Stem Cell Assay Market Future Trends and Forecast to 2027 | Merck & Co., Thermo Fisher Scientific, GE Healthcare, Agilent Technologies, Bio-Rad…

Global Stem Cell Assay Market Report, Sales and Consumption Status and Prospects Professional Research, the report classifies the global Stem Cell Assay Market in a precise manner to offer detailed insights about the aspects responsible for augmenting as well as restraining market growth.

Stem Cell Assay Market report provides a thoroughly researched abstract of the key players with considerable shareholdings at a Global level regarding demand, sales, and income by providing better products and services. Research Report outlines a forecast for the Stem Cell Assay market between 2020 and 2027. In terms of value, the Stem Cell Assay industry is expected to register a steady CAGR during the forecast period.

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* The sample copy includes: Report Summary, Table of Contents, Segmentation, Competitive Landscape, Report Structure, and Methodology.

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The key players profiled in this report include: Merck & Co., Thermo Fisher Scientific, GE Healthcare, Agilent Technologies, Bio-Rad Laboratories, Promega Corporation, Cell Biolabs, PerkinElmer, Miltenyi Biotec, HemoGenix, Bio-Techne Corporation, STEMCELL Technologies, and Cellular Dynamics International.

Regions included:

o North America (United States, Canada, and Mexico)

o Europe (Germany, France, UK, Russia, and Italy)

o Global (China, Japan, Korea, India, and Southeast Asia)

o South America (Brazil, Argentina, Colombia)

o Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

Key Benefits:

o This study gives a detailed analysis of drivers and factors limiting the market expansion of Stem Cell Assay

o The micro-level analysis is conducted based on its product types, end-user applications, and geographie

o Porters five forces model gives an in-depth analysis of buyers and suppliers, threats of new entrants & substitutes and competition amongst the key market players

o By understanding the value chain analysis, the stakeholders can get a clear and detailed picture of this Stem Cell Assay market

Table of Contents

Report Overview: It includes the Stem Cell Assay market study scope, players covered, key market segments, market analysis by application, market analysis by type, and other chapters that give an overview of the research study.

Executive Summary: This section of the report gives information about Stem Cell Assay market trends and shares, market size analysis by region and analysis of Global market size. Under market size analysis by region, analysis of market share and growth rate by region is provided.

Profiles of International Players: Here, key players of the Stem Cell Assay market are studied on the basis of gross margin, price, revenue, corporate sales, and production. This section gives a business overview of the players and shares their important company details.

Regional Study: All of the regions and countries analyzed in the Stem Cell Assay market report is studied on the basis of market size by application, the market size by product, key players, and market forecast.

Note: *The Download PDF brochure only consist of Table of Content, Research Framework, and Research Methodology.

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The research study can answer the following Key questions:

Major Highlights of TOC:

Chapter One: Global Stem Cell Assay Market Industry Overview

1.1 Stem Cell Assay Industry

1.1.1 Overview

1.1.2 Products of Major Companies

1.2 Stem Cell Assay Market Segment

1.2.1 Industry Chain

1.2.2 Consumer Distribution

1.3 Price & Cost Overview

Chapter Two: Global Stem Cell Assay Market Demand

2.1 Segment Overview

2.1.1 APPLICATION 1

2.1.2 APPLICATION 2

2.1.3 Other

2.2 Global Stem Cell Assay Market Size by Demand

2.3 Global Stem Cell Assay Market Forecast by Demand

Chapter Three: Global Stem Cell Assay Market by Type

3.1 By Type

3.1.1 TYPE 1

3.1.2 TYPE 2

3.2 Stem Cell Assay Market Size by Type

3.3 Stem Cell Assay Market Forecast by Type

Chapter Four: Major Region of Stem Cell Assay Market

4.1 Global Stem Cell Assay Sales

4.2 Global Stem Cell Assay Revenue & market share

Chapter Five: Major Companies List

Chapter Six: Conclusion

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Stem Cell Assay Market Future Trends and Forecast to 2027 | Merck & Co., Thermo Fisher Scientific, GE Healthcare, Agilent Technologies, Bio-Rad...

Novel Cell Sorting and Separation Market Supply-Demand, Industry Research and End User Analysis, Outlook 2026 | COVID19 Impact Analysis NanoCellect…

The report titled Novel Cell Sorting and SeparationMarket: Size, Trends and Forecasts (2020-2025), delivers an in depth analysis of the Novel Cell Sorting and Separationmarket by value, by production capacity, by companies, by applications, by segments, by region, etc.

The report assesses the key opportunities in the market and outlines the factors that are and will be driving the growth of the Novel Cell Sorting and Separationindustry. Growth of the overall Novel Cell Sorting and Separationmarket has also been forecasted for the period 2020-2025, taking into consideration the previous growth patterns, the growth drivers and the current and future trends.

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Impact of COVID-19:

Novel Cell Sorting and Separation Market report analyses the impact of Coronavirus (COVID-19) on the Novel Cell Sorting and Separation industry. Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost 180+ countries around the globe with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Novel Cell Sorting and Separation market in 2020.

The outbreak of COVID-19 has brought effects on many aspects, like flight cancellations; travel bans and quarantines; restaurants closed; all indoor events restricted; emergency declared in many countries; massive slowing of the supply chain; stock market unpredictability; falling business assurance, growing panic among the population, and uncertainty about future.

COVID-19 can affect the global economy in 3 main ways: by directly affecting production and demand, by creating supply chain and market disturbance, and by its financial impact on firms and financial markets.

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The major players profiled in this report includeNanoCellect Biomedical, Innovative Biochips, Cesca Therapeutics, Fluidigm, LumaCyte, Union Biometrica, LevitasBio, RareCyte, Cytonome, Namocell, STEMCELL Technologies, Akadeum Life Sciences, QIAGEN, ScreenCell.

Market Segments and Sub-segments Covered in the Report are as per below:

Based on Product Type Novel Cell Sorting and Separationmarket is segmented into Cancer Cell, Immune Cells, Microbial Cell, Red Blood Cell/Platelet, Stem Cell, Other

Based on Application Novel Cell Sorting and Separationmarket is segmented into Cell Research, Biomedical Diagnosis, Other

Regional Coverage of the Novel Cell Sorting and SeparationMarket:

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Novel Cell Sorting and Separation Market Supply-Demand, Industry Research and End User Analysis, Outlook 2026 | COVID19 Impact Analysis NanoCellect...

Global Culture Media Market 2020: Challenges, Drivers, Analysis, Types, Applications and Forecast 2025 – Cole of Duty

Global Culture Media Market Research Report Cover Covid-19 Impact

The Culture Media market research report fabricated by Brand Essence Market Research is an in-depth analysis of the latest trends persuading the business outlook. The report also offers a concise summary of statistics, market valuation, and profit forecast, along with elucidating paradigms of the evolving competitive environment and business strategies enforced by the behemoths of this industry.

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The Detailed Market intelligence report on the Global Culture Media Market applies the most effective of each primary and secondary analysis to weighs upon the competitive landscape and also the outstanding market players expected to dominate Global Culture Media Market place for the forecast 2019 2025.

Culture media is used in microbiological laboratories and research centers to grow and control cells. A cell culture medium is composed of an array of vitamins, amino acids, inorganic salts, glucose as an energy source, and serum as a source of growth & attachment factors & hormones.

The culture media market has evolved considerably in the past decade, owing to rapid progress in the areas of biopharmaceuticals, oncology, and stem cell research. Moreover, increase in funding & investments in R&D and innovation in the life science sector supplement the growth of the market.

In 2019, the market size of Culture Media is 4030 million US$ and it will reach 7570 million US$ in 2025, growing at a CAGR of 8.2% from 2019. In this report, 2018 has been considered as the base year and 2019 to 2025 as the forecast period to estimate the market size for Culture Media.

This report studies the global market size of Culture Media, especially focuses on the key regions like United States, European Union, China, and other regions (Japan, Korea, India and Southeast Asia).

This study presents the Culture Media production, revenue, market share and growth rate for each key company, and also covers the breakdown data (production, consumption, revenue and market share) by regions, type and applications. history breakdown data from 2014 to 2019, and forecast to 2025.

For top companies in United States, European Union and China, this report investigates and analyzes the production, value, price, market share and growth rate for the top manufacturers, key data from 2014 to 2019.

In global market, the following companies are covered:

Thermo Fisher Scientific Merck & Co. GE Healthcare The Sartorius Group Corning Lonza Group Becton Dickinson and Company HiMedia Laboratories Vitro Biopharma Bio-Rad Laboratories, Inc Caisson Laboratories Cell Culture Technologies LLC Fujifilm Holdings Corporation Avantor Performance Materials, LLC Sera Scandia A/S Takara Bio Cyagen Biosciences PeproTech Biomol GmbH

Market Segment by Product Type

Lysogeny Broth Chemically Defined Media Classical Media Serum-free Media Specialty Media Stem Cell Media Others

Market Segment by Application

Cancer Research Biopharmaceuticals Regenerative Medicine & Tissue Engineering Stem Cell Technologies Drug Discovery Others

Key Regions split in this report: breakdown data for each region.

United States China European Union Rest of World (Japan, Korea, India and Southeast Asia)

The study objectives are:

To analyze and research the Culture Media status and future forecast in United States, European Union and China, involving sales, value (revenue), growth rate (CAGR), market share, historical and forecast.

To present the key Culture Media manufacturers, presenting the sales, revenue, market share, and recent development for key players.

To split the breakdown data by regions, type, companies and applications

To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.

To identify significant trends, drivers, influence factors in global and regions

To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market

Request Customization of the Report: https://industrystatsreport.com/Request/Sample?ResearchPostId=1577&RequestType=Methodology

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To gain insightful analyses of the market and a comprehensive understanding of the impact of COVID-19 is likely to have on the Culture Media Market during the forecast period between 2020 and 2026, and its commercial landscape To learn about the market strategies that are being adopted by your competitors and other leading companies To understand the future outlook and prospects of the Culture Media Market post COVID-19 To keep you abreast with the strategies used by other players in the To understand the changes in rules and regulations in various countries during COVID-19 and its possible effects on the market in the future.

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We publish market research reports & business insights produced by highly qualified and experienced industry analysts. Our research reports are available in a wide range of industry verticals including aviation, food & beverage, healthcare, ICT, Construction, Chemicals and lot more. Brand Essence Market Research report will be best fit for senior executives, business development managers, marketing managers, consultants, CEOs, CIOs, COOs, and Directors, governments, agencies, organizations and Ph.D. Students.

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Global Culture Media Market 2020: Challenges, Drivers, Analysis, Types, Applications and Forecast 2025 - Cole of Duty

Top Investment Opportunities in Apoptosis Assay Reagent Market after COVID-19 Outbreak: Strategies by Key Players: Merck, Thermo Fisher Scientific,…

Overview of Global Apoptosis Assay Reagent Market:

The report on Apoptosis Assay Reagent market consists of prominent factors such as latest trends, performance drivers, key players, revenue, growth rate and volume sales, and consumer insights. Through an all-inclusive analysis and insights into developments impacting businesses, detailed information of enterprises on global and regional level have been accommodated in this report.

The report provides updated information on trends and developments and focuses on market capacities, technologies, and the changing structure of the Apoptosis Assay Reagent Market. The new entrants in the market are finding it hard to compete with the international dealers like Merck, Thermo Fisher Scientific, Becton Dickinson, Bio-Rad Laboratories, Promega Corporation, Abcam, etc. based on their quality and reliability in the industry. Financial outlooks of these companies, their research and development statuses, and their expansion strategies for the coming years have been highlighted in the report.

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The report provides a granular analysis of the market share, segmentation, revenue forecasts and geographic regions of the market. Following are some of the segmentations provided in the report ;

Leading players operating in the global Apoptosis Assay Reagent market are: Merck, Thermo Fisher Scientific, Becton Dickinson, Bio-Rad Laboratories, Promega Corporation, Abcam, Bio-Techne, Sartorius, Biotium, Creative Bioarray

Apoptosis Assay Reagent Market Growth by Types: Flow Cytometry, Fluorescence Microscopy

Apoptosis Assay Reagent Market Extension by Applications: Drug Discovery and Development, Clinical Research, Stem Cell Research, Basic Research

The Global version of this report with a geographical classification would cover regions: North America (USA, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia etc.), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

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While segmentations have been provided to list down various facets of the Apoptosis Assay Reagent market, analysis methods such as S.T.E.E.P.L.E., S.W.O.T., Regression analysis, etc. have been utilized to study the underlying factors of the market. Summarization of various aspects consisted in the report have been listed.

Other Key Aspects of Global Apoptosis Assay Reagent Market Report; 1.Identification of factors that could alter the current and forecasted growth of the market. 2.The incorporation of target audience during analytical assessment, to determine the impact of key drivers, restraints, and opportunities in detail. 3.Utilization of ANOVA test and FRAP method to determine the effect of, alteration in strategies by leading players, political occurrence, change in policies, etc. on current trends and future estimations to depict the imminent investment pockets. 4.To understand the lucrative trends and to gain a stronger foothold in the industry, the overall Apoptosis Assay Reagent market potential is determined. 5.To utilize and capture each opportunity Porters five forces analysis is utilized, to illustrate the potency of the buyers and suppliers in the market.

Keeping in mind the pandemic covering the whole of the Earth, we have prepared specialised information regarding Covid-19 which would be available along with the report. Also our reports have been curated to match up with the daily changes occurring due to the pandemic.

Additional points covered to measure the impact of Covid-19 on the Apoptosis Assay Reagent Market; Which markets around the world have maintained their hold on the Apoptosis Assay Reagent Market, and how have the markets dispersed the businesses? What effect will the Covid-19 virus have on the CAGR of the Apoptosis Assay Reagent Market? How the pandemic has transformed the industry of Apoptosis Assay Reagent Market, and what strategies have businesses implied to carry on the change? How have restrictions shaped the supply & demand of the Apoptosis Assay Reagent Market?

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Top Investment Opportunities in Apoptosis Assay Reagent Market after COVID-19 Outbreak: Strategies by Key Players: Merck, Thermo Fisher Scientific,...

3D Cell Culture Market in India-Manufacturing and Consumption, Outlook and Forecast 2020-2026 – Owned

A research report on the global 3D Cell Culture market delivers the growth prospects and current scenario of the 3D Cell Culture market. Likewise, to assess the market size, this study offers a precise analysis of the providers landscape as well as a corresponding detailed study about the manufacturers operating in the 3D Cell Culture market. Moreover, the 3D Cell Culture report offers quantitative and qualitative information which helps in understanding the historical, current, and future market scenario. Moreover, the report offers a complete analysis of the market segmentation and the growth factors influencing the market.

Get Sample Copy of This Report at https://www.orbisresearch.com/contacts/request-sample/4765201

Major Key Companies:

Thermo Fisher Scientific Corning Lonza Group Kuraray Co Merck Kgaa Insphero N3d Bioscience Reprocell Incorporated

Major Key Types:

Scaffold-based Scaffold-free

Important Key Applications:

Cancer Research Stem Cell Research Drug Discovery Regererative Medicine

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The research report comprises significant insights for investors that are looking to increase their market position in the previous and upcoming market scenario. In addition, the report extensively studies the several factors which are expected to influence the direction of the market during the prediction period. The 3D Cell Culture market report offers the value chain analysis, cost structure, and Porters Five analysis which offers market outlook. Moreover, the global 3D Cell Culture market study offers the complete mapping of the market players that are operating in the 3D Cell Culture market with their positioning on the basis of business strengths as well as product offerings that delivers the competitive landscape of the market. The global 3D Cell Culture report offers a holistic view of the industry along with the several factors which are driving as well as restraining the expansion of the global 3D Cell Culture market. This research study offers the business landscape of the top players with their industry overview, revenue, product portfolio by segment and regional outlook.

In addition, the report offers a brief overview of the manufacturing plant of the key companies which contains an analysis of the research & development capacity, manufacturing unit, as well as suppliers of the raw materials. Likewise, the global 3D Cell Culture market report focuses on the major economies including North America, Asia Pacific, Europe, and the Middle East and Africa. This report covers current trends across these regions with several opportunities that are present for the service providers in the country. According to the company level, the 3D Cell Culture market study focuses on the ex-factory pricing, production capacity, market share & revenue for every manufacturer. Likewise, this report includes primary and secondary drivers, leading segments, market share, drivers, and the geographical landscape of the 3D Cell Culture market.

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This report also covers a complete analysis of the major strategies implemented by the service providers in order to gain a market footprint against other providers. In addition to this, the research report focuses on the broad analysis of the strategic overview along with the activities of the market players such as partnerships, merger & acquisition, agreements, collaborations, and others which offers a clear idea of their current market scenario.

The global 3D Cell Culture market study includes a detailed analysis of the value and volume at an international level, company level, as well as regional level. Likewise, from a global point of view, the report offers a complete 3D Cell Culture market size by studying historical data and potential scenarios. Geographically, the 3D Cell Culture market report covers the number of regions along with their revenue analysis.

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3D Cell Culture Market in India-Manufacturing and Consumption, Outlook and Forecast 2020-2026 - Owned

Global Impact of Covid-19 on Hematology Instruments and Reagents Market to Witness Promising Growth Opportunities During 20202026 with Top Leading…

Latest Research Report: Hematology Instruments and Reagents industry

This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

Global Hematology Instruments and Reagents Market documents a detailed study of different aspects of the Global Market. It shows the steady growth in market in spite of the fluctuations and changing market trends. The report is based on certain important parameters.

Hematology instruments are machines that analyze blood. Used in medical labs, hematology instruments can do blood counts, detect proteins or enzymes, and help to diagnose illnesses or genetic defects. Hematology is the branch of medicine which deals with the study, diagnosis, and treatment of blood-related disorders. It diagnoses issues related to white blood cells, red blood cells, platelets, bone marrow, and lymph nodes. Hematology also deals with the liquid portion of blood known as plasma. Some blood-associated diseases are anemia, leukemia, myelofibrosis, blood transfusion, malignant lymphomas, and bone marrow stem cell transplantation.

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Hematology Instruments and Reagents Market competition by top manufacturers as follow: , Sysmex, Danaher, Nihon Kohden, Siemens, Abbott Laboratories, Boule Diagnostics, HORIBA, Diatron, Drew Scientific, EKF Diagnostics, Mindray, Roche

The risingtechnology in Hematology Instruments and Reagentsmarketis also depicted in thisresearchreport. Factors that are boosting the growth of the market, and giving a positive push to thrive in the global market is explained in detail. It includes a meticulous analysis of market trends, market shares and revenue growth patterns and the volume and value of the market. It is also based on a meticulously structured methodology. These methods help to analyze markets on the basis of thorough research and analysis.

The Type Coverage in the Market are: Hematology Instruments Hematology Reagents

Market Segment by Applications, covers: Stand-Alone Hospitals Commercial Organizations Clinical Testing Labs Research Institutes

The research report summarizes companies from different industries. This Hematology Instruments and Reagents Market report has been combined with a variety of market segments such as applications, end users and sales. Focus on existing market analysis and future innovation to provide better insight into your business. This study includes sophisticated technology for the market and diverse perspectives of various industry professionals.

Hematology Instruments and Reagents is the arena of accounting worried with the summary, analysis and reporting of financial dealings pertaining to a business. This includes the training of financial statements available for public ingesting. The service involves brief, studying, checking and reporting of the financial contacts to tax collection activities and objects. It also involves checking and making financial declarations, scheming accounting systems, emerging finances and accounting advisory.

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Market segment by Regions/Countries, this report covers North America Europe China Rest of Asia Pacific Central & South America Middle East & Africa

Report Highlights: Detailed overview of parent market Changing market dynamics in the industry In-depth market segmentation Historical, current and projected market size in terms of volume and value Recent industry trends and developments Competitive landscape Strategies of key players and products offered Potential and niche segments, geographical regions exhibiting promising growth A neutral perspective on market performance Must-have information for market players to sustain and enhance their market footprint

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Global Impact of Covid-19 on Hematology Instruments and Reagents Market to Witness Promising Growth Opportunities During 20202026 with Top Leading...

R3 International Offering New Program for Stem Cell Therapy for Liver Failure in Mexico – Yahoo Finance

R3 International is now offering a new program for stem cell therapy for liver failure in Mexico. The program offers up to 200 million stem cells, with the cost starting at only $8975.

SAN DIEGO, June 29, 2020 /PRNewswire-PRWeb/ -- R3 International is now offering a new program for stem cell therapy for liver failure in Mexico. The program offers up to 200 million stem cells, with the cost starting at only $8975.

Millions of individuals suffer from chronic liver disease, which occurs due to a number of causes such as hepatitis, cirrhosis, metabolic diseases, and other conditions. All too often, conventional therapies fail to provide the desired result.

Stem cell therapy has been shown in several studies to produce beneficial results for liver failure. This includes a study of 43 patients from 2012 in Stem Cells and Translational Medicine noting significant increase in survival rates, along with no adverse events.

In its new program, R3 International uses the same weight based protocol. Each treatment provides up to 50 million stem cells at a time, with the treatment occurring at the stem cell therapy clinic in Tijuana Mexico. To date, hundreds of patients have received stem cell therapy in Mexico with R3 for a variety of conditions. No adverse events have been reported, and outcomes have been sensational for organ failure, arthritis, diabetes, dementia, stroke, stem cells for Lyme disease, Crohns and many more.

In order to receive treatment, patients start with a free phone consultation with the licensed, experienced stem cell doctor from R3 International. After the consult and review of medical records, the doctor provides a treatment recommendation. Then the dedicated patient concierge representative will assist with travel logistics and transportation from San Diego to the clinic is provided.

Simply call (888) 988-0515 to schedule the phone consultation and learn about options for treatment.

SOURCE R3 Stem Cell International

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R3 International Offering New Program for Stem Cell Therapy for Liver Failure in Mexico - Yahoo Finance

Pembrolizumab Approved for First-Line Treatment of Patients With Colorectal Cancer and Key Mutations – AJMC.com Managed Markets Network

The decision comes almost exactly a month after results from KEYNOTE-177 were presented at the annual meeting of the American Society of Clinical Oncology.

Merck, which makes pembrolizumab, sold as Keytruda, announced the approval in a statement.

The approval covers patients who have microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer and is based on results of KEYNOTE-177, a phase 3 trial of 307 patients that found the programmed cell death-1 (PD-1) inhibitor trimmed the risk of death of disease progression 40% compared with chemotherapy, which is the current standard of care (HR = 0.60, 95% CI: 0.45-0.80, P = .0004).

Results presented at ASCO showed that pembrolizumab doubled progression-free survival in these colorectal cancer patients, from 8.2 months to 16.5 months. Lead study author Thierry Andr MD, of the Sorbonne Universit and Hpital Saint Antoine in Paris, said at the time that the findings would change the standard of care. No medical treatment has shown such an improvement, Andr said.

Discussant Michael Overman, MD, of The University of Texas MD Anderson Cancer Center, agreed and said the tumors treated in the study were particularly good candidates for immunotherapy. From now on, he said, It is critical that we test all colorectal cancer patients for mismatch repair or microsatellite status.

The approval came less than a month after Merck submitted a supplemental Biologics License Application, which was handled through FDAs Real-Time Oncology Review pilot program. According to the Merck statement, the approval was reviewed under Project Orbis, an initiative of the FDA Oncology Center of Excellence that allows for concurrent submission and review of oncology drugs among its international partnersin this case, regulators in Australia, Canada, and Switzerland.

Todays approval has the potential to change the treatment paradigm for the first-line treatment of patients with MSI-H colorectal cancer, based on the important findings from KEYNOTE-177 that showed Keytruda monotherapy demonstrated superior progression-free survival compared to standard of care chemotherapy, Roy Baynes, MD, PhD, senior vice president and head of global clinical development, chief medical officer for Merck Research Laboratories, said in the statement.

At ASCO, Andr trumpeted the value of biomarker-driven research, and Baynes did the same today. Our commitment to pursuing biomarker research continues to help us bring new treatments to patients, he said, particularly for those who have few available options.

Immune-related adverse events can include pneumonitis, colitis, hepatitis, skin reactions, renal dysfunction, and endocrinological abnormalities. Patients taking the PD-1 inhibitor may experience solid organ transplant rejection or complications from stem cell transplant.

Luis A. Diaz, MD, head of the division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center. said in the statement that patients with colorectal cancer and the genetic mutations in the study have historically faced poor outcomes, and until today, chemotherapy-containing regimens were the only FDA-approved first-line treatment options.

About 5% of metastatic colorectal cancer patients have MSI-H/dMMR. Pembrolizumabs effectiveness when this mutation is present is well-recognized, and led to FDAs firsttissue-agnostic approvalin May 2017.

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Pembrolizumab Approved for First-Line Treatment of Patients With Colorectal Cancer and Key Mutations - AJMC.com Managed Markets Network

Genespire and the San Raffaele Telethon Institute for Gene Therapy announce publication in Nature Biotechnology on enhanced gene editing technique in…

June 30, 2020 07:00 ET | Source: Genespire

Genespire and the San Raffaele Telethon Institute for Gene Therapy announce publication in Nature Biotechnology on enhanced gene editing technique in hematopoietic stem cells

Italy, Milan, 30 June 2020: The San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) and Genespire, a gene therapy company developing transformative therapies for genetic diseases, announce today the publication of data highlighting progress in the development of an improved targeted gene replacement technology in human hematopoietic stem cells (HSCs) in Nature Biotechnology.

The paper, entitled Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking, outlines technology developed by Pr. Luigi Naldini and his team at SR-Tiget, which is included in the strategic alliance with Genespire. It shows increased homology directed recombination (HDR) efficiency in HSCs by forcing cell-cycle progression and transiently upregulating components of the HDR machinery. The findings are validated by clonal tracking of the edited HSCs in experimental transplantation models, which shows improved polyclonal engraftment by long-term repopulating HSCs.

People with genetic diseases affecting the hematopoietic lineage may benefit from corrective targeted gene therapy in HSCs. These cells are self renewing and can differentiate into all the cell types of the hematopoietic lineage, therefore providing the potential for a one-time therapy. As compared to standard gene replacement approaches, gene editing corrects the disease-causing mutation in situ, restoring both function and physiological expression control of the affected gene. In principle, this targeted strategy may fulfill the goal of precision medicine at the most stringent genetic level. Its realization in HSCs, however, has been hampered until now by low efficiency of HDR-driven repair, likely because of the quiescent state of the more primitive progenitors. Use of the improved gene editing technology developed by SR-Tiget has been shown to yield a greater percentage of gene-edited HSCs and increased clonality, or the number of modified cells transplanted and engrafted in the recipient. In a clinical setting this should lead to increased hematopoietic cells chimerism in the patient receiving the corrective HSC therapy, and could accelerate the hematopoietic recovery after conditioning and increase the size, long-term stability, and safety of the engineered cell graft.

This approach can be applied to genetic diseases originating in the hematopoietic lineage, including primary immune deficiencies (PIDs), a key area of focus for Genespire. Genespire will continue to work with SR-Tiget and apply this technology to its future pipeline of gene therapies.

Julia Berretta, Chief Executive Officer of Genespire, commented: The focus of Genespires alliance with SR-Tiget is to research and develop novel gene therapies, addressing severe diseases with high unmet medical need. We are pleased with the publication of these data in Nature Biotechnology, which provide valuable insights into this pioneering technology developed by SR-Tiget, and we look forward to our future work with them to translate cutting edge science into transformational therapies.

Professor Luigi Naldini, Director of SR-Tiget and scientific co-founder of Genespire, said Our findings elucidate and overcome two main biological barriers to efficient HDR-mediated gene editing in HSCs, and show by clonal tracking that our enhanced editing protocol preserves their multilineage and self-renewal capacity long term after serial transplant. We look forward to our future work with Genespire to explore its potential in primary immunodeficiencies.

The full publication details are below and can be accesed online here.

Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking Samuele Ferrari, Aurelien Jacob, Stefano Beretta, Giulia Unali, Luisa Albano, Valentina Vavassori, Davide Cittaro, Dejan Lazarevic, Chiara Brombin, Federica Cugnata, Anna Kajaste-Rudnitski, Ivan Merelli, Pietro Genovese and Luigi Naldini

Enquiries:

About Genespire

Genespire is a biotechnology company focused on the development of transformative gene therapies for patients affected by genetic diseases, particularly primary immunodeficiencies and inherited metabolic diseases. Based in Milan, Italy, Genespire was founded in March 2020 by the gene therapy pioneer Prof. Luigi Naldini and Dr. Alessio Cantore, Fondazione Telethon and Ospedale San Raffaele. It is a spin-off of SR-Tiget, a world leading cell and gene therapy research institute and is backed by Sofinnova Partners. http://www.genespire.com

About SR-Tiget

Based in Milan, Italy, the San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget) is a joint venture between the Ospedale San Raffaele and Fondazione Telethon. SR-Tiget was established in 1995 to perform research on gene transfer and cell transplantation and translate its results into clinical applications of gene and cell therapies for different genetic diseases. Over the years, the Institute has given a pioneering contribution to the field with relevant discoveries in vector design, gene transfer strategies, stem cell biology, identity and mechanism of action of innate immune cells. SR-Tiget has also established the resources and framework for translating these advances into novel experimental therapies and has implemented several successful gene therapy clinical trials for inherited immunodeficiencies, blood and storage disorders, which have already treated >115 patients and have led through collaboration with industrial partners to the filing and approval of novel advanced gene therapy medicines.

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Covid-19 outbreak imparts profitable opportunities to Stem Cell Therapy market; demand to remain high post pandemic – Jewish Life News

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Covid-19 outbreak imparts profitable opportunities to Stem Cell Therapy market; demand to remain high post pandemic - Jewish Life News