search for a blood donor took them to all corners of the globe.

From America to South Africa, they also shared an appeal on Asian radio station, before two possible matches from Israel were found, only to then fail a medical check.

Earlier this year she was readmitted to Basingstoke hospital, however her family were unable to be with her due to the Covid-19 situation. They were eventually told she had just days to live.

We had to listen to that over the phone because we werent allowed to be with her, he mother said. That poor little girl was just stuck there. She was all on her own even though people were desperate to be with her. It was heart-breaking.

She later returned home, surrounded by her closest friends and family, where she defied doctors expectations one more time.

All her friends from London came down and camped out, said Beverley.

The doctors said she would die within hours but she held on for another four days.

She was a fighter all the way - five years that girl fought for.

She just couldnt carry on. She was in so much pain.

She was well-loved and shes left a lot of people very heartbroken.

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Tribute to Andra Campbell after five-year cancer battle | Romsey Advertiser - Romsey Advertiser

Another four biotechs scratch out the first number and ask for more as IPO boom continues – Endpoints News

Four more biotechs are raising their offers in an already record year for biotech IPOs.

Softbank-backed Relay Therapeutics scratched out its original $200 million filing and proposed a $250 million raise that would make them a $1.5 billion company. CAR-T developer Poseida Therapeutics bumped itself up $74 million to $224 million. Off-the-shelf cell therapy startup Nkarta upped from $150 million to $215 million and then priced even higher, at $252 million. Frances Inventiva did its own modest reset, raising its bar from $102 million to $108 million.

Poseida, Nkarta and Inventiva priced today. Relay will price next week.

Barring a surprise flop, the latest flurry of raisesmeans there will be 13 $200 million-plus biotech IPOs in 2020 before August. By contrast, all of 2019 saw two biotechs pass that mark; 2018 saw 7 do so.

The run of eye-catching deals began in the first days of April when, after a pair of pandemic-driven stock market crashes, the small and little-known biotech Zentalis managed to score $165 million in a public offering. At the time, Nasdaqs Jordan Saxe told Bloomberghe expected biotech to open the IPO market back up, with its investors more focused on the long term than a short term that had the potential to be brutal. He predicted 30-35 IPOs for $3.5 billion and a series of blank check companies, a pair of predictions that have since looked prescient.

Its not just private companies that are getting in on the action. Public biotechs, too, have put out for large raises. This week alone Vir Biotechnology offered $300 million in a secondary offering, Revolution Medicines offered $156 million and Akero Therapeutics offered $188.2 million.

The buzz has allowed, among other things, very early stage companies to attract significant interest, including a single week in June when three preclinical biotechs raised over $200 million in a single week.

That trend has continued into this week. Nkarta, focused on natural killer cell therapies, has yet to bring a candidate into the clinic, although they plan to do so later this year. Relay Therapeutics, focused on solid tumors, only started their first trial earlier this year.

Poseida and Inventiva, though, are further along. With backing from Novartis, Poseidas BCMA CAR-T is already in Phase II and, earlier this year, they started recruiting for a Phase I with another CAR-T therapy. Inventiva is in Phase II for a NASH drug and a mucopolysaccharidosis type VI drug.

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Another four biotechs scratch out the first number and ask for more as IPO boom continues - Endpoints News

Hematopoietic Stem Cell Transplantation (HSCT) Market Demand Analysis and Projected huge Growth by 2025 – Daily Research Advisor

UpMarketResearch offers a latest published report on Global Hematopoietic Stem Cell Transplantation (HSCT) Market industry analysis and forecast 20192025 delivering key insights and providing a competitive advantage to clients through a detailed report. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. The report contains XX pages which highly exhibits on current market analysis scenario, upcoming as well as future opportunities, revenue growth, pricing and profitability.

Hematopoietic Stem Cell Transplantation (HSCT) Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report. The report contains basic, secondary and advanced information pertaining to the Hematopoietic Stem Cell Transplantation (HSCT) global status and trend, market size, share, growth, trends analysis, segment and forecasts from 20192025.

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The scope of the report extends from market scenarios to comparative pricing between major players, cost and profit of the specified market regions. The numerical data is backed up by statistical tools such as SWOT analysis, BCG matrix, SCOT analysis, and PESTLE analysis. The statistics are represented in graphical format for a clear understanding on facts and figures.

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Global Hematopoietic Stem Cell Transplantation (HSCT) Market, by Applications Peripheral Blood Stem Cells Transplant (PBSCT) Bone Marrow Transplant (BMT) Cord Blood Transplant (CBT)

The Major Players Reported in the Market Include: Regen Biopharma Inc China Cord Blood Corp CBR Systems Inc Escape Therapeutics Inc Cryo-Save AG Lonza Group Ltd Pluristem Therapeutics Inc ViaCord I

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About UpMarketResearch: Up Market Research (https://www.upmarketresearch.com) is a leading distributor of market research report with more than 800+ global clients. As a market research company, we take pride in equipping our clients with insights and data that holds the power to truly make a difference to their business. Our mission is singular and well-defined we want to help our clients envisage their business environment so that they are able to make informed, strategic and therefore successful decisions for themselves. Contact Info UpMarketResearch Name Alex Mathews Email [emailprotected] Website https://www.upmarketresearch.com Address 500 East E Street, Ontario, CA 91764, United States.

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Hematopoietic Stem Cell Transplantation (HSCT) Market Demand Analysis and Projected huge Growth by 2025 - Daily Research Advisor

Food Poisoning Bacteria Causes Autoimmunity and May Be Linked to Alzheimers and Parkinsons – Technology Networks

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Salmonella was previously thought to only form biofilms in the environment, such as on food processing surfaces. Biofilms are dense collections of bacteria that stick together on surfaces to protect the bacteria from harsh conditions, including antibiotics and disinfectants. Detecting biofilms in an animal during an infection was a surprise.

In research published today in PLoS Pathogens, a VIDO-InterVac team led by Dr. Aaron White (PhD) discovered that salmonella biofilms were formed in the intestines of infected mice. For the study, the team used a mouse model to replicate human food-borne illness and showed that a biofilm protein called curlithat grows on the surface of bacteriawas connected to negative health outcomes.

Curli are a special type of protein called amyloids. Similar human proteins have been associated with neurodegenerative diseases such as Alzheimers disease, Parkinsons disease, and Amyotrophic lateral sclerosis (ALS, or Lou Gehrigs disease). Scientists don't know how these diseases start, but have speculated that something must trigger the accumulation of amyloids.

We are the first to show that a food-borne pathogen can make these types of proteins in the gut, said White, a leading expert on salmonella biofilms and curli amyloids.

There has been speculation that bacteria can stimulate amyloid plaque formation in Alzheimers, Parkinsons and ALS and contribute to disease progression. The discovery of curli in the gut could represent an important link, pointing to a potentially infectious cause for these diseases.

Collaborator Dr. agla Tkel (PhD) and her team from Temple University determined that the presence of curli led to autoimmunity and arthritistwo conditions that are known complications of salmonella infections in humans.

In mice, these reactions were triggered within six weeks of infection, demonstrating that curli can be a major driver of autoimmune responses, said Tkel.

The next step in the research is to confirm that this also occurs in humans, and test if other food-borne pathogens related to salmonella can cause similar autoimmune reactions.

This important discovery suggests that food-borne pathogens could initiate or worsen autoimmunity and have the potential to contribute to amyloid disorders such as Alzheimers and Parkinsons disease, said VIDO-InterVac Director Dr. Volker Gerdts (DVM).

ReferenceIn vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection. Amanda L. Miller et al. PLOS Pathogens,July 9, 2020, https://doi.org/10.1371/journal.ppat.1008591.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Food Poisoning Bacteria Causes Autoimmunity and May Be Linked to Alzheimers and Parkinsons - Technology Networks

Global and Country Specific Cell Proliferation Kit Market Report 2020 Forecast, Opportunities and Strategies To 2027: COVID 19 Impact and Recovery Top…

Global Cell Proliferation Kit Market analysis 2015-2027, is a research report that has been compiled by studying and understanding all the factors that impact the market in a positive as well as negative manner. Some of the prime factors taken into consideration are: various rudiments driving the market, future opportunities, restraints, regional analysis, various types & applications, Covid-19 impact analysis and key market players of the Cell Proliferation Kit market. nicolas.shaw@cognitivemarketresearch.com or call us on +1-312-376-8303.

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Global Cell Proliferation Kit Market: Product analysis: Colorimetric Detection Method, Fluorescent Detection Method, Others

Global Cell Proliferation Kit Market: Application analysis: Clinical, Industrial & Applied Science, Stem Cell Research

Major Market Players with an in-depth analysis: Biological Industries, Thermo Fisher Scientific, Sigma Aldrich (Merck), BD Biosciences, GE, PerkinElmer, Millipoore (Merck), Bio Rad, Biotium

The research is presented in such a way that it consists of all the graphical representations, pie charts and various other diagrammatic representations of all the factors that are used for the research. Cell Proliferation Kit market research report also provides information on how the industry is anticipated to provide a highly competitive analysis globally, revenues generated by the industry and increased competitiveness and expansions among various market players/companies.

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The global estimations of the market value, market information/definition, classifications of all the types & applications, overall threats & dips that can be assumed and many other factors which consist the overall market scenario and its happening globally along with the forthcoming years are compiled in the Cell Proliferation Kit market research report. Hence this report can serve as a handbook/model for the enterprises/players interested in the Cell Proliferation Kit Market as it consists all the information regarding the Cell Proliferation Kit market.

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About Us: Cognitive Market Research is one of the finest and most efficient Market Research and Consulting firm. The company strives to provide research studies which include syndicate research, customized research, round the clock assistance service, monthly subscription services, and consulting services to our clients. We focus on making sure that based on our reports, our clients are enabled to make most vital business decisions in easiest and yet effective way. Hence, we are committed to delivering them outcomes from market intelligence studies which are based on relevant and fact-based research across the global market. Contact Us: +1-312-376-8303 Email: nicolas.shaw@cognitivemarketresearch.com Web: https://www.cognitivemarketresearch.com/

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Global and Country Specific Cell Proliferation Kit Market Report 2020 Forecast, Opportunities and Strategies To 2027: COVID 19 Impact and Recovery Top...

Stem Cell Antibody to Garner Brimming Revenues by 2019-2025 – Cole of Duty

In this report, the global Stem Cell Antibody market is valued at USD XX million in 2019 and is projected to reach USD XX million by the end of 2025, growing at a CAGR of XX% during the period 2019 to 2025.

For top companies in United States, European Union and China, this report investigates and analyzes the production, value, price, market share and growth rate for the top manufacturers, key data from 2019 to 2025.

The Stem Cell Antibody market report firstly introduced the basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the worlds main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the Stem Cell Antibody market report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.

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Segment by Type, the Stem Cell Antibody market is segmented into Primary Antibodies Secondary Antibodies

Segment by Application, the Stem Cell Antibody market is segmented into Proteomics Drug Development Genomics

Regional and Country-level Analysis The Stem Cell Antibody market is analysed and market size information is provided by regions (countries). The key regions covered in the Stem Cell Antibody market report are North America, Europe, Asia Pacific, Latin America, Middle East and Africa. It also covers key regions (countries), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc. The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by Type, and by Application segment in terms of sales and revenue for the period 2015-2026. Competitive Landscape and Stem Cell Antibody Market Share Analysis Stem Cell Antibody market competitive landscape provides details and data information by players. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on revenue (global and regional level) by players for the period 2015-2020. Details included are company description, major business, company total revenue and the sales, revenue generated in Stem Cell Antibody business, the date to enter into the Stem Cell Antibody market, Stem Cell Antibody product introduction, recent developments, etc.

The major vendors covered: Thermo Fisher Scientific, Inc. (U.S.) Merck Group (Germany), Abcam plc (U.K.) Becton, Dickinson and Company (U.S.) Bio-Rad Laboratories, Inc. (U.S.) Cell Signaling Technology, Inc. (U.S.) Agilent Technologies, Inc. (U.S.) F. Hoffmann-La Roche Ltd (Switzerland) Danaher Corporation (U.S.) GenScript (U.S.), PerkinElmer, Inc. (U.S.) Lonza (Switzerland), and BioLegend, Inc. (U.S.)

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The study objectives of Stem Cell Antibody Market Report are:

To analyze and research the Stem Cell Antibody market status and future forecast in United States, European Union and China, involving sales, value (revenue), growth rate (CAGR), market share, historical and forecast.

To present the Stem Cell Antibody manufacturers, presenting the sales, revenue, market share, and recent development for key players.

To split the breakdown data by regions, type, companies and applications

To analyze the global and key regions Stem Cell Antibody market potential and advantage, opportunity and challenge, restraints and risks.

To identify significant trends, drivers, influence factors in global and regions

To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the keyword market.

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Stem Cell Antibody to Garner Brimming Revenues by 2019-2025 - Cole of Duty

Stem Cell Banking Outsourcing Market Trends, Strong Application Scope, Key Players, Growth and Forecast by 2026 – 3rd Watch News

Stem Cell Banking Outsourcing Market Scope of the Report:

The worldwide market for Stem Cell Banking Outsourcing is expected to grow at a CAGR of roughly xx% over the next five years, will reach xx million US$ in 2025, from xx million US$ in 2019, according to a new study.

This report focuses on the Stem Cell Banking Outsourcing in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application.

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segment by Type, the product can be split into Umbilical Cord Blood Stem Cell Embryonic Stem Cell Adult Stem Cell Other Market segment by Application, split into Diseases Therapy Healthcare

Market segment by Regions/Countries, this report covers North America Europe China Japan Southeast Asia India Central & South America

The study objectives of this report are: To analyze global Stem Cell Banking Outsourcing status, future forecast, growth opportunity, key market and key players. To present the Stem Cell Banking Outsourcing development in North America, Europe, China, Japan, Southeast Asia, India and Central & South America. To strategically profile the key players and comprehensively analyze their development plan and strategies. To define, describe and forecast the market by type, market and key regions.

In this study, the years considered to estimate the market size of Stem Cell Banking Outsourcing are as follows: History Year: 2015-2019 Base Year: 2019 Estimated Year: 2020 Forecast Year 2020 to 2026 For the data information by region, company, type and application, 2019 is considered as the base year. Whenever data information was unavailable for the base year, the prior year has been considered.

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* Analyzing the outlook of the market with the recent trends and SWOT analysis

* Market dynamics scenario, along with growth opportunities of the market in the years to come

* Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and non-economic aspects

* Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.

* Market value (USD Million) and volume (Units Million) data for each segment and sub-segment

* Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years

* Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

* 1-year analyst support, along with the data support in excel format.

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The Stem Cell Banking Outsourcing Market report has 150 tables and figures browse the report description and TOC:

Table of Contents

1 Study Coverage

1.1 Stem Cell Banking Outsourcing Product

1.2 Key Market Segments in This Study

1.3 Key Manufacturers Covered

1.4 Market by Type

1.4.1 Global Stem Cell Banking Outsourcing Market Size Growth Rate by Type

1.5 Market by Application

1.5.1 Global Stem Cell Banking Outsourcing Market Size Growth Rate by Application

2 Executive Summary

2.1 Global Stem Cell Banking Outsourcing Market Size

2.1.1 Global Stem Cell Banking Outsourcing Revenue 2014-2025

2.1.2 Global Stem Cell Banking Outsourcing Production 2014-2025

2.2 Stem Cell Banking Outsourcing Growth Rate (CAGR) 2019-2025

2.3 Analysis of Competitive Landscape

2.3.1 Manufacturers Market Concentration Ratio (CR5 and HHI)

2.3.2 Key Stem Cell Banking Outsourcing Manufacturers

2.3.2.1 Stem Cell Banking Outsourcing Manufacturing Base Distribution, Headquarters

2.3.2.2 Manufacturers Stem Cell Banking Outsourcing Product Offered

2.3.2.3 Date of Manufacturers Enter into Stem Cell Banking Outsourcing Market

2.4 Key Trends for Stem Cell Banking Outsourcing Markets & Products

3 Market Size by Manufacturers

3.1 Stem Cell Banking Outsourcing Production by Manufacturers

3.1.1 Stem Cell Banking Outsourcing Production by Manufacturers

3.1.2 Stem Cell Banking Outsourcing Production Market Share by Manufacturers

3.2 Stem Cell Banking Outsourcing Revenue by Manufacturers

3.2.1 Stem Cell Banking Outsourcing Revenue by Manufacturers (2019-2025)

3.2.2 Stem Cell Banking Outsourcing Revenue Share by Manufacturers (2019-2025)

3.3 Stem Cell Banking Outsourcing Price by Manufacturers

3.4 Mergers & Acquisitions, Expansion Plans

More Information.

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Stem Cell Banking Outsourcing Market Trends, Strong Application Scope, Key Players, Growth and Forecast by 2026 - 3rd Watch News

BioMed Realty fully leases flagship life sciences development at Babraham Research Campus within 12 months as first occupier moves in – Cambridge…

Bit Bio, a world leader in synthetic biology, has agreed to take 25,000 sq. ft. of space on a 10-year lease at the BioMed@Babraham development. The fast-growing company joins the likes of drug discovery and development platformsMission Therapeutics andRxCelerate,as well as liquid biopsy specialistsInivata, with nearly two-thirds of tenants moving from existing facilities on the campus to larger scale-up labs to remain closely connected to the robust on-campus science and research community.

All 100,000 sq. ft. of mixed laboratory and office space at BioMed@Babraham has been leased within 12 months - ahead of schedule. The first business to take up occupancy isPetMedix, a fast-growing biotherapeutics firm.

Launched in 2017,BioMed@Babrahamwas developed by BioMed Realty and is operated in collaboration with Babraham Research Campus, one of the UKs leading campuses to support early stage bioscience enterprises. BioMed@Babraham offers 100,000 sq. ft. of flexible and fully-fitted premium lab and work space, allowing fast-growing businesses to move in and focus solely on science and research.

The research space at BioMed@Babraham has been highly specified to support scale-up companies with pre-installed lab benches, fume hoods, vacuum and gas lines and Trespa shelving.

BioMed is a world leader in providing real estate solutions to the life science and technology communities with more than 13.6 million sq. ft. of space under occupation and development. The company owns and operates approximately 1 million sq. ft. of laboratory space across Cambridge - approximately a quarter of total space in the market.

Since entering the UK market in 2012, BioMed has been dedicated to developing Grade-A lab and office space for the life sciences sector. Many of its global occupiers - including firms such as AstraZeneca and Gilead - are now leading the fight against COVID-19.

Cheffins advised BioMed Realty.

Matt Smith, Director, U.K. Market, BioMed Realty said: The life sciences industry makes a huge contribution to the UK economy, supporting thousands of highly skilled jobs. With the right investment in facilities to help nurture innovation, it will provide the industry a path for growth and compete globally with knowledge clusters across the US, Europe and Asia. Weve seen unprecedented demand for high quality research space and full credit must be given to Derek Jones and the Babraham Research Campus for being one of the first organisations in Britain to recognise the huge value of offering turnkey facilities to spin-outs and scale-ups.

Derek Jones, CEO of Babraham Bioscience Technologies, which develops and manages the Babraham Research Campus, said: We are delighted Bit Bio and PetMedix have chosen to make the Campus their home. They will benefit from being part of the wider Campus community of 60 innovative commercial organisations, as well as co-location with world leading research at the Babraham Institute. Our supportive and highly networked community shares a common objective; to make a positive contribution to the worlds health and we welcome both companies presence and contribution to that aim.

Dr Tom Weaver, PetMedix CEO, said: Were delighted to have new, state-of-the-art premises within such a fantastic community that will benefit our staff both professionally and socially. As our company scales, it will be from this site that PetMedix will continue to innovate and develop novel antibody therapeutics for the companion animal market. The Babraham Research Campus has shown great foresight in creating facilities which we believe can play a key role in helping other spin-outs quickly scale up. We are a science-led company, but it is our people that make us who we are. We have some ambitious plans and this move will help us maintain our trajectory of strong growth.

Bit Bio, founded in 2016 by leading neurosurgeon Dr Mark Kotter, has developed a unique technology to edit the code of stem cells to create specialised cells like neurons and muscle tissue that can then be used for academic and medical research. Bit Bios current projects include cell therapy for cancer patients and finding cures for diseases affecting the central nervous and immune systems. The company closed on a $41.5 million Series A investment last month, bringing the companys total funding to $50 million.

The firm will be joining PetMedix, a fast-growing biotherapeutics company focused on therapeutic antibody research and development for dogs and cats. Antibody therapeutics have been transformative in human medicine, treating a wide range of diseases including cancers and autoimmune diseases, and are just starting to be developed for veterinary applications. The business, which raised 8 million of series A funding last year, has already taken occupancy and recently secured equity investment from Cambridge Innovation Capital.

As part of PetMedixs move, laboratory equipment not required at the new site has been donated to the NHS for use in COVID-19 research, including four laminar flow cabinets suitable for tissue culture.

Cambridge life sciences real estate market

Cambridge is a high growth location at the core of the Oxford-Cambridge Arc - a world-leading hub of pharmaceutical, biomedical and biotechnology companies that is estimated to have contributed over 111 billion to the UK economy in 2019 alone. However, acute demand-supply imbalances threaten to undermine the regions long-term growth and ability to play a leading role in the UKs economic recovery post-coronavirus.

Healthy demand and a lack of suitable lab space has seen rents increase in Cambridge over the last year. In 2019, rents in the sector rose by 12 percent to an historic high of 46.50 per sq ft, according to Bidwells, a Cambridge-based property consultancy. Occupiers are also continuing to focus on Grade-A space, accounting for 64 percent of total take up in last year.

About BioMed Realty

Founded in 2004, and a Blackstone portfolio company since 2016, BioMed Realty owns, operates and develops high quality life science real estate comprising 13.6 million square feet, including 2.5 million square feet of Class A properties in active development to meet the growing demand of the life science industry. BioMed Realtys portfolio is located in the leading innovation markets throughout the United States and United Kingdom, led by Boston-Cambridge, San Francisco, San Diego, Seattle, New York and Cambridge, U.K. With over 200 tenant partners, BioMed Realty provides real estate solutions for global enterprises, established biotechnology and innovation companies, leading universities and premier research institutions. To learn more about BioMed Realty, visitbiomedrealty.com, and please follow us on Twitter @biomedrealty.

About Bit Bio

Bit Bio is a human synthetic biology company based in Cambridge, UK. The Companys mission is the application of computational principles to biology. The team includes world leaders in stem cell biology, cellular reprogramming and cell therapy who are harnessing the power of synthetic biology to tackle the problem of inconsistency in the production of human cells.

Bit Bios current focus is to develop a scalable technology platform capable of producing consistent and functional batches of every human cell. Access to high-quality human cells will allow enhanced research outcomes and drug discovery efficiency, enabling a new generation of cell and tissue therapies.

To find out more, please visitwww.bit.bio

About PetMedix

PetMedix is a Cambridge, UK based research and development stage biopharmaceutical company developing antibody-based therapeutics for companion animals. The growing team have over 30 years experience building platforms that can develop species-specific therapeutic antibodies. Driven by the core value of improving the health and welfare of animals, PetMedix is taking the cutting edge of human medicine and using it to develop innovative new veterinary treatments against a wide range of clinical indications for dogs and for cats.

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About the Babraham Research Campus

Babraham Bioscience Technologies Ltd (BBT) is responsible for the management and commercial development of the Babraham Research Campus.

The Babraham Research Campus is distinct in its colocation of 60 bioscience companies with the Babraham Institute, a worldrenowned research organisation which receives strategic funding from the Biotechnology and Biological Sciences Research Council (BBSRC).

The aim of the campus is to support U.K. bioscience through academic research, but also with facilities and capabilities for early-stage and growing commercial organizations. The campus provides companies laboratory and office space, networking and collaboration opportunities, together with access to outstanding scientific facilities in an ideal geographical location at the core of the Cambridge cluster.

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Could Some of the Benefits of Exercise on the Brain be Captured in a Pill? – Genetic Engineering & Biotechnology News

Can a pill provide the same cognitive benefits as exercise? [University of California, San Francisco]

The results of research in mice suggest that a little-studied liver enzyme called Gpld1 may be responsible for the well-known benefits of exercise on the aging brain, and that its regenerative effects may be transferrable directly from one animal to another. The studies, headed by scientists at the University of California, San Francisco (UCSF), Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, showed that when aged, sedentary mice received plasma transfusions from regularly exercising mice, they gained the same beneficial neurological effects without having to hit the running wheel themselves.

The findings could feasibly lead to new therapies that confer the neuroprotective effects of physical activity on people who cant exercise due to physical limitations. If there were a drug that produced the same brain benefits as exercise, everyone would be taking it, said Saul Villeda, PhD, a UCSF assistant professor in the departments of anatomy and of physical therapy and rehabilitation science. Now our study suggests that at least some of these benefits might one day be available in pill form. Research lead Villeda is senior author of the teams published paper in Science, which is titled, Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.

Exercise is one of the best-studied and most powerful ways of protecting the brain from age-related cognitive decline. Exercise has been shown to improve cognition in individuals at risk of neurodegenerative diseases such as Alzheimers disease (AD) and frontotemporal dementia, even for individuals who carry rare gene variants that inevitably lead to dementia.

In the context of dementia-related neurodegenerative diseases, exercise is correlated with reduced risk for cognitive decline in the elderly, improves cognition in populations at risk for AD, and is associated with better neurobehavioral outcomes even in autosomal dominant AD, the scientists wrote. However, not everyone is able to exercise regularly as they get older, perhaps due to physical limitations or other disabilities. Despite the evident benefit of exercise, its application is hindered in the elderly, as physical frailty or poor health can decrease a persons ability or willingness to exercise, the authors continued. Researchers have long searched for strategies that could confer some of the same neurological benefits of exercise to people with low physical activity levels.

Villedas lab has previously shown thatbiological factorspresent in the blood of young mice can rejuvenate theaging mouse brain, and conversely, factors in the blood of older mice can bring on premature age-related cognitive decline in young mice. transfer of blood from young animals, either by heterochronic parabiosis (in which young and old circulatory systems are joined) or by administration of young blood plasma, improves regenerative capacity and cognition in aged mice, the authors noted.

These previous results led Alana Horowitz, a graduate student in the Villeda lab, and postdoctoral researcher Xuelai Fan, PhD, to look for blood-borne factors that might also confer the benefits of exercise, which is known to rejuvenate the aging brain in a similar fashion to that seen in the labs young blood experiments. Given parallels between the effects of exercise and young blood, we tested whether exercise-induced circulating blood factors could confer the beneficial effects of exercise on regenerative and cognitive function in the aged brain, the scientists continued.

To do this Horowitz and Fan took blood from aged mice who had exercised regularly for seven weeks and administered it to sedentary aged mice. They found that four weeks of this treatment produced dramatic improvements in learning and memory in the older mice, similar to that seen in the mice who had exercised regularly. When they examined the animals brains, they found evidence of enhanced production of new neurons in the hippocampus, a well-documented proxy for the rejuvenating benefits of exercise.

To discover what specific biological factors in the blood might be behind these effects, Horowitz, Fan, and colleagues measured the amounts of different soluble proteins in the blood of active versus sedentary mice. They identified 30 candidate proteins, 19 of which, to their surprise, were predominantly derived from the liver and many of which had previously been linked to functions in controlling the bodys metabolism. Two of these proteins, Gpld1 and Pon1m stood out as particularly important for metabolic processes, and the researchers chose to study Gpld1 in more detail because few previous studies had investigated its function. We figured that if the protein had already been investigated thoroughly, someone would have stumbled upon this effect, Villeda said. I like to sayif youre going to take a risk by exploring something new, you might as well go big!

The team found that Gpld1 increased in the blood circulation of mice following exercise, and that levels of the protein correlated closely with improvements in the animals cognitive performance. Analysis of human data collected as part of the UCSF Memory and Aging Centers Hillblom Aging Network study also found elevated blood levels in healthy, active elderly adults, compared with levels in less active elders. These data identify Gpld1 as an exercise-induced circulating blood factor in aged mice and humans with potential relevance to cognitive function in mice, they wrote.

To test whether Gpld1 itself could drive the observed benefits of exercise, the researchers then engineered mice to overexpress Gpld1 in the liver, and evaluated the animals performance in multiple tests that measure various aspects of cognition and memory. To their amazement, three weeks of the treatment produced effects similar to six weeks of regular exercise, and also generated dramatic increases in new neuron growth in the hippocampus. Together, these data indicate that selectively increasing liver-derived systemic concentrations of Gpld1 is sufficient to improve adult neurogenesis and cognitive function in the aged hippocampus, the scientists stated.

To be honest, I didnt expect to succeed in finding a single molecule that could account for so much of the benefits of exercise on the brain, Villeda noted. It seemed more likely that exercise would exert many small, subtle effects that add up to a large benefit, but which would be hard to isolate. When I saw these data, I was completely floored Through this protein, the liver is responding to physical activity and telling the old brain to get young. Further laboratory experiments have shown that Gpld1 produced by the liver does not pass through the blood-brain barrier. Instead, the protein appears to exert its effects on the brain via pathways that reduce inflammation and blood coagulation throughout the body. Both blood coagulation and inflammation are known to be elevated with age and have been linked to dementia and age-related cognitive decline.

This is a remarkable example of liver-to-brain communication that, to the best of our knowledge, no one knew existed, Villeda continued. It makes me wonder what else we have been missing in neuroscience by largely ignoring the dramatic effects other organs might have on the brain, and vice versa.

The findings could have more broad-ranging implications, the authors suggested. Cumulatively, our data show that beneficial effects of exercise on the aged brain can be transferred through administration of blood components Given that transfer of young blood simultaneously elicits central and peripheral enhancements in regenerative capacity in aged mice, our data raise the possibility that the beneficial effects of exercise could be promoted broadly across tissues through circulating blood factors.

The Villeda lab is now working to better understand precisely how Gpld1 interacts with other biochemical signaling systems to produce its brain-boosting effects. The hope is to identify specific targets for therapeutics that could one day confer many of the protective benefits of exercise for the aging brain.

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Could Some of the Benefits of Exercise on the Brain be Captured in a Pill? - Genetic Engineering & Biotechnology News

Global Cord Blood Stem Cell Market 2020-2029 : Do You Really Need It? This Research Will Help You Decide! – News Monitoring

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Global Cord Blood Stem Cell Market 2020-2029 : Do You Really Need It? This Research Will Help You Decide! - News Monitoring