Here’s Why Pluristem Therapeutics Jumped Over 28% Today – Motley Fool

What happened

Shares of Pluristem Therapeutics (NASDAQ:PSTI) rose as much as 28.3% today after the company announced it had secured non-dilutive financing from the European Investment Bank (EIB) to support the development of treatments for COVID-19. The stem cell developer is eligible to receive up to $54 million (50 million Euros) in funding in three tranches, with the first $21.5 million expected to be distributed before the end of April.

Pluristem Therapeutics can receive the second and third installments by achieving certain clinical, regulatory, and manufacturing milestones. It won't have to begin repaying the loan until April 2025.

As of 1:08 a.m. EDT, the small-cap stock had settled to a 22.9% gain.

Image source: Getty Images.

Today's financing announcement means Pluristem Therapeutics can hit the ground running to develop stem-cell based treatments for COVID-19. Importantly, it also means the company can limit dilutive fundraising transactions to support research and development (R&D) efforts. But investors might still expect a public stock offering to be conducted soon.

Pluristem Therapeutics expects the $54 million financing from EIB to cover up to 50% of R&D expenses related to its COVID-19 project. The business reported only $16 million in cash on its balance sheet at the end of 2019, which means it will need additional funding -- likely raised from public offerings of common stock -- if the project progresses.

To be blunt, Pluristem Therapeutics is a stem cell stock that doesn't belong in your portfolio. The company sported a market valuation of only $60 million just a few weeks ago, but has climbed to $225 million on recent announcements that it was developing treatments for COVID-19. While fellow stem-cell developer Mesoblast reported promising results today from a small clinical trial, investors cannot extrapolate that to Pluristem Therapeutics. This remains a very risky stock.

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Here's Why Pluristem Therapeutics Jumped Over 28% Today - Motley Fool

Global Animal Stem Cell Therapy Market 2020 Future Scenario, Industry Growth Insights and Production Analysis 2025 – Bandera County Courier

Mrinsights.bizhas published a new report titled GlobalAnimal Stem Cell TherapyMarketGrowth 2020-2025 which comprises new statistical data on the changing market scenario and initial and future assessment of the market. The report covers a wide range of business aspects global Animal Stem Cell Therapy trends, future forecasts, growth opportunities, key end-user industries, and market players. The report analyzes the recent developments, investment opportunities, and probable threats in the market. It closely looks at the markets all-purpose evaluation and depicts the important data associated with the global market.

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The report assesses the demand-side and supply-side trends in the global Animal Stem Cell Therapy market. Various segments are scrutinized that involve end-users, regions, and players on the basis of demand patterns, and prospect for 2020 to 2025 time-period. The research report contains a comprehensive database on future market estimation based on historical data analysis. Key players are listed with major collaborations, mergers & acquisitions and upcoming and trending innovation. Primary research involves interviews, news sources and information booths. Secondary research techniques add more in clear and concise understanding with regards to placing of data in the report.

Understanding The Competitive Scenario:

Competitive landscape analysis is presented which involves the global Animal Stem Cell Therapy market share of major players, along with the new projects and strategies adopted by players in the past five years. Comprehensive company profiles comprise the product offerings, key financial information, recent developments, SWOT analysis, capacity, production, price, revenue, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, and strategies employed by the major market players. Additionally, the report covers insights into the production and capacities in terms of manufacturing with price fluctuations of raw materials, process in-flow rate product cost, and production value.

Considering market analysis, the profiled list of companies in the report is:Medivet Biologics LLC, Animal Cell Therapies, VETSTEM BIOPHARMA, U.S. Stem Cell, Inc, VetCell Therapeutics, J-ARM, Kintaro Cells Power, Celavet Inc., Animal Stem Care, Magellan Stem Cells, Cell Therapy Sciences, Animacel

Currently, the research report gives special attention and focus on the following regions:Americas (United States, Canada, Mexico, Brazil), APAC (China, Japan, Korea, Southeast Asia, India, Australia), Europe (Germany, France, UK, Italy, Russia, Spain), Middle East & Africa (Egypt, South Africa, Israel, Turkey, GCC Countries).

Moreover, the report identifies potential customers and suppliers as well as gives an analysis of the companys business structure, operations, major products and services, and business strategy. The study helps you understand the companys core strengths, weaknesses, opportunities, and threats. The report shows factual data about the global Animal Stem Cell Therapy market in the worldwide area, for example, production chain, manufacturing capacity, sales volume, and revenue.

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The Scope of The Global Animal Stem Cell Therapy Report:

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team (sales@mrinsights.biz), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

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Global Animal Stem Cell Therapy Market 2020 Future Scenario, Industry Growth Insights and Production Analysis 2025 - Bandera County Courier

FTC Sends 21 Letters Warning Marketers to Stop Making Unsupported Claims That Their Products and Therapies Can Effectively Treat Coronavirus – Sierra…

Supposed therapies range from stem cell infusions to acupuncture and ozone treatments

April 24, 2020 - The Federal Trade Commission announced it has sent 21 additional letters warning marketers throughout the United States to stop making unsubstantiated claims that their products and therapies can treat or prevent coronavirus (COVID-19). This is third set of warning letters the FTC has sent to sellers of such products as part of its ongoing efforts to protect consumers from COVID-19 related scams.

The FTCpreviously sent warning lettersto the sellers of supplements including colloidal silver, teas, essential oils, and other products pitched as scientifically proven coronavirus treatments. The letters announced today, however, address a wider range of products and supposed treatments, including some that may appear more medically sophisticated to consumers, such as acupuncture, intravenous (IV) therapies with high doses of Vitamin C, ozone therapy, and purported stem cell treatments. However, there is currently no scientific evidence that these products or services can treat or cure coronavirus.

The FTC sent the letters announced today to the companies and individuals listed below. The recipients are grouped based on the type of therapy, product, or service they pitched to supposedly prevent or treat coronavirus disease.

General Therapy Products, Vitamins, and Supplements:

IV Therapy and Related Treatments:

Ozone Therapy:

Stem Cell Therapy:

In the letters, the FTC states that one or more of the efficacy claims made by the marketers are unsubstantiated because they are not supported by scientific evidence, and therefore violate the FTC Act. The letters advise the recipients to immediately cease making all claims that their products can treat or cure coronavirus and to notify the FTC within 48 hours about the specific actions they have taken to address the agencys concerns.

The letters note that if the false claims do not cease, the Commission may seek a federal court injunction and an order requiring money to be refunded to consumers.

The letters announced today are the latest round of warnings the FTC has sent to sellers of products pitched as able treat or prevent coronavirus. The Commission also has sentletters to several Voice over Internet Protocol (VoIP) service providers, warning them that it is illegal to aid or facilitate the transmission of pre-recorded telemarketing robocalls pitching supposed coronavirus-related products or services.

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FTC Sends 21 Letters Warning Marketers to Stop Making Unsupported Claims That Their Products and Therapies Can Effectively Treat Coronavirus - Sierra...

Animal Stem Cell Therapy Market Is Set To Experience Revolutionary Growth By 2025 – Cole of Duty

The Animal Stem Cell Therapy report provides independent information about the Animal Stem Cell Therapy industry supported by extensive research on factors such as industry segments size & trends, inhibitors, dynamics, drivers, opportunities & challenges, environment & policy, cost overview, porters five force analysis, and key companies profiles including business overview and recent development.

Animal Stem Cell Therapy MarketLatest Research Report 2020:

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In this report, our team offers a thorough investigation of Animal Stem Cell Therapy Market, SWOT examination of the most prominent players right now. Alongside an industrial chain, market measurements regarding revenue, sales, value, capacity, regional market examination, section insightful information, and market forecast are offered in the full investigation, and so forth.

Scope of Animal Stem Cell Therapy Market: Products in the Animal Stem Cell Therapy classification furnish clients with assets to get ready for tests, tests, and evaluations.

Animal Stem Cell Therapy Market Report Covers the Following Segments:

Segment1: By Type, Dogs, Horses, Others, By Application, Veterinary Hospitals, Research Organizations

Market Overview:The report begins with this section where product overview and highlights of product and application segments of the global Animal Stem Cell Therapy Market are provided. Highlights of the segmentation study include price, revenue, sales, sales growth rate, and market share by product.

Competition by Company:Here, the competition in the Worldwide Animal Stem Cell Therapy Market is analyzed, By price, revenue, sales, and market share by company, market rate, competitive situations Landscape, and latest trends, merger, expansion, acquisition, and market shares of top companies.

Company Profiles and Sales Data:As the name suggests, this section gives the sales data of key players of the global Animal Stem Cell Therapy Market as well as some useful information on their business. It talks about the gross margin, price, revenue, products, and their specifications, type, applications, competitors, manufacturing base, and the main business of key players operating in the global Animal Stem Cell Therapy Market.

Market Status and Outlook by Region:In this section, the report discusses about gross margin, sales, revenue, production, market share, CAGR, and market size by region. Here, the global Animal Stem Cell Therapy Market is deeply analyzed on the basis of regions and countries such as North America, Europe, China, India, Japan, and the MEA.

Application or End User:This section of the research study shows how different end-user/application segments contribute to the global Animal Stem Cell Therapy Market.

Market Forecast:Here, the report offers a complete forecast of the global Animal Stem Cell Therapy Market by product, application, and region. It also offers global sales and revenue forecast for all years of the forecast period.

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Animal Stem Cell Therapy Market Is Set To Experience Revolutionary Growth By 2025 - Cole of Duty

Stem Cell Therapy Market Overview by 2026: Verified Market Research – Cole of Duty

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Global Stem Cell Therapy Market Segmentation

This market was divided into types, applications and regions. The growth of each segment provides an accurate calculation and forecast of sales by type and application in terms of volume and value for the period between 2020 and 2026. This analysis can help you develop your business by targeting niche markets. Market share data are available at global and regional levels. The regions covered by the report are North America, Europe, the Asia-Pacific region, the Middle East, and Africa and Latin America. Research analysts understand the competitive forces and provide competitive analysis for each competitor separately.

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Global Stem Cell Therapy Market Regions and Countries Level Analysis

The regional analysis is a very complete part of this report. This segmentation highlights Stem Cell Therapy sales at regional and national levels. This data provides a detailed and accurate analysis of volume by country and an analysis of market size by region of the world market.

The report provides an in-depth assessment of growth and other aspects of the market in key countries such as the United States, Canada, Mexico, Germany, France, the United Kingdom, Russia and the United States Italy, China, Japan, South Korea, India, Australia, Brazil and Saudi Arabia. The chapter on the competitive landscape of the global market report contains important information on market participants such as business overview, total sales (financial data), market potential, global presence, Stem Cell Therapy sales and earnings, market share, prices, production locations and facilities, products offered and applied strategies. This study provides Stem Cell Therapy sales, revenue, and market share for each player covered in this report for a period between 2016 and 2020.

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Study Coverage: It includes study objectives, years considered for the research study, growth rate and Stem Cell Therapy market size of type and application segments, key manufacturers covered, product scope, and highlights of segmental analysis.

Executive Summary: In this section, the report focuses on analysis of macroscopic indicators, market issues, drivers, and trends, competitive landscape, CAGR of the global Stem Cell Therapy market, and global production. Under the global production chapter, the authors of the report have included market pricing and trends, global capacity, global production, and global revenue forecasts.

Stem Cell Therapy Market Size by Manufacturer: Here, the report concentrates on revenue and production shares of manufacturers for all the years of the forecast period. It also focuses on price by manufacturer and expansion plans and mergers and acquisitions of companies.

Production by Region: It shows how the revenue and production in the global market are distributed among different regions. Each regional market is extensively studied here on the basis of import and export, key players, revenue, and production.

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Tags: Stem Cell Therapy Market Size, Stem Cell Therapy Market Trends, Stem Cell Therapy Market Forecast, Stem Cell Therapy Market Growth, Stem Cell Therapy Market Analysis

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Stem Cell Therapy Market Overview by 2026: Verified Market Research - Cole of Duty

Researcher says stem cell activation could lie at root of health effects of many natural products – NutraIngredients-usa.com

Gitte Jensen, PhD, is the principal of NIS Labs, a contract research organization based in Klamath Falls, OR. For several decades, starting with a postdoc stint at the Cross Cancer Institute at the University of Alberta, then running her own lab at McGill University in Montreal and at NIS Labs, which she founded in 1999, Jensen has studied how the human body activates and employs stem cells. These initially undifferentiated cells are the foundation of the bodys repair machinery and also play a key role in a healthy immune system response.

Jensen has done research which has explored the effects of compounds found in microalgae. As it turns out, Upper Klamath Lake, which abuts the city of Klamath Falls, plays host every year to abundant blooms of a particular strain of blue green algae long touted for its health benefits. Jensens expertise in algae research has also been employed in the study of astaxanthin-rich Haematococcus pluvialis.

Recently Jensens attention has been focused on compounds found in sea buckthorn berries. Sea buckthorn is a thorny, perennial shrub native to many parts of Asia as well as Northwestern Europe. The best berries with the most bioactives are harvested in various high altitude locations in the Himalayan region.

The plant has long been revered for its medicinal properties. Legend has it that during his push into Asia Alexander the Great released horses injured in battle to fare as they might in an area with many of the shrubs. The horses not only survived but prospered and when the Greeks next looked in on them they found a herd notable for their shiny coats, an outward sign of health. Thus the name of the plant: Hippophae, which combines the Greek words for horse and shiny.

Similar legends hold that Genghis Khan instructed his troops to carry the berries to speed recovery from war wounds. Jensen said the berries of the plant have been an ingredient in Chinese, Tibetan and Mongolian herbal medicine traditions for more than a thousand years.

Jensen conducted a small scale, randomized double-blind, placebo-controlled crossover study to look into how the proanthocyanidins found in the berry affected stem cell activation. The study was published last year in the journal Clinical Interventions in Aging. The study recruited 12 subjects, eight women and four men, who ranged in age an in body composition from slender to borderline obese. The subjects consumed 500 mg of a proanthocyanidin-rich sea buckthorn extract or a placebo at two separate visits to the testing facility. Subjects remained calm and at rest for three hours during the administration of the test material (or the placebo). Blood was drawn at one hour for a baseline measurement, and then one hour and two hours after ingestion of the test material. Participants were also screened for confounding factors such as a high state of anxiety or being short on sleep, which could have skewed the results, in which case visits were rescheduled.

Jensen and her co authors found that the sea buckthorn extract significantly increased the level of some specific endothelial stem cells, but not others. The CD45dim CD34+ CD309- cells, CD45dim CD34+ CD309+ cells, and the CD45- CD31+ CD309+ endothelial stem cells showed significant mobilization above placebo within 2 hours, they wrote.

Regardless of the stem cell type, just having more has been shown to be important, Jensen and her coauthors stated. While pluripotential stems cells are the most important type, there are indications that other kinds of stem cellsendothelial, mesenchymal, and hematopoieticcan revert to the pluripotential state and be available for additional repair processes.

When the number of circulating endothelial progenitor cells was quantified in the blood of 509 individuals at risk for cardiovascular disease and the incidence of cardiovascular events in these individuals was monitored for 1 year, a significantly greater number of events took place in the individuals having fewer circulating stem cells, they said.

By documenting the ability of SBB-PE (sea buckthorn berries proanthycyanidin-rich extract) to support stem cell mobilization and to increase the number of circulating stem cells, we have uncovered a new mechanism of action behind many of the health benefits that have been historically associated with SBB, they concluded.

Jensen said looking more closely at stem cell activation could change how researchers design their studies and help bring forth more trials that show significant results because there is a better understanding of the underlying mechanisms of action.

When we look at plants that have health properties, we look at whether an underlying protective mechanism might be at work. Every time you take a concentrated dose of sea buckthorn extract you make a concerted effortto boost the number of stem cells in your circulation. You kick them into action to go in search of things that need repair, Jensen said.

Jensen said future avenues of research could delver deeper into how this rapid mobilization of stem cells takes place. She said its quite likely that the gut/brain connection is involved, as stem cell levels start to rise before significant amounts of the contents of the berry extract could be digested and cross the blood/gut barrier.

If you are consuming a natural product that works fast it is likely due ot a signal from the gut to the brain likely because of the vagus nerve or other pathways, she said.

Im advocating for a deeper understandingin our industryhow the many natural products we are working with are tapping into and supportingnatural physiological processes, Jensen said.

Source: Clinical Interventions in AgingDOI: 10.2147/CIA.S186893Rapid and Selective Mobilization of Specific Stem Cell Types After Consumption of a Polyphenol-Rich Extract From Sea Buckthorn Berries ( Hippophae) in Healthy Human SubjectsAuthors: Drapeau C, Benson KF, Jensen GS

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Researcher says stem cell activation could lie at root of health effects of many natural products - NutraIngredients-usa.com

Scientists explore using CAR-T and other engineered immune cells to target COVID-19 – FierceBiotech

CAR-T and TCR-T therapies that involve engineering a patients own immune cells with antigen-specific receptors have revolutionized blood cancer treatment. Nowscientists at Duke-NUS Medical School are exploring the possibility of turning the approach against COVID-19.

The idea of using CAR/TCR-T cell therapy has already been proposed for treating chronic viral infections such as HIV and hepatitis B. Based on previous research, Antonio Bertoletti from Duke-NUS emerging infectious diseases research program suggest these immunotherapies might also be useful in treating SARS-CoV-2, the virus causing the current pandemic.

We demonstrated that T cells can be redirected to target the coronavirus responsible for SARS. Our team has now begun exploring the potential of CAR/TCR T cell immunotherapy for controlling the COVID-19-causing virus, SARS-CoV-2, and protecting patients from its symptomatic effects, Bertoletti said in a statement.

Virtual Clinical Trials Online

This virtual event will bring together industry experts to discuss the increasing pace of pharmaceutical innovation, the need to maintain data quality and integrity as new technologies are implemented and understand regulatory challenges to ensure compliance.

These types of therapies involve modifying patients' own T cells with either a chimeric antigen receptor (CAR) or a T-cell receptor (TCR) that can recognize specific antigens associated with cancer,and then guiding the immune cells to eradicate the targets when infused back into the patients.

In a 2011 article published in the Journal of Virology, Bertoletti led a team that generated TCR-T cells that can go after SARS, another coronavirus that caused a deadly outbreak in China and other countries in late 2002 and early 2003.

The team showed that those TCR-redirected T cells displayed a functional profile similar to that of SARS-specific memory CD8 T cells from people who recovered from SARS-CoV infection. Based on the findings, the researchers suggested that TCR-T cells represent a promising prophylactic or therapeutic treatment for SARS.

RELATED:How 'duoCAR-T' cells could clear HIV and prevent resurgence of virus reservoirs

CAR-T cells have been explored in other viruses. A research team from the Albert Einstein College of Medicine and the University of Pittsburgh, for example,designed duoCAR-T cells that target three sites on the HIV envelope glycoprotein. In the lab, the cell therapy eliminated up to 99% of immune cells infected with different strains of HIV.

Despite thepromise of T-cell therapies, however, Bertoletti and colleague Anthony Tanoto Tan cautioned about potential safety concerns of using them to treat viral infections affecting vital organs. For one thing, CAR-T treatments havebeen linked to the dangerous side effect called cytokine release syndrome, in which overreactive immune cells launch an inflammatory response that can destroy organs, they said in a recent Journal of Experimental Medicine commentary. Similar cytokine storm effects have been reported in somesevere COVID-19 patients, leading to potentially life-threatening lung inflammations.

[T]he infusion ofT cells stably expressingpathogen-specific CAR/TCR poses therisk that these T cells might proliferate and wipe out all the infected cells that might be the majority of the infected organ, Bertoletti and Tanoto Tan wrote in their article.

To addressthat problem, Bertoletti and colleagues are using mRNA electroporation to engineer CAR/TCR T cells, which they say can limit their inflammatory capability and shorten the functional activity. That may offer a safer way to use engineered immune cells to treat viral diseases.

Several organizations are also working on cell therapies for COVID-19. AlloVir and Baylor College of Medicine have teamed up to develop an off-the-shelf therapy that entails exposing donor T cells to cytokines combined with viral fragments so the new cells can target the novel coronavirus. Celgene spinoff Celularity just started clinical trial of its cancer treatment CYNK-001 for COVID-19. The drugturns placental stem cells into one-size-fits-all natural killer cells.

Continued here:
Scientists explore using CAR-T and other engineered immune cells to target COVID-19 - FierceBiotech

Researchers use cell therapy to recover damaged brain areas in mice that suffered – Mirage News

Dispositiu per a realitzar registres electrofisiolgics amb les llums LED incorporades per lus doptogentica.

Equip investigador.

Researchers from Lund University (Sweeden) and the Institute of Neurosciences of the University of Barcelona (UBNeuro) have recovered, through cell therapy, the mobility and sensibility of mice that suffered a cardiovascular accident. The results of this study were published in the journal Proceedings of the National Academy of Sciences (PNAS).

Researchers used an ischemic model of ictus in mice to which they transferred stem cells obtained from the skin of a healthy human donor. The cells were reprogramed to become neuronal progenitors of the damaged area of the brain, specifically the brain cortex. Six months after the transplant, researchers could observe how the new cells had repaired the damage that was caused by the cerebrovascular injury. In addition, the sensor and motor problems resulting from the stroke had been reversed as well.

We observed that the fibers of the cells that were put in the cortical area grew and created connections in brain areas that are far from the transplant area, notes Daniel Tornero, researcher in the Laboratory of Stem Cells and Regenerative Medicine in UBNeuro. To identify the transplanted cells, researches used different techniques that enable the monitoring so as to prove the connection in damaged circuits is right. Although there is a lot of work to do -the researcher adds-, the study sheds light on the possibility of replacing the damaged cells for new healthy cells in patients with ictus.

This is the last study of a series of three articles in which the researchers used cell therapy to work on brain healing. Previous studies showed it is possible to transplant nervous cells derived from human stem cells or reprogrammed cells in the brain of mice affected by cardiovascular injuries. However, researchers did not know whether the transformed cells could create new connections in the mice brains and restore the movement and feelings of touch.

The next step is to understand how the transplant affects intellectual functions such as memory, and the potential adverse effects, concludes Tornero.

Article reference:

S. Palma-Tortosa, D. l Tornero, M. Grnning Hansen, E. Monni, M. Hajy, S. Kartsivadze, S. Aktay, O. Tsupykov, M. Parmar, K. Deisseroth, G. Skibo, O. Lindvall, y Z. Kokaia. Activity in grafted human iPS cellderived corticalneurons integrated in stroke-injured rat brain regulatesmotor behavior. Proceedings of the National Academy of Sciences (PNAS). Doi: doi: 10.1073/pnas.2000690117

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Researchers use cell therapy to recover damaged brain areas in mice that suffered - Mirage News

Scientists from IKBFU, Moscow and Kiev conducted research on treating obesity – Science Codex

In the 21st century, the search for methods of treating noncommunicable diseases, such as obesity, metabolic syndrome, and diabetes are among the top priorities. Prevention and treatment of these diseases include changing and controlling lifestyle, diet, and the use of pharmaceuticals.

Despite the progress in medicine and pharmacology (developing new solutions for correcting metabolism) and biotechnologies, new effective approaches are still on demand in treating obesity, metabolic syndrome, and diabetes.

Researchers note that adipose tissue is one of the key players in the development of obesity and diabetes. Adipose tissue is classified both by anatomical location and by function (white and brown fat). So, the main functions of white adipose tissue are to save energy in the form of lipids, and it also has an endocrine function - the secretion of hormones, growth factors, cytokines, chemokines, etc.

The function of brown adipose tissue is to generate heat during adaptive thermogenesis (the process of generating heat in response to cold stimulation). In humans, unlike rodents (laboratory animals most widely used in medical experiments, including modeling of obesity, metabolic syndrome and diabetes), brown adipose tissue is present in significant numbers only in newborns and infants. Recently, the existence of active thermogenic adipose tissue in adults has been shown, but this adipose tissue differs from classical brown adipose tissue in several aspects (development, morphology, gene expression, adipokine production, etc.). This adipose tissue is called "brown".

All types of adipocytes (cells that make up adipose tissue mainly) arise from adipose stem cells during differentiation. Currently, the question of the origin of brown adipocytes (from the same stem cell as white adipocytes, or from the same stem cell as brown adipocytes, or from its own stem cell), as well as the ability of white adipose tissue to differentiate into brown adipose tissue.

The ability to control the formation of new adipose tissue, turn white adipose tissue into brown one, or determine the direction of adipocyte stem cell differentiation into a specific subtype is an attractive goal for the development of new pharmacological substances for the treatment of obesity, metabolic syndrome and diabetes.

In addition to the search for new pharmacological substances designed to control the functions of adipose tissue or various other biochemical aspects of energy homeostasis, it is also important to study the role of water in human health, metabolism and the pathogenesis of various diseases. Water is the most abundant chemical substance on Earth and makes up the largest mass fraction in living organisms as a percentage. Water is also a universal solvent in which the basic biochemical processes of living organisms occur.

An important component of a healthy diet is drinking water instead of sugar and soda. So, the modulation of the biological and physico-chemical properties of water is also a promising opportunity to increase the effectiveness of the treatment of said diseases.

Dr. Larisa Litvinova, Ph.D. in Medicine, Head of the Immunology and Cell Biotechnologies Laboratory^

"One of the focuses of modern medicine is the development of deuterium-containing drugs. Another direction relates to the role of the D/H ratio of isotopology and its change in water, which will be used as

an adjuvant in the treatment of cancer. A different D/H ratio manifests itself in the form of a kinetic isotope effect, which is characterized by a change in the rates of biotransformation and excretion of drugs. Moreover, methodological approaches to the quality control of medicines based on isotopology of water could reduce the toxic load on the body".

IKBFU Scientists Larisa Litvinova and Maria Wulf were conducting the research in cooperation with colleagues from Moscow and Kiev and the goal of the research was to find out whether deuterium is engaged in differentiation of adipose tissue stem cells regulation. Adipogenic differentiation of mesenchymal stem cells was chosen as an in vitro model, where the efficiency of the formation of mature fat cells from precursor cells in media with different deuterium contents was evaluated.

The data on the effect of various concentrations of deuterium on the efficiency and direction (formation of brown/beige or white adipocytes) of differentiation of mesenchymal stem cells in an in vitro model system were obtained in the study. Naturally for the possible practical application of these results, additional studies are needed that would allow a more detailed description of the molecular mechanisms of the influence of various concentrations of deuterium at the cellular level, as well as studies at the body level.

The results of the study are published in the article "The influence of deuterium on the effectiveness and type of adipogenic differentiation of stem cells of human adipose tissue in vitro" in the Scientific Reports journal.

The results can serve as the basis for the development of new approaches in the treatment of obesity, metabolic syndrome and diabetes, by regulating the differentiation of fat stem cells and adipocyte functions.

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Scientists from IKBFU, Moscow and Kiev conducted research on treating obesity - Science Codex

Lessons for medical profession during management of covid-19 pandemic: Is there a silver lining? – Elets

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Covid 19 pandemic caused by corona virus has become a sort of global showstopper with apparently huge negative impact on human life as well as economy worldwide. It has, undeniably, emerged as a daunting challenge for medical profession in 21st century. Despite its glorious victories over the past pandemics of plague, cholera, polio and smallpox, medical profession is bracing itself to take on Covid 19 juggernaut. Currently, every person, layman or medical, is dismayed by ferocity of its spread and rapidity of its killing, particularly among high-risk persons. In various hotspots of this pandemic, healthcare systems are severely overwhelmed by clinical load of patients requiring hospitalization as well as intensive care. This is first time that medical professionals have a dual responsibility- to treat the patient as well as to prevent themselves from succumbing to same illness. While healthcare professionals all over the world are showing exemplary fortitude and gusto in dealing with this uphill task, it is time to decipher few lessons which can be usher in new era of healthcare following covid pandemic.Advantages of recent rationing of routine specialized medical services

Undeniably the patient load at various hospitals (both public as well as private) over last few weeks has hit the rock bottom due to peoples reluctance and doctors hesitance in engaging with medical care. Even suggesting going to hospital is sending shivers down the spine of a person with simple fever or cough. This sudden aversion to hospital visits clearly echoes the scenario 150 years back when hospitals were first established in western world. The hospitals in early America were primarily used as alms-houses for homeless poor and getting hospitalized was a stigma for the society (Health, Illness, and Society: An Introduction to Medical Sociology By Steven E. Barkan). Same stigma has resurfaced now during covid 19 pandemic, though in a different social and medical context.

Elective procedures are almost at standstill for following two reasons: First, as an austerity measure to preserve potential resources for covid patients and second, to protect the vulnerable from exposure to virus. Even, emergency facilities are also witnessing load shedding with recent reports of 40-70% decrease in STEMI (ST Elevated Myocardial Infarction) patients all over the world (https: //www. tctmd. com/ news/ mystery-missing-stemis-during-covid-19-pandemic). In a study published in Spain (by Rodrguez-Leor O et al), interventional cardiology is almost in a state of lockdown and surprisingly corresponding increase in medical management of heart disease patients is still slight. Published reports of activation of cardiac catheterization labs for STEMI patients also showed a decline of 38% (Garcia S, et al. J Am Coll Cardiol. 2020; Accepted Date: 7 April 2020). This should not be alone attributed to serious patients failing to reach hospitals due to fear of corona virus. Literature search easily reveals that false activation rate of catheterization labs ranges from 12.5-40% (by Degheim G et al JRSM Cardiovascular Disease 2019, Vol 8;1-5). Therefore, recent decline of 38% during Covid pandemic is concordance with previously reported false activation rate and thereby reflects avoidable or unnecessary therapeutic demand.

One potential upside of this recent drop in healthcare utilization is the reduction in too much medicine- a term gaining prominence in recent medical lexicon. This is wide ranging concept which encompasses processes like over-detection (diagnosing harmless, static or incidental conditions which will either resolve spontaneously or do not progress), over-definition (where thresholds for diagnosing illnesses are gradually lowered leading to quasi-indications for treatment) and over-selling (by alarming patients with insidious symptoms mirroring serious pathology, carpet testing for some vague symptoms till patient is medically labelled)(BMJ Evidence-Based Medicine February 2018 | volume 23 | number 1). These terms assume importance when we look at the previously published data for out-of-pocket medical expenditure by patients with medical care. A recent study revealed that healthcare spending pushes 3.5 to 6.2% of Indian population below poverty line every year (BMC Public Health19, 1020; 2019). In another study using National Sample Survey Organization (NSSO) data, odds of falling below poverty line were 38% higher for persons hospitalized with cardiovascular disease as compared to communicable disease (Engelgau MM, Karan A, Mahal A. The Economic impact of Noncommunicable Diseases on households in India. Global Health 2012; 8: 9). Importantly, spread of covid 19 is already forcing every hospital or healthcare institute for rationing of medical care and many hospital-based practices including tests and procedures routinely performed before covid 19 catastrophe have suddenly become redundant and avoidable( by Wang X & Bhatt DL in J of Invasive Cardiology 2020; 32 (4): E81-E84).

Since most hospitals are not currently teaming up with non covid patients, the burden of pervasive hospital acquired antibiotic resistance pathogens is also likely to ebb. Past data had shown that 7% of patients from developed countries and 10% from developing countries suffer from hospital acquired nosocomial infections at any given time totaling hundreds of millions worldwide every year (https://www.who.int/gpsc/country_ work/gpsc_ccisc_fact_sheet_en.pdf). This unintended break in continuum of hospital care is a valuable opportunity to sanitize all those hospitals which are not involved in active patient care of covid patients. In addition, medical research (mostly repetitive or redundant) in tertiary institutes has also come to standstill which will save patients from avoidable investigations and additional visits just for the sake of data collection. Finally, it is a rare medical touch point where patients are not being reprimanded by medical healthcare providers for delayed health care seeking and mutually participative healthcare actively guided by doctors on phones has become a new buzzword.

Advantages of emerging public health practices

With widespread practice of hand washing which has now emerged as a globally cherished pastime of human race, it can play a protective role against surge of bacterial infections during ongoing summer season. Also, if this forced ritual becomes a habit (very likely due to so many weeks of rigorous daily practice), the trend for community acquired bacterial infections is likely to be further blunted for longer duration. Food borne illnesses like typhoid, shigellosis and bacterial infections like staphylococcus are going to see notable fall in coming peak season. Worm infestations of children where dirty hands are the key culprit are also likely to recess as well. Recent emphasis on use of warm/hot water for repeated drinking as a guard against covid 19 will certainly play key role in stonewalling common waterborne illness like cholera and hepatitis A or E. Stringent guidelines for not coughing or sneezing in public with widespread use of masks will further stymie the spread of viral infections like measles, mumps, rubella as well as other flu viruses including H1N1.

Advantages of accompanying lockdown

Orthopaedic, neurosurgery and trauma wards are no more brimming with injured patients. It is quite apparent that trauma due to road traffic accidents and criminal acts is almost negligible during the lockdown.

With the rapidly accumulating evidence of fall in pollution levels of air, most medical professionals are going to see far a smaller number of acute exacerbations of asthma in children as well as adults. The impact of improving air quality on the incidence of other respiratory illnesses, cardiovascular disorders as well as lung cancer will be very interesting to monitor in near future.

Earlier most of the urban population was spending time indoors in the air-conditioned offices, cabs, metros or even homes. This lifestyle had morphed almost whole human race into vitamin D endemic species. Fortunately, with strictly imposed lockdown, people are forced to spend good amount of their daytime in the lawns, rooftops, balconies or corridors. Though there may be many who still are not fortunate to have enough sunlight exposure, yet overall lockdown has come as a blessing in disguise for the health of urban population. Availability of ample opportunities for exposure to sun will replenish the chronically depleted vitamin D stores, again a known immune booster which may be crucial during this time of crisis. Most mothers, wives as well as daughters are rediscovering the time tested and traditional recipes with rich repertoire of macro as well as micro nutrients which will further uplift and fortify the nutritional milieu of families. The typical middle-class penchant for enjoying fried, oily and refined sugar laced foods is also likely to be subdued due to limited availability of raw materials at homes during ongoing lockdown. This will further safeguard their health from risk of obesity and its subsequent health consequences. Renewed interest in intake of seasonal and local fruits available easily is another take-away of lockdown.

Party culture with access to unhealthy food as well as substances of abuse is certainly a nonstarter now. College students compelled to be at home are enjoying freshly prepared healthy home food. Most hostel messes providing nutritionally sub optimal meals are closed.

What will be the fate of NCDs-noncommunicable diseases due to lockdown following covid 19 pandemic? The patients with poor control of diabetes and hypertension are at risk of higher covid 19 morbidity as well as mortality. On the positive side, the fear of contagion itself may provide these high-risk patients further incentive to optimize their compliance with the treatment as well as other lifestyle measures like diet and exercise. Lockdown restrictions will certainly block the easy access of diabetic and hypertensive patients to less healthy outdoor food served at popular restaurants or eating joints- usually a rite of passage for urban population. Moreover, limited accessibility to cold drinks, snacks like chips, burgers, pizzas either directly in the market or through online food delivery services will further play a protective role in controlling the needless intake of sugar and salt in such patients. Additional risk factor increasing the human vulnerability to NCDs is trans fats (mainly embedded in food items available from market). Trans fats are the major offender for worsening metabolic as well as vascular health and during lockdown, they are likely to be replaced by healthy polyunsaturated fats and oils routinely available in the kitchens of most homes.

Substance abuse is one more niche area which is likely to see substantial change in coming weeks. Accessibility to regular supply of substances of abuse especially recreational drugs as well as alcohol are in serious jeopardy due to lockdown. Reports of addicts reporting major withdrawal symptoms are already getting media attention. High risk sexual behaviours as well as free access to red light areas have been restrained to large extent, hence expecting fall in STIs as well as HIV incidence.

Hospital driven care for various psycho social needs have also plummeted considerably. Except for major psychiatric illnesses, patients with common mental or psycho social health issues are clearly opting for either self-management or various alternative modes of care to safeguard their mental or psycho social health. Occupational injuries including those due to noise and light pollution have declined due to industrial shutdown and on long term, hazards of occupational exposure to toxins or poisonous substances will show beneficial trend. In addition, palpable decline in crime rate all over the world will have indirect impacts on the health of people in those high-risk localities, especially the children and women.

Emergence of cost-effective models of healthcare with participatory patient doctor relationship

Role of mobile or e-healthcare has skyrocketed in last few weeks as a surrogate for actual care at hospitals or clinics. The need for digitized medical care cannot be overemphasized in the backdrop of the fact that hospitals and their medical staff are emerging as hotspots of covid infection and are likely to act as super-spreaders. Hence, hospitals or medical care centres are no longer the safest niche for persons with routine sickness and people are, instead, voluntarily opting for tele care through their mobile phones. Also, family doctors as well as local health volunteers are efficiently filling the recent void in medical care. Frankly speaking, the covid pandemic lockdown has catalysed the redux of long-forgotten art of medical practice through either family doctors or local health volunteers in the present heavily institutionalized medical ecosystem. The current phase of covid turmoil is, indeed, a salvageable touch point for public health. Covid 19 has clearly proven that more than 80% of our population just needs a sound public health advice (hand washing, cough hygiene and social distancing), another 10-15% of population needs minimal medical support (like paracetamol) while remaining 5-10% population is salvageable with basic medical support (with oxygen, IV fluids and antibiotics/antimalarials). Importantly, none of them require massive public or private health institutes and well-trained health workers or volunteers are competent enough to deal with it. It is only 1% extreme outlier or even lower percentage of population who will be eligible for intensive healthcare with significant chunk of them unlikely to be salvageable. This model of pyramidal approach where only top 1% will require technically advanced medical care is uniformly applicable to rest of the diseases as well. Given the hierarchical needs of healthcare, a highly cost-effective framework of public health needs to be urgently prioritized over overbearingly technocratic medical science, both among lay public as well as policy makers.

The covid 19 pandemic is probably first instance where doctors are clearly finding themselves as or even more susceptible than their patients whom they treat. Reflecting thoughtfully, covid 19 is showing medical fraternity a mirror to judge their much-vaunted prowess as demigods. Never ever a situation has arrived in modern medicine where doctors find themselves at receiving end in treating patients as currently happening with covid pandemic. There is almost a role reversal where instead of patients fearing their doctor, doctors are fearing their patients. Honestly, this is the greatest humbling moment in the history of modern medicine. Have you ever seen doctors repeatedly and pleadingly begging each and every person for such mundane household chores of washing their hands and keeping social distancing? In the era of robotic surgeries, organ transplantations, stem cell therapies and genomic medicine, isnt it an antithesis to the currently hyped medical armamentarium capable of potentially decimating any disease present in the world? On the other hand, almost every grandmother or nanny has been offering this time-tested household wisdom of regular hand washing (the current front line strategy to prevent covid spread) to the kids since time immemorial.

Surely once the crisis settles, there will be serious contemplation about the heavily distorted medical care pyramid which stands exposed by covid like threats looming over the whole humanity. The heavily institutionalized framework of healthcare has proven to be a limitation both for treating increasing burden of covid patients as well as preventing the further spread of infection. The weakened public health foundation of healthcare landscape is a serious caveat which needs urgent makeover. Importantly, people have this rare opportunity to reboot their demagogy of overarching importance of hospital driven medical realm. Most of our health issues are self-limiting, benign or non-threatening or stress precipitated. Let us reclaim the control of such problems from the hands of medical professionals and set up our own roadmap with active participation of public health institutions. Over-reliance on medicines and treatments is self-defeating and preventive measures need to take centre stage in our daily lives. Luckily, there is a golden opportunity for people to allow natural healing of their bodies as well as minds unconfounded by medical care. Analysis of such data will motivate people to rediscover their self confidence in natural healing of body as well as other alternative sciences of healthcare.

Natures Experiment with Covid Intervention

Looking from natures perspective, it seems that a prospective controlled trial has been implemented in the world? It is not a multi-centric or multi-country, but it is a multi-continental research trial. And the intervention being tested is primum non nocere a Hippocratic oath first, do no harm. The data are being sequentially collected from precovid world (baseline or control phase) and covid affected world (study intervention phase). The precovid world which had been heavily dependent upon modernized medical care for last many decades will provide data for control or baseline phase. For the intervention phase, fresh data are being generated from all major hospitals where non-covid medical care has almost completely halted (a constrained form of primum non nocere). The data of baseline phase are already widely available in literature. The results have shown that nearly one in every 10 patients in developed countries is harmed due to hospital care, 50% of which is preventable (www.who.int features fact files patient_safety). The baseline scenario is more alarming in low- and middle-income countries (LMICs) where hazardous hospital care causes 134 million adverse events leading to 2.6 million deaths every year. Now with a global lockdown due to corona virus pandemic, routine hospital care has almost ceased. Only limited cases are being treated and all resources are diverted towards management of patients with Covid 19 illness. In this scenario, it would be quite revealing to know the magnitude of harm inflicted every year due to medical care. If such data are collated from all over the world throughout the covid pandemic, it would provide a unique and valuable comparative insight about the magnitude of harm posed simply by failure of Hippocratic principle of first do no harm.

Actionable Metrics for future roadmap

Few statistical indicators will certainly offer deep insight into the real need of medical care in our modern society. The sales of medicines, the hospital admission as well as readmission rates, number of diagnostic and therapeutic procedures as well as surgeries performed, healthcare spending, baseline rates of commonly reported hospital illness before and during covid 19 pandemic and final mortality data (both non covid as well as covid related deaths) stratified by age, gender, socioeconomic strata as well as severity of underlying illness will be immensely discerning metrics for policy makers and planners. Interestingly, experts with institutionalized mindset of health care model are attributing recent decline in healthcare demands for non covid illnesses as lull before storm. So far, the post covid Wuhan scenario seems to contradict the lull before storm theory of missing non covid illnesses and there are no alarming media reports that non covid mortality has spiked due to shutdown of most hospitals or clinic based medical centres. However, if things do not show the expected resurgence as fore casted by many experts, then it is high time to reboot the mindset of policy makers as well as public for better, safer, cheaper and simpler healthcare paradigms as well as models of care.

Take home message

It is high time that our highly institutionalized medical profession must cross the Rubicon and commit to Home Based Medical Care (HBMC) and Self-Monitoring (SM) as new paradigms of healthcare. Hopefully, the post covid zeitgeist is going to be marked with patient centric as well as patient driven care aided actively by public health institutions over hospital driven management protocols.

(Disclaimer: The author is Dr Sahul Bharti, MD Pediatrics (PGI, Chandigarh), PDCC Pediatric Endocrinology (SGPGI, Lucknow), Dip Statistics (PU, Chandigarh). He is Sat Pal Mittal National Award winner & founder of research based NGO-Build Healthy India Movement (BHIM). Views expressed are a personal opinion.)

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Lessons for medical profession during management of covid-19 pandemic: Is there a silver lining? - Elets