Hemostemix Filed an Injunction Against Accudata Solutions, Inc. for the Return of its Clinical Trial Midpoint Report and Data – Yahoo Finance

Calgary, Alberta--(Newsfile Corp. - July 3, 2020) - Hemostemix Inc. (TSXV: HEM) (OTC: HMTXF) ("Hemostemix" or the "Company") is pleased to announce on June 29, 2020, it filed a Verified Complaint and, on July 2, 2020, Motions for a Preliminary Injunction and Expedited Scheduling seeking to compel the immediate return of all clinical trial data from Defendant Accudata Solutions, Inc. ("Accudata") and enjoining Accudata from continuing to divulge and disclose such highly sensitive and confidential information to third parties who have no ownership or custodial right to it.

Hemostemix engaged the services of Accudata to conduct, pursuant to a Consulting Agreement executed in August 2019, a statistical analysis of the clinical trial midpoint data. All clinical trial data and, in particular, the clinical trial midpoint analysis and supporting data are, and always have been, the property of Hemostemix. Hemostemix has an absolute ownership right over that data and an absolute right to recover the data upon demand. Despite repeated requests, Accudata has failed and refused to return the midpoint data to Hemostemix.

Hemostemix also recently learned that, while refusing to return the clinical trial midpoint data to Hemostemix, Accudata produced a copy of the midpoint data and report to an agent of the former Contract Research Organization ("CRO"), Aspire Health Science, LLC ("Aspire") and Aspire is now blocking Hemostemix from obtaining the return of its clinical trial data. Neither Aspire nor any of its agents or representatives have any ownership or any other right to have, maintain, or withhold such data, or to hold such data to the exclusion of Hemostemix. Hemostemix seeks the Court's immediate intervention to enjoin Accudata's continued breaches of the parties' agreement.

Hemostemix filed in the United States District Court for the District of Delaware.

On June 25, 2020 counsel for Hemostemix presented oral argument to the 9th Circuit Court in and for Orange County, Florida on its motion to dismiss Aspire's lawsuit on grounds that, among other things, Hemostemix's threshold challenge that it is not subject to jurisdiction in Florida. A decision on Hemostemix's motion is pending. In the meantime, the presiding judge has stayed a hearing on Aspire's Motion for a Speedy Hearing previously set for June 29, 2020 pending a decision on Hemostemix's motion to dismiss.

ABOUT HEMOSTEMIX

Hemostemix is a publicly traded autologous stem cell therapy company. A winner of the World Economic Forum Technology Pioneer Award, the Company developed and is commercializing its lead product ACP-01 for the treatment of CLI, PAD, Angina, Ischemic Cardiomyopathy, Dilated Cardiomyopathy and other conditions of ischemia. ACP-01 has been used to treat over 300 patients, and it is the subject of a randomized, placebo-controlled, double blind trial of its safety and efficacy in patients with advanced critical limb ischemia who have exhausted all other options to save their limb from amputation.

On October 21, 2019, the Company announced the results from its Phase II CLI trial abstract entitled "Autologous Stem Cell Treatment for CLI Patients with No Revascularization Options: An Update of the Hemostemix ACP-01 Trial With 4.5 Year Followup" which noted healing of ulcers and resolution of ischemic rest pain occurred in 83% of patients, with outcomes maintained for up to 4.5 years.

The Company owns 91 patents across five patent families titled: Regulating Stem Cells, In Vitro Techniques for use with Stem Cells, Production from Blood of Cells of Neural Lineage, and Automated Cell Therapy. For more information, please visit http://www.hemostemix.com.

Contact: Thomas Smeenk, President, CEO & Co-Founder TSmeenk@Hemostemix.com 905-580-4170

Neither the TSX Venture Exchange nor its Regulation Service Provider (as that term is defined under the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Forward-Looking Information: This news release contains "forward-looking information" within the meaning of applicable Canadian securities legislation. All statements, other than statements of historical fact, included herein are forward-looking information. In particular, this news release contains forward-looking information regarding: the commercialization of ACP-01. There can be no assurance that such forward-looking information will prove to be accurate, and actual results and future events could differ materially from those anticipated in such forward-looking information. This forward-looking information reflects Hemostemix's current beliefs and is based on information currently available to Hemostemix and on assumptions Hemostemix believes are reasonable. These assumptions include, but are not limited to: the results of ACP-01 research, trials and studies being equivalent to or better than previous research, trials or studies as well as management's expectations of anticipated results; Hemostemix's general and administrative costs remaining constant; the receipt of all required regulatory approvals for research, trials or studies as well as any required or desired financings of Hemostemix, including TSX Venture Exchange acceptance and any third party consents; the level of activity, market acceptance and market trends in the healthcare sector; the economy generally; consumer interest in Hemostemix's services and products; competition and Hemostemix's competitive advantages; and obtaining satisfactory financing to fund Hemostemix's operations including any research, trials or studies. Forward-looking information is subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of Hemostemix to be materially different from those expressed or implied by such forward-looking information. Such risks and other factors may include, but are not limited to: the ability of Hemostemix to complete its current CLI clinical trial, complete a satisfactory futility analysis and the results of such and future clinical trials; litigation and potential litigation that Hemostemix may face; general business, economic, competitive, political and social uncertainties; general capital market conditions and market prices for securities; delay or failure to receive board or regulatory approvals; the actual results of future operations including the actual results of future research, trials or studies; competition; changes in legislation affecting Hemostemix; the timing and availability of external financing on acceptable terms; long-term capital requirements and future developments in the Company's markets and the markets in which it expects to compete; lack of qualified, skilled labour or loss of key individuals; and risks related to the COVID-19 pandemic including various recommendations, orders and measures of governmental authorities to try to limit the pandemic, including travel restrictions, border closures, non-essential business closures, service disruptions quarantines, self-isolations, shelters-in-place and social distancing, disruptions to markets, economic activity, financing, supply chains and sales channels, and a deterioration of general economic conditions including a possible national or global recession; the potential impact that the COVID-19 pandemic may have on Hemostemix may include a decreased demand for the services that Hemostemix offers; and a deterioration of financial markets that could limit Hemostemix's ability to obtain external financing. A description of additional risk factors that may cause actual results to differ materially from forward-looking information can be found in Hemostemix's disclosure documents on the SEDAR website at http://www.sedar.com. Although Hemostemix has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking information, there may be other factors that cause results not to be as anticipated, estimated or intended. Readers are cautioned that the foregoing list of factors is not exhaustive. Readers are further cautioned not to place undue reliance on forward-looking information as there can be no assurance that the plans, intentions or expectations upon which they are placed will occur. Forward-looking information contained in this news release is expressly qualified by this cautionary statement. The forward-looking information contained in this news release represents the expectations of Hemostemix as of the date of this news release and, accordingly, is subject to change after such date. However, Hemostemix expressly disclaims any intention or obligation to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, except as expressly required by applicable securities law.

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Hemostemix Filed an Injunction Against Accudata Solutions, Inc. for the Return of its Clinical Trial Midpoint Report and Data - Yahoo Finance

Transplant patient turns to art to raise money for charity which saved her life – Bishop’s Stortford Independent

A young Bishop's Stortford woman who suffers from a rare immune disorder has completed a challenge to paint every day for a month to raise money for the Anthony Nolan charity.

Michelle Peppiatt, 30, received a stem cell transplant last year after the organisation found her a matching donor and is now recovering at her home in Wallace Court where she has been shielding since before the coronavirus outbreak.

Art has proved a great outlet for Michelle in keeping her anxiety at bay and at the completion of her challenge yesterday (June 30) she had raised more than 700. "At the beginning of the month I decided to fundraise for Anthony Nolan, who save the lives of thousands with blood disorders. But I started to wonder how they were getting by during Covid-19 and it suddenly hit me that it could have been me and I might not have had my transplant so I decided to fundraise by taking art every day for the duration of June.

"Post transplant I really struggled to find things I was capable of doing due to the effects of the treatment and just stumbled across art and thought I would give it a go. I fell in love with it - it's been a great outlet for me."

Michelle's condition is known as Haemophagocytic lymphohistiocytosis (HLH), a rare immune disorder where the body reacts inappropriately to a trigger, usually an infection. There are two forms of HLH - primary which is a genetic type and secondary which is caused by a malignant blood cancer or acute infection/virus.

Michelle was diagnosed with lymphoma first and then the HLH was discovered. She said: "I had the treatment that is suggested for HLH which is eight weeks of chemotherapy and immune therapy. I relapsed three times after several rounds of chemotherapy immune therapy and biological therapies - my only chance at surviving was a stem cell transplant.

"The HLH had affected all my organs and muscles. But my medical team turned to Anthony Nolan to help. Anthony Nolan search every stem cell donor register in the world to find some one who is a perfect genetic match. I received my stem cell transplant in January 2019. I have long term effects of treatment and art helps me manage anxiety, pain, fatigue and isolation.

"I spent a number of weeks and months in isolation during treatment, due to infections and after the transplant. I'm adjusted to being sheilded and have learnt to keep myself occupied. I have had to find ways to manage my anxiety and general mental health."

Michelle describes her work as fluid art using acrylics and each day has picked a subject matter out of a pot. "Today was oceans and I made art based on the colours of the ocean. I've been painting every day, usually three paintings a day, and sell them via my Facebook page, but now we're at the end I'm looking to expand because they are still selling and I hope to reach more people," she said.

"And now that I have created a space for continuing after this I possibly will set it up as a business. "

She said the experience of lockdown "wasn't too bad as I have spent the last three and a half years in isolation" and discovering art had been a great help. "It has been incredibly therapeutic for me. It has no boundaries, it's very freeing."

On her Facebook posts, Michelle says: "At the start of this I did begin to wonder what I'd let myself in for. When I look at my paintings I've accomplished I feel something I haven't felt in a long time. Peace. A moment of mindfullness and connection!"

Michelle's remaining paintings will still be on sale until August 1. Visit @chelepep/freedomart on Facebook or her instagram page @chellepep for more details.

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Transplant patient turns to art to raise money for charity which saved her life - Bishop's Stortford Independent

Artificial Blood Substitutes Market – Insights into how contours of market will change in coming years – BioSpace

The global artificial blood substitutes market is predicted to register stellar growth rate in the forthcoming years. The presence of a large patient population that requires blood transfusion during surgeries, trauma, and for other blood disorders, which remains unmet due to shortage of blood supply has necessitated creation of artificial blood substitutes.

Artificial blood substitutes are primarily used to mimic oxygen carrying capacity of biological blood and expand the blood volume in the human body. Use of artificial blood substitutes is at present considered an alternate method for blood transfusion. Further research is underway to develop more alternate methods for blood transfusion, including developing human red blood cells (RBCs) from stem cells of donors blood.

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The research report provides an in-depth analysis of the artificial blood substitutes market over the forecast period. The report covers each and every key aspect pertinent to the market, including market dynamics, segmentation, and competitive scenario. The assessment of artificial blood substitutes market presented herein could serve as a valuable guide for both existing market participants, and the ones seeking entry in this market.

Artificial Blood Substitutes Market: Competitive Landscape and Notable Developments

The initial clinical trials for blood substitutes are recorded as early as early 1600, wherein milk, beer, urine, sheeps blood, and perfluorochemicals were administered as blood substitutes for animal and human subjects.

In successive periods, clinical trials of milk transfusion, including goats milk in large quantities were carried out but in vain. Clinical trials also involved injecting human milk that were futile too, which led researchers concede human milk not to be a substitute for blood.

With continual extensive research, over long periods, scientists have attained some success to develop blood substitutes. Artificial blood thus far developed can substitute red blood cells. While biological human blood performs several different functions, artificial blood performs the sole purpose of transporting oxygen and carbon dioxide in the body.

Established biotechnology companies in the ambit are engaged to develop blood substitutes. Such pursuits primarily involve developing oxygen carriers similar or above the capacity of biological blood. With concerted efforts of some top-notch biotechnology companies, namely HEMARINA SA, KaloCyte Inc. and Hemoglobin Oxygen Therapeutics LLC blood substitutes are available as oxygen carrier based on hemoglobin and perfluorocarbon-based oxygen carrier.

Nevertheless, presence of several well-established biotechnology companies engaged in the development of blood substitutes portrays a competitive yet moderately consolidated vendor landscape of the artificial blood substitutes market.

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Artificial Blood Substitutes Market: Key Trends

Worldwide, excessive blood loss due to traumatic injuries and diseases is responsible for vast number of deaths every year. Limited availability of fresh blood and small storage periods of fresh blood for such situations have necessitated development of artificial blood substitutes.

With continual experiments over long periods, scientists have thus far been able to create substitutes to mimic oxygen carrier capacity of biological blood. Development of perfluorochemical-based oxygen carrier and hemoglobin-based oxygen carrier and provide thrust to the artificial blood substitutes market.

Besides this, advent of stem cell therapy is poised to create new opportunities for demand of artificial blood substitutes.

However, on the downside, lower shelf life of artificial blood products and stringent regulatory approval process for these products restrain the growth of artificial blood substitutes market.

Artificial Blood Substitutes Market: Regional Outlook

North America is at the fore for demand within overall artificial blood substitutes market. Presence of advanced healthcare combined with awareness of individuals for alternate demonstrated therapies account for leading revenue share of the region.

Continual advances in stem cell therapy further indicates sustained growth of artificial blood substitutes market in the region.

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Artificial Blood Substitutes Market - Insights into how contours of market will change in coming years - BioSpace

Global Stem Cell Therapy Market 2020 Segmentation, Top Manufacturers, Demand, Growth, Trend, Opportunity and Forecast to 2025 – 3rd Watch News

The global Stem Cell Therapy market size is expected to gain market growth in the forecast period of 2020 to 2025, with a CAGR of 18.9% in the forecast period of 2020 to 2025 and will expected to reach USD 828.7 million by 2025, from USD 415.3 million in 2019. The Stem Cell Therapy market report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, impact of domestic and global market players, value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.

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Market segmentation Stem Cell Therapy market is split by Type and by Application. For the period 2015-2025, the growth among segments provide accurate calculations and forecasts for sales by Type and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.

By Type, Stem Cell Therapy market has been segmented into Autologous, Allogeneic, etc.

By Application, Stem Cell Therapy has been segmented into Musculoskeletal Disorder, Wounds & Injuries, Cornea, Cardiovascular Diseases, Others, etc.

Regions and Countries Level Analysis Regional analysis is another highly comprehensive part of the research and analysis study of the global Stem Cell Therapy market presented in the report. This section sheds light on the sales growth of different regional and country-level Stem Cell Therapy markets. For the historical and forecast period 2015 to 2025, it provides detailed and accurate country-wise volume analysis and region-wise market size analysis of the global Stem Cell Therapy market. The report offers in-depth assessment of the growth and other aspects of the Stem Cell Therapy market in important countries (regions), including United States, Canada, Mexico, Germany, France, United Kingdom, Russia, Italy, China, Japan, Korea, India, Southeast Asia, Australia, Brazil and Saudi Arabia, etc. It also throws light on the progress of key regional Stem Cell Therapy markets such as North America, Europe, Asia-Pacific, South America and Middle East & Africa.

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Competitive Landscape and Stem Cell Therapy Market Share Analysis Stem Cell Therapy competitive landscape provides details by vendors, including company overview, company total revenue (financials), market potential, global presence, Stem Cell Therapy sales and revenue generated, market share, price, production sites and facilities, SWOT analysis, product launch. For the period 2015-2020, this study provides the Stem Cell Therapy sales, revenue and market share for each player covered in this report.

The major players covered in Stem Cell Therapy are: Osiris Therapeutics, Molmed, JCR Pharmaceutical, NuVasive, Anterogen, Chiesi Pharmaceuticals, Medi-post, Pharmicell, Takeda (TiGenix), etc. Among other players domestic and global, Stem Cell Therapy market share data is available for global, North America, Europe, Asia-Pacific, Middle East & Africa and South America separately. Global Info Research analysts understand competitive strengths and provide competitive analysis for each competitor separately.

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Major Point of TOC:

Chapter One: Stem Cell Therapy Market Overview

Chapter Two: Company Profiles

Chapter Three: Market Competition, by Players

Chapter Four: Market Size by Regions

Chapter Five: North America Stem Cell Therapy Revenue by Countries

Chapter Six: Europe Stem Cell Therapy Revenue by Countries

Chapter Seven: Asia-Pacific Stem Cell Therapy Revenue by Countries

Chapter Eight: South America Stem Cell Therapy Revenue by Countries

Chapter Nine: Middle East & Africa Revenue Stem Cell Therapy by Countries

Chapter Ten: Market Size Segment by Type

Chapter Eleven: Global Stem Cell Therapy Market Segment by Application

Chapter Twelve: Global Stem Cell Therapy Market Size Forecast (2021-2025)

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Duchenne Muscular Dystrophy Treatment Market to Witness over XX% Growth ‘in Revenue During the COVID-19 Pandemic Scenario – Kentucky Journal 24

Duchenne Muscular Dystrophy (DMD) is a muscle degeneration and is a genetic disorder which is X-linked recessive. However, it is also inherited from parents or caused due to a new mutation. There are various therapies and drugs to control DMD, however, there is still no cure for duchenne muscular dystrophy.

Major driving factors in the global duchenne muscular dystrophy market are the introduction of novel drugs and therapies, disease-modifying therapies, strong support from various companies for drug development and support from patient advocacy groups on the regulatory approval process. Moreover, mutation-specific therapies are likely to emerge as a major breakthrough in the duchenne muscular dystrophy treatment. Drug developers are also focusing on developing new drugs and therapies targeting newborns, young infants and also the last-stage DMD patients. In the last few years, there has been rapid development in the duchenne muscular dystrophy therapeutics. However, there is still a large number of patients who are not able to benefit from therapies and drugs due to its high cost and lack of awareness.

Duchenne Muscular Dystrophy (DMD) is a type of muscular disorder due to which most of the people are unable to walk at a very early stage and the affected muscles look larger due to the fat content. The symptoms include muscle weakness, difficulty in walking and breathing and intellectual disability. Although, the treatment to control and reduce the signs and symptoms is available, yet there is no cure for DMD. Key players in the market are also trying to spread awareness about DMD along with the investment in finding a treatment for the disease. Meanwhile, human clinical trials are also underway to find out effective therapy.

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Various pharmaceutical companies and organizations are increasingly investing in the research and development activities to come up with an effective treatment for duchenne muscular dystrophy. Meanwhile, there is an ongoing research on gene therapy, exon skipping drugs, and stem cell therapy to treat duchenne muscular dystrophy in a better way. Current pharmacological interventions for duchenne muscular dystrophy include approaches to mitigate downstream and secondary pathological mechanisms and solutions targeting primary defect. Patients with DMD are not able to produce a protein known as dystrophin. Hence, a variety of new medications are being developed to replace dystrophin. Moreover, new therapies aim to repair muscle damage caused due to the absence of dystrophin. However, delay in diagnosis and the high cost of treatment and drugs are some of the factors restricting the growth of the market.

The global duchenne muscular dystrophy market is segmented into therapy, distribution channel, product type, and region. The product type is further segmented into corticosteroids, NSAIDs, and other products. Among these, corticosteroids are likely to witness the highest growth during the forecast period. By the end of 2026, corticosteroids are estimated to bring in more than US$ 9,000 million revenue.

Based on the distribution channel, the global duchenne muscular dystrophy market segmentation includes online pharmacies, retail pharmacies, and hospital pharmacies. Hospitals pharmacies are expected to be the largest distributors in the duchenne muscular dystrophy market. Hospital pharmacies are anticipated to exceed US$ 6,000 million revenue towards the end of 2026.

On the basis of therapy, the market segmentation includes Exon Skipping Approach, Mutation Suppression, and other therapies. Mutation suppression therapy is expected to witness strong growth throughout the forecast period. By the end of 2026, mutation suppression therapy is estimated to bring in more than US$ 6,400 million revenue.

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Europe is expected to be the dominating region in the global duchenne muscular dystrophy market during the forecast period. Owing to the high rate of people suffering from duchenne muscular dystrophy, Europe is witnessing the growth in adoption of treatment for muscular dystrophy. Also, various treatments are approved or under review to treat duchenne muscular dystrophy in Europe. This is also one of the reasons for the growth of the market in Europe.

Some of the players in Duchenne Muscular Dystrophy Treatment Market are Bristol-Myers Squibb(U.S), FibroGen, Inc (U.S), ITALFARMACO S.p.A. (Italy), Catabasis Pharmaceuticals, Inc.(U.S) , NS Pharma, Inc. (U.S), Marathon Pharmaceuticals, LLC (U.S), ReveraGen BioPharma, Inc. (U.S), Pfizer (U.S), Summit Therapeutics plc (U.K), Taiho Pharmaceutical Co (Japan), Sarepta Therapeutics (U.S), Inc., Santhera Pharmaceuticals, PTC Therapeutics (Switzerland)

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Duchenne Muscular Dystrophy Treatment Market to Witness over XX% Growth 'in Revenue During the COVID-19 Pandemic Scenario - Kentucky Journal 24

Hodgkin’s Lymphoma in 8 Major Markets, 2019-2029 – Anticipated Label Expansions of Currently Marketed Therapies is a Key Driver – GlobeNewswire

July 03, 2020 06:24 ET | Source: Research and Markets

Dublin, July 03, 2020 (GLOBE NEWSWIRE) -- The "Hodgkin's Lymphoma - Opportunity Analysis and Forecasts to 2029" report has been added to ResearchAndMarkets.com's offering.

The World Health Organization (WHO) classifies HL into two main types: classical HL (CHL) and nodular lymphocyte-predominant HL (NLPHL), which CHL accounts for 95% of cases. Historically, treatment of HL has been mostly reliant on chemotherapies, radiotherapy and SCT and has lacked a rapidly advancing pipeline.

In recent years however, the arrival of three novel agents reflect a change in the treatment paradigm, shifting from cytotoxic therapies to immunotherapies and novel cell-based therapies.

The publisher is expecting a total of 6 new entrants to launch over the forecast period in the 8MM from 2019-2029, while specific marketed agents are expected to move into earlier lines of treatment as novel combinations. The main competition will between drug entering the first-line setting and novel combinations within the salvage setting for relapsed and refractory patients. Given the high cure rate for this indication, these two early setting are the most determinant of global sales for Hodgkin's lymphoma.

Key Highlights

Report Scope

Key Questions Answered

Key Topics Covered

1 Table of Contents 1.1 List of Tables 1.2 List of Figures

2 Hodgkin's Lymphoma: Executive Summary 2.1 Moderate Market Growth Expected for Hodgkin's Lymphoma During 2019-2029 2.2 Drug Developers Focusing On Combination Therapies Featuring Marketed Products with Novel Therapies 2.3 Need for More Effective Therapies to Reduce the Use of Chemotherapy and Delay Stem Cell Transplant is Partially Attainable 2.4 Growth in the 8MM Is Driven by Label Expansions of Existing Therapies and Less Impacted by Novel Agents 2.5 What Do Physicians Think?

3 Introduction

4 Disease Overview 4.1 Etiology and Pathophysiology 4.2 Diagnosis and Symptoms

5 Epidemiology 5.1 Disease Background 5.2 Risk Factors and Comorbidities 5.3 Global and Historical Trends 5.4 Forecast Methodology 5.4.1 Sources 5.4.2 Sources Not Used 5.5 Forecast Assumptions and Methods 5.5.1 8MM 5.6 Epidemiological Forecast for HL (2019-2029) 5.6.1 Diagnosed Incident Cases of HL 5.6.2 Diagnosed Incident Cases of Classical HL 5.6.3 Age-Specific Diagnosed Incident Cases of Classical HL 5.6.4 Sex-Specific Diagnosed Incident Cases of Classical HL 5.6.5 Diagnosed Incident Cases of Classical HL by Cancer Stage 5.6.6 Diagnosed Incident Cases of Classical HL by Cancer Subtypes 5.6.7 Five-Year Diagnosed Prevalent Cases of Classical HL 5.6.8 Diagnosed Incident Cases of Nodular Lymphocyte Predominant HL 5.7 Discussion 5.7.1 Epidemiological Forecast Insight 5.7.2 Limitations of the Analysis 5.7.3 Strengths of the Analysis

6 Current Treatment Options 6.1 Treatment Overview

7 Unmet Needs and Opportunity Assessment

8 R&D Strategies

9 Pipeline Assessment

10 Pipeline Valuation Analysis

11 Appendix

Companies Mentioned

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Hodgkin's Lymphoma in 8 Major Markets, 2019-2029 - Anticipated Label Expansions of Currently Marketed Therapies is a Key Driver - GlobeNewswire

Potential Impact of COVID-19 on Research report explores the Autoimmune Disorders Treatment Market for the forecast period, 2020-2026 – 3rd Watch News

Autoimmune Disorders Treatment Marketreport provides in-depth COVID19 impact analysis ofMarket Overview, Product Scope, Market Drivers, Trends, Opportunities,Market Driving Force and Market Risks. It also profile the topmost prime manufacturers (Abbott Laboratories, Roche Diagnostics, Siemens Healthcare, Johnson & Johnson, Boehringer Ingelheim, GlaxoSmithKline, AstraZeneca, Sanofi, Merck, Pfizer) are analyzed emphatically by competitive landscape contrast, with respect toPrice, Sales,Capacity, Import, Export, Consumption, Gross, Gross Margin, Revenue and Market Share. Autoimmune Disorders Treatment industry breakdown data are shown at the regional level, to show the sales, revenue and growth by regions.Autoimmune Disorders Treatment Market describe Autoimmune Disorders Treatment Sales Channel,Distributors, Customers, Research Findings and Conclusion, Appendix and Data Source.

Key Target Audience of Autoimmune Disorders Treatment Market:Manufacturers of Autoimmune Disorders Treatment, Raw material suppliers, Market research and consulting firms, Government bodies such as regulating authorities and policy makers, Organizations, forums and alliances related to Autoimmune Disorders Treatment market.

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In-Depth Qualitative Analyses Include Identification and Investigation Of The Following Aspects:Autoimmune Disorders Treatment Market Structure, Growth Drivers, Restraints and Challenges, Emerging Product Trends & Market Opportunities, Porters Fiver Forces.

Summary of Autoimmune Disorders Treatment Market:Graves disease, Multiple sclerosis, Myasthenia gravis, Rheumatoid arthritis, Pernicious anemia and Systemic lupus erythematosus are the most prevalent types of autoimmune disorders. The prevalence of autoimmune diseases is high in women than in men, which results from the influence of estrogen on immune system.

On the basis on the end users/applications,this report focuses on the status and outlook for major applications/end users, sales volume, market share and growth rate of Autoimmune Disorders Treatment market foreach application, including-

Systemic autoimmune diseases Localized autoimmune diseases

On the basis of product,this report displays the sales volume, revenue (Million USD), product price, market share and growth rate ofeach type, primarily split into-

Bridge therapy Recombinant technology Fecal bacteriotherapy Hematopoietic stem-cell transplantation Phototherapy Helminthic therapy Activation-induced assays Cytometry by time-of-flight mass spectrometry

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Potential Impact of COVID-19 on Research report explores the Autoimmune Disorders Treatment Market for the forecast period, 2020-2026 - 3rd Watch News

Lysosomal Disease Treatment Market Size, Global Analytical Overview, Growth Factors, Technologies, Trends and Forecast To 2025 – 3rd Watch News

The Global Lysosomal Disease Treatment Market report gives a detailed overview of the key market drivers, restraints, and trends and analyzes the way they will affect markets development over the forecast period 2020-2025

This Global Lysosomal Disease Treatment Industry 2020 report also gives comprehensive insight of, in-depth overview of the competitive landscape of the Lysosomal Disease Treatment Market, Industry Size, Share, Market Productions, Pricing, and Global Revenues 2018-2020 Import-Export Figures & SWOT Analysis, PEST analysis, PORTER analysis and Forecast till 2025

You may request sample of this report to glance through the outline of report coverage that typically includes report description, table of contents, lists of tables and figures, regional taxonomy, competition analysis, strategic developments, and innovations of key market players. All this data is based on the outcome of an extensive research methodology and helps businesses comprehend overall market scenario.

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The market is segmented by types:

Hematopoietic Stem Cell Transplantation

Enzyme Replacement Therapy

Substrate Reduction

Chaperone Therapies

It can be also divided by applications:

Hospitals

Clinics

Stem Cell Transplant Center

Research Organizations

Others

And this report covers the historical situation, present status and the future prospects of the global Lysosomal Disease Treatment market for 2015-2025. In this report, we analyze global market from 5 geographies: Asia-Pacific, Europe, North America, Middle East & Africa, South America.

Finally, the report provides detailed profile and data information analysis of leading company.

Astellas Pharma

Astrazeneca

Actelion Pharmaceuticals Ltd.

Eli Lilly and Co.

Merck & Co.

Novo Nordisk A/S

Shire

Pfizer

Sanofi

BioMarin

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Table of Contents

GlobalLysosomal Disease TreatmentMarketReport2020,Forecastto2025

Chapter 1ScopeoftheStudy

Chapter 2Lysosomal Disease TreatmentIndustryOverview

Chapter 3UpstreamandDownstreamMarketAnalysis

Chapter 4GlobalLysosomal Disease TreatmentMarketSizeCategorizedbyRegions

Chapter 5EuropeLysosomal Disease TreatmentMarketSizeCategorizedbyCountries

Chapter 6Asia-PacificLysosomal Disease TreatmentMarketSizeCategorizedbyCountries

Chapter7NorthAmericaLysosomal Disease TreatmentMarketSizeCategorizedbyCountries

Chapter8SouthAmericaLysosomal Disease TreatmentMarketSizeCategorizedbyCountries

Chapter9MiddleEastandAfricaLysosomal Disease TreatmentMarketSizeCategorizedbyCountries

Chapter 10GlobalLysosomal Disease TreatmentMarketSegmentbyType

Chapter 11GlobalLysosomal Disease TreatmentMarketSegmentbyApplication

Chapter 12MarketForecastforLysosomal Disease Treatment

Chapter 13AnalysisofLysosomal Disease TreatmentIndustryKeyManufacturers

Chapter 14ResearchFindingsandConclusion

Chapter 15Appendix

Research objectives:

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Lysosomal Disease Treatment Market Size, Global Analytical Overview, Growth Factors, Technologies, Trends and Forecast To 2025 - 3rd Watch News

In Vitro Toxicology Testing Market to Exhibit Rapid Surge in Consumption in the COVID-19 Crisis 2024 – 3rd Watch News

[112 Report Pages] This market research report identifies Laboratory Corporation of America Holdings, Charles River Laboratories, Inc, Thermo Fisher Scientific, Eurofins Scientific, Agilent Technologies, Inc., as the major vendors operating in the global in vitro toxicology testing market. This report also provides a detailed analysis of the market by toxicology end points (systemic toxicity, cytotoxicity testing, genotoxicity testing, ocular toxicity, organ toxicity, dermal toxicity, neurotoxicity, and others), industry type (pharmaceutical and biopharmaceutical, cosmetics, chemical, diagnostics, and food industry), and region (North America, Europe, Asia Pacific, and Rest of the World).

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Infoholicsmarket research report predicts that theglobalin vitro toxicology testingmarketwill grow at a CAGR of8.2%during the forecast period 20182024.The market for in vitro toxicology testing is driven by high opposition to animal testing, increased cost related to animal-based toxicity testing, and increasing R&D expenditure for early stage toxicity testing. Whereas, the lack of in vitro models and decreased adoption rate are limiting the growth of the in vitro toxicology testingmarket to an extent.

According to the in vitro toxicology testingmarket analysis, Europe accounted for the largest share of the global in vitro toxicology testingmarket followed by North America in 2017. The reason is the upsurge in the investments by the European Commission in R&D to develop substitute methods to in vitro testing is driving the demand in this region. Asia Pacific is expected to grow at a high CAGR during the forecast period due to increasing number of contract research organizations offering testing services, advancements in healthcare infrastructure, increasing investments in the biopharmaceutical sector, and upward economic conditions in the region.

Competitive Analysis and Key Vendors:

There is an increase in collaborations between companies on in vitro testing of compounds. For instance, in December 2016, Evotec and Celgene entered into a drug discovery collaboration for neurodegenerative diseases. According to agreement terms, Celgene will use Evotecs unique induced pluripotent stem cell (iPSC) platform that enables systematic drug screening in patient-derived disease models. In June 2017, Censo Biotechnologies Ltd. collaborated with Evotec AG to source and provide patient-derived induced pluripotent stem cells to support Evotecs drug discovery iPSC platform. In addition, the companies are also coming up with new products for in vitro testing. For instance, in January 2018, STEMCELL Technologies Inc. released two product lines for organoid research that will enable scientists to create powerful models for studying human disease in the laboratory.

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Some of the In Vitro Toxicology Testing Market key vendorsare:

Other prominent vendors in the global in vitro toxicology testing market are Bio-Rad Laboratories, GE Healthcare, SGS SA, BioIVT, Abbott Laboratories, Gentronix Limited, Promega Corporation, MB Research Laboratories, Evotec AG (Cyprotex plc), Catalent, Inc., Qiagen N.V., and niche players.

In Vitro Toxicology Testing Market by Toxicology End Points:

In 2017, the systemic toxicity accounted for the highest market share due to the availability of a wide range of sub-studies, which ensure total analysis of toxicity and safety margin of the testing compounds.

In Vitro Toxicology Testing Market by Industry type:

In 2017, the pharmaceutical and biopharmaceutical industry occupied significant market share and the cosmetics industry is expected to hold a high percentage during the forecast period. Increased support of regulatory authorities to use in vitro and in silico methods instead of animal testing to check toxicology is driving the growth of the cosmetic industry.

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In Vitro Toxicology Testing Market Benefits:

The report provides detailed information about the services offered by in vitro toxicology testingin various therapeutic verticals and regions. With that, key stakeholders can find out the major trends, drivers, investments, and vertical players initiatives. Moreover, the report provides details about the major challenges that are going to have an impact on market growth. Additionally, the report gives complete details about the business opportunities to key stakeholders to expand their business and capture revenues in the specific verticals. The report will help companies interested or established in this market to analyze the various aspects of this domain before investing or expanding their business in the in vitro toxicology testingmarket.

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In Vitro Toxicology Testing Market to Exhibit Rapid Surge in Consumption in the COVID-19 Crisis 2024 - 3rd Watch News

First time ever successful operation with a single-use endoscope on immunodepressed child – Emergency-Live

The advantage of a single-use endoscope is that, since they do not have to be sanitized and reprocessed they do not expose to the danger of infections during endoscopic procedures. Thats why they turned out to be so useful in immunodepressed patients, like the child of this case.

Given the high costs, they are reserved for immunodepressed adult patients and have come back of great use in the middle of the pandemic emergency from COVID-19.

At the Policlinico Universitario A. Gemelli IRCCS (Italy) the disposable endoscope Exalt has been successfully used for the first time also on a pediatric immunodepressed child with congenital immunodeficiency. Thanks to the UOC team of Digestive Surgical Endoscopy directed by Professor Guido Costamagna, Professor of General Surgery at the Catholic University in Rome, this operation was possible-

Below, the official communication by Policlinico Gemelli.

Exalt is the name of the brand-new disposable endoscope model and was first used in the world at Policlinico Gemelli. It has been used to assist a 7-year-old child suffering from biliary narrowing who was dilated with this high-tech instrument, explains the note.

The most important thing about these disposable instruments (the one used is Boston Scientifics Exalt Model-D) is that, although expensive, they overcome all the problems linked to the meticulous disinfection and reprocessing that traditional endoscopes undergo after each use. When operating immunodepressed patients, such as the little patient admitted to the Policlinico Gemelli suffering from a very rare form of congenital immunodeficiency (DOCK8 deficiency, Dedicator of Cytokinesis 8), this fact is very important.

This rare disease exposed this child to a very high risk of infection.

The patient had developed primary sclerosing cholangitis while waiting for a hematopoietic stem cell transplant (marrow transplant). This is a disease that affects the biliary tract that causes bile to flow from the liver to the gallbladder and then to the duodenum and a narrowing of the biliary sphincter, to be treated by biliary sphinctomy using the ERCP (Endoscopic retrograde cholangiopancreatography) procedure, i.e. an incision of the outlet of the biliary tract in the duodenum, which is performed in endoscopy.

It is a delicate operation but necessary to prevent the stagnation of bile in the biliary tract. This may cause a possible infection (cholangitis), very dangerous in immunodepressed children, continues the official note of the polyclinic.

The endoscopic surgery was performed at the beginning of this month and the little one, assisted in collaboration with the doctors of the Pediatric Oncology Unit of Policlinico Gemelli, was discharged in excellent condition 48 hours after the treatment.

So far the Exalt single-use duodenoscope has been used only on adult patients, explains Professor Guido Costamagna director of the UO of Digestive Surgical Endoscopy Department. At Policlinico Gemelli, the medical staff have had it available since last March and they used it to treat two COVID-19 patients, in the middle of the pandemic.

For the first time in the world, we used this disposable endoscope on a 7-year-old girl weighing just 24 kilos.

The single-use endoscope (a duodenoscope, precisely) represents a still expensive device, but certainly very useful in selected cases, such as immunodepressed patients. According to our experience, Exalt can be used safely even in small pediatric patients.

The Exalt Model-D, the worlds first single-use endoscope was awarded by the US Food and Drug Administration (FDA) with the Breakthrough Device Designation last December and received the CE mark in January this year, concludes the official note.

Each year, 1.5 million ERCP procedures are performed worldwide, 500,000 of which are performed in Europe.

KNOW MORE

Primary Sclerosing Cholangitis

SOURCE

Official Website of Policlinico Gemelli

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First time ever successful operation with a single-use endoscope on immunodepressed child - Emergency-Live