Mesenchymal stem cell based therapies for uveitis: a systematic review of preclinical studies | Eye – Nature.com


Wakefield D, Chang JH. Epidemiology of uveitis. Int Ophthalmol Clin. 2005;45:113.

Article PubMed Google Scholar

Miserocchi E, Fogliato G, Modorati G, Bandello F. Review on the worldwide epidemiology of uveitis. Eur J Ophthalmol. 2013;23:70517.

Article PubMed Google Scholar

Babu K, Mahendradas P. Medical management of uveitis - current trends. Indian J Ophthalmol. 2013;61:27783.

Article PubMed PubMed Central Google Scholar

Zhao PT, Zhang LJ, Shao H, Bai LL, Yu B, Su C, et al. Therapeutic effects of mesenchymal stem cells administered at later phase of recurrent experimental autoimmune uveitis. Int J Ophthalmol. 2016;9:13819.

PubMed PubMed Central Google Scholar

Li J, Qiu C, Zhang Z, Yuan W, Ge Z, Tan B, et al. Subretinal transplantation of human amniotic epithelial cells in the treatment of autoimmune uveitis in rats. Cell Transpl. 2018;27:150414.

Article Google Scholar

Zhang L, Zheng H, Shao H, Nian H, Zhang Y, Bai L, et al. Long-term therapeutic effects of mesenchymal stem cells compared to dexamethasone on recurrent experimental autoimmune uveitis of rats. Investig Ophthalmol Vis Sci. 2014;55:556171.

Article CAS Google Scholar

Margiana R, Markov A, Zekiy AO, Hamza MU, Al-Dabbagh KA, Al-Zubaidi SH, et al. Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review. Stem Cell Res Ther. 2022;13:366.

Article CAS PubMed PubMed Central Google Scholar

Kanda P, Davis DR. Cellular mechanisms underlying cardiac engraftment of stem cells. Expert Opin Biol Ther. 2017;17:112743.

Article CAS PubMed Google Scholar

Levy O, Kuai R, Siren EMJ, Bhere D, Milton Y, Nissar N, et al. Shattering barriers toward clinically meaningful MSC therapies. Sci Adv. 2020;6:eaba6884.

Article CAS PubMed PubMed Central Google Scholar

Li Y, Ren X, Zhang Z, Duan Y, Li H, Chen S, et al. Effect of small extracellular vesicles derived from IL-10-overexpressing mesenchymal stem cells on experimental autoimmune uveitis. Stem Cell Res Ther. 2022;13:100.

Article CAS PubMed PubMed Central Google Scholar

Wei W, Ao Q, Wang X, Cao Y, Liu Y, Zheng SG, et al. Mesenchymal stem cell-derived exosomes: a promising biological tool in nanomedicine. Front Pharm. 2020;11:590470.

Article CAS Google Scholar

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.

Article PubMed PubMed Central Google Scholar

Kung J, Chiappelli F, Cajulis OO, Avezova R, Kossan G, Chew L, et al. From systematic reviews to clinical recommendations for evidence-based health care: validation of Revised Assessment of Multiple Systematic Reviews (R-AMSTAR) for grading of clinical relevance. Open Dent J. 2010;4:8491.

PubMed PubMed Central Google Scholar

Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLEs risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14:43.

Article PubMed PubMed Central Google Scholar

McHugh ML. Interrater reliability: the kappa statistic. Biochem Med. 2012;22:27682.

Article Google Scholar

Zhang X, Ren X, Li G, Jiao C, Zhang L, Zhao S, et al. Mesenchymal stem cells ameliorate experimental autoimmune uveoretinitis by comprehensive modulation of systemic autoimmunity. Investig Ophthalmol Vis Sci. 2011;52:314352.

Article CAS Google Scholar

Tasso R, Ilengo C, Quarto R, Cancedda R, Caspi RR, Pennesi G. Mesenchymal stem cells induce functionally active T-regulatory lymphocytes in a paracrine fashion and ameliorate experimental autoimmune uveitis. Investig Ophthalmol Vis Sci. 2012;53:78693.

Article CAS Google Scholar

Qin Y, Chan AM, Chang YL, Matynia A, Kouris NA, Kimbrel EA, et al. Human embryonic stem cell-derived mesenchymal stromal cells decrease the development of severe experimental autoimmune Uveitis in B10.RIII Mice. Ocul Immunol Inflamm. 2018;26:122836.

Article CAS PubMed Google Scholar

Oh JY, Kim TW, Jeong HJ, Lee HJ, Ryu JS, Wee WR, et al. Intraperitoneal infusion of mesenchymal stem/stromal cells prevents experimental autoimmune uveitis in mice. Mediat Inflamm. 2014;2014:624640.

Article Google Scholar

Li G, Yuan L, Ren X, Nian H, Zhang L, Han ZC, et al. The effect of mesenchymal stem cells on dynamic changes of T cell subsets in experimental autoimmune uveoretinitis. Clin Exp Immunol. 2013;173:2837.

Article CAS PubMed PubMed Central Google Scholar

Lee HJ, Ko JH, Jeong HJ, Ko AY, Kim MK, Wee WR, et al. Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells. J Immunol. 2015;194:363445.

Article CAS PubMed Google Scholar

Ko JH, Lee HJ, Jeong HJ, Kim MK, Wee WR, Yoon SO, et al. Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye. Proc Natl Acad Sci USA. 2016;113:15863.

Article CAS PubMed Google Scholar

Chen X, Shao H, Zhi Y, Xiao Q, Su C, Dong L, et al. CD73 pathway contributes to the immunosuppressive ability of mesenchymal stem cells in intraocular autoimmune responses. Stem Cells Dev. 2016;25:33746.

Article PubMed Google Scholar

Mu Y, Xu W, Liu J, Wang Y, Chen J, Zhou Q. Mesenchymal stem cells moderate experimental autoimmune uveitis by dynamic regulating Th17 and Breg cells response. J Tissue Eng Regen Med. 2022;16:2635.

Article CAS PubMed Google Scholar

Bai L, Shao H, Wang H, Zhang Z, Su C, Dong L, et al. Effects of mesenchymal stem cell-derived exosomes on experimental autoimmune uveitis. Sci Rep. 2017;7:4323.

Article PubMed PubMed Central Google Scholar

Kang M, Choi JK, Jittayasothorn Y, Egwuagu CE. Interleukin 35-Producing exosomes suppress neuroinflammation and autoimmune uveitis. Front Immunol. 2020;11:1051.

Article CAS PubMed PubMed Central Google Scholar

Shigemoto-Kuroda T, Oh JY, Kim DK, Jeong HJ, Park SY, Lee HJ, et al. MSC-derived extracellular vesicles attenuate immune responses in two autoimmune murine models: Type 1 diabetes and uveoretinitis. Stem Cell Rep. 2017;8:121425.

Article CAS Google Scholar

Caspi RR. Experimental autoimmune uveoretinitis in the rat and mouse. Curr Protoc Immunol. 2003;15:15.16.120.

Google Scholar

Horai R, Caspi RR. Cytokines in autoimmune uveitis. J Interferon Cytokine Res. 2011;31:73344.

Article CAS PubMed PubMed Central Google Scholar

Foussat A, Gregoire S, Clerget-Chossat N, Terrada C, Asnagli H, Lemoine FM, et al. Regulatory T Cell therapy for uveitis: a new promising challenge. J Ocul Pharm Ther. 2017;33:27884.

Article CAS Google Scholar

Muthu S, Bapat A, Jain R, Jeyaraman N, Jeyaraman M. Exosomal therapy-a new frontier in regenerative medicine. Stem Cell Investig. 2021;8:7.

Article CAS PubMed PubMed Central Google Scholar

Nikfarjam S, Rezaie J, Zolbanin NM, Jafari R. Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine. J Transl Med. 2020;18:449.

Article PubMed PubMed Central Google Scholar

Moller-Hansen M, Larsen AC, Toft PB, Lynggaard CD, Schwartz C, Bruunsgaard H, et al. Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease. Ocul Surf. 2021;19:4352.

Article PubMed Google Scholar

Calonge M, Perez I, Galindo S, Nieto-Miguel T, Lopez-Paniagua M, Fernandez I, et al. A proof-of-concept clinical trial using mesenchymal stem cells for the treatment of corneal epithelial stem cell deficiency. Transl Res. 2019;206:1840.

Article PubMed Google Scholar

Ozmert E, Arslan U. Management of retinitis pigmentosa by Whartons jelly derived mesenchymal stem cells: preliminary clinical results. Stem Cell Res Ther. 2020;11:25.

Article CAS PubMed PubMed Central Google Scholar

Galderisi U, Peluso G, Di Bernardo G. Clinical trials based on mesenchymal stromal cells are exponentially increasing: where are we in recent years? Stem Cell Rev Rep. 2022;18:2336.

Article PubMed Google Scholar

Siqueira RC, Messias A, Voltarelli JC, Scott IU, Jorge R. Intravitreal injection of autologous bone marrow-derived mononuclear cells for hereditary retinal dystrophy: a phase I trial. Retina. 2011;31:120714.

Article PubMed Google Scholar

Oner A, Gonen ZB, Sinim N, Cetin M, Ozkul Y. Subretinal adipose tissue-derived mesenchymal stem cell implantation in advanced stage retinitis pigmentosa: a phase I clinical safety study. Stem Cell Res Ther. 2016;7:178.

Article PubMed PubMed Central Google Scholar

Ezquer M, Urzua CA, Montecino S, Leal K, Conget P, Ezquer F. Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice. Stem Cell Res Ther. 2016;7:42.

Article PubMed PubMed Central Google Scholar

Mastrolia I, Foppiani EM, Murgia A, Candini O, Samarelli AV, Grisendi G, et al. Challenges in clinical development of mesenchymal stromal/stem cells: concise review. Stem Cells Transl Med. 2019;8:113548.

Article PubMed PubMed Central Google Scholar

Kharbikar BN, Mohindra P, Desai TA. Biomaterials to enhance stem cell transplantation. Cell Stem Cell. 2022;29:692721.

Article CAS PubMed PubMed Central Google Scholar

Read the rest here:
Mesenchymal stem cell based therapies for uveitis: a systematic review of preclinical studies | Eye - Nature.com

Related Posts