Joint Oncology/IRDB Imperial Seminar Series, Thursday 24.03.22 @ 13.30, hosted by Dr David MacIntyre.

We are delighted to have Professor Ten Feizi, Director of The Glycosciences Laboratory, Faculty of Medicine, Department of Metabolism, Digestion and Reproduction at Imperial College.

Professor Feizi gained her MB BS in 1961 and MD in 1969 at the Royal Free Hospital Medical School. Thereafter, she held fellowships from MRC and US Arthritis Foundation as guest investigator in the laboratories of Richard Krause and Henry Kunkel at Rockefeller University, and Elvin A Kabat at Columbia Medical Center in New York.

In 1985, Ten Feizi and colleagues introduced the innovative neoglycolipid (NGL) technology for linking a glycan sequence to a lipid molecule as a means of immobilization on matrices and probing for binding by diverse glycan recognition systems. In 2002, this became the basis of the first glycoarray system designed to encompass entire glycomes. This is currently still the most diverse glycoarray system in the world, revolutionizing the molecular dissection of glycan-recognition systems in health, in infectious and inflammatory disorders and cancer. Notable among the assignments are the host cell attachment sites for simian virus 40 (SV40),Toxoplasma gondiiand the pandemic A(H1N1) 2009 influenza virus; elucidation of the structures of F77, the elusive prostate cancer antigen; and R10G a marker of induced human pluripotent stem cells.

More here:
Technologies and tools to decipher cell surface glycans as onco-developmental and stem cell markers of man and mouse - Imperial College London