Postdoctoral positions are immediately available in the laboratory of Dr. Jian Xu, in the Childrens Research Institute of UTSouthwestern Medical Center to study the epigenetic regulation of normal and malignant blood stem cell development. Our laboratory focuses on the intersection of transcriptional control with stem cell biology, hematopoiesis and cancer. We employ epigenetics, functional genomics, genome editing, and mouse genetics to define epigenetic and genetic programs controlling blood stem cell development, and how these processes go awry in cancer progression. By comparing the ontogeny of gene networks in normal and neoplastic hematopoiesis, we aim to understand how non-coding regulatory genome, lineage-specifying regulators, and epigenetic modulators cooperate to control developmental potency, and how aberrations lead to cancer development. The laboratory is equipped with cutting-edge genomics and bioinformatics platforms, and has access to numerous shared facilities including metabolomics, imaging, and flow cytometry. Our laboratory brings together enthusiastic scientists with diverse backgrounds, and provides a wide range of perspectives in a multi-disciplinary and collaborative team setting. Please refer to our representative publications for details about the ongoing research: Nature 460:1093-1097; Science 334:993-996; Cell, 151:929-931; Dev Cell, 23:796-811; Mol Cell, 57:304-316; Cell Stem Cell 14:68-80; NEJM, 365:807-814; G&D 23:2824-2838.

The successful candidate must hold a Ph.D. and/or M.D. degree with a strong background in mouse genetics, blood cell development and disorders, molecular biology, or a related field. The ideal candidate will exhibit independence, flexibility and creativity with a record of scientific productivity. Previous experience in generating and analyzing mouse models, epigenetics, genomic engineering, and/or hematology-oncology is strongly preferred.

To apply please submit CV, a short summary of research interest and experience, and a list of three references to:

Jian Xu, PhD

Assistant Professor, Childrens Research Institute

CPRIT Scholar in Cancer Research

American Society of Hematology Scholar

UT Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, TX 75390-8502

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Postdoctoral position in Stem Cell Development and Cancers