Stem Cell Therapy for Charcot-Marie-Tooth DiseaseMay 26th, 2015

By Like Wu, Xiaojuan Wang, Sherry Xi, Bo Cheng, Susan Chu

Wu Medical Center

The patient is 34-year-old female. She was presented with involuntary movement of fingers and extremities prior weakness for the past 13 years without any apparent cause. The disease progressed gradually. She had nerve biopsy and gene analysis at a local hospital and was diagnosed with Charcot-Marie-Tooth disease (CMT). She took vitamins without any improvement. Her four limbs were weak. Her balance was bad. She always falls because of bad balance and lower limbs weakness. She had difficulty to hold objects. The distal ends of four limbs were depauperated, numbness and painful.

Physical examination: The general examination was normal. Her speech and spirit was good. The cranial nerves was normal. The distal ends of four limbs were depauperated. The proximal end muscle power of both upper limbs was at level 4, the distal ends muscle power of both upper limbs was at level 3, and the muscle power of all fingers was at level 3-. The proximal end muscle power of both lower limbs was at level 4. The distal ends muscle power of both lower limbs was at level 3. The muscle tension of four limbs was normal. The tendon reflex of four limbs disappeared, the pathology sign was negative. The deep and shallow sensation of her four limbs distal ends were not good.

Diagnosis: Charcot-Marie-Tooth disease (CMT)

Treatment target: Replace the heredodegeneration nerve cells with normal stem cells to repair the nerves, improve the nerve function, and also to improve equilibrium function and motor function.

Treatment procedure and results: We gave the patient 4 times neural stem cells (NSCs) and 4 times mesenchymal stem cells (MSCs) implantation treatment. The stem cells were activated in the patients body to repair the nerve damage. Together with nourishment of the neurons, improvement of circulation and regulating the immune, daily rehabilitation training was incorporated. During the treatment, the patient was happy, had a regular eating and sleeping pattern. With our doctors help, she was able to complete the treatment. After the treatment, the patient had significant improvement, her four limbs had less pain, numbness and weakness. Her exercise tolerance was better. The proximal end muscle power of both upper limbs was at level 5-. The distal ends muscle power of both upper limbs was at level 4, the muscle power of all fingers was at level 4-. The proximal end muscle power of both lower limbs was at level 5-. The distal ends muscle power of both lower limbs was at level 4-. Her balance and coordinate movement were better. Her life had been noticeably improved.

Charcot-Marie-Tooth disease (CMT) is also called Hereditary Motor and Sensory Neuropathy (HMSN), it has visible heredity. The main clinical characteristics: the distal ends of four limbs has progressive weakness, atrophia and sensory disturbance. CMT is one of the most common hereditary peripheral neuropathy (the incidence is around 1/2500). CMT is classified two types according to clinical and electrophysiological characteristics; CMT1 (demyelinating type) and CMT2 (axon type).

The patient had this disease when she was growing up, and the disease progressed slowly. She gradually had four limbs weakness, the distal ends of four limbs were depauperated, hypesthesia, tendon reflex of four limbs disappeared and balance disturbance. All the accessory examinations supported the diagnosis.

The rest is here:
Charcot-Marie-Tooth Disease - Wu Medical Center - A ...