Stem Cell Clinic

Stem Cell and Cancer Research Institute terminated by McMaster University – TheSpec.com

McMaster University is terminating a high-profile research institute that investigates novel stem cell and cancer therapies.

The loss of the multimillion dollar Stem Cell and Cancer Research Institute (SCC-RI) may extend to its prominent leader as questions remain about whether Mick Bhatia will stay in Hamilton. Two other researchers Kristin Hope and Karun Singh are already leaving for Toronto.

McMaster and Bhatia tell very different stories about how a university board of governors meeting on June 4 came to include the recommendation to end the nationally known institute.

My vision was to have an international presence and supremacy in stem cells, said Bhatia. McMaster, in the end, in my interpretation, really just didnt have the appetite to go in that direction.

The university claims SCC-RI has run its course because its researchers werent collaborating, which is the entire purpose of an institute.

They werent working together, said Jonathan Bramson vice-dean of research for the faculty of health sciences. We put people together because we think they will work together and achieve a situation where the sum is greater than the parts and that wasnt the case here.

Bhatia says he cant possibly compute that explanation, pointing out he has published at least one paper with every researcher at SCC-RI and the other researchers have done the same.

It doesnt make sense, he said. Its like saying the Raptors arent good at basketball.

In fact, it was collaboration that lured Bhatia to McMaster from California in 2006 in the first place. He was working toward leading a stem cell institute there when Dr. John Kelton, who was dean of the faculty of health sciences at the time, made Bhatia believe it would work better back home in Ontario.

I was completely enchanted of the idea that in Canada you could achieve that level of excellence and there was support to build something, he said. It was a great opportunity that I thought couldnt happen here in Canada and yet here it was in front of me.

The institute was set up with $10 million from Michael G. DeGroote and, over time, got another $15 million from David Braley and $24 million from the Boris family.

We were really starting from scratch, said Bhatia. There were no people working deeply in stem cell biology you had to recruit from outside because there is no pre-existing expertise, equipment or infrastructure.

At its height, SCC-RI had 13,000 square feet of state-of-the art facilities, 130 staff and millions in grants including $13 million from the Ontario Research Fund, roughly $10 million from the Canadian Foundation of Innovation and in the last fiscal year alone its scientists were awarded $3.28 million in research grants.

It had findings that were paradigm shifting for stem cell research, collaborated with biochemists which was a first for the field and took potential new cancer drugs into clinical trials.

John Kelton . was pretty visionary, said Bhatia. He was looking for areas to be truly excellent and his definition of excellence was very akin to mine ... It excited me that you could do this level of science and there was like-minded people thinking about that direction.

But at the 10-year-mark in 2016, Bhatia describes the beginning of a rift between his future vision of SCC-RI and that of McMaster. It was at the same time Kelton retired and was replaced by Dr. Paul OByrne.

We got to a point where I saw this as a Stage 1 achievement, whereas I think they were feeling this is where we needed to be and they were quite happy with it, said Bhatia. I thought we could do more.

About two years ago, funding ran out for two researchers Bhatia had recruited and trained over 10 years, and they ended up leaving McMaster. He also saw no way to recruit the senior scientists he felt he could now attract at the established institute.

By December 2019, Bhatia said he saw the writing on the wall and resigned as director of SCC-RI.

To some degree its understandable, said Bhatia. This type of science and at this level is very, very expensive. It requires an immense commitment There is a certain risk measure that comes with that.

In the wake of Bhatias resignation, McMaster spent about $8,000 on an external review which Bramson said concluded there was no collaboration.

Its a series of individuals who are operating independently, he said. Some of those individuals are quite successful which is great and they continue to operate independently but there was no value gained by having them work together.

Bramson said he doesnt know why they werent collaborating and the review didnt shed any light on that either.

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I cant tell you why people can or cannot work together, he said. Its their choice, they dont have to, youre not obliged to collaborate.

In fact, he says its not in a researchers nature to work together.

Scientists are mavericks, said Bramson. They are stallions, they are not trained to work together, theyre trained to work independently.

He also said this happens all the time about research institutes being terminated.

It didnt work out, I dont really see that as being a surprise, he said. Science is an experiment ... When you create an institute, you dont know how its going to shake out.

At some point between December and the board of governors meeting in June, two other principle investigators announced they were leaving.

People leave for their own reasons, said Bramson. Clearly, if they felt that they were gaining something from being part of the institute, they would have stayed.

Other principle investigators including Dr. Sheila Singh and Dr. Tobias Berg appear to be staying at McMaster and continuing their research independently.

The group was not the reason they were successful, said Bramson. Disbanding the group is not going to diminish that success. Theyre going to continue doing what theyre doing.

No principle investigators responded to The Spectators request for comment. Although Bhatia says the university made it clear to all that it was speaking on the institutes behalf. He was originally unable to speak himself but eventually got permission from McMaster.

For now, Bhatia is continuing on with his research here.

I love Canada, he said. I love McMaster.

But he added his priority is moving stem cell and cancer therapy science forward.

Well have to see how that unfolds, he said.

As for OByrnes decision to recommend terminating the institute, Bhatia says, It was the obvious decision.

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Stem Cell and Cancer Research Institute terminated by McMaster University - TheSpec.com

Autologous Stem Cell and Non-Stem Cell Based Therapies Market Detailed Analysis of Current Industry Figures with Forecasts Growth – 3rd Watch News

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Market Size And Forecast

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Bargaining Power Of Buyers

Bargaining Power Of Suppliers

Threat Of New Entrants

Threat Of Substitutes

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Market Condition

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Autologous Stem Cell and Non-Stem Cell Based Therapies Market Detailed Analysis of Current Industry Figures with Forecasts Growth - 3rd Watch News

3D Cell Culture Market Size, Global Analytical Overview, Growth Factors, Technologies, Trends and Forecast To 2025 – 3rd Watch News

3D cell culture is a highly regulated environment, where cells are provided with the optimum conditions to replicate and migrate within different habitats outside living organisms. 3D cell culture harbors tissue organization and cell differentiation that may not be viable in 2D culture systems. 3D cell culture offers a greater degree of cell cohesion and tissue divergence, explaining their rising popularity in early drug discovery and other kinds of R&D activity. Researchers deploy this technique to fabricate physiologically similar cell cultures that assist new drug development. In addition, the pervasive need to raise efficiency in pharmaceutical R&D encourages the growth of the 3D cell culture market.

3D cell culture is witnessing a golden era in the healthcare segment on account of its versatility in cancer research, regenerative medicine, and in-vitro environments. The ability of 3D cell culture to strengthen tissue organization and maturation, cell differentiation, and organogenesis has made it particularly useful. 3D cell culture has begun to substitute animal prototypes in clinical testing environments, as they are relatively similar to in-vivo cells. There has been a marked adoption of 3D cell culture in hospitals, biotech companies, tissue regeneration, regenerative medicine, and diagnostic centers. There is constant R&D to deliver better options for 3D cell cultures in order to conduct additional research or gain previously unknown knowledge.

The 3D cell culture market can be classified on the basis of region, product type, application, and end user. By product type, the 3D cell culture market is further divided into scaffold free 3D cell culture, scaffold-based 3D cell culture, 3D bioreactors, 3D petri dishes, 3D bioprinting, and magnetic levitation. When it comes to application, the 3D cell culture market is subdivided into cancer and stem cell research, drug discovery and toxicology, and tissue engineering & regenerative medicine. There are two main end users in the 3D cell culture market research labs & institutes and pharmaceutical & biotech companies.

Traditionally, drug discovery was carried out via animal models. However, the exponential growth of drugs synthesized or discovered in the last twenty years has resulted in high-throughput screening. Drug discovery is quite a time-intensive process, and there are ethical concerns to deal with when it comes to animal testing. Thus, there has been a push towards alternative models for drug delivery and drug testing. A key application of 3D cell culture when it comes to drug discovery is organ-on-chips. This new technology is being exploited by cancer drug manufacturers to improve the risk-benefit balance by targeting a specific receptor, defined biomechanics, or a cell type. The recent trend in therapeutic cancer research should fuel the demand for 3D cell cultures. A number of novel cancer therapies are likely to gain market approval, which should fuel the 3D cell culture market.

North America is the largest regional contributor in the 3D cell culture market with the US accounting for a major portion. The US has a well-developed research infrastructure, leading to a number of technological advancements in the nation. American corporations have filed a number of patents in the 3D cell culture market, both in their home market and in APAC. There have been large-scale international collaborations between the US, UK, and the Netherlands, with the objective of growing 1000 new cell lines for scientists to carefully assess. Such collaborations should use state-of-the-art technologies such as organoids, along with 3D culture cells that have been programmed to grow infinitely.

TableofContentChapter 1IndustrialChainOverview Chapter 2GlobalProduction&ConsumptionbyGeography Chapter 3MajorManufacturersIntroduction Chapter 4MarketCompetitionPattern Chapter 5ProductTypeSegment Chapter 6End-UseSegment Chapter 7MarketForecast&Trend Chapter 8Price&Channel Chapter 9MarketDrivers&InvestmentEnvironment Chapter 10ResearchConclusion

KEY QUESTIONS ANSWERED IN THE REPORT

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3D Cell Culture Market Size, Global Analytical Overview, Growth Factors, Technologies, Trends and Forecast To 2025 - 3rd Watch News

Impacts of the COVID-19-Mesenchymal Stem Cells Market Size Current and Future Industry Trends, 2020-2028 – 3rd Watch News

A recent report published by QMI on mesenchymal stem cells market is a detailed assessment of the most important market dynamics. After carrying out a thorough research of mesenchymal stem cells market historical as well as current growth parameters, business expectations for growth are obtained with utmost precision. The study identifies specific and important factors affecting the market for mesenchymal stem cells during the forecast period. It can enable manufacturers of mesenchymal stem cells to change their production and marketing strategies in order to envisage maximum growth.

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According to the report, the mesenchymal stem cells market has been segmented by source (bone marrow, umbilical cord blood, peripheral blood, lung tissue, synovial tissues, amniotic fluids, adipose tissues), by application (injuries, drug discovery, cardiovascular infraction, others). Insights about the regional distribution of market: The market has been segmented in major regions to understand the global development and demand patterns of this market.

For the mesenchymal stem cells market, the segments by region are North America, Asia Pacific, Western Europe, Eastern Europe, Middle East, and Rest of the World. During the forecast period, North America, Asia Pacific and Western Europe are expected to be major regions on the mesenchymal stem cells market.

North America and Western Europe have been one of the key regions as they have an established healthcare infrastructure for product innovations and early adaptations. This is estimated to drive demand for the mesenchymal stem cells market in these regions. In addition to this, some of the major companies operating in this market are headquartered in these regions.

Asia Pacific is estimated to register a high CAGR mesenchymal stem cells market. The APAC region has witnessed strategic investments by global companies to cater to the growing demand for healthcare solutions in recent years. The Middle East and Rest of the World are estimated to be emerging regions for the mesenchymal stem cells market.

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Market Players Cell Applications, Inc., Cyagen Biosciences Inc. Axol Bioscience Ltd., Cytori Therapeutics Inc., Stem Cell Technologies Inc., Celprogen, Inc.

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Market Segmentation: By Source: o Bone Marrow o Umbilical Cord Blood o Peripheral Blood o Lung Tissue o Synovial Tissues o Amniotic Fluids o Adipose Tissues

By Application: o Injuries o Drug Discovery o Cardiovascular Infraction o Others

By Region: o North America o North America, by Country ? US ? Canada ? Mexico o North America, by Source o North America, by Application

o Western Europe o Western Europe, by Country ? Germany ? UK ? France ? Italy ? Spain ? The Netherlands ? Rest of Western Europe o Western Europe, by Source o Western Europe, by Application

o Asia Pacific o Asia Pacific, by Country ? China ? India ? Japan ? South Korea ? Australia ? Indonesia ? Rest of Asia Pacific o Asia Pacific, by Source o Asia Pacific, by Application

o Eastern Europe o Eastern Europe, by Country ? Russia ? Turkey ? Rest of Eastern Europe o Eastern Europe, by Source o Eastern Europe, by Application

o Middle East o Middle East, by Country ? UAE ? Saudi Arabia ? Qatar ? Iran ? Rest of Middle East o Middle East, by Source o Middle East, by Application o Rest of the World o Rest of the World, by Country ? South America ? Africa o Rest of the World, by Source o Rest of the World, by Application

Years Covered in the Study: Historic Year: 2016-2017 Base Year: 2018 Estimated Year: 2019 Forecast Year: 2028

Objectives of this report: o To estimate the market size for mesenchymal stem cells market on a regional and global basis. o To identify major segments in mesenchymal stem cells market and evaluate their market shares and demand.

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Stem Cell Banking Market Size, Analysis, Trends and Segmented Data by Top Companies and Opportunities 2020-2027 – Apsters News

China Cord Blood Corporation

The research report is broken down into chapters, which are introduced by the executive summary. Its the introductory part of the chapter, which includes details about global market figures, both historical and estimates. The executive summary also provides a brief about the segments and the reasons for the progress or decline during the forecast period. The insightful research report on the global Stem Cell Banking market includes Porters five forces analysis and SWOT analysis to understand the factors impacting consumer and supplier behavior.

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Legalization of abortion produced identity crisis for pro-life Irish Catholics – Crux: Covering all things Catholic

[Editors Note: Jonathon Van Maren is a public speaker, writer, and pro-life activist. His commentary has appeared in National Review, First Things, The American Conservative, the National Post, and elsewhere. Van Maren is the author of The Culture War and Seeing Is Believing: Why Our Culture Must Face the Victims of Abortion as well as the co-author with Blaise Alleyne of A Guide to Discussing Assisted Suicide. He spoke to Charles Camosy about Patriots: The Untold Story of Ireland s Pro-Life Movement.]

Camosy: I must admit, knowing that the final chapter covered the loss of the 8th Amendment protecting equal justice under law for prenatal children under Irish law, a bit of hesitancy to get invested into a story which culminates in that tragic loss. Did you share any of that in making a decision to write this book? And what ultimately drove you to take on this project in the first place?

Van Maren: Interestingly, it was the loss of the 8th Amendment that drove me to research and tell this story. I was in Ireland for a few weeks prior to the 2018 abortion referendum, and the pro-lifers I met there crisscrossing the country, going door-to-door, and putting up with the contempt of the media and the betrayals of so many politicians were simply some of the best people Ive met. And yet, the narrative of what happened started taking shape before the vote: That a movement of progressives and feminists saved Ireland from a handful of misogynist, medieval men and women driven to fanaticism by religion.

(Credit: Courtesy to Crux.)

Like any pro-lifer, Im used to narratives of that sort. But this time, it genuinely upset me. To see so many men and women who fought for decades and saved hundreds of thousands of livesand then left everything on the field to save Irelands constitutional protection for the pre-bornslandered in this way was disgusting. These people fought for the children of others because they cared so deeply. I remember one elderly woman on the Life Canvass, moving slowly from door to door in Dublin. Someone told her that hed be voting for repeal, and the woman said, in a trembling voice: But what about the babies? Thats why so many people took off work, skipped university classes, and poured their own time and money into the pro-life movement.

We in the pro-life movement rarely tell our own stories. As a result, our stories are told by those who slander us, hate us, and at the end of the day, do not understand our motivations. (Recent smear jobs include Norma McCorvey and Phyllis Schlafly.) I thought it would be a crying shame if the beautiful history of the Irish movement ended up being told by a handful of pro-choice journalists and abortion activists.

What lessons can the US, Canadian, and other pro-life movements around the world learn from the glory days of the Irish pro-life movement?

There are many answers to this question. First, the Irish movement was relentless. Keep in mind they were putting activists on the streets every day in a country where abortion was already illegal. They took nothing for granted, and they refused to be reactive. One of the reasons Ireland held on for so much longer than the rest of the West is that they responded to every threat as if it were existential, because it was.

Jonathon Van Maren. (Credit: Courtesy to Crux.)

The Irish movement has also given much to the international pro-life cause. For example, the Dublin Declaration, a document signed by over 1,000 medical professionals affirming that abortion is never necessary to address the health circumstances of the mother, is used by pro-lifers around the world in debate, on campus, and in street outreach. From embryonic stem cell research to difficult health circumstances, the Irish movement was always ready to present a compelling and coherent response to the deceits of the abortion industry, and to take those arguments to the streets and millions of doorsteps. They perfected the fusion of advertising, activism, and the distribution of essential information.

What lessons can such movements learn from the stinging defeat that the loss of the 8th Amendment represents?

To cite just one: That the media, the abortion industry, and the politicians will exploit any crisisand any corpse, to put it crudelyto get abortion on demand. The tragic death of Savita Halappanavar was used as a blood libel against the pro-life movement despite the fact that every inquest and investigation proved that she died of septicemia, and that she did not need an abortion to save her life. That fact was buried. The false narrative that the 8th Amendment killed a womanand would kill morewas relentlessly pounded into the consciousness of Middle Ireland. During the final week leading up to the referendum, abortion activists were simply hanging up photos of her face.

That storythe story of how the 8th was actually lostalso needed to be told.

One often hears folks say that the fall of the 8th can be directly connected to the fall of the Catholic Church more generally in Irish society. Whats your take on this?

It was definitely a significant factor, but can be somewhat overstated. Without Savitas death, it is unlikely that the abortion activists would have been able to achieve repeal of the 8th, at least this time around. That said, the hatred and hostility of many young people towards the Catholic Church is very real and very vitriolic. I examine the impact of secularization and how scandals in the Catholic Church deeply damaged her moral standing in Ireland in the book. For example, many clergy did not speak up during the referendum for fear that their endorsement of the pro-life cause might accomplish the opposite of the intended effect.

As a person with 50 percent Irish heritage myself, I took great pride in being Irish and couldnt wait to go back to visit. Now, however, I must admit feeling ashamed that a people with which I so closely identified could have done something like this. Any advice for folks like me? Do we have any reason for short- or medium-term hope that Ireland can work toward protecting and supporting both prenatal children and their mothers under Irish law?

You are not alone in this. In fact, the loss of the 8th Amendment triggered an identity crisis for many Irish pro-lifers, something I detail in the final chapters. That was a question that came up often: If Ireland is no longer pro-life, what does it mean to be Irish? It was that question that partially inspired the title to the book, Patriots. It has often been a minority fighting for a righteous cause, and the Irish have a tradition of this. For inspiration, the Irish need only to look to her own pastincluding the pro-life heroism I detail in my book.

In terms of what comes next, the Irish are now fighting a battle that resembles the fight in other nations. That said, keep in mind that 33 percent of voters cast their ballots to keep abortion illegal in all circumstances. That is a solid base to work from. I forget precisely where I read this quote, but after one referendum loss in another country, the spokesman for the losing side noted that there had been much support for their position, and that the battle would begin anew immediately. To paraphrase his words: Let us start from 33 percent. I have every confidence in the ingenuity and tenacity of the Irish movement.

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Legalization of abortion produced identity crisis for pro-life Irish Catholics - Crux: Covering all things Catholic