Politicians Turn Their Backs on Public Safety and Will Want More of Your Money in November – City Watch

RANTZ & RAVEZ-Los Angeles Mayor Eric Garcetti (who called police officers killers) and City Councilmembers responded to the demands of protestors and rioters by slashing $150 million from the 2020-2021 LAPD budget.

LAs taxpaying residents and business owners were ignored by city officials who continue to permit the city to turn more neighborhoods into homeless camps with expanding decay and rising violent crime trends.

All but two voting councilmembers approved Garcettis 2020-2021 city budget which took $150 million from the LAPD and passed it to various organizations that serve minority communities in LA. Following the hatchet job on the LAPDs budget, the council adjourned, canceling future July meetings in order to go on a near month-long summer recess. This is happening while our City is on semi-lockdown due to the coronavirus that is spreading and infecting more people in the region and other American cities.

The FBI continues to investigate elected and appointed officials at City Hall, and two elected councilmembers have already been arrested; one has agreed to go to prison without a trial. A cloud of suspicion remains over the question of when the next arrest or arrests will occur as the investigation of illegal activity, bribes, and corruption continues to be conducted by FBI agents.

While members of the council enjoy their extended summer vacation and annual salary of over $207,000, the taxpayers of Los Angeles continue to struggle to find jobs, pay bills and find funds to repair the damages caused by the recent riots in large sections of the city. The lack of leadership and support displayed by the Mayor and Councilmembers for the LAPD and people of LA is truly a sad situation for Angelenos.

While the majority of the council voted to slash $150 million in public safety funds from the police budget, only two councilmembers had the courage to stand up to the anti-police groups calling for the financial reduction and redistribution to other causes. Councilmembers John Lee from the 12th District in the San Fernando Valley and Joe Buscaino from CD 15 in South Los Angeles and San Pedro. The rest of the council followed the lead of our spineless mayor and those pushing for the reduction in police funding. Keep this in mind when you call 911 in the future and there is a delay in the response time of officers.

Remember the names of the councilmembers who have turned their backs on public safety for all people in Los Angeles. Remember them when they ask you to vote for new tax increases which will appear on future ballots. Since they have turned their backs on public safety for you and your family, they might be better suited to find jobs in the private sector. I will remind you of those names this November and in future years. They do not deserve your votes.

On the subject of the November 3 election, let me share what Sacramento officials have in store for you and your wallets on the statewide ballot. There are currently 12 propositions that have qualified for the November election.

It is time to clean your guns and purchase fresh ammo. Be prepared to protect yourself and your family as we approach November and the state and national elections.

(Dennis P. Zine is a native of Los Angeles who retired from the LAPD after serving 33 years. Dennis remains an active Level 1 LAPD Reserve Officer. Dennis served for two years as the vice chairman on the Elected Los Angeles City Charter Reform Commission and was a member of the Los Angeles City Council for 12 years.) Edited for CityWatch by Linda Abrams.

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Politicians Turn Their Backs on Public Safety and Will Want More of Your Money in November - City Watch

In the middle of pandemic, this young mom fights second cancer diagnosis – INFORUM

Two years ago, Bustos was happy. She was 20, recently married and had just found out she was pregnant with her first child. Taylor and her husband, Mark, 21, envisioned moving from Duluth to California and raising half a dozen kids. But those plans would have to wait.

Five months into her pregnancy, Bustos felt a lump on her neck. On Oct. 5, 2018, just a month after giving birth to her son, Solomon, she was diagnosed with nodular sclerosis classical Hodgkins lymphoma. Its the most common type of Hodgkins lymphoma, a cancer that affects the bodys immune system.

I was told, This is the good cancer, its curable, Bustos said. She underwent six months of chemotherapy at St. Lukes Radiation Oncology Associates in Duluth and was declared in remission in April 2019. After that, life went pretty much back to normal.

But last November, just before her first follow-up PET CT scan, Bustos prepared for the worst. A few weeks earlier, she had felt the lump in her neck return.

Soon later, she was back at St. Lukes, prepared to receive whatever news may come. Mark tossed a bright pink ball to Solomon to distract the boy and himself from the mounting anxiety as they waited for what felt like an eternity in the small examination room.

The young father was also trying to manage his stress from recently learning he was being laid off from his construction job. The doctor finally stepped in.

Taylor and Mark shared a kiss in their kitchen, taking any quiet moment they can to show their love to one another while raising a one-year-old. Taylor had been diagnosed with Hodgkin's Lymphoma only a month after giving birth to their first son, Solomon. She had just spent the better part of a year battling cancer and was now cancer free. So she was trying to enjoy any sense of normalcy she could. Alex Kormann / Minneapolis Star Tribune/TNS

Im sitting there with a one-year-old and my husband of two years and theyre telling me at 22 years old that I have cancer for the second time, Bustos said.

She had gone into the meeting with the mindset that she would never endure chemotherapy again. It was physically and mentally unlike any other suffering Ive ever gone through in my life and I didnt want to willingly say yes to going back there, Bustos said.

After a week of thinking and praying, Bustos stumbled across a Facebook post from a friend who had recently lost his father in a house fire. His words resonated so deeply with her that she decided she couldnt just lay down and die. This cancer could kill me, but dont I want my sweet son to know I tried? she said.

Once again, she went in for treatments, then slept for three days. The big difference this time was that, to make sure the cancer never came back, she was going to have to follow the doctors next recommendation.

On March 2, the Bustos family picked up and moved 200 miles across the state to Rochester for three months where she would undergo some of the most toxic chemotherapy available at the Mayo Clinic. The mix was so potent that she had to first undergo a stem cell collection; those stem cells would be transplanted afterward to regrow her immune system and other healthy cells decimated by the chemo.

Marks layoff, which at first seemed like a disaster, was now a gift. He could assume a larger role as the family caretaker. Some people might call that luck, but the Bustoss dont believe in luck. For them, it was an act of God.

When it came time to move, Taylors parents, Pam and Jerry, who live across the street from the Bustoses in Duluth, moved with them to help take care of Solomon and Taylor.

It really wasnt a difficult decision, said Jerry, who is a warehouse operator at a Duluth paper supply business.

For me, he said, I would do whatever it takes to get her healthy.

The whole family joined hands and prayed before dinner. God and faith are extremely important to them and has helped Taylor get through this difficult chapter in her life. The COVID-19 pandemic forced church to be held via live stream so Taylor was able to follow along even from 200 miles away. Her faith helped Taylor push through even the darkest moments of treatment. "Knowing I'm in the hands of such a faithful father made it peaceful," she said. Alex Kormann / Minneapolis Star Tribune/TNS

Their family squeezed as much as they could into their two cars, boxes stacked to the roof, rendering the rearview mirror useless. The family settled into a small house only a mile away from the Mayo Clinic.

Just over a week later, COVID-19 hit.

We knew Id have a weakened immune system and wed have to quarantine, Bustos said, but suddenly the whole world had to quarantine, too.

They stayed closely connected with their church through video chat and live streams. In solidarity, her entire family shaved their heads along with Bustos.

A little over a month after moving, Bustos prepared for her most difficult round of chemotherapy. All the effects of normal chemo, including nausea, exhaustion, loss of appetite and body pain would be amplified. And because of the coronavirus, she would be doing it alone. She packed her keyboard piano, a weeks worth of clothes, a few mementos from home and headed to the hospital. She would have to stay in a heavily filtered room by herself for a full week as she underwent treatment.

Masked nurses came and went as Bustos tried to picture what they looked like under all the PPE. Most days, she felt immensely lonely and sad. Originally, she was told shed be able to go home to see her family for one hour per day. The pandemic scrapped those plans. I would cry and nurses couldnt put their hand on my shoulder to tell me, Its OK, because of the coronavirus, Bustos said.

When she was finally able to return to her family a full week later, Bustos was ecstatic. To be able to be hugged was a very welcome relief from despair, she said.

She began to try and process what had happened to her over the last five months. She felt distant from and misunderstood by nearly everyone around her. It can look like its going well from the outside but when you literally want to die, the emotional side of things needs to be handled, she said.

Bustos has since begun therapy and is taking anti-depressants to help manage her mental pain.

As the family moved out of Rochester, the snow was gone. Birds chirped and flowers bloomed; a sign of rebirth and a new beginning.

When they pulled up in front of their apartment in Duluth, chalk drawings graced their sidewalk welcoming them home. Their front door was covered in balloons and a welcome banner was strung across the door frame, all put together by members of Bustoss church youth group.

Bustos collapsed on her old bed. She thought shed feel different in their own apartment, but it oddly felt the same. She had come to realize that home was no longer a physical space. Cancer changed that.

Home for me has become Mark and Solomon, she said, and so whether were in Rochester, Duluth or Timbuktu, Im home when Im with them.

2020 Star Tribune (Minneapolis)

Visit the Star Tribune (Minneapolis) at http://www.startribune.com

Distributed by Tribune Content Agency, LLC.

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In the middle of pandemic, this young mom fights second cancer diagnosis - INFORUM

Radiation Response of Murine Embryonic Stem Cells

To understand the mechanisms of disturbed differentiation and development by radiation, murine CGR8 embryonic stem cells (mESCs) were exposed to ionizing radiation and differentiated by forming embryoid bodies (EBs). The colony forming ability test was applied for survival and the MTT test for viability determination after X-irradiation. Cell cycle progression was determined by flow cytometry of propidium iodide-stained cells, and DNA double strand break (DSB) induction and repair by H2AX immunofluorescence. The radiosensitivity of mESCs was slightly higher compared to the murine osteoblast cell line OCT-1. The viability 72 h after X-irradiation decreased dose-dependently and was higher in the presence of leukemia inhibitory factor (LIF). Cells exposed to 2 or 7 Gy underwent a transient G2 arrest. X-irradiation induced H2AX foci and they disappeared within 72 h. After 72 h of X-ray exposure, RNA was isolated and analyzed using genome-wide microarrays. The gene expression analysis revealed amongst others a regulation of developmental genes (Ada, Baz1a, Calcoco2, Htra1, Nefh, S100a6 and Rassf6), downregulation of genes involved in glycolysis and pyruvate metabolism whereas upregulation of genes related to the p53 signaling pathway. X-irradiated mESCs formed EBs and differentiated toward cardiomyocytes but their beating frequencies were lower compared to EBs from unirradiated cells. These results suggest that X-irradiation of mESCs deregulate genes related to the developmental process. The most significant biological processes found to be altered by X-irradiation in mESCs were the development of cardiovascular, nervous, circulatory and renal system. These results may explain the X-irradiation induced-embryonic lethality and malformations observed in animal studies.

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Radiation Response of Murine Embryonic Stem Cells

Human Embryonic Stem Cells (HESC) Market Growth By Manufacturers, Type And Application, Forecast To 2026 – 3rd Watch News

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Human Embryonic Stem Cells (HESC) Market Growth By Manufacturers, Type And Application, Forecast To 2026 - 3rd Watch News

Cell Therapy Market Analysis Of Global Trends, Demand And Competition 2020-2028 – Jewish Life News

Trusted Business Insights answers what are the scenarios for growth and recovery and whether there will be any lasting structural impact from the unfolding crisis for the Cell Therapy market.

Trusted Business Insights presents an updated and Latest Study on Cell Therapy Market 2019-2026. The report contains market predictions related to market size, revenue, production, CAGR, Consumption, gross margin, price, and other substantial factors. While emphasizing the key driving and restraining forces for this market, the report also offers a complete study of the future trends and developments of the market.The report further elaborates on the micro and macroeconomic aspects including the socio-political landscape that is anticipated to shape the demand of the Cell Therapy market during the forecast period (2019-2029). It also examines the role of the leading market players involved in the industry including their corporate overview, financial summary, and SWOT analysis.

Get Sample Copy of this Report @ Cell Therapy Market Size, Share, Market Research and Industry Forecast Report, 2020-2027 (Includes Business Impact of COVID-19)

Industry Insights, Market Size, CAGR, High-Level Analysis: Cell Therapy Market

The global cell therapy market size was valued at USD 5.8 billion in 2019 and is projected to witness a CAGR of 5.4% during the forecast period. The development of precision medicine and advancements in Advanced Therapies Medicinal Products (ATMPS) in context to their efficiency and manufacturing are expected to be the major drivers for the market. In addition, automation in adult stem cell and cord blood processing and storage are the key technological advancements that have supported the growth of the market for cell therapy. The investment in technological advancements for decentralizing manufacturing of this therapy is anticipated to significantly benefit the market. Miltenyi Biotec is one of the companies that has contributed to the decentralization in manufacturing through its CliniMACS Prodigy device. The device is an all-in-one automated manufacturing system that exhibits the capability of manufacturing various cell types.

An increase in financing and investments in the space to support the launch of new companies is expected to boost the organic revenue growth in the market for cell therapy. For instance, in July 2019, Bayer invested USD 215 million for the launch of Century Therapeutics, a U.S.-based biotechnology startup that aimed at developing therapies for solid tumors and blood cancer. Funding was further increased to USD 250 billion by a USD 35 million contribution from Versant Ventures and Fujifilm Cellular Dynamics. The biomanufacturing companies are working in collaboration with customers and other stakeholders to enhance the clinical development and commercial manufacturing of these therapies. Biomanufacturers and OEMs such as GE healthcare are providing end-to-end flexible technology solutions to accelerate the rapid launch of therapies in the market for cell therapy. The expanding stem cells arena has also triggered the entry of new players in the market for cell therapy. Celularity, Century Therapeutics, Rubius Therapeutics, ViaCyte, Fate Therapeutics, ReNeuron, Magenta Therapeutics, Frequency Therapeutics, Promethera Biosciences, and Cellular Dynamics are some startups that have begun their business in this arena lately. Use-type Insights The clinical-use segment is expected to grow lucratively during the forecast period owing to the expanding pipeline for therapies. The number of cancer cellular therapies in the pipeline rose from 753 in 2018 to 1,011 in 2019, as per Cancer Research Institute (CRI). The major application of stem cell treatment is hematopoietic stem cell transplantation for the treatment of the immune system and blood disorders for cancer patients. In Europe, blood stem cells are used for the treatment of more than 26,000 patients each year. These factors have driven the revenue for malignancies and autoimmune disorders segment. Currently, most of the stem cells used are derived from bone marrow, blood, and umbilical cord resulting in the larger revenue share in this segment. On the other hand, cell lines, such as Induced Pluripotent Stem Cells (iPSC) and human Embryonic Stem Cells (hESC) are recognized to possess high growth potential. As a result, a several research entities and companies are making significant investments in R&D pertaining to iPSC- and hESC-derived products. Therapy Type Insights of Cell Therapy Market

An inclination of physicians towards therapeutic use of autologous and allogeneic cord blood coupled with rising awareness about the use of cord cells and tissues across various therapeutic areas is driving revenue generation. Currently, the allogeneic therapies segment accounted for the largest share in 2019 in the cell therapy market. The presence of a substantial number of approved products for clinical use has led to the large revenue share of this segment.

Furthermore, the practice of autologous tissue transplantation is restricted by the limited availability of healthy tissue in the patient. Moreover, this type of tissue transplantation is not recommended for young patients wherein tissues are in the growth and development phase. Allogeneic tissue transplantation has effectively addressed the above-mentioned challenges associated with the use of autologous transplantation. However, autologous therapies are growing at the fastest growth rate owing to various advantages over allogeneic therapies, which are expected to boost adoption in this segment. Various advantages include easy availability, no need for HLA-matched donor identification, lower risk of life-threatening complications, a rare occurrence of graft failure, and low mortality rate.

Regional Insights of Cell Therapy Market

The presence of leading universities such as the Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, and Yale Stem Cell Center that support research activities in U.S. is one of the key factor driving the market for cell therapy in North America. Moreover, strong regulatory and financing support from the federal bodies for expansion of this arena in U.S. as well as Canada is driving the market. In Asia Pacific, the market is anticipated to emerge as a lucrative source of revenue owing to the availability of therapies at lower prices coupled with growing awareness among the healthcare entities and patients pertaining the potential of these therapies in chronic disease management. Japan is leading the Asian market for cell therapy, which can be attributed to its fast growth as a hub for research on regenerative medicine. Moreover, the Japan government has recognized regenerative medicine and cell therapy as a key contributor to the countrys economic growth. This has positively influenced the attention of global players towards the Asian market, thereby driving marketing operations in the region.

Market Share Insights of Cell Therapy Market

Some key companies operating in this market for cell therapy are Fibrocell Science, Inc.; JCR Pharmaceuticals Co. Ltd.; Kolon TissueGene, Inc.; PHARMICELL Co., Ltd.; Osiris Therapeutics, Inc.; MEDIPOST; Cells for Cells; NuVasive, Inc.; Stemedica Cell Technologies, Inc.; Vericel Corporation; and ANTEROGEN.CO.,LTD. These companies are collaborating with the blood centers and plasma collection centers in order to obtain cells for use in therapeutics development. Several companies have marked their presence in the market by acquiring small and emerging therapy developers. For instance, in August 2019, Bayer acquired BlueRock Therapeutics to establish its position in the market for cell therapy. BlueRock Therapeutics is a U.S. company that relies on a proprietary induced pluripotent stem cell (iPSC) platform for cell therapy development. Several companies are making an entry in the space through the Contract Development and Manufacturing Organization (CDMO) business model. For example, in April 2019, Hitachi Chemical Co. Ltd. acquired apceth Biopharma GmbH to expand its global footprint in the CDMO market for cell and gene therapy manufacturing.

Segmentations, Sub Segmentations, CAGR, & High-Level Analysis overview of Cell Therapy Market Research Report This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2019 to 2030. For the purpose of this study, this market research report has segmented the global cell therapy market on the basis of use-type, therapy-type, and region:

Use-Type Outlook (Revenue, USD Million, 2019 2030)

Clinical-use

By Therapeutic Area

Malignancies

Musculoskeletal Disorders

Autoimmune Disorders

Dermatology

Others

By Cell Type

Stem Cell Therapies

BM, Blood, & Umbilical Cord-derived Stem Cells

Adipose derived cells

Others

Non-stem Cell Therapies

Research-use

Therapy Type Outlook (Revenue, USD Million, 2019 2030)

Allogeneic Therapies

Autologous Therapies

Quick Read Table of Contents of this Report @ Cell Therapy Market Size, Share, Market Research and Industry Forecast Report, 2020-2027 (Includes Business Impact of COVID-19)

Trusted Business Insights Shelly Arnold Media & Marketing Executive Email Me For Any Clarifications Connect on LinkedIn Click to follow Trusted Business Insights LinkedIn for Market Data and Updates. US: +1 646 568 9797 UK: +44 330 808 0580

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Cell Therapy Market Analysis Of Global Trends, Demand And Competition 2020-2028 - Jewish Life News

Why we still haven’t cloned humans it’s not just ethics – Business Insider – Business Insider

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Following is a transcript of the video.

Narrator: We've been able to clone human embryos for about seven years. But as far as we know, no one's actually cloned a whole person. Turns out, ethics aren't the only thing holding scientists back. Cloning isn't the sci-fi marvel we think it is. It can be dangerous, often ineffective, and, most of all, we just haven't thought of a good enough reason to do it. So, here's why you'll probably never have to fight your evil clone.

This is Dolly. Just kidding, that's a regular sheep. This is Dolly, the first mammal cloned successfully from an adult cell. She was born in 1996 after scientists figured out how to remove the DNA from the egg cell of a Scottish Blackface sheep and basically replace it with the DNA of a mammary cell from a Finn Dorset sheep. They gave it a little electric shock to fuse the cell and get it replicating, placed the cells in the uterus of another sheep, and boom, clone. This method, called reproductive cloning, could theoretically be used on humans. But this is a best-case scenario. It took 277 tries for the scientists to get one Dolly. Nowadays, cloning mammals generally has a success rate of about 10% to 20%. Better than one in 277, but still a majorly inefficient process.

Jose Cibelli: Technically, it's not difficult to produce a clone embryo, but human cloning has other hurdles that need to be considered.

Narrator: To even research human cloning, scientists would need to ethically collect a large amount of donated eggs and find enough surrogates to carry them. But even if they made it through that logistical nightmare, the biggest issue is this:

Cibelli: They're gonna hurt the baby, or they're gonna hurt the person carrying the cloned fetus.

Narrator: Across the board, scientists have found that some embryos expire before they're implanted. Others result in miscarriages. And those that make it to term often die soon after birth or end up with severe abnormalities. Simply, these are risks that are easier to take when it comes to experimenting with sheep than with people. But arguably the biggest reason we haven't cloned a human being? There's not a good enough reason to.

In pop culture, cloning is used to bring people back from the dead. But that's not how it works. Cloning someone would only create a twin, not a replica, since identical twins have the same genetics, but not necessarily personalities. And a "Never Let Me Go" scenario, where organs are harvested from clones to save the rich, is not only unethical, but unnecessary. Why clone an entire person when you can just make the part you need? Something, theoretically, therapeutic cloning can solve.

Therapeutic cloning is almost identical to reproductive, except the cloned embryo is never implanted in a uterus. Instead, the embryo is cloned for the sole purpose of extracting stem cells. Stem cells have the incredible ability to turn into any other cell in the human body, which means they're great for developing new treatments for disease and have the potential to repair or regenerate tissues and organs.

But, no surprise, there are a lot of downsides with therapeutic cloning. The thing about stem cells is that they're a pretty limited resource. The most substantial source for embryonic stem cells? Three- to five-day-old embryos, cloned or otherwise. And when someone else's stem cells are transplanted into a patient, the body will sometimes fight them off like a disease. Some researchers believe that cloned stem cells, since they share the patient's DNA, would be less likely to be rejected. But this use case is still in the research stage.

And, finally, therapeutic cloning is an individualized treatment in a world where drug companies are more interested in standardized ones. And there are easier ways to create multipurpose cells nowadays, like the method for creating induced pluripotent stem cells. They're basically adult cells that have been reprogrammed to be a different type of cell.

Cibelli: The problem with therapeutic cloning, of course, is that you need a lab personnel that is qualified to do it, specific equipment to do it. Whereas the other technique, you can just buy a kit and one person can do it in a lab that has some expertise in tissue culture.

Narrator: Cloned cells still have an advantage when it comes to healthier mitochondria and the ability to grow into entire animals, whereas iPSCs often peter out. But since iPSCs safely and reliably do most everything but create entire living animals, why fund the harder, ethically ambiguous thing? So, cloning might actually have a bigger place in movies than it does in real life, because the money just isn't there. And just because we can do something doesn't mean we need to.

Ian: Your scientists were so preoccupied with whether or not they could, they didn't stop to think if they should.

Abby Tang: So, in the research for this video, I did come across one very interesting tidbit, and that is the announcement of cloned human baby Eve, who was born on December 26, 2002. And the source of this announcement is a company called Clonaid, which was formed in 1997 by the Raelian cult. And they're a cult that believes that humans were cloned from aliens and the only way for us to reach immortality is to clone ourselves. It's been 18 years, and we haven't gotten any proof that baby Eve exists or has ever existed, but the company is still alive and well. So if any proof does come through, we will update you.

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Why we still haven't cloned humans it's not just ethics - Business Insider - Business Insider

COVID-19 Impact and Recovery Analysis on Cell Freezing Media for Cell Therapy Market 2020-2026 by BioLife Solutions, Akron Biotechnology, GE…

Heres recently issued report on the Global Cell Freezing Media for Cell Therapy Market that allows you to offer a brief analysis of the market size, demand, supply chain, distribution channels, futuristic trends, market growth elements and so on. It offers a comprehensive analysis of assorted business aspects like global Cell Freezing Media for Cell Therapy market trends, recent technological advancements, market shares, size and new innovations. What is more, this analytical knowledge has been compiled through knowledge searching techniques like primary and secondary analysis for Cell Freezing Media for Cell Therapy industry. Moreover, an professional team of researchers throws lightweight on numerous static additionally as dynamic aspects of the worldwide Cell Freezing Media for Cell Therapy market.

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BioLife Solutions Akron Biotechnology GE Healthcare Thermo Fisher Scientific Biological Industries Merck WAK-Chemie Medical Zenoaq

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The Cell Freezing Media for Cell Therapy market report is segmented into Type by following categories; With FBS Without FBS

The Cell Freezing Media for Cell Therapy market report is segmented into Application by following categories; Human Embryonic Stem Cells CAR-T Cell Therapy Neural Stem Cell Therapy Mesenchymal Stem Cell Therapy Hematopoietic Stem Cell Transplantation Other

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COVID-19 Impact and Recovery Analysis on Cell Freezing Media for Cell Therapy Market 2020-2026 by BioLife Solutions, Akron Biotechnology, GE...

Why are scientists trying to manufacture organs in space? – The Conversation US

This Bioculture System will let biologists learn about how space impacts human health by studying cells grown in the microgravity environment of the International Space Station.

Gravity can be a real downer when you are trying to grow organs.

Thats why experiments in space are so valuable. They have revealed a new perspective into biological sciences, including insights into making human tissues.

Gravity influences cellular behavior by impacting how protein and genes interact inside the cells, creating tissue that is polarized, a fundamental step for natural organ development. Unfortunately, gravity is against us when we try to reproduce complex three dimensional tissues in the lab for medical transplantation. This is difficult because of the intrinsic limitations of bio-reactors used on Earth.

I am a stem cell biologist and interested on brain health and evolution. My lab studies how the human brain is formed inside the womb and how alterations in this process might have lifelong consequences to human behavior, such as in autism or schizophrenia. Part of that work includes growing brain cells in space.

To build organized tissues in the lab, scientists use scaffolds to provide a surface for cells to attach based on a predetermined rigid shape. For example, an artificial kidney needs a structure, or scaffold, of a certain shape for kidney cells to grow on. Indeed, this strategy helps the tissue to organize in the early stages but creates problems in the long run, such as eventual immune reactions to these synthetic scaffolds or inaccurate structures.

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By contrast, in weightless conditions, cells can freely self-organize into their correct three-dimensional structure without the need for a scaffold substrate. By removing gravity from the equation, we researchers might learn new ways of building human tissues, such as cartilage and blood vessels that are scaffold-free, mimicking their natural cellular arrangement in an artificial setting. While this is not exactly what happens in the womb (after all the womb is also subject to gravity), weightless conditions does give us an advantage.

And this is precisely what is happening at the International Space Station.

These experiments help researchers optimize tissue growth for use in basic science, personalized medicine and organ transplantation.

But there are other reasons why we should manufacture organs in space. Long-term space missions create a series of physiological alterations in the body of astronauts. While some of these alterations are reversible with time, others are not, compromising future human spaceflights.

Studying astronauts bodies before and after their mission can reveal what goes wrong on their organs, but provides little insights on the mechanisms responsible for the observed alterations. Thus, growing human tissues in space can complement this type of investigation and reveal ways to counteract it.

Finally, all forms of life that we know about have evolved in the presence of microgravity. Without gravity, our brains might have evolved in a different trajectory, or our livers might not filter liquids as it does on Earth.

By recreating embryonic organ formation in space, we can anticipate how the human body in the womb would develop. There are several research initiatives going on in my lab with human brain organoids at ISS, designed to learn the impact of zero gravity on the developing human brain. These projects will have profound implications for future human colonization (can humans successfully reproduce in space?). These studies will also improve the generation of artificial organs that are used for testing drugs and treatments on Earth. Will better treatments for neurodevelopmental and neurodegenerative conditions that affects millions of people come from research in space?

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Why are scientists trying to manufacture organs in space? - The Conversation US

Cellular Analysis Market Promising Growth Opportunities and Forecast 2017-2025 – Owned

The compositional, genetic, or functional heterogeneousness between diseased and healthy tissues is one of the key challenges faced by the field of drug development and discovery. The lack of knowledge in this field challenges the development of accurate disease models that can be used for drug development, can lead to misinterpretation of the levels of biomarkers, and responses of patients to specific therapies.

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The complex nature of heterogeneous tissues has encouraged the development of several tools for the analysis of single cell. A number of such tools, for applications such as transcriptomic analysis, cell genomic analysis, and multiplex proteomic analysis have surfaced in the global market in the past few years and continue to be used at an enormous pace across a number of applications, especially in the field of drug development and discovery.

There has been significant advancements in the functionality and level of accuracy of cell analysis tools and companies are increasingly investing in research and development activities to introduce more accurate tools. The competitive landscape and the variety of products that the market has to offer are changing at a rapid pace and a number of new technologies capable of comprehensively analyzing cells at a molecular-level are expected to hit the market in the next few years. Even at present, several cellular analysis technologies exist that can assay for a large number of cell surface markets and secreted proteins. The cellular analysis market is expected to expand at a promising pace in the next few years as well, thanks to the rising investments from across the globe.

Cellular analysis technology has wide applications in cell identification, target identification and validation, and cell counting. The technology is widely used in analysis of cell interaction, cell proliferation, cell structure, cell viability, and cell signaling/cell transduction. Prominent applications of cellular analysis include its uses in various phases of the drug discovery process, oncology, bloodcell analysis, and toxicity testing. Increased applications of cellular analysis in understanding the development processes of various cells types occupies a seminal role in the discovery of personalized medicine and in finding potential treatment of different diseases, which has offered momentum to the cellular analysis market growth.

The cellular analysis market is anticipated to witness significant growth opportunities along the forecast period. General rise in healthcare spending, coupled with increasing corporate funding for cell-based researches, has boosted the growth of the market across various regions. Cell identification is one of the key applications of cellular analysis and helps in the identification of blood cells based on their size and morphology; this helps in tumor detection. Along with other target identification technologies, the high-content screening in cellular analysis technology helps in getting accurate information on drug toxicity and hence facilitates drug discovery.

The report cellular analysis market provides the market share and size of key application segments in different countries across key regions. The research analysis provides in-depth analysis into major drivers and market challenges, current and emerging trends, and technological advances in life sciences, new product launches, and the factors shaping the competitive landscape of the cellular analysis market. The insights offered in the report help new and established players devise impactful strategies to strengthen their market presence.

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The cellular analysis market is primarily driven by the rising incidence of chronic and infectious diseases, increased corporate funding for cell-based research activities, and the increasing number of patients suffering from cancer. Furthermore, technological advancements in cellular analysis instruments, combined with potential developments in life-sciences industry related to drug discovery, are the crucial factors boosting the cellular analysis market.

However, the high costs of installing cell analysis systems, coupled with substantial investments required for cell-based researches for oncology and drug discovery, are likely to hinder the growth of the cellular analysis market. In addition, the ethical concerns related to embryonic stem cell research along with stringent regulations for the approval of new cellular analysis systems are major challenges faced by the market players. On the other hand, automation in oncology and the emergence of contract research organizations offering high-content screening services, combined with a large untapped market in the Asia Pacific region, are expected to create promising growth opportunities for the cellular analysis market players.

Based on geography, North America, Europe, and Asia occupy a major share in the cellular analysis market. North America is a prominent region for growth, led by technological advancements in cellular analysis systems and considerable funding by the different governments and private players. Asia Pacific is fast emerging as a promising region to create new revenue streams for market players. A large part of untapped markets in countries such as India, Japan, and China, combined with the increasing government support for cancer and stem cell research, are the crucial factors fuelling the growth of the cellular analysis market in the region.

The research study provides an extensive analysis of the key offerings of the market players and the strategies adopted by them to strengthen their market share. Companies in the cellular analysis market actively launch new products, enter into partnerships and agreements, and make acquisitions to consolidate their market presence. Prominent players operating in the cellular analysis market include Thermo Fisher Scientific, Inc, Beckman Coulter Inc. Bio-Rad Laboratories, Inc., Merck KGaA, Agilent Technologies, Inc, GE Healthcare, Olympus Corporation, Tecan Group Ltd., Nikon Corporation, and Becton, Dickinson and Company.

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Cellular Analysis Market Promising Growth Opportunities and Forecast 2017-2025 - Owned

R3 International Now Offering Stem Cell Therapy Program for Crohns Disease, IBD and Ulcerative Colitis – Benzinga

SAN DIEGO, July 8, 2020 /PRNewswire-PRWeb/ --R3 International is now offering effective stem cell therapy for Crohns disease, Ulcerative Colitis and IBD with a new program in Mexico. The new program provides up to 200 million stem cells for patients, with treatment starting at only $2975.

Millions of individuals worldwide suffer from chronic abdominal issues that affect every aspect of daily life and lead to difficulty with functioning. Traditional treatments are often insufficient and entail significant side effects.

According to R3 CEO David Greene, MD, MBA, "Stem cell therapy for Crohns, UC and IBD is not only safe and effective, but you don't have the bad side effects like you do with traditional drugs. We've been very successful in Mexico because the therapies are not only clinically and cost effective, but we offer very high numbers of stem cells for pricing exponentially less than the US, Panama or others!"

Studies on stem cell therapy for inflammatory diseases such as Crohns are showing that they are highly effective at regulating one's immune response (Nat Rev Nephrol 2018). This typically helps reduce flare ups and pain in patients, helping to increase quality of life tremendously.

Since R3 Stem Cell International opened in Tijuana, outcomes for these inflammatory conditions have been tremendous, with patients receiving anywhere from 30 million to 200 million stem cells.

The cells offered at R3 International come from a lab with a perfect safety record and quality assurance standards that exceed those of the FDA. No preservative is necessary, so the cell viability for the biologic exceeds 95% typically.

According to CEO Dr. Greene, "We made sure to partner with a lab that has a perfect safety record and only cultures cells between three and five generations. This means counts are high, and so is the potency of the cells!"

The treatment process starts with a free phone consultation with one of R3's licensed, experienced stem cell doctors. Once the treatment recommendation is made and the procedure is scheduled, the patient's designated concierge representative will assist with travel logistics. Transportation is included to and from the clinic from San Diego International Airport, which is only 20 minutes away.

Treatment starts at $2975 for 30 million live stem cells, and goes up $1000 for a total of 50 million. If a patient desires, a five day stay will include three treatments totaling 150 to 200 million stem cells. Or there is an option for four visits over a year as well, both starting at $8975 all inclusive.

To start the seamless process of obtaining treatment, visit for more information and call (888) 988-0515 to schedule the phone consultation.

SOURCE R3 Stem Cell International

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R3 International Now Offering Stem Cell Therapy Program for Crohns Disease, IBD and Ulcerative Colitis - Benzinga