NEW HAVEN, Conn., May 15, 2020 (GLOBE NEWSWIRE) -- Kleo Pharmaceuticals, Inc., a leading company in the field of developing next-generation, fully synthetic bispecific compounds designed to emulate or enhance the activity of biologics, today announced preclinical data for the companys lead program, KP1237 in combination with autologous, cytokine-induced, memory-like (CIML) natural killer (NK) cells with low dose IL-2 in multiple myeloma (MM). KP1237 is a CD38-targeting antibody recruiting molecule (ARMTM). These data, to be presented as a poster at the 2020 American Society of Clinical Oncology (ASCO) Annual Meeting being held May 2931, will support the initiation of an upcoming Phase 1/2 clinical trial for MM patients receiving an autologous stem cell transplant (ASCT), who remain minimum residual disease positive (MRD+)
This research, in collaboration with Dr. Rizwan Romee, Director of the Haploidentical Donor Transplantation Program at the Dana Farber Cancer Institute, will be presented as a poster and highlight the activity of the combination of KP1237 with CIML NK cells against CD38-expressing MM target cells. Several in vitro and ex vivo experiments show how KP1237 targets the NK cell therapy to the tumor cells and increases their cytotoxicity. These data led to the clinical exploration of this combination product in the high unmet medical need population of multiple myeloma patients who are MRD+ pre-ASCT.
These data mark an important milestone for the ARM platform as we advance towards the first clinical trials for our growing company, said Doug Manion, Kleos Chief Executive Officer and Chairman of the Board. Initiation of these trials will allow us to demonstrate clinical proof of concept and, ultimately, facilitate the expansion of our technology platforms across indications. Additionally, this milestone moves us closer to our primary goal of having a meaningful impact on patient survival and quality of life.
ARMs are unique, bispecific molecules composed of two active ends connected by a linker. One of the ends binds to a target molecule on a cancer cell, while the other end can bind to and thus recruit all endogenous IgG antibodies circulating in the body, which then bind to and activate NK cells. Therefore, ARMTM molecules behave similarly to chimeric antigen receptors to target immune cells to tumors, though their synthetic nature eliminates the need for genetic engineering of the cells. KP1237, by targeting CD38 expressed on the surface of multiple myeloma cells, facilitates NK-cell mediated killing of these tumor cells. The modular design enable ARMTM molecules to be broadly applicable as targeting tolls for all types of NK cell products across a range of tumor types.
Details of the poster presentation are as follows:
Title: A first-in-class ex vivo combination between cytokine-induced memory like (CIML) NK cells and a CD38 targeting antibody recruiting molecule (ARM) as a novel approach to target NK cells without cellular engineering for the treatment of multiple myeloma.Session: Hematologic MalignanciesPlasma Cell DyscrasiaAbstract: #8523
This ASCO abstract is now available at https://meetinglibrary.asco.org/record/187657/abstract. The poster presentation will include additional data not available in the abstract.
About Kleo Pharmaceuticals, Inc.
Kleo Pharmaceuticals is a unique biotechnology company developing next-generation, bispecific compounds designed to emulate or enhance the activity of biologics based on the groundbreaking research of its scientific founder Dr. David Spiegel at Yale University. Kleos compounds are designed to direct the immune system to destroy cancerous or virally infected cells and are currently in development for the treatment of various diseases, including multiple myeloma and COVID-19. Compared to biologics, Kleos compounds are smaller and more versatile, leading to potentially improved safety and efficacy. They are also much faster and more efficient to design and produce, particularly against novel targets. Kleo develops drug candidates based on its proprietary technology platforms, all of which are modular in design and enable rapid generation of novel immunotherapies that can be optimized against specified biological targets and combined with existing cell- or antibody-based therapies. These include Antibody Recruiting Molecules (ARMs) and Monoclonal Antibody Therapy Enhancers (MATEs). Biohaven Pharmaceutical Holding Company (NYSE:BHVN) and PeptiDream Inc. (Nikkei:PPTDF) are investors in Kleo Pharmaceuticals. For more information visit http://kleopharmaceuticals.com.
Forward-Looking StatementsThis news release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements involve substantial risks and uncertainties, including statements that are based on the current expectations and assumptions of the Company's management. All statements, other than statements of historical facts, included in this press release regarding the Company's plans and objectives, expectations and assumptions of management are forward-looking statements. The use of certain words, including the words "estimate," "project," "intend," "expect," "believe," "anticipate," "will, "plan," "could," "may" and similar expressions are intended to identify forward-looking statements. The forward-looking statements are made as of this date and the Company does not undertake any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.
CONTACT INFORMATION
LifeSci Advisors (Investors)
Irina Koffler
646-970-4681
Kleo Pharmaceuticals (Press)
Brian Dowd, PhD
203-390-9375
- SIRA: Could Stem Cell Therapy Renew Your Body Cells? - Private ... [Last Updated On: April 23rd, 2011] [Originally Added On: April 23rd, 2011]
- Stem Cell Series: Part 1 [Last Updated On: August 4th, 2011] [Originally Added On: August 4th, 2011]
- Huntington's Disease: Stem Cell Treatment Strategies at UC Davis [Last Updated On: August 4th, 2011] [Originally Added On: August 4th, 2011]
- Tianjin heart hospital the largest in Asia with stem cell treatment as well.mp4 [Last Updated On: August 4th, 2011] [Originally Added On: August 4th, 2011]
- Researchers hope stem cell treatment can improve heart healing [Last Updated On: August 4th, 2011] [Originally Added On: August 4th, 2011]
- Testimonial for Fetal Stem Cell Treatment of Duchenne Muscular Dystrophy [Last Updated On: August 5th, 2011] [Originally Added On: August 5th, 2011]
- MS Views and News Podcast - Stem Cell Treatment [Last Updated On: August 6th, 2011] [Originally Added On: August 6th, 2011]
- Duchenne's Muscular Dystrophy Stem Cell Treatment - Reelabs India [Last Updated On: August 7th, 2011] [Originally Added On: August 7th, 2011]
- Stem cell treatment for Macular Degeneration - Graham Leach [Last Updated On: August 7th, 2011] [Originally Added On: August 7th, 2011]
- The New World of Medicine: Stem Cell Therapy [Last Updated On: August 8th, 2011] [Originally Added On: August 8th, 2011]
- Stem Cell Treatment for Cerebral Palsy (Periventricular Leukomalacia) [Last Updated On: August 8th, 2011] [Originally Added On: August 8th, 2011]
- Medra Inc - Breakthrough Stem Cell Treatment [Last Updated On: August 9th, 2011] [Originally Added On: August 9th, 2011]
- Patricia VS Autism: Adult Stem Cell Treatment Part 1 [Last Updated On: August 10th, 2011] [Originally Added On: August 10th, 2011]
- Stem Cell Treatment for Multiple Sclerosis - Community Outreach San Diego: Xenia C. [Last Updated On: August 10th, 2011] [Originally Added On: August 10th, 2011]
- Stem Cell Treatment for Cerebral Palsy at the XCell-Center in Germany [Last Updated On: August 11th, 2011] [Originally Added On: August 11th, 2011]
- Bone Marrow Aspiration - Stem Cell Therapy [Last Updated On: August 13th, 2011] [Originally Added On: August 13th, 2011]
- Dr. William Rader - Breakthrough Stem Cell Treatment [Last Updated On: August 13th, 2011] [Originally Added On: August 13th, 2011]
- Clinical Advances in Adult Stem Cell Therapy - Dr. Jorge Paz Rodriguez (Miami) [Last Updated On: August 14th, 2011] [Originally Added On: August 14th, 2011]
- Stem cell treatment on horse a success, vet says [Last Updated On: August 15th, 2011] [Originally Added On: August 15th, 2011]
- Patricia VS Autism: Adult Stem Cell Treatment Part 2 [Last Updated On: August 15th, 2011] [Originally Added On: August 15th, 2011]
- Adult Stem Cell Therapy Clinical Advances - Dr. Jorge Paz in San Diego, CA March 2011 [Last Updated On: August 17th, 2011] [Originally Added On: August 17th, 2011]
- Dr. Ulrich Friedrichson, Geneticist, and Stem Cell Therapy pioneer [Last Updated On: August 19th, 2011] [Originally Added On: August 19th, 2011]
- Bone Marrow Stem Cells/Gene Therapy [Last Updated On: August 19th, 2011] [Originally Added On: August 19th, 2011]
- Regenerative Medicine With Stem Cell Therapy Injections at an Arizona pain clinic (602) 507-6550 [Last Updated On: August 19th, 2011] [Originally Added On: August 19th, 2011]
- Diabetes - Stem Cell Treatment [Last Updated On: August 21st, 2011] [Originally Added On: August 21st, 2011]
- Stem Cell Treatments for Autism: Community Outreach Miami, Florida - Juliana Ubinas [Last Updated On: August 22nd, 2011] [Originally Added On: August 22nd, 2011]
- Post Stem Cell Therapy Testimony of Cerebral Palsy [Last Updated On: August 26th, 2011] [Originally Added On: August 26th, 2011]
- VetCell's StemRegen - the original and best stem cell therapy for equine tendon injuries [Last Updated On: August 26th, 2011] [Originally Added On: August 26th, 2011]
- Stem cell treatment cures blind girl. More at http://www.stemcellfusion.com [Last Updated On: August 30th, 2011] [Originally Added On: August 30th, 2011]
- ALS Patient Interview, Stem Cell Treatments and ALS www.stemcellregenmed.com [Last Updated On: September 1st, 2011] [Originally Added On: September 1st, 2011]
- Stem Cell Treatment for Rheumatoid Arthritis - "I got my life back" [Last Updated On: September 1st, 2011] [Originally Added On: September 1st, 2011]
- Stem Cell Treatment for Autism: Community Outreach Miami, Florida - May 2011 [Last Updated On: September 2nd, 2011] [Originally Added On: September 2nd, 2011]
- Rylea returns home after stem cell treatment in China [Last Updated On: September 3rd, 2011] [Originally Added On: September 3rd, 2011]
- Stem Cell Treatments and ALS - www.StemCellRegenMed.com [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- Patient with ALS Receiving Stem Cell Treatment - www.StemCellRegenMed.com [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Stem Cell Therapy Success [Last Updated On: September 6th, 2011] [Originally Added On: September 6th, 2011]
- Lisa Ray Opens Up About Her Stem Cell Treatment Experience [Last Updated On: September 17th, 2011] [Originally Added On: September 17th, 2011]
- Repair Your Joint Injuries With Stem Cell Therapy | Los Angeles | Beverly Hills | Hollywood [Last Updated On: September 18th, 2011] [Originally Added On: September 18th, 2011]
- What could stem cell therapy do for Peyton? [Last Updated On: September 21st, 2011] [Originally Added On: September 21st, 2011]
- Peyton Manning Stem Cell Therapy: Some Doctors Cry Foul Over European Treatment [Last Updated On: September 22nd, 2011] [Originally Added On: September 22nd, 2011]
- Adickes: Stem cell therapy [Last Updated On: September 27th, 2011] [Originally Added On: September 27th, 2011]
- Webinar 1, Stem cell therapy basics, what is available today? [Last Updated On: September 30th, 2011] [Originally Added On: September 30th, 2011]
- Stem Cell Treatment for Leukemia at UCH [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Testimonial 4 of Duchenne Muscular Dystrophy after Stem Cell Therapy [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- The Spinal Cord Journey - Stem cell therapy stories from three spinal cord injury patients [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- Parkinson Stem Cell Treatment [Last Updated On: October 7th, 2011] [Originally Added On: October 7th, 2011]
- " Embryonic" and "Adult" Stem Cell Research explained by David Kupelian [Last Updated On: October 11th, 2011] [Originally Added On: October 11th, 2011]
- Stem Cell Treatment for Heart Failure [Last Updated On: October 12th, 2011] [Originally Added On: October 12th, 2011]
- Stem Cell Therapy for Sickle Cell Anemia - Video [Last Updated On: October 14th, 2011] [Originally Added On: October 14th, 2011]
- Stem Cell Therapy Skin Repair and Anti-Wrinkle Cream - Video [Last Updated On: October 14th, 2011] [Originally Added On: October 14th, 2011]
- Stem Cell Treatment for Multiple Sclerosis - Community Outreach, San Diego: David Oliver - Video [Last Updated On: October 15th, 2011] [Originally Added On: October 15th, 2011]
- Spinal Cord Injury Patient after Stem Cell Treatment - Juan Carlos Murillo - Video [Last Updated On: October 16th, 2011] [Originally Added On: October 16th, 2011]
- Macular degeneration - Stem Cell therapy (English subtitles) - Video [Last Updated On: October 18th, 2011] [Originally Added On: October 18th, 2011]
- stem cell research - Video [Last Updated On: October 18th, 2011] [Originally Added On: October 18th, 2011]
- Diabetes- Stem cell therapy (english) - Video [Last Updated On: October 19th, 2011] [Originally Added On: October 19th, 2011]
- First Spinal-Cord Surgery With Stem Cells - Video [Last Updated On: October 21st, 2011] [Originally Added On: October 21st, 2011]
- The Skin Gun - Video [Last Updated On: October 23rd, 2011] [Originally Added On: October 23rd, 2011]
- Heart Congestion Failure- stem cell therapy (english) - Video [Last Updated On: October 24th, 2011] [Originally Added On: October 24th, 2011]
- Improvement seen in Duchenne Muscular Dystrophy after Stem Cell Therapy - Video [Last Updated On: October 24th, 2011] [Originally Added On: October 24th, 2011]
- Joseph, Friedreich's Ataxia, before stem cell treatment at Tiantan Puhua Hospital Beijing - Video [Last Updated On: October 25th, 2011] [Originally Added On: October 25th, 2011]
- Ataxia - Stem Cell Treatment TV Special (Part 1) - Video [Last Updated On: October 25th, 2011] [Originally Added On: October 25th, 2011]
- COPD and Stem Cell Treatments - www.StemCellRegenMed.com - Video [Last Updated On: October 26th, 2011] [Originally Added On: October 26th, 2011]
- Rheumatoid Arthritis Stem Cell Treatment - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- Stem Cells Repair Joint Cartilage - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- Soon stem cell cure for hearing loss - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- Extra: The Promise of Stem Cell Treatment - Video [Last Updated On: October 28th, 2011] [Originally Added On: October 28th, 2011]
- Batten Disease: Spotlight on Stem Cell Research - A Father's Story - Video [Last Updated On: October 28th, 2011] [Originally Added On: October 28th, 2011]
- Stem cell treatment by Adiva Health Care India after Spinal Cord Injury - Video [Last Updated On: October 29th, 2011] [Originally Added On: October 29th, 2011]
- Macular Degeneration: Spotlight on Stem Cell Research - Mark Humayun - Video [Last Updated On: October 29th, 2011] [Originally Added On: October 29th, 2011]
- Stem Cells to Treat Acne Scarring | Los Angeles | Hollywood | Beverly Hills - Video [Last Updated On: October 30th, 2011] [Originally Added On: October 30th, 2011]
- Stem Cell Treatment Kidney Failure - Video [Last Updated On: November 5th, 2011] [Originally Added On: November 5th, 2011]
- Stem Cell Miracle From Cord Blood - Video [Last Updated On: November 7th, 2011] [Originally Added On: November 7th, 2011]
- Stem Cell Therapy: Psoriatic Arthritis Treatment - Video [Last Updated On: November 8th, 2011] [Originally Added On: November 8th, 2011]
- Deafness: Spotlight on Stem Cell Research - Karen Doyle - Video [Last Updated On: November 9th, 2011] [Originally Added On: November 9th, 2011]
- Daniel Deeter Testimonial for Fetal Stem Cell Treatment at Kyiv, Ukraine - Video [Last Updated On: November 12th, 2011] [Originally Added On: November 12th, 2011]
- Stem Cell Treatment Fibromyalgia - Video [Last Updated On: November 13th, 2011] [Originally Added On: November 13th, 2011]
- Stem Cell Treatment Kidney Disease - Video [Last Updated On: November 14th, 2011] [Originally Added On: November 14th, 2011]
- Heart patient sees results in stem cell study - Video [Last Updated On: November 15th, 2011] [Originally Added On: November 15th, 2011]
- Heart health: Patient's own stem cells repaired damage - Video [Last Updated On: November 15th, 2011] [Originally Added On: November 15th, 2011]
- StemCellTV Daily Report-November 15, 2011 - Video [Last Updated On: November 16th, 2011] [Originally Added On: November 16th, 2011]