LILLEY: Trudeau government needs to stop taking COVID orders from WHO – Toronto Sun

Some days it really does feel like Canada has farmed out its entire health policy during this COVID-19 crisis to the World Health Organization.

From the early days, answers to questions on testing, on the spread of the virus, on approving treatments or even rapid testing, have been to cite what the WHO recommends.

That is nothing short of a dereliction of duty by Canadas top health officials.

The latest example is the decision of Health Canada not to approve a cheap and rapid test for COVID-19, one made right here in Canada, because of what the WHO says. BTNX Inc. of Markham, Ont. makes a test that can have results in 15 minutes and costs just $10 a piece.

The test cant be used for early detection but can confirm COVID-19 for people who have been showing symptoms for several days. It also tests for anti-bodies to determine if someone has already had the disease and therefore is possibly immune.

Despite the sale of this test kit in the U.S., the U.K. and across Europe, Health Canada turned the company down this past week. As CBC reported, the company was rejected by Health Canada over the advice given by the WHO.

In an email to CBC News, Health Canada said it is following the advice of the World Health Organization, which does not currently recommend serological (blood) tests for clinical diagnosis, CBC reported on Sunday.

Let me get this straight: We have a company that can provide accurate results using a blood test and we wont use it because an international body in Geneva says no?

Can you imagine that being the case when Banting and Best discovered how to extract insulin and treat diabetics at their University of Toronto lab? Or the invention of Pablum to fight off malnutrition in the 1930s?

Would Canadian doctors and researchers have had breakthroughs in open heart surgery, stem cell transplants, vaccines for childhood diseases, gene therapies, treatments for stroke, cystic fibrosis, HIV and more if we had to simply follow WHO guidelines?

No, in fact, following the rules of a bureaucratic organization like the WHO is the opposite of what researchers do.

Im not for a moment advocating that Canada should ignore the WHO, should play no part in it. The WHO has a role to play but that role is not in setting health policy for Canada.

Were we a less developed country with a less robust medical system, without more than a century of continuously evolving medical research, then perhaps listening to the WHO first and following their advice would make sense. For Canada it does not, it slows things down, it stops innovation.

Could and should Canada be working in coordination with the WHO? Sure, but not following their orders. This is an organization that has already been shown to have been slow off the mark by believing misinformation from the Chinese government at the start of this outbreak.

Sadly, though, whether the answers have come from Health Canada bureaucrats, the chief medical officer, the health minister or the prime minister, too often what Canadians have been told is a series of WHO talking points.

Canada has the medical ingenuity, the depth of research and the quality of doctors needed to chart our own path that at times will follow the WHO and at other times diverge. When time is of the essence in finding better ways to test, better ways to treat and better ways to counter the spread of this virus, Ill take Canadian doctors over a United Nations body in far off Geneva any day.

Lets hope the Trudeau government starts realizing that they should trust and champion Canadas medical community as well.

blilley@postmedia.com

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LILLEY: Trudeau government needs to stop taking COVID orders from WHO - Toronto Sun

Cell Culture Protein Surface Coating Market to Witness Robust Expansion by 2025 – Germany English News

Global Cell Culture Protein Surface Coating Market: Snapshot

The global market for cell culture protein surface coatings is slated to expand at a highly promising pace in the next few years, thanks to the vast rise in investments by governments and market players in stem cell research and development activities. Cell culturing is a method used for growing artificial living cells outside the natural environment, under controlled physical conditions. These cells are used to develop model systems for study and research of cellular structures as well as for drug discovery and genetic engineering.

Thus, the growing scope of cell cultures in various applications has led to the development of the 3D cell culture technique, which has been considered one of the key factors responsible for the overall past development of the cell culture protein surface coatings market. Earlier, only a meager percentage of researchers preferred using 3D cell culture technique for drug discovery. However, there has been a dynamic shift from the traditional methods to the current cell culture methods.

Moreover, commercial production of drugs and biologics such as proteins, antibodies, and vaccines using cell culture has helped expand the scope of the latter in the global market. Commercial production has provided extensive business opportunities to manufacturers in the global market. Diverse applications of stem cells such as development of bone grafts and artificial tissue are also expected to fuel the demand for cell culture protein surface coatings over the forecast period. In addition, increasing cell culture applications in toxicology studies and cell-based assays are further pushing the growth of the market.

Global Cell Culture Protein Surface Coating Market: Overview

Cell culture protein surface coatings help in improving cell attachment, growth, and differentiation. They facilitate consistent performance in various cell-based assays and in-vitro culture by improving cell adhesion. A variety of adhesion proteins and other biological materials derived from various sources are being used to enhance performance in cell culture, especially in cell lines that are hard to attach, such as transfected cells. The major types of cell culture are animal-derived protein, human-derived protein, synthetic protein, and plant-derived protein. Good cell attachment has gained increased significance in recent years for improving the recovery of cells from frozen cultures and increasing the stability of attached surfaces. With constant advances in stem cell therapies, a number of advanced protein surface coatings have emerged to study stem cells and to further the potential of regenerative medicine. These developments have positively affected the growth of the global cell culture protein surface coating market.

Global Cell Culture Protein Surface Coating Market: Key Trends

The increasing focus of numerous biotechnology companies and research laboratories on stem cell research to develop therapies for a range of chronic diseases is a key factor propelling the cell culture protein market. Considerable investment by the governments of various countries to fund several R&D activities related to regenerative medicine has fuelled the market. Coupled with this, the rising demand for biopharmaceutical products such as antibodies, vaccines, and drugs has stimulated the demand for cell culture protein surface coatings. The growing research on stem cells for finding therapies for various cardiovascular and neurological diseases is expected to boost the market in the coming years. The growing prominence of 3D cell culture over 2D cell cultures is expected to unlock exciting opportunities in the cell culture protein surface coating market.

Global Cell Culture Protein Surface Coating Market: Market Potential

The American Heart Association (AHA), together with the Paul G. Allen Frontiers Group, announced in April, 2017 two grantseach worth US$1.5 millionto scientists working on cardiovascular extracellular matrix (ECM) research. Interested researchers have to apply for grants by May 10, and each of the two winners will be entitled to the magnanimous sum.

The ECM regulates all vital cell functions and is considered a highly useful biomaterial for investigators. This can be applied as a stable coating to be used in a variety of cell cultures. The initiative focused on investigating the role of ECM in the initiation and progression of a number of cardiovascular diseases, such as hypertensive heart disease, ischemic heart disease, cardiomyopathies, congenital cardiovascular malformations, and atherosclerosis and vascular diseases. The funding will further the investigation into the diagnosis, prevention, and treatment of cardiovascular diseases. One of the most commonly used protein surface coatings used in ECM is collagen, which facilitates cell adherence, growth, migration, differentiation, and proliferation. The major research initiatives, opine the AHA, will be greatly useful in setting up a new paradigm in research in cell structure in biosciences.

Global Cell Culture Protein Surface Coating Market: Regional Outlook

North America is a prominent market for cell culture protein surface coatings and is expected to exhibit significant growth over the forecast period. The impressive growth in the regional market is attributed to the presence of a robust healthcare infrastructure and considerable advances in stem cell research. In addition, the soaring demand for regenerative medicines for a range of autoimmune therapies is expected to fuel the demand for surface coatings for improving the performance of in-vivo culture.

The Asia Pacific market for cell culture protein surface coating is poised to offer lucrative avenues for players in the market. Favorable regulations for biologics development and a burgeoning biotechnology industry are the factors expected to lead to substantial demand for cell culture protein surface coatings.

Global Cell Culture Protein Surface Coating Market: Competitive Analysis

The market is fairly competitive due to the presence of a large number of regional and global vendors. Leading vendors are actively focused on providing solutions having cell attachment ability and promoting in-vitro cell functions for a variety of cell types to gain competitive edge over others. Leading players operating in this market include Sigma-Aldrich Corporation, Agilent Technologies, Thermo Fisher Scientific, EMD Millipore, Corning Incorporated, Biomedtech Laboratories Inc., Neuvitro Corporation, and Progen Biotechnik GmbH.

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Cell Culture Protein Surface Coating Market to Witness Robust Expansion by 2025 - Germany English News

What Acts of Kindness Have You Heard About or Participated In During Coronavirus? – The New York Times

Find all of our Student Opinion questions here.

In The Science of Helping Out Tara Parker-Pope argues, During a crisis, the people who cope best are those who help others. Does that concept resonate with you? Have you ever received any personal benefits by helping others?

Her article begins:

At a time when we are all experiencing an extraordinary level of stress, science offers a simple and effective way to bolster our own emotional health.

To help yourself, start by helping others.

Much of the scientific research on resilience which is our ability to bounce back from adversity has shown that having a sense of purpose, and giving support to others, has a significant impact on our well-being.

There is a lot of evidence that one of the best anti-anxiety medications available is generosity, said Adam Grant, an organizational psychologist at Wharton and author of Give and Take: A Revolutionary Approach to Success. The great thing about showing up for other people is that it doesnt have to cost a whole lot or anything at all, and it ends up being beneficial to the giver.

The article continues:

The challenge many of us are facing today is how to give support from a distance. Rules that require us to be physically apart during the pandemic mean that our traditional ways of volunteering in person are no longer possible. The good news is that the type of support that can be helpful to both giver and receiver can be given in a variety of small and big ways. It can include giving money or time to a cause. Or it can be as simple as a phone call, giving advice or just lending a listening ear.

In fact, the act of giving advice has been shown to be more beneficial than receiving it. In a series of studies of 2,274 people, researchers from the University of Pennsylvania and the University of Chicago found that after middle-school students mentored younger students about studying, they ended up spending more time on their own homework. Overweight people who counseled others on weight loss were more motivated to lose weight themselves.

During the current coronavirus crisis, have you heard about any acts of generosity?

Below are excerpts from three Times articles reporting on how people have tried to help out in their communities.

In This Brooklyn Landlord Just Canceled Rent for Hundreds of Tenants, Matthew Haag writes about Mario Salerno, an owner of 18 apartment buildings, who said he did not want renters to stress about their payment during the coronavirus pandemic":

He is likely forgoing hundreds of thousands of dollars in income by canceling April rent.

His only interest, he said, was in alleviating stress for his renters, even those who were still employed and now working from home.

My concern is everyones health, said Mr. Salerno, 59, whose rent gesture was first reported by the local news site Greenpointers.com. I told them just to look out for your neighbor and make sure that everyone has food on their table.

In He Beat Coronavirus. Now His Blood May Help Save Lives. Tracey Tully writes about Benjamin C. Planer, a New Jersey doctor who, upon recovering from the coronavirus, was found to have high levels of virus antibodies in his blood, which researchers at Hackensack University Medical Center plan to use to treat other patients:

At Hackensack, Dr. Planer, 58, has become known as the superdonor.

He and his family live in Teaneck, N.J., the hardest-hit town in the states hardest-hit county amid the outbreak. He, his wife and their 17-year-old son contracted the virus, and they all recovered after several days of experiencing relatively minor symptoms.

When his hospital asked for volunteers for a study of an emerging Covid-19 therapy, Dr. Planer was among the first to sign up. His blood carries an especially valuable quantity of antibodies, Dr. Michele Donato, the chief of stem cell transplantation and cellular therapy at John Theurer Cancer Center, part of Hackensack University Medical Center, said.

My body obviously had it, Dr. Planer said in an interview. My body responded. My immunity worked. And I hear that I made a lot of antibodies. I was very happy to hear that and very happy to share.

In In Praise of Quarantine Clapping, Amanda Hess chronicles her experiences with the communal applause that breaks out in her neighborhood every night for workers who put themselves at risk during the crisis:

Every night at 7, my Brooklyn neighborhood comes to life with the calculated whimsy of a cuckoo clock. It starts with a single neighbor clapping. Soon dozens more join in, throwing open their front doors or hanging from their windows to put their hands together and say wooooo. Perhaps 20 seconds into the proceedings, a man emerges from the garden apartment across from me, banging a pot with a spoon, and a woman appears on the stoop of the house next door, her spaniel barking helpfully at her side. Often there is a special guest: On a recent evening, a guy motored by on a delivery bike, a whistle blaring from between his lips. Its all over within five minutes.

The Clapping first spread through New York City on a Friday night in late March. Following similar gestures in Italy, India and Spain, the New York iteration was seeded by a strategic marketing firm and circulated over social media to thank workers on the front lines of the coronavirus outbreak. It was originally presented as a one-off event, and after that, residents were asked to repeat it once a week. But now we do it every single night.

The Clapping has surely been heard by doctors and nurses and E.M.T.s, by UPS workers and Instacart delivery people and the many other New Yorkers who are putting themselves at risk to protect their city. I live just a couple of blocks from the choked I.C.U. of the Brooklyn Hospital Center, and on Tuesday, firefighters lined up right outside the center to cheer the staff on.

But the more the ritual is repeated, the more it feels as if its for the rest of us, too. We used to go out to concerts or movies or plays and clap for the performances. Now the clapping is the performance. It is our regularly scheduled programming, live and in person when basically nothing else is.

Students, read one or more of the articles in their entirety, then tell us:

What acts of generosity have you heard about in your community or anywhere else in which someone has helped others during the coronavirus crisis? Who was on the receiving end of those acts? How do you think the person or people in the helping role also may have been helped by the experience?

What experiences have you had in your life with volunteering, donating or otherwise assisting others? Do you think the act of giving was beneficial to you in any way? If so, how?

Do you think there is truth in the adage its better to give than to receive? Explain.

What might someone who claps every night for workers at a nearby hospital have in common with a landlord who tells his tenants he wont collect their rent or a blood donor who donates plasma to try to help coronavirus victims?

The first article above mentions that while volunteering is difficult to do right now because of social distancing measures, you can still feel good by doing something as simple as a phone call, giving advice or just lending a listening ear. Have you done anything, no matter how small, to help others during the pandemic that also made you feel good? Explain.

Students 13 and older are invited to comment. All comments are moderated by the Learning Network staff, but please keep in mind that once your comment is accepted, it will be made public.

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What Acts of Kindness Have You Heard About or Participated In During Coronavirus? - The New York Times

Cryopreservation Equipment Market Development and New Market Opportunities and Forecasts 2025 – Germany English News

Global Cryopreservation Equipment Market:Snapshot

Cryopreservation equipment market has been gaining traction due to its widening applications. The increasing investments in research and development of stem cells is expected to fuel the growth of the global market in the near future. Rapid advancements in technologies and increasing healthcare expenditure have also been identified as the key factors likely to influence the trajectory of the global cryopreservation equipment market. The rising interest in bioengineered products for dealing with the various issues of the human body have also resulted in the soaring revenues for the global cryopreservation equipment market.

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On the downside, the global cryopreservation equipment market is likely to be hampered by the lack of skilled personnel to handle the equipment. The slightest slip in handling can lead to severe injuries, which is discouraging many to take up careers in this field. Furthermore, market is also likely to be hampered by the use of salts that can prove to be extremely toxic. However, growth of industries such as pharmaceutical, biotechnology, and contract research organizations are projected to offer the global cryopreservation equipment market several avenues for growth in the foreseeable future.

The growing number of government initiatives to raise awareness about preservation of stem cells has been noticed as the key emerging trend in the global market. If equipment manufacturers overcome the challenge of high cost and complicated operations systems, the global cryopreservation equipment market could have a wider consumer base. Companies are also expected to invest in product innovation to offer the global market a wider and a better choice of products.

Global Cryopreservation Equipment Market: General Outline

Cryopreservation refers to the preserving of intact biological cells and tissues at extremely low temperatures. It commonly involves the preservation of sperms, plant seeds, embryos and eggs are some of the most common applications of cryopreservation. Cryopreservation is when the cells or tissues are frozen off, generally in liquid nitrogen at a temperature of at least (-148) degrees. At this temperature, metabolic processes of the biological tissues slow down to a near halt and results in a delayed decaying process, successfully preserving them for future purposes and storage.

During cryopreservation, however, there is a possibility of the destruction of cells as the liquids present in the cells may undergo anomalous expansion as they solidify. It is therefore essential to replace the liquid present in the tissue by cryoprotectants aids that increase the concentration of solutes in a system reducing the amount of ice at any given temperature. Dimethyl sulfoxide and glycerol are commonly used as replacements and are mixed with a media or serum in which the cells or tissues are suspended.

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Global Cryopreservation Equipment Market: Scope of the Study

The media used in cryopreservation generally comprises protein sources, base mediums, and cryopreservative. The role of a cryopreservative is to protect the cell from both physical and mechanical stresses and also to reduce water content in the cells, thereby decreasing the creation of cell-lysing ice crystals. The optimum cell density required to freeze per 1 ml of cell suspension is dependent on the type of the cell to be preserved. For instance, mammalian cells are frozen at a concentration between 1106 cells/ml and 1107 cells/ml. The cryopreservation process is facilitated by the use of various cryopreservation equipment such as sample preparation, storage systems, and ultra-low freezers.

The equipment in the global cryopreservation equipment market can be segmented into freezers, storage systems, sample preparation systems, and accessories. Regulatory and approval policies are the core governing factors of the market currently. Geographically, North America and Europe exhibit a very high potential for growth in the global cryopreservation equipment market, owing to the extensive use of preservation systems in various applications. Asia Pacific and the rest of the world show high promise to be lucrative regions for the growth and acceptance of these systems.

Global Cryopreservation Equipment Market: Key Trends and Prospects

The top factors favoring the growth of the global cryopreservation equipment market include a continuous rate of technological advancement, an increased use of cryopreservation equipment, and an increased investment by key players into the development of advanced systems that offer multiple freezing profiles and automated controls. However, high cost of cryopreservation systems, complicated operations and inaccessibility due to high costs of use are some of the factors that might restrain the global cryopreservation equipment markets growth.

Cryopreservation equipment holds multiple applications because of their growing utility in commercial and academic projects in stem cell research. These platforms are used in various setups, including stem cell banks, biotechnology and pharmaceutical manufacturers, contract research organizations, and stem cells research laboratories. Currently, several players from the global cryopreservation market are introducing products with specific or custom advanced features that can be capable of providing multiple freezing profiles along with enhanced connectivity through microprocessor controls and printers.

Global Cryopreservation Equipment Market: Companies Mentioned in the Report

Thermo Fisher Scientific, Inc., Praxair Technology, Inc., Advanced Cell Technology, Inc., Angioblast Systems, Inc., Boehringer Ingelheim, Gmbh, Cryologic Pty. Ltd., Custom Biogenic Systems, Haimen United Laboratory Equipment Development Co., Ltd., Genzyme Corp., Cell Therapeutics, Inc., Aastrom Biosciences, Inc. and Millipore Corporation are some of the leading players engaged in development of the global cryopreservation equipment market.

Read Comprehensive Overview of Report @https://www.tmrresearch.com/cryopreservation-equipment-market

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TMR Research is a premier provider of customized market research and consulting services to business entities keen on succeeding in todays supercharged economic climate. Armed with an experienced, dedicated, and dynamic team of analysts, we are redefining the way our clients conduct business by providing them with authoritative and trusted research studies in tune with the latest methodologies and market trends.

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Cryopreservation Equipment Market Development and New Market Opportunities and Forecasts 2025 - Germany English News

Global Stem Cell Therapy Market 2020: Growth, Demand, Service, Types, Applications, Key Players and Industry Forecast till 2025 – Curious Desk

Global Stem Cell Therapy market report presents an overview of the market on the basis of key parameters such as market size, revenue, sales analysis and key drivers. The market size of global Stem Cell Therapy market is anticipated to grow at large scale over the forecast period (2020-2025). The main purpose of the study report is to give users an extensive viewpoint of the market. So that users can apply strategic processes to benchmark themselves against rest of the world. Key drivers as well as challenges of the market are discussed in the report. Also reports provides an in depth analysis of the Stem Cell Therapy market with current and future trends.

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In addition, study report offers an array of opportunities for the players participating in the industry. This ultimately leads into the growth of the global Stem Cell Therapy market. Furthermore, report offers a comprehensive study on market size, revenue, sales, growth factors and risks involved in the growth of the market during the forecast period. The factors which are influencing the growth the market are mentioned in the report as well as the challenges which can hamper the growth of the market over the forecast period.

In addition, report presents quantitative as well as qualitative narration of global Stem Cell Therapy market. The research report is beneficial for educators, researchers, strategy managers, academic institutions and analysts. Thus report helps all types of users to identify the strategic initiatives so that they can understand how to expand the global Stem Cell Therapy market business across the globe for the product development. Moreover, research report provides in depth analysis of all the segments which can impact on the market growth.

Browse the complete report @ https://www.adroitmarketresearch.com/industry-reports/stem-cell-therapy-market

Global Stem Cell Therapy market is segmented based by type, application and region.

Based on cell source, the market has been segmented into,

Adipose Tissue-Derived Mesenchymal SCsBone Marrow-Derived Mesenchymal SCsEmbryonic SCsOther Sources

Based on therapeutic application, the market has been segmented into,

Musculoskeletal DisordersWounds & InjuriesCardiovascular DiseasesGastrointestinal DiseasesImmune System DiseasesOther Applications

The company profile section also focusses on companies planning expansions along with mergers & acquisitions, new initiatives, R&D updates and financial updates. But, one of the most important aspects focused in this study is the regional analysis. Region segmentation of markets helps in detailed analysis of the market in terms of business opportunities, revenue generation potential and future predictions of the market. For Stem Cell Therapy report, the important regions highlighted are North America, South America, Asia, Europe and Middle East. The companies focused on in this report are pioneers in the Stem Cell Therapy market. Right from history to future plans the report give a detailed roadmap of the industry that the readers can rely on. The uplifting of any region in the global market is dependent upon the market players working in that region.

In the final section of the report on Stem Cell Therapy Market, the dashboard view of the companies is provided, to compare the current industrial scenario and their contribution in total Stem Cell Therapy Market. Moreover, it is primarily designed to provide clients with an objective and detailed comparative assessment of key providers specific to a market segment. Report audiences can gain segment-specific manufacturer insights to identify and evaluate key competitors based on the in-depth assessment of their capabilities and success in the Stem Cell Therapy Marketplace.

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Global Stem Cell Therapy Market 2020: Growth, Demand, Service, Types, Applications, Key Players and Industry Forecast till 2025 - Curious Desk

Adult Stem Cell – an overview | ScienceDirect Topics

Adult Stem Cells

Adult stem cells are those cells found in tissues after birth that are able to self-renew and yield differentiated cell types. Initially it was thought that adult stem cells were only located in a limited selection of organs and could differentiate into just those phenotypes found in the originating tissue. The field is still developing, however, and recent studies have identified stem cells in more tissues and indicate a greater range of potential than that originally believed. Already stem cells have been derived from human bone marrow (Edwards, 2004), blood (Ogawa, 1993; Asahara et al., 1997), brain (Steindler and Pincus, 2002), fat (Zuk et al., 2002), liver (Tosh and Strain, 2005), muscle (Alessandri et al., 2004), pancreas (Zulewski et al., 2001), and umbilical cord blood (Erices et al., 2000; Benito et al., 2004).

As with many rapidly expanding fields, the use of non-standardized methods makes interpreting results from different investigators difficult, and this thus has led to controversy. Since adult stem cells are often a very small percentage of the total cells isolated from a given tissue, generating a pure population is difficult. In many cases different investigators use different means of isolating the stem cells from a given tissue. The question then arises whether the stem cells generated from the various techniques are identical or distinct stem cell populations. This difficulty is further exacerbated as these cells are commonly identified using a range of criteria, such as isolation procedure, morphology, protein expression, etc., leaving some question as to the defining characteristics of these stem cell populations.

The potential to yield mature phenotypes is typically shown through either differentiation in vitro using biochemical cues or implantation in vivo in immunosuppressed mice. The lack of lineage tracing and clonal expansion in some studies has called into question whether observed phenotypes are due to the differentiation potential of a stem cell or to a heterogeneous initial population. As standardized protocols develop for adult stem cells, more rigorous criteria will develop for determining stem cell populations and their differentiation potential.

There is a growing argument that all adult stem cells may have a signature expression profile. It is possible that self-renewing capabilities combined with multipotency, regardless of the cell origin, are associated with a set of characteristic properties. While such properties have not yet been determined, one candidate may be dye exclusion. When stained with Hoechst, some adult stem cells have been found to actively exclude the dye using transmembrane pumps. These cells have been coined side population cells, as they appear in a peripheral area when analyzed by flow cytometry using a UV laser. Originally identified in murine bone marrow (Goodell et al., 1996), the commonality of this functional property across adult stem cells has best been shown in the mouse model, where side population cells have been found in muscle, liver, lung, brain, kidney, heart, intestine, mammary tissue, and spleen (Asakura and Rudnicki, 2002). Expression of the ABCG2 protein, which plays a role in the transmembrane pump (Scharenberg et al., 2002), may be a convenient expression marker of this functional property. It is still unclear, however, which signature expressions, if any, are inherently associated with all adult stem cells.

While adult stem cells may ultimately be derived from practically every tissue in the body, there is a subset, based on ease of isolation, availability, or potency, that is most likely to contribute to regenerative medicine. These stem cells, and the phenotypic lineages they have been shown to generate, are indicated in Table 3.2. Bone marrow- and blood-derived stem cells are fairly easy to isolate and have been the most thoroughly investigated. Both contain hematopoietic stem cells (HSCs) (Ogawa, 1993; Tao and Ma, 2003), which give rise to blood cells, and endothelial progenitor cells (EPCs) (Asahara et al., 1997; Kocher et al., 2001). Bone marrow additionally contains mesenchymal stem cells (MSCs) (Pittenger et al., 1999; Jiang et al., 2002), which have been shown to differentiate into mesodermal phenotypes, including orthopedic and vascular. The low yield of stem cells from marrow and blood motivates efforts to find alternative adult stem cell sources. HSCs and MSCs can also be derived from umbilical cord blood (Broxmeyer et al., 1989; Erices et al., 2000). As a widely available source of stem cells with extensive expansion capabilities in vitro, stored umbilical cord blood is considered an exciting resource for regenerative medicine applications (Chiu et al., 2005). One plentiful autologous adult stem cell source is fat. Lipoaspirate-derived stem cells have yet to be thoroughly investigated, but have already been shown to differentiate into multiple phenotypes (Zuk et al., 2002; Ashjian et al., 2003; Huang, J.I., et al., 2004). Overall, the proven differentiation potential of human adult stem cells is limited. Research in stem cell plasticity and animal adult stem cells, however, implies that the full potential of human adult stem cells is likely to be more extensive than has been currently shown.

Table 3.2. Differentiated cells derived from human adult stem cells

PLA: processed lipoaspirate

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Adult Stem Cell - an overview | ScienceDirect Topics

Coronavirus updates: Masks required for take out; N.J. hospitalizations to peak within 3 weeks; Stimulus paym – NJ.com

The number of people in New Jersey hospitalized with the coronavirus could peak at around 16,000 in the next two to three weeks, state officials said Saturday.

Under normal circumstances, the state has 18,000 total hospital beds, including 2,000 in critical care, state Health Commissioner Judith Persichilli said.

Another big concern is protective gear for healthcare workers, enough workers in general, and medical equipment especially much-needed ventilators, Persichilli said.

For example, New Jersey is down to just 61 reserve ventilators in its state stockpile. The state has been seeking more from the federal government and private companies.

Persichilli emphasized that officials have worked in recent weeks to aggressively expand the number of beds in the Garden State, including doubling critical care beds, to handle the peak. That includes placing patients at closed hospitals, field hospitals, hotel rooms, and dormitories.

On Saturday, officials announced 251 new deaths and 3,599 cases. There have been 2,183 COVID-19 related deaths and at least 58,151 cases, though some have recovered. Officials estimate 80 to 85% of cases involve mild or moderate symptoms.

The latest updates on coronavirus news:

45 dead at 3 nursing homes in Elizabeth: There have been at least 45 deaths at three different nursing homes in Elizabeth in recent days, but it is unclear how many were due to the coronavirus, city officials said.

More than two dozen residents have died at the Elizabeth Nursing and Rehabilitation Center on Grove Street since at least March 21, a city spokeswoman said Saturday. NJ Advance Media previously reported at least 12 of those who died had tested positive for COVID-19.

First batch of stimulus payments has arrived for some, IRS says: Americans are starting to see the first wave of payments from the coronavirus stimulus package, the IRS said in a tweet on Saturday.

The first batch of deposits was expected to start with those who have filed tax returns for 2019 or 2018, or those who have their direct deposit information on file with Social Security.

Murphy cuts NJ Transit capacity to 50%, requires face masks: Gov. Phil Murphy on Saturday announced new rules and restrictions for public transportation in New Jersey as part of his continued use of executive orders to increase social distancing and slow the spread of the coronavirus.

Murphys latest executive order cuts NJ Transit trains and buses to 50% capacity and requires employees and riders to wear face coverings. It takes effect Monday at 8 pm.

N.J. hospital is 1st in U.S to try placenta therapy on critically ill coronavirus patient: Using a cutting-edge experimental therapy, doctors at a Bergen County hospital on Saturday injected stem cells into a critically ill coronavirus patient, in the hope they will bolster his immune system and save his life.

Its believed to be the first time the procedure was performed in the United States to combat COVID-19, according to Holy Name Medical Center in Teaneck. The cells, drawn from a human placenta, will hopefully aide the previously healthy 49-year-old mans immune response and could potentially also heal tissue damage to his lungs.

The show must go on. See how 3 N.J. churches are creating a virtual Easter this year: Amid the coronavirus pandemic, worshippers in New Jersey wont be packing into pews on what is normally the highest-attended service of the year, and one that takes months of meticulous planning. But churches across the state are continuing to bring consolation to congregants during dark times albeit from a safe distance through Facebook and Youtube.

Longtime N.J. firefighter who died from coronavirus gets heros goodbye from afar: An 85-year-old man who served as a firefighter in his Somerset County hometown for the majority of his adult life died of the coronavirus after contracting pneumonia. Only his son was allowed to attend the funeral in person, while the rest of the family watched on Zoom.

The Bound Brook Fire Department honored him with a funeral procession Friday that featured 52 pieces of apparatus from around the county. Due to social distancing guidelines, a maximum of two firefighters occupied each vehicle.

Worldwide coronavirus cases: At least 405,792 of the approximately 1.78 million people who have tested positive for the virus have recovered as of early Sunday, according to the Center for Systems Science and Engineering at Johns Hopkins University. There have been more than 109,000 deaths.

U.S. coronavirus cases: More than 206,00 of the roughly 530,000 people who have tested positive for COVID-19 have died, Johns Hopkins University said early Sunday. The center says more than 32,000 in the U.S. have recovered.

If you would like updates on New Jersey-specific coronavirus news, subscribe to our Coronavirus in N.J. newsletter. Tell us your coronavirus stories, whether its a news tip, a topic you want us to cover, or a personal story you want to share. If you would like updates on New Jersey-specific coronavirus news, subscribe to our Coronavirus in N.J. newsletter.

NJ Advance Media staff writers Rebecca Everett, Rebecca Panico, Karin Price Mueller, Chris Ryan, Chris Sheldon, Riley Yates and Avalon Zoppo contributed to this report.

Jeff Goldman may be reached at jeff_goldman@njadvancemedia.com. Follow him on Twitter @JeffSGoldman. Find NJ.com on Facebook.

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Coronavirus updates: Masks required for take out; N.J. hospitalizations to peak within 3 weeks; Stimulus paym - NJ.com

Celularity Expands Strategic Collaboration with United Therapeutics Corporation to COVID-19 Infection and Acute Respiratory Distress Syndrome – The…

WARREN, N.J., April 9, 2020 /PRNewswire/ --Celularity Inc. ("Celularity" or the "Company"), a clinical-stage company developing allogeneic cellular therapies from human placentas, today announced the expansion of its existing collaborative license agreement with United Therapeutics Corporation's (Nasdaq: UTHR) wholly-owned subsidiary, Lung Biotechnology PBC, to include the treatment of COVID-19 and Acute Respiratory Distress Syndrome (ARDS).

This announcement builds on recent pioneering work by Celularity for the use of its proprietary CYNK-001 for the treatment of the SARS-CoV-2 virus that causes the coronavirus disease, COVID-19, and extends this application of the technology to ARDS. The U.S. Food and Drug Administration recently cleared Celularity's investigational new drug application (IND 019650) to evaluate CYNK-001's safety, tolerability, and efficacy for the treatment of COVID-19.

ARDS, the most devastating complication of COVID-19, is a serious inflammatory lung injury that causes hypoxemia, or below-normal oxygen level in the blood. Hypoxemia can lead to multi-organ system failure and death. Recent findings indicate that ARDS may develop in as many as 17-29% of COVID-19 patients who are hospitalized with pneumonia.

Celularity founder and Chief Executive Officer, Dr. Robert Hariri, said, "This promising, novel approach to treating COVID-19 and the pulmonary complications associated with this infection may unlock a powerful new therapeutic option for patients. The exceptional expertise in pulmonary disease, cellular medicine, and manufacturing makes this strategic collaboration particularly well suited to tackle this urgent, global medical crisis."

Under the amended collaborative agreement, Celularity will seek regulatory approval for CYNK-001 in COVID-19, and Lung Biotechnology will seek regulatory approval for CYNK-001 in ARDS. Lung Biotechnology has global rights under the amended collaborative agreement to commercialize CYNK-001 in COVID-19 and ARDS. The collaboration will be governed by a Joint Steering Committee to oversee development and commercialization activities. Financial terms were not disclosed.

Celularity's CYNK-001 is the only cryopreserved allogeneic, off-the-shelf Natural Killer (NK) cell therapy being developed from placental hematopoietic stem cells and is being investigated as a potential treatment option for various hematologic cancers and solid tumors, and is the first cell therapy granted an IND to treat COVID-19. NK cells are a unique class of immune cells, innately capable of targeting cancer cells and virally infected cells and interacting with adaptive immunity. CYNK-001 cells derived from the postpartum placenta have been shown to be well-tolerated in early clinical trials and are currently being investigated as a treatment for acute myeloid leukemia (AML), multiple myeloma (MM), and glioblastoma multiforme (GBM).

Media and Investor RelationsMedia Contact:Factory PRcelularity@factorypr.com

Investor Relations Contact:John R. Haines, Executive Vice Presidentjohn.haines@celularity.com

About Celularity: Celularity, headquartered in Warren, N.J., is a clinical-stage cell therapeutics company delivering transformative allogeneic cellular therapies derived from the postpartum human placenta. Using proprietary technology in combination with its IMPACT platform, Celularity is the only company harnessing the purity and versatility of placental-derived cells to develop and manufacture innovative and highly scalable off-the-shelf treatments for patients with cancer, inflammatory, infectious, and age-related diseases. To learn more, please visit http://www.celularity.com.

Forward-Looking Statements: This press release contains forward-looking statements. These forward-looking statements are based on expectations and are subject to certain factors, risks, and uncertainties that may cause actual results, the outcome of events, timing and performance to differ materially from those expressed or implied by such statements. The information contained in this press release is believed to be current as of the date of the original issue. Celularity expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based.

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Celularity Expands Strategic Collaboration with United Therapeutics Corporation to COVID-19 Infection and Acute Respiratory Distress Syndrome - The...

UC San Diego to advance stem cell therapies in new space station lab – – KUSI

April 9, 2020

Posted: April 9, 2020

Updated: 5:22 PM

KUSI Newsroom

SAN DIEGO (KUSI) UC San Diego and Space Tango receive NASA award to develop first dedicated stem cell research laboratory within the International Space Station.

UCSDs website reports, A three-year, nearly $5 million award from NASA will allow researchers at the Sanford Stem Cell Clinical Center at UC San Diego Health, Sanford Consortium for Regenerative Medicine and their partners at Space Tango to develop a new integrated space stem cell orbital research laboratory within the International Space Station (ISS) and launch three collaborative research projects within it.

Stem cells self-renew, generating more stem cells, and specialize into tissue-specific cells, such as blood, brain and liver cells, making them ideal for biological studies far from Earths resources. The goal of the new effort is to leverage microgravity and these unique properties of stem cells to better understand how space flight affects the human body. The studies will also inform how aging, degenerative diseases, cancers and other conditions develop in a setting with increased exposure to ionizing radiation and pro-inflammatory factors. The findings from these studies may speed the development of new therapeutics for a broad array of degenerative diseases on Earth.

Dr. Catriona Jamieson, the lead researcher on this NASA award story, visited KUSI News to tell us all about it.

For more information, click here.

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UC San Diego to advance stem cell therapies in new space station lab - - KUSI

Stem Cell Banking Storage Market Size Analysis, Top Manufacturers, Shares, Growth Opportunities and Forecast to 2026 – Science In Me

New Jersey, United States:The new report has been added by Market Research Intellect to provide a detailed overview of the Stem Cell Banking Storage Market. The study will help to better understand the Stem Cell Banking Storage industry competitors, the sales channel, Stem Cell Banking Storage growth potential, potentially disruptive trends, Stem Cell Banking Storage industry product innovations and the value / volume of size market (regional / national level, Stem Cell Banking Storage- Industrial segments), market share of the best actors / products.

Information has been added to the report to provide a realistic view of the industry based on data from Stem Cell Banking Storage manufacturers, i.e. H. Shipping, price, sales, gross profit, business distribution, etc., SWOT analysis, consumer preference, current developments and trends, drivers and limiting factors, company profile, investment opportunities, analysis of the demand gap, market size value / volume, services and products, Porters five models , socio-economic factors, official regulations in the Stem Cell Banking Storage branch. Market participants can use the report to take a look at the future of the Stem Cell Banking Storage market and make significant changes to their operating style and marketing tactics in order to achieve sustainable growth.

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The report examines the competitive environment scenario observed with key players in Stem Cell Banking Storage sales, the profile of their business, their earnings, their sales, their business tactics, and the forecasting situations of the Stem Cell Banking Storage sales industry. According to studies, the Stem Cell Banking Storage sales market is very competitive and diverse due to global and local suppliers.

The Stem Cell Banking Storage Sales Market Report mainly contains the following Manufacturers:

Market Competition

The competitive landscape of the Stem Cell Banking Storage market is examined in detail in the report, with a focus on the latest developments, the future plans of the main players and the most important growth strategies that they have adopted. The analysts who compiled the report have created a portrait of almost all of the major players in the Stem Cell Banking Storage market, highlighting their key commercial aspects such as production, areas of activity and product portfolio. All companies analyzed in the report are examined on the basis of important factors such as market share, market growth, company size, production, sales and earnings.

Report Highlights

Assessment of sales channels

innovation trends

sustainability strategies

Niche market trends

Market entry analysis

market size and forecast

The geographic department provides data that give you an overview of the turnover of companies and sales figures for the growth activity Stem Cell Banking Storage for electrical meters. Here are the strengths of the geographic divisions: North America (United States, Canada and Mexico), Europe (Germany, Spain, France, Great Britain, Russia and Italy and more), Asia-Pacific (China, Japan, Korea, India and Southeast Asia) and more ), South America (Brazil, Argentina, Colombia), the Middle East and Africa (Saudi Arabia, United Arab Emirates, Egypt, Nigeria and South Africa) and ROW.

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Table of Content

1 Introduction of Stem Cell Banking Storage Market1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Stem Cell Banking Storage Market Outlook4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Stem Cell Banking Storage Market, By Deployment Model5.1 Overview

6 Stem Cell Banking Storage Market, By Solution6.1 Overview

7 Stem Cell Banking Storage Market, By Vertical7.1 Overview

8 Stem Cell Banking Storage Market, By Geography8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Stem Cell Banking Storage Market Competitive Landscape9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix11.1 Related Research

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Tags: Stem Cell Banking Storage Market Size, Stem Cell Banking Storage Market Growth, Stem Cell Banking Storage Market Forecast, Stem Cell Banking Storage Market Analysis, Stem Cell Banking Storage Market Trends, Stem Cell Banking Storage Market

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Stem Cell Banking Storage Market Size Analysis, Top Manufacturers, Shares, Growth Opportunities and Forecast to 2026 - Science In Me