What is so neat about PRP is how it works. Years ago, scientists unraveled some of the action mechanisms in the lab, and what was found is that the PDGF (platelet derived growth factor) activates pericytes. Later it was discovered that these pericytes were unactivated mesenchymal stem cells. Once these cells become activated, they act as general directors of healing and regeneration and release a myriad of cytokines and other factors that have trophic, anti-inflammatory, mitogenic, anti-scarring, and anti-infection attributes. In the case of the dental implants, osteoblasts were activated by the pericytes to realize improved bony in-growth of the implants. This action has been confirmed by laboratory investigations. In the case of osteoarthritis of the knee, the cartilage that is lost as an after-effect of the normal ageing process is not regrown but the environment is altered so that there is less pain, and less further loss of the knee cartilages. In many respects it alters the progression or worsening of the disease, and it is hoped by many that surgeries, such as knee replacements, are delayed or avoided all together. Today, PRP is used in many areas of medicine in the US and Europe for treating musculoskeletal problems, plastics, aesthetics, dermatology, general surgery, ENT, rheumatology, primary care, pain management, and physical medicine and rehabilitation. Negative side effects and complications are uncommon as with many current treatments and medications in use today.

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Stem Cell - Dr. Humeira Badsha Medical Center