Surgeon offers innovative treatments – Brunswick News

From a young age, David M. Sedory, MD was focused on making his dream of becoming a doctor into a reality. And he set his course to do just that.

Using an ROTC scholarship, he attended Washington University in St. Louis, Mo., where he completed his undergraduate work. Sedory went on to Case Western Reserve University School of Medicine in Cleveland, Ohio.

I owed the military some time, so when I completed medical school I matched into the orthopedic residency at Brooke Army Medical Center in San Antonio, Texas. I was there for five years, he said.

In 2010, Sedory was stationed at Fort Stewart in Savannah and was deployed to Afghanistan in 2011. He finished out his military career at Hunter Airfield as team surgeon for the Army Rangers, while simultaneously working with Optim Orthopedics, which has a clinic in Brunswick.

Taking care of soldiers, their families and some of the wounded coming back from overseas was an incredible honor, he commented. When youre caring for soldiers in combat, you really have to have a team approach and I have tried to apply some of those philosophies and lessons to my current job with Optim.

Once his military time ended, Sedory transitioned into full-time work as a surgeon with Optim Orthopedics. Today, he specializes in sports medicine, focusing on areas often prone to injury.

I do shoulder, hip, and knee reconstruction. A lot of high-end cartilage repair, as well as joint replacements, he said.

Sedory has long been a noted expert in arthroscopic surgery, especially of the hip. This is a minimally invasive procedure that can treat a number of ailments, including impingement, labral tears, and tendon tears. He has lectured at national meetings and is an instructor at courses for other surgeons trying to learn these techniques.

Hip arthroscopy is mainly aimed at younger, active patients with the majority being between the ages of late teens to early 50s. They have a hip that is causing them pain from a labral tear, impingement or cartilage damage but its not broken down to the point of arthritis or needing a full hip replacement, he explained.

I also treat a lot of older patients with tendon tears around their hips that are causing a lot of pain and function issues. Many of them have been getting the run around for years and have been told that they have bursitis. Often times the underlying problem is actually a tear, much like a rotator cuff tear in the shoulder.

The knee, too, can also present similar deterioration or damage. And, like the hip, new modalities can offer a great deal of relief. Sedory has taken a great interest in cartilage reconstruction and transplantation, which can be used in either the knee or hip. This procedure is also offered to younger patients who have had some previous issues but do not qualify for a full knee replacement.

Ideal candidates for cartilage reconstruction surgery are between the ages of 18 and 50, Sedory commented.

There are a variety of methods for cartilage repair. These include stem cell or biological injections; debridement; microfracture; and implantation of juvenile cartilage to regenerate new cartilage.

Dr. Sedory noted that the cartilage can even be taken from ones own body, regrown in a lab, then implanted during a second surgery. This is known as MACI (matrix-induced autologous cartilage implantation). Cartilage can also be obtained from a healthy tissue donor and implanted in the leg.

These are often combined with other procedures such as ligament reconstruction, meniscus transplantation (replaces the shock absorber in the knee), or osteotomy to correct malalignment, Sedory said.

It is kind of like having the tires on your car wear out from bad alignment; you cant just slap on new tires, you have to fix the underlying stability or alignment problem as well to get the best outcome.

Once the procedure has been completed, most patients go on to spend four to six weeks on crutches followed by several months of physical therapy.

Dr. Sedory treats patients in Savannah and the surrounding area. He is currently expanding his practice in Brunswick. The Optim clinic is located at 1111 Glynco Parkway, off Spur 25, and adjacent to Applecare.

I mostly am seeing hip reconstruction patients. Either for an anterior hip replacement or hip arthroscopy, he said.

But a big part of my practice in Savannah is complex knee reconstruction and cartilage repair. I want patients to know that those are options available to them as well.

To make an appointment with Dr. Sedory, call 912-644-5300 or find out more at optimorthopedics.com

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Health Tech: Dallas-based American Heart Association Awards $14M in Research Grants for Heart, Brain, and COVID-19 Innovation – dallasinnovates.com

Dallas-based American Heart Association (AHA) awarded more than $14 million in scientific research grants for health technology solutions focused on heart and brain health, including special projects related to COVID-19, last week. The grants went to four multidisciplinary teams around the country to create the AHAs 10th Strategically Focused Research Network. The newest network centers on Health Technologies and Innovation.

Consumer adoption of healthcare technology on digital mediums like tablets, smartphones, and wearable devices offer a unique outlet to find new solutions to improve health outcomes, American Heart Association president Robert A. Harrington said in a statement.

The AHA peer review team moved forward with its selection of the centers for its latest strategically focused research network when the COVID-19 pandemic in the U.S. broke. The nonprofit science-based organization knows the times are challenging as it works towards its mission of a culture of health.

It felt this was an incredible opportunity for us to provide additional support in harnessing new innovations to tackle the challenges that are crippling the nation, and frankly the globe, Harrington said.

Grantees that will create the 10th network are research teams at Cincinnati Childrens Hospital, The Johns Hopkins University, Stanford University School of Medicine and the University of Michigan. Each team will receive $2.5 million each for their individual projects aimed at reducing health care disparities, empowering people to better manage their health and wellness, and enhancing patient/provider connectivity, the AHA said.

Collectively the teams will also receive $4 million to work on at least one highly impactful project and form a national Health Technology Research Collaborative, it said. The Collaborative may ultimately serve as an American Heart Association research think tank to assist with identifying, creating, testing and bringing to scale future innovative health technologies.

In addition, each research team also can apply for supplemental research grants of up to $200,000 for rapid action projects to develop technology solutions to address the COVID-19 pandemic, the AHA said. Those projects might provide aid for health care systems, doctors or care providers, first responders, patients or consumers.

These supplemental grants are part of the AHAs $2.5 million commitment to research efforts to better understand this unique coronavirus and its interaction with the bodys cardiovascular and cerebrovascular systems.

The peer review committee has assembled an exceptional network to move this work forward and I want to recognize the dedication and commitment of that panel of many renowned experts, Harrington said. The Association uses an intense, multi-stage review process in selecting the centers for our focused research networks and were very appreciative of the committee members who lend their time and expertise to this critical process.

The AHA program brings together basic, clinical, and population researchers with engineers, IT developers, policy leaders, health care clinicians and patients. That lets the teams improve existing technology, and also identify new and innovative ways to put technology to work in addressing heart and brain health, American Heart Association volunteer James A. Weyhenmeyer, Ph.D. said.

Weyhenmeyer is vice president for research and economic development at Auburn University and chair of the Associations peer review team for the selection of the new grant recipients. Its especially important that all of these projects be focused with an equity-first lens to ensure our most vulnerable populations are being served, he noted.

The AHA is currently funding seven Strategically Focused Research Networks (SFRN) with focuses on Go Red For Women, Heart Failure, Obesity, Children, Vascular Disease, Atrial Fibrillation, and Arrhythmias & Sudden Cardiac Death. Three of AHAs networksPrevention, Hypertension, and Disparitieshave been completed. Locally, the University of Texas Southwestern was a grantee in the completed Prevention SFRN.

With the launch of its newest network, the American Heart Association has invested more than $190 million to establish 12 SFRNs since the program was launched in 2010-2011. The idea behind the science networks is the collaboration of scientists to focus research to address key strategic issues that were identified by the AHAs Board of Directors, in areas such as hypertension, womens health, heart failure, obesity, children, vascular disease, atrial fibrillation, sudden cardiac death, and type 2 diabetes. Each established network centers around the understanding, prevention, diagnosis and treatment of a key research topic. Four to six research centers make up each network, AHA said, which brings together investigators with expertise.

More networks can be expected in 2020 and beyond, AHA said.

The latest projects funded by the $14.5 million in grants commenced on April 1. Here they are, per the AHA:

Active Detection and Decentralized Dynamic Registry to Improve Uptake of Rheumatic Heart Disease Secondary Prevention (ADD-RHD) at Cincinnati Childrens HospitalLed by Andrea Beaton, M.D., a pediatric cardiologist at Cincinnati Childrens Hospital, this team will address the global health issue of rheumatic heart disease which affects more than 40 million people, most living in poor countries or poor areas in wealthier countries. The team will concentrate on getting more people living with rheumatic heart disease into guideline-based care using technology to find more people with rheumatic heart disease, keep them in care and generate the investment case to scale up national rheumatic heart disease action plans in low-income countries. Additionally, theyll be looking for early career doctors and scientists who want to help people get better care using technology and educate this next generation in solutions developed to improve global health in the future. The team consists of a collaborative with the Rheumatic Heart Disease Research Collaborative in Uganda (RRCU) including the Uganda Heart Institute, Childrens National Medical Center and the University of Washington in Seattle; the Cincinnati Childrens Digital Experience and Bioinformatics Centers; Northern Kentucky Universitys Biostatistics Department, Health Innovation Center and Health Sciences Institute; REACH (a global technical organization in rheumatic heart disease) and an industry partnership with Caption Health. While the project and solutions will be made for people living in developing countries, the team hopes to learn a lot about how to help people have better health in the United States.

Center for Mobile Technologies to Achieve Equity in Cardiovascular Health at The Johns Hopkins University in BaltimoreLed by cardiologist Seth Martin, M.D., M.H.S., and neurologist David Newman-Toker, M.D., Ph.D., this teams mission is to leverage mobile and wearable technologies to empower patients and clinicians, enhance the quality of care, increase value and improve the diagnosis and management of heart diseases and stroke. Early and accurate diagnoses are essential to ensure the appropriate delivery of guideline-recommended management to engage patients and their caregivers to achieve the best patient outcomes possible. The collaborative project will span the patient experience from diagnosis to management to improve patient care throughout the patient journey. Specifically, the team will develop and test a smartphone application for stroke diagnosis, following their experience with a goggle-based eye-tracking technology in the Armstrong Institute Center for Diagnostic Excellence. On the management side, the team will work on a virtual cardiovascular rehab that builds on their Corrie Health platform to empower patients in guideline-based prevention. Patients and their families from demographically diverse backgrounds will join as partners in the technology advancement process.

Center for Heart Health Technology (H2T): Innovation to Implementation at Stanford University Led by Mintu Turakhia, M.D. M.A.S., Executive Director of Stanfords Center for Digital Health, associate professor of medicine and a cardiac electrophysiologist at the VA Palo Alto Health Care System, the H2T Centers mission is to rapidly develop technologies that address unmet needs for heart health, evaluate them quickly and then implement these solutions at scale. The team will address the issue of high blood pressure, which affects more than 115 million Americans and costs the U.S. health care system more than $22 billion each year. The team will develop a clinician- and patient-facing digital health system for semi-automated management and evidence-based titration of blood pressure medications. The app will be tested in a randomized trial conducted in Northern California and New Jersey in people of different races, educations, and backgrounds and in a population of gig economy workers (rideshare drivers), who can be at increased risk of heart disease.

Wearables In Reducing Risk and Enhancing Daily Lifestyle (WIRED-L) at the University of MichiganLed by Brahmajee Nallamothu, M.D., M.P.H., a professor in the Division of Cardiovascular Diseases at the University of Michigan, this team plans to establish the Wearables In Reducing risk and Enhancing Daily Lifestyle (WIRED-L) Center dedicated to building and testing mobile health (mHealth) apps that leverage wearables like smartwatches to improve physical activity and nutrition in hypertensive patients. The apps will use just-in-time-adaptive digital interventions to deliver notifications to participants when they are most likely to be responsive using contextual information obtained from their devices. WIRED-L will enroll diverse communities that include African Americans and older adults rarely included in mHealth studies, to better close the digital divide between rich and poor. Additionally, WIRED-L will train a diverse and inclusive set of future leaders in mHealth through a highly integrated program that focuses on the key and complementary areas of clinical trials, data science, and health equity research.

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Hubert Zajicek wants to tap the strong innovation community in North Texas to share know-how, combat shortages, and come up with new solutions during the COVID-19 pandemic.

The Plano-based remote patient monitoring startup is now offering providers a no-cost solution for low-risk patients or those with mild symptoms simply by answering a series of questions.

The collaboration will allow physicians to virtually diagnose medical conditions, heightening safety for everyone.

A professor at the University of North Texas Health Science Center is collaborating with an international team to test whether stem cells can combat COVID-19 pneumonia.

Due to the effects of COVID-19, Southlake-based SmartCounseling is working to reduce costs for mental health services. The company's new platform also allows licensed professionals to expand their services online quickly.

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Metrion Biosciences and International Scientific Consortium Publish Data and New Recommendations for in Vitro Risk Assessment of the Cardiac Safety of…

Part of the US FDAs Comprehensive in vitro Proarrythmia Assay (CiPA) Initiative

Metrion Biosciences Limited (Metrion), the specialist ion channel CRO and drug discovery company, today announced it has contributed to two new peer-reviewed papers under the U.S. Food and Drug Administrations (FDA) CiPA (Comprehensive in vitro Proarrhythmia Assay) initiative. The papers, in Nature Scientific Reports1 and Toxicology and Applied Pharmacology2, focus on application of improved cardiac safety testing protocols and recommendations for best practice for the drug discovery industry.

The CiPA Initiative (www.cipaproject.org), which began in July 2013 following a workshop at the US FDA, has the objective to revise and enhance the regulatory framework assessing cardiac safety of new chemical entities. Under current guidelines, new therapeutics undergo initial assessment of proarrhythmic risk by measuring activity against the hERG cardiac ion channel, before progressing to studies in preclinical animal models and ultimately, a Thorough QT interval study in the clinic. The CiPA initiative aims to extend the use of advances in early electrophysiology-based cardiac ion channel screening, in silico predictive modelling, and human induced pluripotent stem cell derived cardiomyocytes to improve the accuracy and reduce the cost of predicting the cardiac liability of new drug candidates. Metrions research forms part of the first stage of the proposed harmonisation work, to provide clarity on how to standardise cardiac ion channel assays to ensure they deliver consistent data for in silico models of clinical cardiac arrythmia risk.

The first paper1, published in Nature Scientific Reports on 27th March 2020 by an international group of authors drawn from 20 different commercial and academic laboratories, including Metrion Biosciences, was coordinated by the Health and Environmental Sciences Institute (HESI). It reviews data from a multi-year, multi-site collaboration across industry, academia and the FDA regulatory agency to optimize experimental protocols and reduce experimental variability and bias. The goal of the study was to guide the development of best practices for the use of automated patch clamp technologies in early cardiac safety screening. High quality in vitro cardiac ion channel data is required for accurate and reliable characterisation of the risk of delayed repolarisation and proarrhythmia in the human heart and to guide subsequent clinical studies and regulatory submissions.

The second paper2, to be published formally in Toxicology and Applied Pharmacology paper on 1st May 2020 but currently available online, uses automated patch clamp data from the CiPA consortium to address the lack of statistical quantification of variability, which hinders the use of primary hERG potency data to predict cardiac arrhythmia. The consortium establishes a more systematic approach to estimate hERG block potency and safety margins.

Dr Marc Rogers, CSO, Metrion Biosciences, said: "The Metrion team has been a participant in the international CiPA Initiative since inception and we are now pleased to be able to announce the publication of our data from this global collaborative scientific effort. We believe these projects will make a significant contribution to the eventual revision of cardiac safety testing guidelines by the FDA and other international regulatory agencies. They also contribute to deepening our knowledge of the underlying causes of proarrhythmia, which will help prevent early attrition of potentially promising drugs."

Contributing organisations to the Nature Scientific Reports CiPA study include: Charles River Laboratories; Bayer AG; Sophion Bioscience A/S; Nanion Technologies; GlaxoSmithKline PLC; Pfizer; Sanofi R&D; Astra Zeneca; BSYS GmbH; Bristol-Myers Squibb Company; Eurofins Discovery; Merck; Metrion Biosciences Ltd.; Natural and Medical Science Institute at the University of Tbingen; Northwestern Feinberg School of Medicine, Chicago; Roche Innovation Center Basel; Novoheart; Health and Environmental Sciences Institute, Washington, DC; AbbVie.

Contributing organisations to the Toxicology and Applied Pharmacology hERG study include: Center for Drug Evaluation and Research, Food and Drug Administration; Eli Lilly and Company; AstraZeneca; CiPA LAB; NMI-TT GmbH; Sophion Bioscience A/S; B'SYS GmbH; The Ion Channel Company; F. Hoffmann-La Roche AG; Eurofins Discovery; Bristol-Myers Squibb; Merck & Co., Inc; Metrion Biosciences Ltd.; Nanion Technologies; Charles River Laboratories; Bayer AG; University of Nottingham; Universit de Lille.

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BioIVT Opens New Blood Donor Center to Support Boston-area Research into COVID-19 Therapies, Vaccines and Diagnostics – Salamanca Press

WESTBURY, N.Y., April 6, 2020 /PRNewswire/ --BioIVT, a leading provider of research models and services for drug and diagnostic development, today announced the opening of its new blood donor center on the Tufts University campus in Medford, MA to support academic and pharmaceutical researchers involved in COVID-19, cell and gene therapy research.

"BioIVT wants to play a leading role in supporting COVID-19 research efforts and blood donations are a vital resource for the research and development of new therapies, vaccines, and diagnostics. We have many years' experience developing blood products, including blood-derived immune cells for cell and gene therapy research, and we want to make that expertise count," said BioIVT CEO Jeff Gatz. "Researchers recognize and appreciate BioIVT's rapid response and commitment to high quality, fresh blood products and this new donor center will allow us to offer those attributes and services to additional US clients."

BioIVT's new Boston blood donor center is its seventh. The company has similar facilities located in California, Tennessee and Pennsylvania to serve US clients and in London, UK for EU-based clients.

"While the initial focus at our Boston donor center will be on delivering fresh blood, leukopaks and buffy coats within hours of collection, we plan to add more capabilities and donors over time," said Jeff Widdoss, Vice President of Donor Center Operations at BioIVT.

Leukopaks, which contain concentrated white blood cells, are used to help identify promising new drug candidates, assess toxicity levels, and conduct stem cell and gene therapy research. They are particularly useful for researchers who need to obtain large numbers of leukocytes from a single donor.

BioIVT blood products can be supplied with specific clinical data, such as the donor age, ethnicity, gender, BMI and smoking status. Its leukopaks are also human leukocyte antigen (HLA), FC receptor and cytomegalovirus typed. HLA typing is used to match patients and donors for bone marrow or cord blood transplants. FC receptors play an important role in antibody-dependent immune responses.

COVID-19-related Precautions Blood donor centers are considered essential businesses and will remain open during the COVID-19 quarantine. BioIVT is taking additional safety measures to protect both blood donors and its staff during this difficult time. It has instituted several social distancing measures, including increasing the space between chairs in the waiting room and between donor beds, and limiting the entrance of non-essential personnel. The screening rooms are disinfected between donors and all areas of the center continue to be cleaned at regular intervals.

As soon as each blood donor signs their informed consent form, their temperature is taken. If they have a fever, their appointment is postponed, and they are referred to their physician. Any donor who develops COVID-19 symptoms after donating blood is required to inform the center immediately.

All BioIVT blood collections are conducted under institutional review board (IRB) oversight and according to US Food and Drug Administration (FDA) regulations and American Association of Blood Banks (AABB) guidelines.

Those who would like to donate blood at BioIVT's new Boston-area donor center should call 1-833-GO-4-CURE or visit http://www.biospecialty.com to make an appointment.

Further information about the products available from BioIVT's new donor center can be found at https://info.bioivt.com/ma-donor-ctr-req.

About BioIVTBioIVT is a leading global provider of research models and value-added research services for drug discovery and development. We specialize in control and disease-state biospecimens including human and animal tissues, cell products, blood and other biofluids. Our unmatched portfolio of clinical specimens directly supports precision medicine research and the effort to improve patient outcomes by coupling comprehensive clinical data with donor samples. Our PHASEZERO Research Services team works collaboratively with clients to provide target and biomarker validation, phenotypic assays to characterize novel therapeutics, clinical assay development and in vitro hepatic modeling solutions. And as the premier supplier of hepatic products, including hepatocytes and subcellular fractions, BioIVT enables scientists to better understand the pharmacokinetics and drug metabolism of newly-discovered compounds and their effects on disease processes. By combining our technical expertise, exceptional customer service, and unparalleled access to biological specimens, BioIVT serves the research community as a trusted partner in elevating science. For more information, please visit http://www.bioivt.com or follow the company on Twitter @BioIVT.

BioIVT Contact: Courtney Noah, SVP, Marketing & Client Services, 516-483-1196Media Contact: Lisa Osborne, Rana Healthcare Solutions, 206-992-5245, lisa@ranahealth.com

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Rafarma Establishes Advisory Board, Appoints First Member and Will Acquire Additional Patents and Intellectual Property – GlobeNewswire

Ljubljana, Slovenia, April 06, 2020 (GLOBE NEWSWIRE) -- RAFARMA PHARMACEUTICALS INC. OTC:(RAFA) - In establishing its Advisory Board, Rafarma Pharmaceuticals announces the appointment of its first board member, Vladislav N. Laskavy, PhD., who will begin advising the company and assisting with the development of multiple treatment options as the company rolls out detox spas throughout Thailand and Europe. Dr. Laskavy is a well-known research scientist and has worked on numerous research projects studying Cancer, Autoimmune Deficiency, Viral Diseases, AIDS and many other diseases and treatments. Rafarma will also enter into non-dilutive agreements with Dr. Laskavy to acquire all of his intellectual property and patents, including multiple United States, Australian and other International patents which include patents for cancer treatment and stem cell therapy.

The addition of Dr. Laskavy enables Rafarma to add multiple treatment options to the companys current Medicinal Marijuana treatment protocols. Rafarma CEO Vladimir Dolgolenko stated: We feel the addition of Dr. Vladislav Laskavy to our advisory board will assist us in providing truly unique treatment options at our cutting-edge detox spas. We have an aggressive growth plan to implement our detox spas all throughout Thailand and Europe. With the current research from our Thailand partners and the new addition of Dr. Laskavy, we feel we will be able to provide an amazing health experience to our customers and patients.

One of the new products Rafarma plans to roll out in its spas will be XR. XR belongs to a new class of immunomodulating drugs that contribute to the activation of an antigen-specific immune response, the development of which eliminates the infectious agent. More details and specifications for use of this drug will be released as the company moves forward. Rafarma is also excited to implement its own stem cell activation therapy using Dr. Laskavys patented techniques throughout the spas. All of the acquisitions will take place under agreements that will not cause dilution to the current holdings of the existing shareholders of Rafarma.

Dr. Laskavy stated: I am very excited to be a part of the Rafarma Pharmaceuticals team and I look forward to the progress we can make treating those in need of help. Rafarma expects the addition of Dr. Laskavy and his expertise to greatly enhance its current medical marijuana treatment offerings as well as other ground-breaking treatments to help people live healthier and stronger lives.

Forward-Looking Statements: This press release contains forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934. Except for historical matters contained herein, statements made in this press release are forward-looking statements. Without limiting the generality of the foregoing, words such as may, will, to, plan, expect, believe, anticipate, intend, could, would, estimate, or continue, or the negative other variations thereof or comparable terminology are intended to identify forward-looking statements. Forward-looking statements involve known and unknown risk, uncertainties and other factors which may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Also, forward-looking statements represent our managements beliefs and assumptions only as of the date hereof. Additional information regarding the factors that may cause actual results to differ materially from these forward-looking statements is available in the Company's filings with OTC Markets. Except as required by law, we assume no obligation to update these forward-looking statements publicly or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future.

For more information contact:RAFARMA(307) 429-2029

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Rafarma Establishes Advisory Board, Appoints First Member and Will Acquire Additional Patents and Intellectual Property - GlobeNewswire

Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market Size, Growth Analysis, Opportunities, Trends, Developments and Forecast to 2026 -…

New Jersey, United States:The Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market is analyzed in depth in the report, with the primary aim of providing accurate market data and useful recommendations so that players can achieve strong growth in the future. The report is compiled by experts and experienced market analysts, which makes it very authentic and reliable. Readers have a thorough analysis of historical and future market scenarios to get a good understanding of market competition and other important issues. The report provides comprehensive information on market dynamics, key segments, key players and various regional markets. It is a complete set of in-depth analysis and research on the Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies market.

The authors of the report highlighted lucrative business prospects, eye-catching trends, regulatory situations and Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies market price scenarios. It is important to note that the report includes a detailed analysis of the macroeconomic and microeconomic factors affecting the growth of the Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies market. It is divided into several sections and chapters so that you can easily understand every aspect of the Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies market. Market participants can use the report to take a look at the future of the Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies market and make significant changes to their operating style and marketing tactics in order to achieve sustainable growth.

The Global Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market is growing at a faster pace with substantial growth rates over the last few years and is estimated that the market will grow significantly in the forecasted period i.e. 2019 to 2026.

Key Players Mentioned in the Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market Research Report:

The competitive landscape of the Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies market is examined in detail in the report, with a focus on the latest developments, the future plans of the main players and the most important growth strategies that they have adopted. The analysts who have written the report have drawn a picture of almost all the main players in the Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies market and highlighted their crucial commercial aspects such as production, areas of activity and product portfolio. All companies analyzed in the report are examined on the basis of important factors such as market share, market growth, company size, production volume, turnover and profit.

Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market: Segmentation

The report provides an excellent overview of the key Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies market segments, focusing on their CAGR, market size, market share and potential for future growth. The Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies market is mainly divided by product type, application and region. Each segment in these categories is the subject of in-depth research to familiarize yourself with its growth prospects and key trends. The segment analysis is very important to identify the most important growth pockets of a global market. The report provides specific information on market growth and demand for various products and applications so that players can focus on profitable sectors of the Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies market.

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Table of Content

1 Introduction of Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology of Verified Market Research3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market Outlook4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market, By Deployment Model5.1 Overview

6 Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market, By Solution6.1 Overview

7 Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market, By Vertical7.1 Overview

8 Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market, By Geography8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Stem Cell And Platelet Rich Plasma (PRP) Alopecia Therapies Market Competitive Landscape9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix11.1 Related Research

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Fate Inks $100M Deal With Janssen for Stem Cell-Derived Cancer Therapies – Xconomy

XconomySan Diego

Fate Therapeutics has signed an agreement with Janssen Biotech to develop new cancer cell therapies that are derived from stem cells and landed $100 million up front as part of the global collaboration deal.

The San Diego-based biotech has built a pipeline of experimental cell therapies that use induced pluripotent stem cells (iPSCs) to create chimeric antigen receptor (CAR) T-cell and CAR natural killer (NK) cell treatments. Fate (NASDAQ: FATE) has used iPSCs to make clonal cell lines that it likens to the cell lines used to create make monoclonal antibodies and other drugs.

Sourcing material for cell therapies this way is meant to reduce the manufacturing challenges associated with currently available cell therapy products. The two FDA-approved cell therapies, CAR-Ts, use a patients own living cells. Off-the-shelf versions in development, which use cells from healthy donors, face similar obstacles when it comes to cost-effective mass production, including variability between batches.

Janssen will provide Fate with proprietary antigen-binding domains for up to four targets associated with antigens that are overexpressed on tumors. Fate will use them to research and develop new preclinical iPSC-derived cell therapy candidates, both CAR-T-cell and CAR NK cell product candidates. Janssen will reimburse Fate for that R&D work.

Once a candidate is submitted to the FDA for permission to move into the clinic, Janssen will have the option to exclusively license it.

SVB Leerink analyst Daina Graybosch, in a research note, called the deal a major validation of Fates regenerative medicine platforms. The agreement also removes near-term cash concerns for Fate at a time when clinical research across the biotech industry is being delayed by COVID-19 disruptions, she wrote.

Under the deal terms, Fate gets $50 million in cash and $50 million from a sale of newly issued shares of its stock to Janssen parent company Johnson & Johnson (NYSE: JNJ) at $31 per share, a 47 percent premium over Fates closing price Thursday of $21.07 apiece.

The deal makes Fate eligible for payments of up to $1.8 billion tied to development and regulatory milestones and up to $1.2 billion if candidates are commercialized, plus royalties. The company also retains the option to co-commercialize each collaboration candidate in the US.

Fates stock price popped about 9 percent on the news Friday, reaching nearly $23 per share as of market close.

Previous collaborations Fate has struck include a 2018 deal with Japans Ono Pharmaceutical for joint development and commercialization of two off-the-shelf iPSC-derived CAR-Ts, and a four-year deal to help Juno Therapeutics (now part of Bristol Myers Squibb) find small molecules to enhance its T-cell immunotherapies, an agreement that concluded last year.

Fate, which launched in 2007, has four of its own iPSC-derived cell therapies in Phase 1 testing: two targeting blood cancers and two designed to treat advanced solid tumors.

The company also has three iPSC programs in preclinical testing, and two in research. Two of the preclinical programs are on track to be submitted to the FDA for its OK to move into the clinic in the second quarter of this year, Fate said.

In addition, the biotech has developed off-the-shelf cell therapies not derived from iPSCs that use NK cells from healthy donors modified to improve their biological properties and therapeutic function, but according to the companys latest annual report, it doesnt plan to further develop those therapies.

Since its initial public offering in 2013, the company has raised about $363 million across three stock sales, the most recent in September 2019.

Image: iStock/seb_ra

Sarah de Crescenzo is an Xconomy editor based in San Diego. You can reach her at sdecrescenzo@xconomy.com.

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Fate Inks $100M Deal With Janssen for Stem Cell-Derived Cancer Therapies - Xconomy

Mesoblast’s remestemcel-L receives FDA IND clearance for treating COVID-19 patients with acute respiratory distress – Small Caps

Regenerative medicine company Mesoblast (ASX: MSB) has received US Food and Drug Administration Investigational New Drug (IND) clearance for its remestemcel-L treatment to be used in COVID-19 patients presenting with acute respiratory distress syndrome.

According to Mesoblast chief medical officer Dr Fred Grossman, the FDA IND approval now enables US-based COVID-19 patients with poor prognosis to be treated with remestemcel-L under compassionate usage grounds and in a planned randomised controlled trial.

Remestemcel-L is an anti-inflammatory treatment that has been developed for use in various inflammatory conditions including steroid-refractory acute graft versus host disease.

Mesoblast claims the drug works by counteracting the inflammatory processes in these diseases by down-regulating the production of pro-inflammatory cytokines, while boosting production of anti-inflammatory cytokines and enabling recruitment of the ant-inflammatory cells to the involved tissues.

To-date, the safety and therapeutic impact of remestemcel-L intravenous infusions have been evaluated in over 1,100 patients in clinical trials.

In a phase 3 trial, remestemcel-L was found useful in treating acute graft versus host disease, which Mesoblast claims produces a similar cytokine storm process as seen in COVID-19 patients with acute respiratory distress syndrome.

Additionally, post hoc analysis of a previous study involving 60 patients with chronic obstructive pulmonary demonstrated remestemcel-L significantly improved respiratory function in patients with the same elevated inflammatory biomarkers that are also seen in COVID-19 acute respiratory distress syndrome patients.

COVID-19 patients most at risk of developing acute respiratory distress syndrome include the elderly and those with co-morbidities such as diabetes.

According to Mesoblast, patients with COVID-19 that have developed acute respiratory distress syndrome have an almost 50% fatality rate.

Remestemcel-L is an allogeneic mesenchymal stem cell product, with preliminary data from China indicating allogeneic mesenchymal stem cells have either cured or significantly improved functional outcomes for seven patients with COVID-19 in the small trial.

By mid-morning trade, Mesoblasts shares were up almost 30% to $1.74.

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Mesoblast's remestemcel-L receives FDA IND clearance for treating COVID-19 patients with acute respiratory distress - Small Caps

Stem Cell Therapy for Colon Cancer – The Ritz Herald

An article published in Experimental Biology and Medicine(Volume 245, Issue 6, March 2020)examines the safety of stem cell therapy for the treatment of colon cancer.The study, led by Dr. J. Liu in the State Key Laboratory of Bioreactor Engineering and Shanghai Key Laboratory of New Drug Design at the East China University of Science and Technology in Shanghai (China), reports that mesenchymal stem cells from a variety of sources promote the growth and metastasis of colon cancer cells in an animal model.

Mesenchymal stem (MSCs), a category of adult stem cells, are being evaluated as a therapy for numerous cancers.MSCs are excellent carriers for tumor treatment because they migrate to tumor tissues, can be genetically modified to secrete anticancer molecules and do not elicit immune responses.Clinical trials have shown that MSCs carrying modified genes can be used to treat colon cancer as well as ulcerative colitis. However, some studies have demonstrated MSCs can differentiate into cancer-associated fibroblasts and promote tumor growth.Therefore, additional studies are needed to evaluate the safety of MSCs for targeted treatment of colon cancer.

In the current study, Dr. Liu and colleagues examined the effects of mesenchymal stem cells (MSCs) from three sources (bone marrow, adipose, and placenta) on colon cancer cells.MSCs from all three sources promoted tumor growth and metastasis in vivo. In vitro studies demonstrated that MSCs promote colon cancer cell stemness and epithelial to mesenchymal transition, which would enhance tumor growth and metastasis respectively.Finally, the detrimental effects of MSCs could be reversed by blocking IL-8 signaling pathways. Dr. Ma, a co-author of the study, said that Mesenchymal stem cells have a dual role: promoting and/or suppressing cancer. Which effect is dominant depends on the type of tumor cell, the tissue source of the MSC and the interaction between the MSC and the cancer cell. This is the major issue in the clinical application research of MSCs, and additional preclinical experimental data will be needed to evaluate the safety of MSCs for colon cancer treatment.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology & Medicine, said: Lui and colleagues have performed elegant studies on the impact of mesenchymal stem cells (MSCs), from various sources, upon the proliferation, stemness, and metastasis of colon cancer stem cells (CSCs) in vitro and in vivo. They further demonstrate that IL-8 stimulates the interaction between colon CSCs and MSCs, and activates the MAPK signaling pathway in colon CSCs.This provides a basis for the further study of MSCs as a biologic therapy for colon cancer.

Experimental Biology and Medicine is a global journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. The journal was first established in 1903. Experimental Biology and Medicine is the journal of the Society of Experimental Biology and Medicine. To learn about the benefits of society membership, visit sebm.org.

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Stem Cell Therapy for Colon Cancer - The Ritz Herald

Symtomax: the science behind producing high quality medical cannabis – Health Europa

Indeed, such research has enabled consumers to look beyond the assumption that all forms of cannabis will make them high an assumption attributed to tetrahydrocannabinol (THC), the psychoactive compound within the cannabis plant. Now, non-psychoactive compounds such as Cannabidiol (CBD) are starting to enter consumer markets in a variety of products such as vapes, edibles, and dietary supplements.

However, the cannabis plant (Cannabis Sativa), has not solely been used for recreational purposes. For thousands of years, cannabis has been used in ancient medicine for its pain-relieving qualities. At the present time, medical research has suggested that cannabinoids can be used by a large number of patients worldwide to lessen the symptoms of conditions as wide-ranging as anxiety and Parkinsons disease, to migraines and multiple sclerosis.

With the prevalence of medicinal cannabis on the up, the cannabis industry is changing, which begs the question how is it produced, and what should we as an industry be doing to ensure that the manufacture of medicinal cannabis is always of the highest possible quality?

Many would point towards cultivation as an important factor in the production of high-quality medicinal cannabis.

In order for medical cannabis to thrive, certain environmental conditions are required for optimal growth; these include overall air quality, genetics, adequate light, temperature, humidity, soil and water quality.

There is a reason that California in particular is hailed as a hub for the medical cannabis industry; its greatest asset is its warm climate, rich soil and abundant sunlight all which make the outdoor production of high-quality cannabis a viable prospect. This of course is a very similar climate to Portugal, where Symtomax have started the development of their medical cannabis cultivation facility, an enormous 105-hectare site in the Alentejo region of the country.

Of course, similar conditions can be replicated using greenhouses, where ventilation then becomes the most crucial factor. The right ventilation prevents the growth of mildew, or mould, and overheating, so an intake and outtake fan on the ceiling or the top of the grow room are required for adequate ventilation.

Likewise, temperature is also a crucial factor. The ideal temperature for a medical cannabis plant to grow tends to be between 20 and -30 degrees Celsius; such conditions mean they are able to grow stronger and thicker stems, with denser buds. At temperatures below 15 degrees Celsius, plant growth begins to slow, so it is crucial that this is monitored closely.

Indeed, more and more companies are understanding the benefits in investing in state-of-the-art greenhouses, to create the best conditions for cannabis growth. For example, Symtomax has recently begun work on new greenhouses with advanced engineering work to ensure all cannabis plants receive optimal growing conditions.

However, producing the highest quality medicinal cannabis doesnt stop at the growing stage. Indeed, given the vast array of potential health benefits, experts are always in the process of conducting new studies into the cannabis plant itself, so that manufacturers and health professionals alike can better understand its properties. In particular, research into lesser known cannabinoids and the qualities they possess are key drivers in the improvement of medicinal cannabis quality.

CBD (cannabidiol) is one of the most common compounds (also known as a cannabinoid), and has been found to possess anti-inflammatory, calming and pain-relieving properties due to its interactions with the serotonin receptors on the brain. As it stands, there is insufficient evidence for CBD to be formally recognised as medicine; that said new studies are emerging every day and consequently, more consumers are experimenting with various CBD products, including oil or edible supplements to relieve ailments.

However, there is more to the cannabis plant than CBD. In recent years, the focus of research is shifting towards other compounds, such as CBG (cannabigerol) and TCHV (tetrahydrocannabivarin). CBG in particular has shown promise as an antibacterial agent and its anti-inflammatory properties. Known widely as the stem cell of cannabis, but despite its vast medical appeal and health benefits, the compound is notoriously expensive to produce.

Consequently, CBG is not readily available for the consumer market, meaning that the majority are largely unaware of its potential benefits. That said, with more research being conducted into this cannabinoid, the tides could change over the coming years.

Increasingly, formulation technologies, which act as a bridge between the active components (such as CBD or THC) and the finished products (like CBD oil), are playing an important role in the development of cannabinoid products. Proper formulation strategies lead to products with increased efficacy, better dose control, decreased variability, and increased patient acceptance.

So, knowing the best extraction processes for the right cannabinoids is vital in ensuring the high quality of a product. Likewise, a solid grounding in how different combinations of compounds will most benefit consumers is fundamental to new innovations and discoveries within the industry.

Already, expertise surrounding different formulation technologies have resulted in some exciting innovations. For example, the Symtomax CBD oral tab, which is built on a thin film and adheres to the inside of the cheek. The proprietary technology releases cannabinoids in a controlled, timed manner through the lining of the mouth. Oral Tab can be developed to release doses at different times, so that this method is a practical option for both those needing an instant dose, and those requiring a slower release, over a longer timeframe. The flexibility of time release is therefore improved, as is the quantity of CBD available to enter the blood stream, therefore contributing to better efficiency and systemic absorption rate than any other delivery methods available at present.

All in all, although medicinal cannabis is still a young industry in the western world, and naturally, there is still much research to be done in order to dispel pre-existing taboos and prove its efficacy, there is a lot to be said for its increasing popularity. I look forward to seeing how the industry, and indeed the products, advance over the coming years.

Paul Segal is the Chairman & co-founder of Symtomax. Symtomax have been approved by Infarmed to start the development of Europes largest medical cannabis facility. The organisation is dedicated to the production, research, cultivation, processing and distribution of medicinal cannabis oil to pharmaceutical companies worldwide.

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Symtomax: the science behind producing high quality medical cannabis - Health Europa