Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391405.

Article CAS PubMed Google Scholar

Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022;140:120028.

Article CAS PubMed PubMed Central Google Scholar

Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia. 2022;36:170319.

Article PubMed PubMed Central Google Scholar

Voso MT, Falconi G, Fabiani E. Whats new in the pathogenesis and treatment of therapy-related myeloid neoplasms. Blood. 2021;138:74957.

Article CAS PubMed Google Scholar

Kuzmanovic T, Patel BJ, Sanikommu SR, Nagata Y, Awada H, Kerr CM, et al. Genomics of therapy-related myeloid neoplasms. Haematologica. 2020;105:e98101.

Article PubMed PubMed Central Google Scholar

McNerney ME, Godley LA, Le Beau MM. Therapy-related myeloid neoplasms: when genetics and environment collide. Nat Rev Cancer. 2017;17:51327.

Article CAS PubMed PubMed Central Google Scholar

Kayser S, Dhner K, Krauter J, Khne CH, Horst HA, Held G, et al. The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML. Blood. 2011;117:213745.

Article CAS PubMed Google Scholar

Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, et al. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature. 2015;518:5525.

Article CAS PubMed Google Scholar

Al Hamed R, Bazarbachi AH, Malard F, Harousseau JL, Mohty M. Current status of autologous stem cell transplantation for multiple myeloma. Blood Cancer J. 2019;9:44.

Article PubMed PubMed Central Google Scholar

Nadiminti K, Sidiqi MH, Meleveedu K, Alkhateeb HB, Hogan WJ, Litzow M, et al. Characteristics and outcomes of therapy-related myeloid neoplasms following autologous stem cell transplantation for multiple myeloma. Blood Cancer J. 2021;11:63.

Article PubMed PubMed Central Google Scholar

Sevilla J, Rodrguez A, Hernndez-Maraver D, de Bustos G, Aguado J, Ojeda E, et al. Secondary acute myeloid leukemia and myelodysplasia after autologous peripheral blood progenitor cell transplantation. Ann Hematol. 2002;81:1115.

Article CAS PubMed Google Scholar

Nagata Y, Makishima H, Kerr CM, Przychodzen BP, Aly M, Goyal A, et al. Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes. Nat Commun. 2019;10:5386.

Article PubMed PubMed Central Google Scholar

Kalaycio M, Rybicki L, Pohlman B, Sobecks R, Andresen S, Kuczkowski E, et al. Risk factors before autologous stem-cell transplantation for lymphoma predict for secondary myelodysplasia and acute myelogenous leukemia. J Clin Oncol. 2006;24:360410.

Article PubMed Google Scholar

Metayer C, Curtis RE, Vose J, Sobocinski KA, Horowitz MM, Bhatia S, et al. Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a multicenter case-control study. Blood. 2003;101:201523.

Article CAS PubMed Google Scholar

Hosing C, Munsell M, Yazji S, Andersson B, Couriel D, de Lima M, et al. Risk of therapy-related myelodysplastic syndrome/acute leukemia following high-dose therapy and autologous bone marrow transplantation for non-Hodgkins lymphoma. Ann Oncol. 2002;13:4509.

Article CAS PubMed Google Scholar

Beauchamp-Nicoud A, Feneux D, Bayle C, Bernheim A, Lonard C, Koscielny S, et al. Therapy-related myelodysplasia and/or acute myeloid leukaemia after autologous haematopoietic progenitor cell transplantation in a prospective single centre cohort of 221 patients. Br J Haematol. 2003;122:10917.

Article PubMed Google Scholar

Micallef IN, Lillington DM, Apostolidis J, Amess JA, Neat M, Matthews J, et al. Therapy-related myelodysplasia and secondary acute myelogenous leukemia after high-dose therapy with autologous hematopoietic progenitor-cell support for lymphoid malignancies. J Clin Oncol. 2000;18:94755.

Article CAS PubMed Google Scholar

Jaiswal S, Ebert BL. Clonal hematopoiesis in human aging and disease. Science. 2019;366:eaan4673.

Article CAS PubMed PubMed Central Google Scholar

Weeks LD, Niroula A, Neuberg D, Wong W, Lindsley RC, Luskin M, et al. Prediction of risk for myeloid malignancy in clonal hematopoiesis. NEJM Evid. 2023;2:EVIDoa2200310.

Article Google Scholar

Hirsch CM, Nazha A, Kneen K, Abazeed ME, Meggendorfer M, Przychodzen BP, et al. Consequences of mutant TET2 on clonality and subclonal hierarchy. Leukemia. 2018;32:175161.

Article CAS PubMed PubMed Central Google Scholar

Patel BJ, Przychodzen B, Thota S, Radivoyevitch T, Visconte V, Kuzmanovic T, et al. Genomic determinants of chronic myelomonocytic leukemia. Leukemia. 2017;31:281523.

Article CAS PubMed PubMed Central Google Scholar

Coombs CC, Zehir A, Devlin SM, Kishtagari A, Syed A, Jonsson P, et al. Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and associated with adverse clinical outcomes. Cell Stem Cell. 2017;21:37482.e374.

Article CAS PubMed PubMed Central Google Scholar

Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, et al. Prediction of acute myeloid leukaemia risk in healthy individuals. Nature. 2018;559:4004.

Article CAS PubMed PubMed Central Google Scholar

Guermouche H, Ravalet N, Gallay N, Deswarte C, Foucault A, Beaud J, et al. High prevalence of clonal hematopoiesis in the blood and bone marrow of healthy volunteers. Blood Adv. 2020;4:35507.

Article PubMed PubMed Central Google Scholar

Kewan T, Durmaz A, Bahaj W, Gurnari C, Terkawi L, Awada H, et al. Molecular patterns identify distinct subclasses of myeloid neoplasia. Nat Commun. 2023;14:3136.

Article CAS PubMed PubMed Central Google Scholar

Benard BA, Leak LB, Azizi A, Thomas D, Gentles AJ, Majeti R. Clonal architecture predicts clinical outcomes and drug sensitivity in acute myeloid leukemia. Nat Commun. 2021;12:7244.

Article CAS PubMed PubMed Central Google Scholar

Kewan T, Bahaj W, Durmaz A, Aly M, Ogbue OD, Carraway HE, et al. Validation of the Molecular International Prognostic Scoring System in patients with myelodysplastic syndromes. Blood. 2023;141:176872.

Article CAS PubMed PubMed Central Google Scholar

Mouhieddine TH, Sperling AS, Redd R, Park J, Leventhal M, Gibson CJ, et al. Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant. Nat Commun. 2020;11:2996.

Article CAS PubMed PubMed Central Google Scholar

Soerensen JF, Aggerholm A, Kerndrup GB, Hansen MC, Ewald IKL, Bill M, et al. Clonal hematopoiesis predicts development of therapy-related myeloid neoplasms post-autologous stem cell transplantation. Blood Adv. 2020;4:88592.

Article CAS PubMed PubMed Central Google Scholar

Husby S, Favero F, Nielsen C, Srensen BS, Bch J, Grell K, et al. Clinical impact of clonal hematopoiesis in patients with lymphoma undergoing ASCT: a national population-based cohort study. Leukemia. 2020;34:325668.

Article CAS PubMed Google Scholar

Gibson CJ, Lindsley RC, Tchekmedyian V, Mar BG, Shi J, Jaiswal S, et al. Clonal hematopoiesis associated with adverse outcomes after autologous stem-cell transplantation for lymphoma. J Clin Oncol. 2017;35:1598605.

Article CAS PubMed PubMed Central Google Scholar

Lackraj T, Ben Barouch S, Medeiros JJF, Pedersen S, Danesh A, Bakhtiari M, et al. Clinical significance of clonal hematopoiesis in the setting of autologous stem cell transplantation for lymphoma. Am J Hematol. 2022;97:153847.

Article CAS PubMed Google Scholar

Gramegna D, Bertoli D, Cattaneo C, Almici C, Re A, Belotti A, et al. The role of clonal hematopoiesis as driver of therapy-related myeloid neoplasms after autologous stem cell transplantation. Ann Hematol. 2022;101:122737.

Article CAS PubMed Google Scholar

Soerensen JF, Aggerholm A, Rosenberg CA, Bill M, Kerndrup GB, Ebbesen LH, et al. Clonal evolution in patients developing therapy-related myeloid neoplasms following autologous stem cell transplantation. Bone Marrow Transpl. 2022;57:4605.

Article CAS Google Scholar

Genovese G, Khler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014;371:247787.

Article PubMed PubMed Central Google Scholar

Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014;371:248898.

Article PubMed PubMed Central Google Scholar

Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, et al. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. Blood. 2015;126:916.

Article CAS PubMed PubMed Central Google Scholar

Diamond BT, Ziccheddu B, Maclachlan KH, Taylor J, Boyle EM, Arango Ossa JE, et al. Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures. Blood 2023;19:235971.

Gurnari C, Pagliuca S, Prata PH, Galimard JE, Catto LFB, Larcher L, et al. Clinical and molecular determinants of clonal evolution in aplastic anemia and paroxysmal nocturnal hemoglobinuria. J Clin Oncol. 2023;41:13242.

Article CAS PubMed Google Scholar

Hsu JI, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, et al. PPM1D mutations drive clonal hematopoiesis in response to cytotoxic chemotherapy. Cell Stem Cell. 2018;23:70013.e706.

Article CAS PubMed PubMed Central Google Scholar

Stelmach P, Richter S, Sauer S, Fabre MA, Gu M, Rohde C, et al. Clonal hematopoiesis with DNMT3A and PPM1D mutations impairs regeneration in autologous stem cell transplant recipients. Haematologica. 2023;108:330820.

Article CAS PubMed PubMed Central Google Scholar

Voso MT, Pandzic T, Falconi G, Deni-Fekete M, De Bellis E, Scarfo L, et al. Clonal haematopoiesis as a risk factor for therapy-related myeloid neoplasms in patients with chronic lymphocytic leukaemia treated with chemo-(immuno)therapy. Br J Haematol. 2022;198:10313.

Article CAS PubMed Google Scholar

Read the original here:
Clonal hematopoiesisderived therapy-related myeloid neoplasms after autologous hematopoietic stem cell transplant ... - Nature.com